{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:02:43Z","timestamp":1791302563042,"version":"4.1.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002569","name":"Wonkwang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A5A2015805"],"award-info":[{"award-number":["NRF-2017R1A5A2015805"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00246085"],"award-info":[{"award-number":["RS-2023-00246085"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1A2C2004218"],"award-info":[{"award-number":["NRF-2022R1A2C2004218"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2022R1C1C2005820"],"award-info":[{"award-number":["NRF-2022R1C1C2005820"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.intimp.2024.112284","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T16:08:04Z","timestamp":1717171684000},"page":"112284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Myricetin ameliorates the severity of pancreatitis in mice by regulating cathepsin B activity and inflammatory cytokine production"],"prefix":"10.1016","volume":"136","author":[{"given":"Ji-Won","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonyeon","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Joon","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Sang","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min Seuk","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6227-6681","authenticated-orcid":false,"given":"Sung-Joo","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112284_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107496","article-title":"Cathepsin B aggravates acute pancreatitis by activating the NLRP3 inflammasome and promoting the caspase-1-induced pyroptosis","volume":"94","author":"Wang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112284_b0010","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1172\/JCI9411","article-title":"Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitis","volume":"106","author":"Halangk","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.112284_b0015","doi-asserted-by":"crossref","first-page":"14717","DOI":"10.1074\/jbc.M116.718999","article-title":"Cathepsin B activity initiates apoptosis via digestive protease activation in pancreatic acinar cells and experimental pancreatitis","volume":"291","author":"Sendler","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0020","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1053\/j.gastro.2016.06.042","article-title":"Release of cathepsin B in cytosol causes cell death in acute pancreatitis","volume":"151","author":"Talukdar","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0025","first-page":"H1143","article-title":"Cathepsin B deficiency attenuates cardiac remodeling in response to pressure overload via TNF-\u03b1\/ASK1\/JNK pathway","volume":"308","author":"Wu","year":"2015","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.intimp.2024.112284_b0030","doi-asserted-by":"crossref","first-page":"G794","DOI":"10.1152\/ajpgi.00363.2001","article-title":"Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity","volume":"283","author":"Van Acker","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2024.112284_b0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3390\/md15020045","article-title":"Propylene glycol alginate sodium sulfate alleviates cerulein-induced acute pancreatitis by modulating the MEK\/ERK pathway in mice","volume":"15","author":"Zhang","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.intimp.2024.112284_b0040","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1159\/000066090","article-title":"Acute experimental pancreatitis and NF-kappaB\/Rel activation","volume":"2","author":"Alg\u00fcl","year":"2002","journal-title":"Pancreatology"},{"key":"10.1016\/j.intimp.2024.112284_b0045","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/gutjnl-2011-300771","article-title":"Tumour necrosis factor \u03b1 secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in mice","volume":"62","author":"Sendler","year":"2013","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2024.112284_b0050","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.gastro.2017.10.018","article-title":"Cathepsin B-mediated activation of trypsinogen in endocytosing macrophages increases severity of pancreatitis in mice","volume":"154","author":"Sendler","year":"2018","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0055","doi-asserted-by":"crossref","first-page":"G967","DOI":"10.1152\/ajpgi.00181.2009","article-title":"Protease activation during in vivo pancreatitis is dependent on calcineurin activation","volume":"297","author":"Shah","year":"2009","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2024.112284_b0060","doi-asserted-by":"crossref","first-page":"zqaa026","DOI":"10.1093\/function\/zqaa026","article-title":"Calcium signaling in pancreatic immune cells in situ","volume":"2","author":"Gryshchenko","year":"2021","journal-title":"Function (oxf)"},{"key":"10.1016\/j.intimp.2024.112284_b0065","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1136\/gut.2007.124115","article-title":"The role of NF-kappaB activation in the pathogenesis of acute pancreatitis","volume":"57","author":"Rakonczay","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2024.112284_b0070","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ejphar.2015.09.019","article-title":"Loganin protects against pancreatitis by inhibiting NF-\u03baB