{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:52:12Z","timestamp":1791611532366,"version":"4.3.4"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.intimp.2024.112118","type":"journal-article","created":{"date-parts":[[2024,5,4]],"date-time":"2024-05-04T12:28:01Z","timestamp":1714825681000},"page":"112118","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: Regulation of miR-155 and miR-146a\/BDNF\/ Klotho\/Foxo3a cue"],"prefix":"10.1016","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8372-4682","authenticated-orcid":false,"given":"Amira A.","family":"El-Gazar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-4659","authenticated-orcid":false,"given":"Soad Z.","family":"El-Emam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shorouk","family":"M. El-Sayyad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8151-6778","authenticated-orcid":false,"given":"Shereen S.","family":"El-Mancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar M.","family":"Fayez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin M.","family":"Sheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa K.","family":"Al-Mokaddem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada M.","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0005","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/cells9010245","article-title":"RhoA-ROCK signaling as a therapeutic target in traumatic brain injury","volume":"9","author":"Mulherkar","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0010","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/fampra\/cmq075","article-title":"Sports-related injuries in primary health care","volume":"28","author":"Baarveld","year":"2011","journal-title":"Fam. Pract."},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0015","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/s13311-022-01306-8","article-title":"Tackling Neuroinflammation after traumatic brain injury: complement inhibition as a therapy for secondary injury","volume":"20","author":"van Erp","year":"2023","journal-title":"Neurotherapeutics"},{"issue":"4","key":"10.1016\/j.intimp.2024.112118_b0020","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/biom12040597","article-title":"Cerebral glutamate regulation and receptor changes in perioperative neuroinflammation and cognitive dysfunction","volume":"12","author":"Zhang","year":"2022","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0025","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3390\/pharmaceutics14010152","article-title":"Revisiting excitotoxicity in traumatic brain injury: From bench to bedside","volume":"14","author":"Baracaldo-Santamar\u00eda","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2024.112118_b0030","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neuroscience.2017.10.046","article-title":"The role of microRNA in traumatic brain injury","volume":"367","author":"Pan","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2024.112118_b0035","first-page":"1","article-title":"Recent advances in the role of miRNAs in post-traumatic stress disorder and traumatic brain injury","author":"Zhu","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0040","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3390\/ijms23010090","article-title":"MiR-155: an important regulator of Neuroinflammation","volume":"23","author":"Zingale","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112118_b0045","series-title":"Increase in NF-\u03baB-sensitive miRNA-146a and miRNA-155 in multiple sclerosis (MS) and pro-inflammatory neurodegeneration","first-page":"5","author":"Devier","year":"2015"},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0050","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.3390\/ijms24032584","article-title":"The expression of FOXO3a as a forensic diagnostic tool in cases of traumatic brain injury: an immunohistochemical study","volume":"24","author":"Maiese","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112118_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135882","article-title":"Expression of FOXO transcription factors in the brain following traumatic brain injury","volume":"753","author":"Liu","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.intimp.2024.112118_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135669","article-title":"Altered mRNA expression levels of autophagy-and apoptosis-related genes in the FOXO pathway in schizophrenia patients treated with olanzapine","volume":"746","author":"Gu","year":"2021","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.intimp.2024.112118_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107205","article-title":"Klotho gene might antagonize ischemic injury in stroke rats by reducing the expression of AQP4 via P38MAPK pathway","volume":"32","author":"Zhu","year":"2023","journal-title":"J. Stroke Cerebrovasc. Dis."