{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:47:20Z","timestamp":1783720040703,"version":"3.55.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.intimp.2024.112212","type":"journal-article","created":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T03:32:57Z","timestamp":1715225577000},"page":"112212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Dynamic Single-Cell RNA-Seq reveals mechanism of Selinexor-Resistance in Chronic myeloid leukemia"],"prefix":"10.1016","volume":"134","author":[{"given":"Yunqi","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiamei","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7869-6851","authenticated-orcid":false,"given":"Zhengxu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-5417","authenticated-orcid":false,"given":"Xiaoyan","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112212_b0005","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/ajh.26455","article-title":"Chronic myelomonocytic leukemia: 2022 update on diagnosis, risk stratification, and management","volume":"97","author":"Patnaik","year":"2022","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.intimp.2024.112212_b0010","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1182\/blood.2021011722","article-title":"How I treat chronic-phase chronic myelogenous leukemia","volume":"139","author":"Berman","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.112212_b0015","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41375-022-01736-5","article-title":"Pathogenesis and management of accelerated and blast phases of chronic myeloid leukemia","volume":"37","author":"Senapati","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2024.112212_b0020","first-page":"117","article-title":"Chronic myeloid leukemia: a model disease of the past","volume":"10","author":"Minciacchi","year":"2021","journal-title":"Present and Future, Cells"},{"key":"10.1016\/j.intimp.2024.112212_b0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13045-021-01055-9","article-title":"Third-line therapy for chronic myeloid leukemia: current status and future directions","volume":"14","author":"Cortes","year":"2021","journal-title":"J. Hematol. Oncol J Hematol Oncol"},{"key":"10.1016\/j.intimp.2024.112212_b0030","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41571-020-00442-4","article-title":"The nuclear export protein XPO1 \u2014 from biology to targeted therapy","volume":"18","author":"Azmi","year":"2020","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.intimp.2024.112212_b0035","doi-asserted-by":"crossref","unstructured":"XPO1 Inhibitor Approved for Multiple Myeloma, Cancer Discov. 9 (2019) 1150\u20131151. Doi: 10.1158\/2159-8290.CD-NB2019-085.","DOI":"10.1158\/2159-8290.CD-NB2019-085"},{"key":"10.1016\/j.intimp.2024.112212_b0040","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/s41420-018-0049-2","article-title":"KPT-330 inhibition of chromosome region maintenance 1 is cytotoxic and sensitizes chronic myeloid leukemia to Imatinib","volume":"4","author":"Nie","year":"2018","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.intimp.2024.112212_b0045","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/s41375-020-0708-1","article-title":"Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells","volume":"34","author":"Than","year":"2020","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2024.112212_b0050","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1093\/nar\/gky1173","article-title":"scFTD-seq: freeze-thaw lysis based, portable approach toward highly distributed single-cell 3\u2032 mRNA profiling","volume":"47","author":"Dura","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2024.112212_b0055","doi-asserted-by":"crossref","first-page":"3796","DOI":"10.1016\/j.csbj.2021.06.043","article-title":"UCell: robust and scalable single-cell gene signature scoring","volume":"19","author":"Andreatta","year":"2021","journal-title":"Comput. Struct Biotechnol. J."},{"key":"10.1016\/j.intimp.2024.112212_b0060","first-page":"1064","article-title":"Effect of inhibiting NCL expression on drug-resistance of chronic myeloid leukemia cell line K562 and Its resistant cells","volume":"27","author":"Lin","year":"2019","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"10.1016\/j.intimp.2024.112212_b0065","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51754","article-title":"Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells","volume":"9","author":"Domingues","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2024.112212_b0070","doi-asserted-by":"crossref","first-page":"e76637","DOI":"10.1371\/journal.pone.0076637","article-title":"The T-cell oncogene Tal2 Is a Target of PU.1 and upregulated during osteoclastogenesis","author":"Courtial","year":"2013","journal-title":"PloS One 8"},{"key":"10.1016\/j.intimp.2024.112212_b0075","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/s41587-020-0480-9","article-title":"Sci-fate characterizes the dynamics of gene expression in single cells","volume":"38","author":"Cao","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2024.112212_b0080","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/s41592-020-0935-4","article-title":"Massively parallel and time-resolved RNA sequencing in single cells with