activation","volume":"765","author":"Kim","year":"2015","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112284_b0075","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1053\/j.gastro.2015.05.004","article-title":"Exposure to radiocontrast agents induces pancreatic inflammation by activation of nuclear factor-\u03baB, calcium signaling, and calcineurin","volume":"149","author":"Jin","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0080","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1053\/j.gastro.2020.05.051","article-title":"The protective effects of calcineurin on pancreatitis in mice depend on the cellular source","volume":"159","author":"Wen","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0085","doi-asserted-by":"crossref","first-page":"21065","DOI":"10.1074\/jbc.M113.471425","article-title":"Pancreatic acinar cell nuclear factor \u03baB activation because of bile acid exposure is dependent on calcineurin","volume":"288","author":"Muili","year":"2013","journal-title":"J. Biol. Chem.."},{"key":"10.1016\/j.intimp.2024.112284_b0090","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1182\/blood-2012-02-404475","article-title":"NFAT control of innate immunity","volume":"120","author":"Fric","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.112284_b0095","doi-asserted-by":"crossref","first-page":"G1594","DOI":"10.1152\/ajpgi.00500.2006","article-title":"Caerulein-induced intracellular pancreatic zymogen activation is dependent on calcineurin","volume":"292","author":"Husain","year":"2007","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2024.112284_b0100","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000515933","article-title":"Calcineurin inhibitor toxicity in solid organ transplantation","volume":"106","author":"Karolin","year":"2021","journal-title":"Pharmacology"},{"key":"10.1016\/j.intimp.2024.112284_b0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1053\/j.ackd.2019.08.006","article-title":"The many faces of calcineurin inhibitor toxicity-what the FK?","volume":"27","author":"Farouk","year":"2020","journal-title":"Adv. Chronic Kidney Dis."},{"key":"10.1016\/j.intimp.2024.112284_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.111017","article-title":"Myricetin: A review of the most recent research","volume":"134","author":"Song","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.112284_b0115","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.4155\/fmc-2018-0172","article-title":"Myricetin attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models","volume":"10","author":"Hou","year":"2018","journal-title":"Fut. Med. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0120","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/jsfa.5733","article-title":"Myricetin attenuates lipopolysaccharide-stimulated activation of mouse bone marrow-derived dendritic cells through suppression of IKK\/NF-\u03baB and MAPK signalling pathways","volume":"93","author":"Fu","year":"2013","journal-title":"J. Sci. Food Agric."},{"key":"10.1016\/j.intimp.2024.112284_b0125","doi-asserted-by":"crossref","first-page":"16252","DOI":"10.1002\/jcp.28288","article-title":"Myricetin relieves LPS-induced mastitis by inhibiting inflammatory response and repairing the blood-milk barrier","volume":"234","author":"Kan","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2024.112284_b0130","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/sj.bjp.0706246","article-title":"Flavonols inhibit proinflammatory mediator release, intracellular calcium ion levels and protein kinase C theta phosphorylation in human mast cells","volume":"145","author":"Kempuraj","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112284_b0135","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.taap.2018.12.019","article-title":"Myricetin inhibits NLRP3 inflammasome activation via reduction of ROS-dependent ubiquitination of ASC and promotion of ROS-independent NLRP3 ubiquitination","volume":"365","author":"Chen","year":"2019","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112284_b0140","doi-asserted-by":"crossref","first-page":"e1801393","DOI":"10.1002\/mnfr.201801393","article-title":"Myricetin ameliorates ethanol-induced lipid accumulation in liver cells by reducing fatty acid biosynthesis","volume":"63","author":"Guo","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2024.112284_b0145","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/S0016-5085(85)80079-2","article-title":"Caerulein-induced acute necrotizing pancreatitis in mice: protective effects of proglumide, benzotript, and secretin","volume":"88","author":"Niederau","year":"1985","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0150","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2015.05.012","article-title":"Complement component 5 mediates development of fibrosis, via activation of stellate cells, in 2 mouse models of chronic pancreatitis","volume":"149","author":"Sendler","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0155","first-page":"50514","article-title":"Isolation and culture of mouse primary pancreatic acinar cells","volume":"13","author":"Gout","year":"2013","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.intimp.2024.112284_b0160","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1053\/gast.2002.35951","article-title":"Cyclooxygenase-2 gene disruption attenuates the severity of acute pancreatitis and pancreatitis-associated lung