},{"issue":"9","key":"10.1016\/j.intimp.2024.112118_b0070","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1134\/S0006297917090024","article-title":"Klotho protein: its role in aging and central nervous system pathology","volume":"82","author":"Boksha","year":"2017","journal-title":"Biochem. Mosc."},{"key":"10.1016\/j.intimp.2024.112118_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127149","article-title":"Selenium homeostasis in human brain cells: effects of copper (II) and Se species","volume":"78","author":"Raschke","year":"2023","journal-title":"J. Trace Elem. Med Biol."},{"issue":"9","key":"10.1016\/j.intimp.2024.112118_b0080","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/j.injury.2017.07.005","article-title":"Early selenium treatment for traumatic brain injury: Does it improve survival and functional outcome?","volume":"48","author":"Khalili","year":"2017","journal-title":"Injury"},{"key":"10.1016\/j.intimp.2024.112118_b0085","article-title":"Boswellic acids as promising agents for the management of brain diseases","author":"Rajabian","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.112118_b0090","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jpba.2018.12.018","article-title":"Ex-vivo intestinal absorption study of boswellic acid, cyclodextrin complexes and poloxamer solid dispersions using everted gut sac technique","volume":"167","author":"Tambe","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.intimp.2024.112118_b0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jddst.2017.11.025","article-title":"Enhanced solubility and drug release profile of boswellic acid using a poloxamer-based solid dispersion technique","volume":"44","author":"Tambe","year":"2018","journal-title":"J. Drug Delivery Sci. Technol."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2024.112118_b0100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ijpharm.2014.10.003","article-title":"Optimization of long circulating mixed polymeric micelles containing vinpocetine using simple lattice mixture design, in vitro and in vivo characterization","volume":"477","author":"El-Dahmy","year":"2014","journal-title":"Int. J. Pharm."},{"issue":"5","key":"10.1016\/j.intimp.2024.112118_b0105","first-page":"975","article-title":"Pegylated niosomal nanoparticles loaded with vincristine: Characterization and in vitro evaluation","volume":"16","author":"Mehrabi","year":"2017","journal-title":"Trop. J. Pharm. Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0110","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1080\/21691401.2019.1646265","article-title":"Preparation, characterization and in vitro evaluation of PEGylated nanoliposomal containing etoposide on lung cancer","volume":"47","author":"Zare Kazemabadi","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.intimp.2024.112118_b0115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.colsurfb.2015.11.063","article-title":"X-ray-responsive selenium nanoparticles for enhanced cancer chemo-radiotherapy","volume":"139","author":"Yu","year":"2016","journal-title":"Colloids and Surfaces b: Biointerfaces"},{"key":"10.1016\/j.intimp.2024.112118_b0120","first-page":"3939","article-title":"PEG-nanolized ultrasmall selenium nanoparticles overcome drug resistance in hepatocellular carcinoma HepG2 cells through induction of mitochondria dysfunction","author":"Zheng","year":"2012","journal-title":"Int. J. Nanomed."},{"issue":"11","key":"10.1016\/j.intimp.2024.112118_b0125","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/j.2042-7158.2010.01187.x","article-title":"Microwave induced solubility enhancement of poorly water soluble atorvastatin calcium","volume":"62","author":"Maurya","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112118_b0130","doi-asserted-by":"crossref","first-page":"e0182011","DOI":"10.1371\/journal.pone.0182011","article-title":"Influence of the microwave technology on solid dispersions of mefenamic acid and flufenamic acid","volume":"12","author":"Alshehri","year":"2017","journal-title":"PLoS One"},{"issue":"13","key":"10.1016\/j.intimp.2024.112118_b0135","doi-asserted-by":"crossref","first-page":"7318","DOI":"10.1039\/D0RA09334C","article-title":"The metabolomic analysis of five Mentha species: cytotoxicity, anti-Helicobacter assessment, and the development of polymeric micelles for enhancing the anti-Helicobacter activity","volume":"11","author":"Bakr","year":"2021","journal-title":"RSC Adv."