scNT-seq","volume":"17","author":"Qiu","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.intimp.2024.112212_b0085","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41586-019-1369-y","article-title":"scSLAM-seq reveals core features of transcription dynamics in single cells","volume":"571","author":"Erhard","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.112212_b0090","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/cells9010060","article-title":"Heat shock proteins: agents of cancer development and therapeutic targets in anti-cancer therapy","volume":"9","author":"Yun","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.112212_b0095","first-page":"4258","article-title":"Loss of expression of a new member of the DNAJ protein family confers resistance to chemotherapeutic agents used in the treatment of ovarian cancer","volume":"61","author":"Shridhar","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2024.112212_b0100","doi-asserted-by":"crossref","first-page":"689","DOI":"10.3892\/mmr.2015.4600","article-title":"Suppression of HSP27 increases the anti-tumor effects of quercetin in human leukemia U937 cells","volume":"13","author":"Chen","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.112212_b0105","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1038\/s41375-019-0490-0","article-title":"Chronic myeloid leukemia stem cells","volume":"33","author":"Houshmand","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.intimp.2024.112212_b0110","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1186\/s13287-021-02659-1","article-title":"Chronic myeloid leukemia stem cells: targeting therapeutic implications","volume":"12","author":"Mojtahedi","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.intimp.2024.112212_b0115","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.1182\/blood-2013-07-516807","article-title":"The core autophagy protein ATG4B is a potential biomarker and therapeutic target in CML stem\/progenitor cells","volume":"123","author":"Rothe","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.112212_b0120","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1111\/bph.12183","article-title":"Targeting survival pathways in chronic myeloid leukaemia stem cells","volume":"169","author":"Sinclair","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112212_b0125","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/bjh.16074","article-title":"Energy metabolism and drug response in myeloid leukaemic stem cells","volume":"186","author":"Bencomo-Alvarez","year":"2019","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.intimp.2024.112212_b0130","doi-asserted-by":"crossref","first-page":"8039","DOI":"10.1038\/ncomms9039","article-title":"Dipeptide species regulate p38MAPK-Smad3 signalling to maintain chronic myelogenous leukaemia stem cells","volume":"6","author":"Naka","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112212_b0135","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nm.4336","article-title":"Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia","volume":"23","author":"Giustacchini","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2024.112212_b0140","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/nm.4399","article-title":"Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells","volume":"23","author":"Kuntz","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2024.112212_b0145","doi-asserted-by":"crossref","first-page":"R1292","DOI":"10.1016\/j.cub.2020.09.068","volume":"30","author":"Tang","year":"2020","journal-title":"Ferroptosis Curr. Biol."},{"key":"10.1016\/j.intimp.2024.112212_b0150","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41568-022-00459-0","article-title":"Targeting ferroptosis as a vulnerability in cancer","volume":"22","author":"Lei","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.intimp.2024.112212_b0155","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s11658-021-00271-y","article-title":"Induction of ferroptosis by ATF3 elevation alleviates cisplatin resistance in gastric cancer by restraining Nrf2\/Keap1\/xCT signaling","volume":"26","author":"Fu","year":"2021","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.intimp.2024.112212_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101413","article-title":"AR ubiquitination induced by the curcumin analog suppresses growth of temozolomide-resistant glioblastoma through disrupting GPX4-Mediated redox homeostasis","volume":"30","author":"Chen","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.112212_b0165","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.7150\/thno.44705","article-title":"Combinative treatment of \u03b2-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924007306?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924007306?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T14:04:11Z","timestamp":1735308251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924007306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":33,"alternative-id":["S1567576924007306"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112212","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dynamic Single-Cell RNA-Seq reveals mechanism of Selinexor-Resistance in Chronic myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112212"}}