{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:00:55Z","timestamp":1792101655640,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101125"],"award-info":[{"award-number":["82101125"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81974133"],"award-info":[{"award-number":["81974133"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271089"],"award-info":[{"award-number":["82271089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.intimp.2024.112545","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T19:01:25Z","timestamp":1719860485000},"page":"112545","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Irisin attenuates acute glaucoma-induced neuroinflammation by activating microglia-integrin \u03b1V\u03b25\/AMPK and promoting autophagy"],"prefix":"10.1016","volume":"138","author":[{"given":"Qiuxiang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sifei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Rong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6290-8709","authenticated-orcid":false,"given":"Chaohua","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4335-037X","authenticated-orcid":false,"given":"Junming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112545_b0005","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s12974-015-0360-2","article-title":"HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-\u03baB pathway in acute glaucoma","volume":"12","author":"Chi","year":"2015","journal-title":"J. Neuroinflam."},{"issue":"8","key":"10.1016\/j.intimp.2024.112545_b0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a017269","article-title":"The complex role of neuroinflammation in glaucoma","volume":"4","author":"Soto","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.112545_b0015","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/jnc.14070","article-title":"Involvement of microglia in early axoglial alterations of the optic nerve induced by experimental glaucoma","volume":"142","author":"Bordone","year":"2017","journal-title":"J. Neurochem."},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0020","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J. Comp. Neurol."},{"issue":"12","key":"10.1016\/j.intimp.2024.112545_b0025","doi-asserted-by":"crossref","first-page":"6448","DOI":"10.1167\/iovs.10-5284","article-title":"Microglial activation in the visual pathway in experimental glaucoma: spatiotemporal characterization and correlation with axonal injury","volume":"51","author":"Ebneter","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2024.112545_b0030","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","article-title":"Glaucoma","volume":"105","author":"Kang","year":"2021","journal-title":"Med. Clin. North Am."},{"issue":"11","key":"10.1016\/j.intimp.2024.112545_b0035","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2013from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.112545_b0040","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","article-title":"Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury","volume":"13","author":"Qin","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.112545_b0045","doi-asserted-by":"crossref","unstructured":"A. Heijl, M.C. Leske, B. Bengtsson, L. Hyman, B. Bengtsson, M. Hussein, Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial, Archives of ophthalmology (Chicago, Ill. : 1960) 120(10) (2002) 1268-79.","DOI":"10.1001\/archopht.120.10.1268"},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0050","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"PLoS Genet."},{"issue":"7382","key":"10.1016\/j.intimp.2024.112545_b0055","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostr\u00f6m","year":"2012","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0060","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001","article-title":"Detection and quantitation of circulating human Irisin by tandem mass spectrometry","volume":"22","author":"Jedrychowski","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2024.112545_b0065","article-title":"Neuroprotective effects of irisin against cerebral ischemia\/ reperfusion injury via Notch signaling pathway","volume":"120","author":"Jin","year":"2019","journal-title":"Biomed. Pharmacother. = Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0070","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000505961","article-title":"Irisin protects brain against ischemia\/reperfusion injury through suppressing TLR4\/MyD88 pathway","volume":"49","author":"Yu","year":"2020","journal-title":"Cerebrovasc. Diseases (Basel, Switzerland)"},{"issue":"12","key":"10.1016\/j.intimp.2024.112545_b0075","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1002\/jcp.25857","article-title":"Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury","volume":"232","author":"Wang","year":"2017","journal-title":"J. Cell. Physiol."