},{"key":"10.1016\/j.intimp.2024.112118_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122666","article-title":"Coconut oil based self-nano emulsifying delivery systems mitigate ulcerogenic NSAIDs side effect and enhance drug dissolution: Formula optimization, in-vitro, and in-vivo assessments","volume":"634","author":"Fayez","year":"2023","journal-title":"International Journal of Pharmaceutics"},{"key":"10.1016\/j.intimp.2024.112118_b0145","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2019.04.003","article-title":"Morin post-treatment confers neuroprotection in a novel rat model of mild repetitive traumatic brain injury by targeting dementia markers, APOE, autophagy and Wnt\/\u03b2-catenin signaling pathway","volume":"1717","author":"El-Gazar","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.intimp.2024.112118_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108123","article-title":"Further insights for the role of Morin in mRTBI: Implication of non-canonical Wnt\/PKC-\u03b1 and JAK-2\/STAT-3 signaling pathways","volume":"100","author":"Soubh","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112118_b0155","first-page":"199","article-title":"Comparative evaluation of the protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats","volume":"60","author":"El-Shenawy","year":"2008","journal-title":"Pharmacol. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2024.112118_b0160","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00210-020-02000-2","article-title":"Selenium nanoparticles and metformin ameliorate streptozotocin-instigated brain oxidative-inflammatory stress and neurobehavioral alterations in rats","volume":"394","author":"Ebokaiwe","year":"2021","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112118_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173612","article-title":"Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: role of hippocampal klotho and AKT signaling pathways","volume":"889","author":"Yossef","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112118_b0170","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.ijdevneu.2013.07.006","article-title":"Anti-amnestic properties of Ginkgo biloba extract on impaired memory function induced by aluminum in rats","volume":"31","author":"Abd-Elhady","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0175","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3390\/md21030149","article-title":"Enhanced wound healing potential of spirulina platensis nanophytosomes: metabolomic profiling, molecular networking, and modulation of HMGB-1 in an excisional wound rat model","volume":"21","author":"Refai","year":"2023","journal-title":"Mar. Drugs"},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0180","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/ph16010006","article-title":"Possible implication of Nrf2, PPAR-\u03b3 and MAPKs signaling in the protective role of mangiferin against renal ischemia\/reperfusion in rats","volume":"16","author":"Gendy","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.intimp.2024.112118_b0185","unstructured":"Bancroft, J.D. and M. Gamble, Theory and practice of histological techniques. 2008: Elsevier health sciences."},{"key":"10.1016\/j.intimp.2024.112118_b0190","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuro.2022.07.005","article-title":"Galangin mitigates DOX-induced cognitive impairment in rats: Implication of NOX-1\/Nrf-2\/HMGB1\/TLR4 and TNF-\u03b1\/MAPKs\/RIPK\/MLKL\/BDNF","volume":"92","author":"Abd El-Aal","year":"2022","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.intimp.2024.112118_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jfoodeng.2020.110463","article-title":"Physical properties and stability of quercetin loaded niosomes: stabilizing effects of phytosterol and polyethylene glycol in orange juice model","volume":"296","author":"Elmi","year":"2021","journal-title":"Journal of Food Engineering"},{"issue":"11","key":"10.1016\/j.intimp.2024.112118_b0200","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3390\/pharmaceutics13111869","article-title":"Formulation and development of oral fast-dissolving films loaded with nanosuspension to augment paroxetine bioavailability: In vitro characterization, ex vivo permeation, and pharmacokinetic evaluation in healthy human volunteers","volume":"13","author":"Elshafeey","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2024.112118_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2023.131352","article-title":"Properties of Pluronic F68 and F127 micelles interacting furosemide from coarse-grained molecular simulations as validated by experiments","volume":"666","author":"Dalgakiran","year":"2023","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.4103\/0974-8490.199774","article-title":"The Influence of pluronic F68 and F127 nanocarrier on physicochemical properties, in vitro release, and antiproliferative activity of thymoquinone drug","volume":"9","author":"Shaarani","year":"2017","journal-title":"Pharmacognosy