injury","volume":"123","author":"Ethridge","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0165","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.intimp.2024.112284_b0170","doi-asserted-by":"crossref","first-page":"32926","DOI":"10.1074\/jbc.M114.579961","article-title":"The lysosome rupture-activated TAK1-JNK pathway regulates NLRP3 inflammasome activation","volume":"289","author":"Okada","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0175","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1074\/jbc.M207454200","article-title":"Early changes in pancreatic acinar cell calcium signaling after pancreatic duct obstruction","volume":"278","author":"Mooren","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0180","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jcmgh.2016.08.006","article-title":"Targeted inhibition of pancreatic acinar cell calcineurin is a novel strategy to prevent post-ERCP pancreatitis","volume":"3","author":"Orabi","year":"2017","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2024.112284_b0185","doi-asserted-by":"crossref","first-page":"G898","DOI":"10.1152\/ajpgi.00545.2011","article-title":"Pharmacological and genetic inhibition of calcineurin protects against carbachol-induced pathological zymogen activation and acinar cell injury","volume":"302","author":"Muili","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2024.112284_b0190","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1074\/jbc.M111.336032","article-title":"Calcium\/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses","volume":"287","author":"Racioppi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0195","doi-asserted-by":"crossref","first-page":"11793","DOI":"10.1038\/s41598-017-12139-3","article-title":"Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD","volume":"7","author":"York","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.112284_b0200","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1053\/j.gastro.2007.01.055","article-title":"Acute pancreatitis: bench to the bedside","volume":"132","author":"Pandol","year":"2007","journal-title":"Gastroenterology."},{"key":"10.1016\/j.intimp.2024.112284_b0205","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1189\/jlb.0411195","article-title":"Role of neutrophils in the activation of trypsinogen in severe acute pancreatitis","volume":"90","author":"Abdulla","year":"2011","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2024.112284_b0210","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.3390\/ijms22136871","article-title":"Betulinic acid ameliorates the severity of acute pancreatitis via inhibition of the NF-\u03baB signaling pathway in mice","volume":"22","author":"Zhou","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112284_b0215","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.molimm.2019.09.002","article-title":"8\u03b1-Hydroxypinoresinol isolated from Nardostachys jatamansi ameliorates cerulein-induced acute pancreatitis through inhibition of NF-\u03baB activation","volume":"114","author":"Choi","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2024.112284_b0220","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pan.2016.05.001","article-title":"NF-\u03baB in acute pancreatitis: Mechanisms and therapeutic potential","volume":"16","author":"Jakkampudi","year":"2016","journal-title":"Pancreatology"},{"key":"10.1016\/j.intimp.2024.112284_b0225","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1038\/s41467-022-31935-8","article-title":"Calcium\/calmodulin-dependent protein kinase IV promotes imiquimod-induced psoriatic inflammation via macrophages and keratinocytes in mice","volume":"13","author":"Yong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112284_b0230","doi-asserted-by":"crossref","first-page":"798","DOI":"10.21037\/atm-22-3118","article-title":"The ciliary protein Spef2 stimulates acinar Ampk\u03b1\/Sirt1 signaling and ameliorates acute pancreatitis and associated lung injury","volume":"10","author":"Zhang","year":"2022","journal-title":"Ann. Trans.l Med."},{"key":"10.1016\/j.intimp.2024.112284_b0235","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1007\/s12035-017-0520-8","article-title":"17\u03b2-Estradiol via SIRT1\/Acetyl-p53\/NF-\u03baB signaling pathway rescued postnatal rat brain against acute ethanol intoxication","volume":"55","author":"Khan","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2024.112284_b0240","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3892\/ijmm.2017.3012","article-title":"Resveratrol protects against L-arginine-induced acute necrotizing pancreatitis in mice by enhancing SIRT1-mediated deacetylation of p53 and heat shock factor 1","volume":"40","author":"Wang","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2024.112284_b0245","doi-asserted-by":"crossref","first-page":"e46201","DOI":"10.1371\/journal.pone.0046201","article-title":"Netrin-1 protects against L-Arginine-induced acute pancreatitis in mice","volume":"7","author":"Chen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.112284_b0250","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1089\/107999099313785","article-title":"Cytokine expression and induction of acinar cell apoptosis after pancreatic duct ligation in mice","volume":"19","author":"Yasuda","year":"1999","journal-title":"J. Interferon Cytokine Res."},{"key":"10.1016\/j.intimp.2024.112284_b0255","first-page":"RA147","article-title":"Acute pancreatitis: a literature review","volume":"15","author":"Jha","year":"2009","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.intimp.2024.112284_b0260","first-page":"1165","article-title":"Gabexate mesilate in human acute pancreatitis","volume":"104","author":"B\u00fcchler","year":"1993","journal-title":"German Pancreatitis Study Group, Gastroenterology."