{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:01:28Z","timestamp":1792641688881,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["604090352\/640"],"award-info":[{"award-number":["604090352\/640"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271747"],"award-info":[{"award-number":["82271747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY24H020008"],"award-info":[{"award-number":["LY24H020008"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LQ21H040009"],"award-info":[{"award-number":["LQ21H040009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.intimp.2024.112372","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T05:45:14Z","timestamp":1717739114000},"page":"112372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Echinatin alleviates inflammation and pyroptosis in hypoxic-ischemic brain damage by inhibiting TLR4\/ NF-\u03baB pathway"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4575-1700","authenticated-orcid":false,"given":"Xiaoyue","family":"Tao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niping","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingchu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-6249","authenticated-orcid":false,"given":"Xiaoling","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112372_b0005","doi-asserted-by":"crossref","unstructured":"C. Acun, S. Karnati, S. Padiyar, S. Puthuraya, H. Aly, M. Mohamed, Trends of neonatal hypoxic-ischemic encephalopathy prevalence and associated risk factors in the United States, 2010 to 2018, Am J Obstet Gynecol 227(5) (2022) 751 e1-751 e10.","DOI":"10.1016\/j.ajog.2022.06.002"},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0010","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-023-02961-0","article-title":"Hypothermia combined with extracellular vesicles from clonally expanded immortalized mesenchymal stromal cells improves neurodevelopmental impairment in neonatal hypoxic-ischemic brain injury","volume":"20","author":"Labusek","year":"2023","journal-title":"J. Neuroinflammation"},{"issue":"3","key":"10.1016\/j.intimp.2024.112372_b0015","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jpeds.2013.10.067","article-title":"Biomarkers for severity of neonatal hypoxic-ischemic encephalopathy and outcomes in newborns receiving hypothermia therapy","volume":"164","author":"Chalak","year":"2014","journal-title":"J. Pediatr."},{"issue":"5","key":"10.1016\/j.intimp.2024.112372_b0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1136\/archdischild-2020-320902","article-title":"Trends in the incidence and management of hypoxic-ischaemic encephalopathy in the therapeutic hypothermia era: a national population study","volume":"106","author":"Shipley","year":"2021","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1089\/ars.2020.8093","article-title":"Hypoxic-Ischemic Encephalopathy and Mitochondrial Dysfunction: Facts","volume":"33","author":"Rodriguez","year":"2020","journal-title":"Unknowns, and Challenges, Antioxid Redox Signal"},{"key":"10.1016\/j.intimp.2024.112372_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114450","article-title":"Exogenous lactate administration: A potential novel therapeutic approach for neonatal hypoxia-ischemia","volume":"367","author":"Deng","year":"2023","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2024.112372_b0035","doi-asserted-by":"crossref","unstructured":"D. Azzopardi, B. Strohm, N. Marlow, P. Brocklehurst, A. Deierl, O. Eddama, J. Goodwin, H.L. Halliday, E. Juszczak, O. Kapellou, M. Levene, L. Linsell, O. Omar, M. Thoresen, N. Tusor, A. Whitelaw, A.D. Edwards, T.S. Group, Effects of hypothermia for perinatal asphyxia on childhood outcomes, N Engl J Med 371(2) (2014) 140-9.","DOI":"10.1056\/NEJMoa1315788"},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0040","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/nrneurol.2015.13","article-title":"The role of inflammation in perinatal brain injury","volume":"11","author":"Hagberg","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0045","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.22620","article-title":"Inflammation during fetal and neonatal life: implications for neurologic and neuropsychiatric disease in children and adults","volume":"71","author":"Hagberg","year":"2012","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112372_b0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0165-3806(94)00177-2","article-title":"Microglia activation after neonatal hypoxic-ischemia","volume":"84","author":"McRae","year":"1995","journal-title":"Brain Res Dev Brain Res"},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0055","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1203\/01.PDR.0000113546.03897.FC","article-title":"Timing of neutrophil depletion influences long-term neuroprotection in neonatal rat hypoxic-ischemic brain injury","volume":"55","author":"Palmer","year":"2004","journal-title":"Pediatr. Res."},{"issue":"6","key":"10.1016\/j.intimp.2024.112372_b0060","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1038\/jcbfm.2014.41","article-title":"Mechanisms of perinatal arterial ischemic stroke","volume":"34","author":"Fernandez-Lopez","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"12","key":"10.1016\/j.intimp.2024.112372_b0065","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/nri2873","article-title":"Sterile inflammation: sensing and reacting to damage","volume":"10","author":"Chen","year":"2010","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0070","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.intimp.2024.112372_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1092799","article-title":"Multiple TLRs elicit alternative NLRP3 inflammasome activation in primary human monocytes independent of RIPK1 kinase activity","volume":"14","author":"Unterberger","year":"2023","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112372_b0080","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153499","article-title":"Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction","volume":"23","author":"Li","year":"2022","journal-title":"EMBO Rep."