Research"},{"key":"10.1016\/j.intimp.2024.112118_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118891","article-title":"Improved solubility, dissolution, and oral bioavailability for atorvastatin-Pluronic\u00ae solid dispersions","volume":"574","author":"Shaker","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.intimp.2024.112118_b0220","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3248519","article-title":"Traumatic brain injury by weight-drop method causes transient amyloid-\u03b2 deposition and acute cognitive deficits in mice","volume":"2019","author":"Shishido","year":"2019","journal-title":"Behav. Neurol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0225","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/brain\/awx357","article-title":"Dopaminergic abnormalities following traumatic brain injury","volume":"141","author":"Jenkins","year":"2018","journal-title":"Brain"},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0230","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1179\/1743132813Y.0000000289","article-title":"Changes in dopamine transporter expression in the midbrain following traumatic brain injury: an immunohistochemical and in situ hybridization study in a mouse model","volume":"36","author":"Shimada","year":"2014","journal-title":"Neurol. Res."},{"key":"10.1016\/j.intimp.2024.112118_b0235","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3389\/fnins.2019.01417","article-title":"A new model of repetitive traumatic brain injury in mice","volume":"13","author":"Chen","year":"2020","journal-title":"Front. Neurosci."},{"issue":"11","key":"10.1016\/j.intimp.2024.112118_b0240","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.3390\/ijms23115954","article-title":"Neurotransmitters\u2014key factors in neurological and neurodegenerative disorders of the central nervous system","volume":"23","author":"Teleanu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0245","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s40035-021-00278-7","article-title":"Excitotoxicity, calcium and mitochondria: A triad in synaptic neurodegeneration","volume":"11","author":"Verma","year":"2022","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/j.intimp.2024.112118_b0250","article-title":"Pharmacological potential of zonisamide and Nigella sativa per se and combination in high-impact trauma device-induced traumatic brain injury in Drosophila melanogaster","author":"Kumar","year":"2022","journal-title":"Fundamental & Clinical Pharmacology"},{"key":"10.1016\/j.intimp.2024.112118_b0255","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuroscience.2023.01.034","article-title":"GABAA receptor and serotonin transporter expression changes dissociate following mild traumatic brain injury: influence of sex and estrus cycle phase in rats","volume":"514","author":"Fox","year":"2023","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2024.112118_b0260","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.726457","article-title":"Micronutrients may Be a unique weapon against the neurotoxic triad of excitotoxicity, oxidative stress and neuroinflammation: A perspective","volume":"15","author":"Holton","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.intimp.2024.112118_b0265","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbi.2017.04.012","article-title":"Transforming growth factor-beta 1 signaling regulates neuroinflammation and apoptosis in mild traumatic brain injury","volume":"64","author":"Patel","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.intimp.2024.112118_b0270","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3390\/cells11040666","article-title":"Research progress on neuroprotection of insulin-like growth factor-1 towards glutamate-induced neurotoxicity","volume":"11","author":"Ge","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.112118_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-017-0337-4","article-title":"Selenium suppresses glutamate-induced cell death and prevents mitochondrial morphological dynamic alterations in hippocampal HT22 neuronal cells","volume":"18","author":"Ma","year":"2017","journal-title":"BMC Neurosci."},{"issue":"12","key":"10.1016\/j.intimp.2024.112118_b0280","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1007\/s42452-022-05208-4","article-title":"The effects of selenium supplementation on inflammatory markers in critically ill patients","volume":"4","author":"Mahmoodpoor","year":"2022","journal-title":"SN Applied Sciences"},{"key":"10.1016\/j.intimp.2024.112118_b0285","series-title":"Seminars in Cancer Biology","article-title":"Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities","author":"Efferth","year":"2022"},{"issue":"8","key":"10.1016\/j.intimp.2024.112118_b0290","doi-asserted-by":"crossref","first-page":"7425","DOI":"10.1007\/s11033-022-07544-5","article-title":"Pro-inflammatory cytokine molecules from Boswellia serrate suppresses lipopolysaccharides induced inflammation demonstrated in an in-vivo zebrafish larval model","volume":"49","author":"Siddhu","year":"2022","journal-title":"Mol. Biol. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0295","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s11011-023-01172-z","article-title":"miRNA dysregulation in traumatic brain injury and epilepsy: A systematic review to identify putative biomarkers for post-traumatic epilepsy","volume":"38","author":"Kumar","year":"2023","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0300","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41398-022-02108-4","article-title":"Differential microRNA expression analyses across two brain regions in Alzheimer\u2019s disease","volume":"12","author":"Dobricic","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.intimp.2024.112118_b0305","doi-asserted-by":"crossref","first-page":"319","DOI":"10.2174\/1570159X17666191113100808","article-title":"MicroRNAs: the new challenge for traumatic brain injury diagnosis","volume":"18","author":"Pinchi","year":"2020","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.intimp.2024.112118_b0310","first-page":"1","article-title":"Dynamic changes in peripheral blood-targeted miRNA expression profiles in patients with severe traumatic brain injury at high altitude","volume":"6","author":"Ma","year":"2019","journal-title":"Mil. Med. Res."},{"key":"10.1016\/j.intimp.2024.112118_b0315","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s12017-020-08599-y","article-title":"miR-146a mimics ameliorates traumatic brain injury involving JNK and NF-\u03baB signaling pathway","volume":"22","author":"Zhang","year":"2020","journal-title":"NeuroMol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0320","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/s41467-017-00972-z","article-title":"An NF-\u03baB-microRNA regulatory network tunes macrophage inflammatory responses","volume":"8","author":"Mann","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112118_b0325","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3389\/fnmol.2017.00228","article-title":"Induction of miR-155 after brain injury promotes type 1 interferon and has a neuroprotective effect","volume":"10","author":"Harrison","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2024.112118_b0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2021.126898","article-title":"Selenium enhances the expression of miR-9, miR-124 and miR-29a during neural differentiation of bone marrow mesenchymal stem cells","volume":"69","author":"Jalali","year":"2022","journal-title":"J. Trace Elem. Med Biol."},{"issue":"21","key":"10.1016\/j.intimp.2024.112118_b0335","doi-asserted-by":"crossref","first-page":"13000","DOI":"10.3390\/ijms232113000","article-title":"Oxidative stress in traumatic brain injury","volume":"23","author":"Fesharaki-Zadeh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.112118_b0340","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3390\/antiox11010076","article-title":"Adaptative Up-regulation of PRX2 and PRX5 expression characterizes brain from a mouse model of chorea-acanthocytosis","volume":"11","author":"Federti","year":"2021","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.intimp.2024.112118_b0345","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/bph.15346","article-title":"Astaxanthin ameliorates oxidative stress and neuronal apoptosis via SIRT1\/NRF2\/Prx2\/ASK1\/p38 after traumatic brain injury in mice","volume":"178","author":"Zhang","year":"2021","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112118_b0350","article-title":"Acetyl-11-Keto-Beta Boswellic Acid (AKBA) protects lens epithelial cells against H2O2-induced oxidative injury and attenuates cataract progression by activating keap1\/Nrf2\/HO-1 signaling","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112118_b0355","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1177\/0960327118816134","article-title":"Protective effects of selenium and nano-selenium on bisphenol-induced reproductive toxicity in male rats","volume":"38","author":"Khalaf","year":"2019","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.intimp.2024.112118_b0360","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fneur.2020.00703","article-title":"The multifaceted role of astrocyte connexin 43 in ischemic stroke through forming hemichannels and gap junctions","volume":"11","author":"Liang","year":"2020","journal-title":"Front. Neurol."