},{"key":"10.1016\/j.intimp.2024.112284_b0265","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02786117","article-title":"Gabexate mesilate vs aprotinin in human acute pancreatitis (GA.ME.P.A.). A prospective, randomized, double-blind multicenter study","volume":"14","author":"Pederzoli","year":"1993","journal-title":"Int. J. Pancreatol."},{"key":"10.1016\/j.intimp.2024.112284_b0270","first-page":"488","article-title":"Action of antiproteases on the inflammatory response in acute pancreatitis","volume":"8","author":"Chen","year":"2007","journal-title":"JOP"},{"key":"10.1016\/j.intimp.2024.112284_b0275","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-0031-1280385","article-title":"SNARE-wedging polyphenols as small molecular botox","volume":"78","author":"Yang","year":"2012","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2024.112284_b0280","doi-asserted-by":"crossref","first-page":"G367","DOI":"10.1152\/ajpgi.00315.2001","article-title":"Trypsin activity is not involved in premature, intrapancreatic trypsinogen activation","volume":"282","author":"Halangk","year":"2002","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.intimp.2024.112284_b0285","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1053\/j.gastro.2008.05.026","article-title":"Direct activation of cytosolic Ca2+ signaling and enzyme secretion by cholecystokinin in human pancreatic acinar cells","volume":"135","author":"Murphy","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112284_b0290","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1074\/jbc.M311088200","article-title":"Organelle selection determines agonist-specific Ca2+ signals in pancreatic acinar and beta cells","volume":"279","author":"Yamasaki","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0295","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/0092-8674(91)90124-H","article-title":"Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes","volume":"66","author":"Liu","year":"1991","journal-title":"Cell."},{"key":"10.1016\/j.intimp.2024.112284_b0300","first-page":"706","article-title":"The Ca(2+)\/Calmodulin\/CaMKK2 Axis: Nature's Metabolic CaMshaft, Trends","volume":"27","author":"Marcelo","year":"2016","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.112284_b0305","doi-asserted-by":"crossref","first-page":"31658","DOI":"10.1074\/jbc.R112.356485","article-title":"Calcium\/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology","volume":"287","author":"Racioppi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112284_b0310","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1007\/s12272-001-2110-5","article-title":"Flavonoids Inhibit Histamine Release and Expression of Proinflammatory Cytokines in Mast Cells","volume":"31","author":"Park","year":"2008","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.intimp.2024.112284_b0315","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s00210-003-0836-y","article-title":"L-type Ca2+ channels activation and contraction elicited by myricetin on vascular smooth muscles, Naunyn. Schmiedebergs","volume":"368","author":"Fusi","year":"2003","journal-title":"Arch. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112284_b0320","article-title":"CaMK4 promotes acute lung injury through NLRP3 inflammasome activation in type II alveolar epithelial cell","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112284_b0325","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10753-017-0678-2","article-title":"Calcium\/calmodulin-dependent protein kinase IV (CaMKIV) mediates acute skeletal muscle inflammatory response","volume":"41","author":"Shi","year":"2018","journal-title":"Inflammation."},{"key":"10.1016\/j.intimp.2024.112284_b0330","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1096\/fj.201800535R","article-title":"Calcium\/calmodulin-dependent protein kinase IV (CaMKIV) activation contributes to the pathogenesis of experimental colitis via inhibition of intestinal epithelial cell proliferation","volume":"33","author":"Cunningham","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2024.112284_b0335","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s11914-019-00518-w","article-title":"CaMKK2 signaling in metabolism and skeletal disease: a new axis with therapeutic potential","volume":"17","author":"Williams","year":"2019","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.intimp.2024.112284_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2020.115162","article-title":"Berberine attenuates severity of chronic pancreatitis and fibrosis via AMPK-mediated inhibition of TGF-\u03b21\/Smad signaling and M2 polarization","volume":"403","author":"Bansod","year":"2020","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692400804X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692400804X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:46:28Z","timestamp":1791301588000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692400804X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":68,"alternative-id":["S156757692400804X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112284","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myricetin ameliorates the severity of pancreatitis in mice by regulating cathepsin B activity and inflammatory cytokine production","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112284"}}