},{"key":"10.1016\/j.intimp.2024.112372_b0085","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.psychres.2016.04.002","article-title":"Protective effect of liquiritigenin on depressive-like behavior in mice after lipopolysaccharide administration","volume":"240","author":"Su","year":"2016","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.intimp.2024.112372_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105452","article-title":"Revisiting Licorice as a functional food in the management of neurological disorders: Bench to trend","volume":"155","author":"Sharma","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.intimp.2024.112372_b0095","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.foodchem.2013.03.089","article-title":"Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice","volume":"141","author":"Fu","year":"2013","journal-title":"Food Chem."},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0100","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s10059-009-0130-z","article-title":"Suppression of the TRIF-dependent signaling pathway of toll-like receptors by isoliquiritigenin in RAW264.7 macrophages","volume":"28","author":"Park","year":"2009","journal-title":"Mol. Cells"},{"issue":"18","key":"10.1016\/j.intimp.2024.112372_b0105","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301775120","article-title":"Bioactive compounds from Huashi Baidu decoction possess both antiviral and anti-inflammatory effects against COVID-19","volume":"120","author":"Xu","year":"2023","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.intimp.2024.112372_b0110","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.134601","article-title":"Echinatin effectively protects against NLRP3 inflammasome-driven diseases by targeting HSP90","volume":"6","author":"Xu","year":"2021","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.intimp.2024.112372_b0115","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.freeradbiomed.2003.11.023","article-title":"Flavonoid permeability across an in situ model of the blood-brain barrier","volume":"36","author":"Youdim","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2024.112372_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2024.105676","article-title":"Echinatin protects from ischemic brain injury by attenuating NLRP3-related neuroinflammation","volume":"175","author":"Sun","year":"2024","journal-title":"Neurochem. Int."},{"issue":"6","key":"10.1016\/j.intimp.2024.112372_b0125","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.mibio.2003.09.014","article-title":"Determination of lipophilicity and its use as a predictor of blood-brain barrier penetration of molecular imaging agents","volume":"5","author":"Waterhouse","year":"2003","journal-title":"Mol. Imag. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0130","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1080\/13880209.2022.2123941","article-title":"Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress","volume":"60","author":"Xu","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2024.112372_b0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2016.02.020","article-title":"Omega-3 polyunsaturated fatty acids mitigate blood-brain barrier disruption after hypoxic-ischemic brain injury","volume":"91","author":"Zhang","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"22","key":"10.1016\/j.intimp.2024.112372_b0140","doi-asserted-by":"crossref","first-page":"15988","DOI":"10.1074\/jbc.M112.428789","article-title":"Mechanisms of neuroprotection from hypoxia-ischemia (HI) brain injury by up-regulation of cytoglobin (CYGB) in a neonatal rat model","volume":"288","author":"Tian","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.intimp.2024.112372_b0145","doi-asserted-by":"crossref","first-page":"14731","DOI":"10.1073\/pnas.97.26.14731","article-title":"Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors","volume":"97","author":"Sarnyai","year":"2000","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2024.112372_b0150","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neurobiolaging.2015.11.018","article-title":"Ketones block amyloid entry and improve cognition in an Alzheimer's model","volume":"39","author":"Yin","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"3A","key":"10.1016\/j.intimp.2024.112372_b0155","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1590\/S0004-282X2009000400014","article-title":"Effects of aquatic exercises in a rat model of brainstem demyelination with ethidium bromide on the beam walking test","volume":"67","author":"Nassar","year":"2009","journal-title":"Arq. Neuropsiquiatr."},{"key":"10.1016\/j.intimp.2024.112372_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107621","article-title":"Suppression of NLRP3 inflammasome by Platycodin D via the TLR4\/MyD88\/NF-kappaB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats","volume":"96","author":"Wu","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"13","key":"10.1016\/j.intimp.2024.112372_b0165","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1055\/s-0038-1676973","article-title":"Neurodevelopmental Outcomes in Neonates with Mild Hypoxic Ischemic Encephalopathy Treated with Therapeutic Hypothermia","volume":"36","author":"Rao","year":"2019","journal-title":"Am. J. Perinatol."},{"key":"10.1016\/j.intimp.2024.112372_b0170","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.earlhumdev.2018.02.007","article-title":"Mild hypoxic ischaemic encephalopathy and long term neurodevelopmental outcome - A systematic review","volume":"120","author":"Conway","year":"2018","journal-title":"Early Hum. Dev."},{"issue":"6","key":"10.1016\/j.intimp.2024.112372_b0175","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ptr.2362","article-title":"Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds","volume":"22","author":"Asl","year":"2008","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0180","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.apsb.2015.05.005","article-title":"The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb","volume":"5","author":"Wang","year":"2015","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.intimp.2024.112372_b0185","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.jep.2013.09.055","article-title":"Liquorice, a unique \u201cguide drug\u201d of traditional Chinese medicine: a review of its role in drug interactions","volume":"150","author":"Wang","year":"2013","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.112372_b0190","article-title":"Metabolic engineering to enhance the accumulation of bioactive flavonoids licochalcone A and echinatin in Glycyrrhiza inflata (Licorice) hairy roots","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Plant Sci."