},{"issue":"6","key":"10.1016\/j.intimp.2024.112118_b0365","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s10571-021-01070-x","article-title":"GJA1-20K enhances mitochondria transfer from astrocytes to neurons via Cx43-TnTs after traumatic brain injury","volume":"42","author":"Ren","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0370","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/acel.12586","article-title":"Disruption of the Cx43\/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging","volume":"16","author":"Davis","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2024.112118_b0375","article-title":"Fraxin promotes the activation of Nrf2\/ARE pathway via increasing the expression of connexin43 to ameliorate diabetic renal fibrosis","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112118_b0380","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1080\/00207454.2016.1212854","article-title":"Neuroinflammation pathways: a general review","volume":"127","author":"Shabab","year":"2017","journal-title":"International Journal of Neuroscience"},{"key":"10.1016\/j.intimp.2024.112118_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577672","article-title":"Doxycycline alleviates acute traumatic brain injury by suppressing neuroinflammation and apoptosis in a mouse model","volume":"359","author":"Marjani","year":"2021","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2024.112118_b0390","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148383","article-title":"Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury","volume":"1812","author":"Jia","year":"2023","journal-title":"Brain Res."},{"issue":"9","key":"10.1016\/j.intimp.2024.112118_b0395","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.3390\/cells8091110","article-title":"FOXO3a from the nucleus to the mitochondria: a round trip in cellular stress response","volume":"8","author":"Fasano","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.112118_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118472","article-title":"Acetyl-11-keto-\u03b2-boswellic acid prevents testicular torsion\/detorsion injury in rats by modulating 5-LOX\/LTB4 and p38-MAPK\/JNK\/Bax\/Caspase-3 pathways","volume":"260","author":"Ahmed","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.112118_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2022.111716","article-title":"Selenium ameliorates mercuric chloride-induced brain damage through activating BDNF\/TrKB\/PI3K\/AKT and inhibiting NF-\u03baB signaling pathways","volume":"229","author":"Li","year":"2022","journal-title":"J. Inorg. Biochem."},{"issue":"7","key":"10.1016\/j.intimp.2024.112118_b0410","doi-asserted-by":"crossref","first-page":"9613","DOI":"10.18632\/aging.202706","article-title":"Hypoxia-induced microRNA-155 overexpression in extracellular vesicles promotes renal cell carcinoma progression by targeting FOXO3","volume":"13","author":"Meng","year":"2021","journal-title":"Aging (albany NY)"},{"issue":"22","key":"10.1016\/j.intimp.2024.112118_b0415","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.3390\/molecules24224153","article-title":"Regulation of MicroRNA-155 and its related genes expression by inositol hexaphosphate in colon cancer cells","volume":"24","author":"Kapral","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2024.112118_b0420","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejphar.2017.12.019","article-title":"Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice","volume":"820","author":"Long","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2024.112118_b0425","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1111\/jcmm.13766","article-title":"Acetyl-11-keto-\u03b2-boswellic acid ameliorates renal interstitial fibrosis via Klotho\/TGF-\u03b2\/Smad signalling pathway","volume":"22","author":"Liu","year":"2018","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2024.112118_b0430","first-page":"1","article-title":"Effectiveness of new selenium-enriched mutated probiotics in reducing inflammatory effects of piroxicam medication in liver and kidney","author":"Darwish","year":"2022","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2024.112118_b0435","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmcl.2021.127913","article-title":"Effect of resveratrol on the repair of kidney and brain injuries and its regulation on klotho gene in d-galactose-induced aging mice","volume":"40","author":"Chu","year":"2021","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.intimp.2024.112118_b0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113548","article-title":"Huangkui capsule in combination with metformin ameliorates diabetic nephropathy via the Klotho\/TGF-\u03b21\/p38MAPK signaling pathway","volume":"281","author":"Gu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112118_b0445","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.canlet.2015.03.035","article-title":"Reduced expression and growth inhibitory activity of the aging suppressor klotho in epithelial ovarian cancer","volume":"362","author":"Lojkin","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.intimp.2024.112118_b0450","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12031-019-01345-5","article-title":"Klotho ameliorates cellular inflammation via suppression of cytokine release and upregulation of miR-29a in the PBMCs of diagnosed Alzheimer\u2019s disease patients","volume":"69","author":"Sedighi","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2024.112118_b0455","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12888-021-03578-4","article-title":"BDNF, GDNF, NGF and Klotho levels and neurocognitive functions in acute term of schizophrenia","volume":"21","author":"Turkmen","year":"2021","journal-title":"BMC Psychiatry"},{"issue":"9","key":"10.1016\/j.intimp.2024.112118_b0460","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1080\/10717544.2016.1199609","article-title":"Brain-derived neurotrophic factor delivered to the brain using poly (lactide-co-glycolide) nanoparticles improves neurological and cognitive outcome in mice with traumatic brain injury","volume":"23","author":"Khalin","year":"2016","journal-title":"Drug Deliv."},{"issue":"12","key":"10.1016\/j.intimp.2024.112118_b0465","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.4103\/1673-5374.339494","article-title":"Acetyl-11-keto-beta-boswellic acid promotes sciatic nerve repair after injury: Molecular mechanism","volume":"17","author":"Wang","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0470","doi-asserted-by":"crossref","first-page":"437","DOI":"10.34172\/apb.2020.053","article-title":"The effect of beta-boswellic acid on the expression of Camk4 and Camk2\u03b1 genes in the PC12 cell line","volume":"10","author":"Jebelli","year":"2020","journal-title":"Advanced Pharmaceutical Bulletin"},{"issue":"35","key":"10.1016\/j.intimp.2024.112118_b0475","doi-asserted-by":"crossref","first-page":"24700","DOI":"10.1074\/jbc.M114.567321","article-title":"The neuroprotective effect of Klotho is mediated via regulation of members of the redox system","volume":"289","author":"Zeldich","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112118_b0480","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112122","article-title":"Berberine-loaded nanostructured lipid carriers mitigate warm hepatic ischemia\/reperfusion-induced lesion through modulation of HMGB1\/TLR4\/NF-\u03baB signaling and autophagy","volume":"145","author":"Gendy","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.112118_b0485","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s11671-017-2346-8","article-title":"Improved antitumor efficacy and pharmacokinetics of bufalin via PEGylated liposomes","volume":"12","author":"Yuan","year":"2017","journal-title":"Nanoscale Res. Lett."},{"issue":"3","key":"10.1016\/j.intimp.2024.112118_b0490","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/scipharm89030036","article-title":"Enhancement of antimicrobial and antiproliferative activities of standardized frankincense extract using optimized self-nanoemulsifying delivery system","volume":"89","author":"El-Mancy","year":"2021","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.intimp.2024.112118_b0495","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nfs.2018.04.001","article-title":"Enhanced absorption of boswellic acids by a micellar solubilized delivery form of Boswellia extract","volume":"11","author":"Meins","year":"2018","journal-title":"NFS J."},{"key":"10.1016\/j.intimp.2024.112118_b0500","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.jff.2017.11.043","article-title":"Self-nanoemulsifying system (SNES) enhanced oral bioavailability of boswellic acids","volume":"40","author":"Ting","year":"2018","journal-title":"J. Funct. Foods"},{"issue":"27","key":"10.1016\/j.intimp.2024.112118_b0505","doi-asserted-by":"crossref","first-page":"22936","DOI":"10.1039\/C5RA25109E","article-title":"PEG functionalized selenium nanoparticles as a carrier of crocin to achieve anticancer synergism","volume":"6","author":"Mary","year":"2016","journal-title":"RSC Adv."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924006362?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924006362?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T09:02:18Z","timestamp":1735290138000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924006362"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":101,"alternative-id":["S1567576924006362"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112118","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pegylated polymeric micelles of boswellic acid-selenium mitigates repetitive mild traumatic brain injury: Regulation of miR-155 and miR-146a\/BDNF\/ Klotho\/Foxo3a cue","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112118"}}