},{"issue":"20","key":"10.1016\/j.intimp.2024.112372_b0195","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1016\/j.bmc.2017.08.018","article-title":"Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl(4)-induced liver injury in mice","volume":"25","author":"Lin","year":"2017","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.intimp.2024.112372_b0200","doi-asserted-by":"crossref","first-page":"409","DOI":"10.2147\/JIR.S344071","article-title":"NLRP3 Inflammasome Pharmacological Inhibitors in Glycyrrhiza for NLRP3-Driven Diseases Treatment: Extinguishing the Fire of Inflammation","volume":"15","author":"Wang","year":"2022","journal-title":"J. Inflamm. Res."},{"issue":"3","key":"10.1016\/j.intimp.2024.112372_b0205","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1159\/000487913","article-title":"Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time","volume":"114","author":"Salas","year":"2018","journal-title":"Neonatology"},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1186\/s12974-022-02499-7","article-title":"Persistent cortical and white matter inflammation after therapeutic hypothermia for ischemia in near-term fetal sheep","volume":"19","author":"Zhou","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.intimp.2024.112372_b0215","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.112372_b0220","doi-asserted-by":"crossref","first-page":"e526","DOI":"10.1212\/WNL.0000000000007867","article-title":"The link between concussion and inflammation","volume":"93","author":"Karceski","year":"2019","journal-title":"Neurology"},{"issue":"22","key":"10.1016\/j.intimp.2024.112372_b0225","doi-asserted-by":"crossref","first-page":"e2223","DOI":"10.1212\/WNL.0000000000207744","article-title":"Association of EEG Background and Neurodevelopmental Outcome in Neonates With Hypoxic-Ischemic Encephalopathy Receiving Hypothermia","volume":"101","author":"Glass","year":"2023","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0230","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/s12974-020-01796-3","article-title":"IRE1alpha inhibition attenuates neuronal pyroptosis via miR-125\/NLRP1 pathway in a neonatal hypoxic-ischemic encephalopathy rat model","volume":"17","author":"Huang","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"4","key":"10.1016\/j.intimp.2024.112372_b0235","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bbrc.2019.11.003","article-title":"The role of microglia mediated pyroptosis in neonatal hypoxic-ischemic brain damage","volume":"521","author":"Lv","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.112372_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2022.114291","article-title":"Toll-like receptor 4 (TLR4) inhibitors: Current research and prospective","volume":"235","author":"Zhang","year":"2022","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0245","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s10753-022-01715-z","article-title":"PCSK9 Promotes Endothelial Dysfunction During Sepsis Via the TLR4\/MyD88\/NF-kappaB and NLRP3 Pathways","volume":"46","author":"Huang","year":"2023","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.intimp.2024.112372_b0250","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s10753-021-01588-8","article-title":"TLR4-IN-C34 Inhibits Lipopolysaccharide-Stimulated Inflammatory Responses via Downregulating TLR4\/MyD88\/NF-kappaB\/NLRP3 Signaling Pathway and Reducing ROS Generation in BV2 Cells","volume":"45","author":"Zhang","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.112372_b0255","doi-asserted-by":"crossref","unstructured":"R. Miao, C. Jiang, W.Y. Chang, H. Zhang, J. An, F. Ho, P. Chen, H. Zhang, C. Junqueira, D. Amgalan, F.G. Liang, J. Zhang, C.L. Evavold, I. Hafner-Bratkovic, Z. Zhang, P. Fontana, S. Xia, M. Waldeck-Weiermair, Y. Pan, T. Michel, L. Bar-Peled, H. Wu, J.C. Kagan, R.N. Kitsis, P. Zhang, X. Liu, J. Lieberman, Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis, Immunity 56(11) (2023) 2523-2541 e8.","DOI":"10.1016\/j.immuni.2023.10.004"},{"issue":"12","key":"10.1016\/j.intimp.2024.112372_b0260","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/cns.12441","article-title":"NF-kappaB Signaling is Involved in the Effects of Intranasally Engrafted Human Neural Stem Cells on Neurofunctional Improvements in Neonatal Rat Hypoxic-Ischemic Encephalopathy","volume":"21","author":"Ji","year":"2015","journal-title":"CNS Neurosci. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.112372_b0265","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1600-065X.2012.01111.x","article-title":"Celebrating 25 years of NF-kappaB research","volume":"246","author":"Ghosh","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2024.112372_b0270","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1742-2094-10-24","article-title":"Cerebral ischemia initiates an immediate innate immune response in neonates during cardiac surgery","volume":"10","author":"Algra","year":"2013","journal-title":"J. Neuroinflammation"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924008920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924008920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:43:01Z","timestamp":1791301381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924008920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":54,"alternative-id":["S1567576924008920"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112372","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Echinatin alleviates inflammation and pyroptosis in hypoxic-ischemic brain damage by inhibiting TLR4\/ NF-\u03baB pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112372"}}