},{"issue":"6","key":"10.1016\/j.intimp.2024.112545_b0080","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/FJC.0000000000000608","article-title":"Irisin protects heart against ischemia-reperfusion injury through a SOD2-dependent mitochondria mechanism","volume":"72","author":"Wang","year":"2018","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112545_b0085","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.redox.2018.10.019","article-title":"Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress","volume":"20","author":"Bi","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.112545_b0090","doi-asserted-by":"crossref","first-page":"9911167","DOI":"10.1155\/2022\/9911167","article-title":"Postconditioning with Irisin attenuates lung ischemia\/reperfusion injury by suppressing ferroptosis via induction of the Nrf2\/HO-1 signal axis","volume":"2022","author":"Wang","year":"2022","journal-title":"oxid. Med. Cell. Longev."},{"issue":"418","key":"10.1016\/j.intimp.2024.112545_b0095","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao6298","article-title":"Irisin protects mitochondria function during pulmonary ischemia\/reperfusion injury","volume":"9","author":"Chen","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.112545_b0100","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1002\/jcp.29903","article-title":"Involvement of GPX4 in irisin's protection against ischemia reperfusion-induced acute kidney injury","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell. Physiol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112545_b0105","article-title":"Irisin is induced in renal ischemia-reperfusion to protect against tubular cell injury via suppressing p53","volume":"1866","author":"Liu","year":"2020","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.intimp.2024.112545_b0110","doi-asserted-by":"crossref","unstructured":"B. Gen\u00e7er Tarak\u00e7\u0131, A. Girgin, S. Timurkaan, M.H. Yal\u00e7\u0131n, F.M. G\u00fcr, M. Karan, Immunohistochemical localization of irisin in skin, eye, and thyroid and pineal glands of the crested porcupine (Hystrix cristata), Biotechnic & histochemistry : official publication of the Biological Stain Commission 91(6) (2016) 423-7.","DOI":"10.1080\/10520295.2016.1183820"},{"issue":"6","key":"10.1016\/j.intimp.2024.112545_b0115","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1167\/iovs.63.6.21","article-title":"Irisin attenuates pathological neovascularization in oxygen-induced retinopathy mice","volume":"63","author":"Zhang","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2024.112545_b0120","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.cell.2018.10.025","article-title":"Irisin mediates effects on bone and fat via \u03b1V integrin receptors","volume":"175","author":"Kim","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.112545_b0125","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1742-2094-8-157","article-title":"Microglia use multiple mechanisms to mediate interactions with vitronectin; non-essential roles for the highly-expressed \u03b1v\u03b23 and \u03b1v\u03b25 integrins","volume":"8","author":"Welser-Alves","year":"2011","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.intimp.2024.112545_b0130","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev-vision-091517-034425","article-title":"Microglia in the retina: roles in development, maturity, and disease","volume":"4","author":"Silverman","year":"2018","journal-title":"Ann. Rev. Vis. Sci."},{"issue":"13","key":"10.1016\/j.intimp.2024.112545_b0135","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.136277","article-title":"Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage-related diseases","volume":"5","author":"Bi","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.intimp.2024.112545_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109704","article-title":"Targeting AMP-activated protein kinase (AMPK) for treatment of autosomal dominant polycystic kidney disease","volume":"73","author":"Song","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2024.112545_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2022.110323","article-title":"Targeting AMPK signaling in ischemic\/reperfusion injury: from molecular mechanism to pharmacological interventions","volume":"94","author":"Paskeh","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.intimp.2024.112545_b0150","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1146\/annurev-cellbio-100818-125242","article-title":"Autophagy in neurons","volume":"35","author":"Stavoe","year":"2019","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2024.112545_b0155","doi-asserted-by":"crossref","unstructured":"K.C. Huang, C. Gomes, Y. Shiga, N. Belforte, K.B. VanderWall, S.S. Lavekar, C.M. Fligor, J. Harkin, A. Di Polo, J.S. Meyer, Autophagy disruption reduces mTORC1 activation leading to retinal ganglion cell neurodegeneration associated with glaucoma, bioRxiv : the preprint server for biology (2023).","DOI":"10.1101\/2023.01.04.522687"},{"issue":"13","key":"10.1016\/j.intimp.2024.112545_b0160","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1002\/jnr.21738","article-title":"Activation of autophagy in retinal ganglion cells","volume":"86","author":"Kim","year":"2008","journal-title":"J. Neurosci. Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0165","doi-asserted-by":"crossref","first-page":"e290","DOI":"10.1038\/cddis.2012.26","article-title":"Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model","volume":"3","author":"Park","year":"2012","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0170","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13024-020-00372-w","article-title":"NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma","volume":"15","author":"Chen","year":"2020","journal-title":"Mol. Neurodegener."},{"issue":"16","key":"10.1016\/j.intimp.2024.112545_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/polym14163265","article-title":"Covalent Organic Framework (COF): a drug and carrier to attenuate retinal ganglion cells death in an acute glaucoma mouse model","volume":"14","author":"Yao","year":"2022","journal-title":"Polymers"},{"issue":"3","key":"10.1016\/j.intimp.2024.112545_b0180","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.63.3.18","article-title":"Intravitreal injection of PACAP attenuates acute ocular hypertension-induced retinal injury via anti-apoptosis and anti-inflammation in mice","volume":"63","author":"Lu","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0185","doi-asserted-by":"crossref","first-page":"e12716","DOI":"10.1111\/jpi.12716","article-title":"Melatonin protects inner retinal neurons of newborn mice after hypoxia-ischemia","volume":"71","author":"Huang","year":"2021","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.intimp.2024.112545_b0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.860070","article-title":"Neuroinflammation, microglia and implications for retinal ganglion cell survival and axon regeneration in traumatic optic neuropathy","volume":"13","author":"Au","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112545_b0195","doi-asserted-by":"crossref","first-page":"C873","DOI":"10.1152\/ajpcell.00604.2020","article-title":"The intersection of metformin and inflammation","volume":"320","author":"Bharath","year":"2021","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.intimp.2024.112545_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172797","article-title":"Salidroside ameliorates endothelial inflammation and oxidative stress by regulating the AMPK\/NF-\u03baB\/NLRP3 signaling pathway in AGEs-induced HUVECs","volume":"867","author":"Hu","year":"2020","journal-title":"Eur. J. Pharmacol."},{"issue":"34","key":"10.1016\/j.intimp.2024.112545_b0205","doi-asserted-by":"crossref","first-page":"5120","DOI":"10.3748\/wjg.v25.i34.5120","article-title":"Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1\/AMPK and NF-\u03baB signaling pathways","volume":"25","author":"Li","year":"2019","journal-title":"World J. Gastroenterol."},{"issue":"6","key":"10.1016\/j.intimp.2024.112545_b0210","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4161\/auto.4600","article-title":"How to interpret LC3 immunoblotting","volume":"3","author":"Mizushima","year":"2007","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2024.112545_b0215","article-title":"The changes of Irisin and inflammatory cytokines in the age-related macular degeneration and retinal vein occlusion","volume":"13","author":"Li","year":"2022","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0220","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12974-022-02438-6","article-title":"Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin \u03b1V\u03b25\/AMPK signaling pathway after intracerebral hemorrhage in mice","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.intimp.2024.112545_b0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.metabol.2016.12.003","article-title":"The novel exercise-induced hormone irisin protects against neuronal injury via activation of the Akt and ERK1\/2 signaling pathways and contributes to the neuroprotection of physical exercise in cerebral ischemia","volume":"68","author":"Li","year":"2017","journal-title":"Metab. Clin. Exp."},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0230","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","article-title":"Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer's models","volume":"25","author":"Lourenco","year":"2019","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041605","article-title":"FNDC5\/Irisin system in neuroinflammation and neurodegenerative diseases: update and novel perspective","volume":"22","author":"Pignataro","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0240","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/s12974-021-02309-6","article-title":"The semantics of microglia activation: neuroinflammation, homeostasis, and stress","volume":"18","author":"Woodburn","year":"2021","journal-title":"J. Neuroinflam."},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0245","doi-asserted-by":"crossref","first-page":"e12774","DOI":"10.1111\/acel.12774","article-title":"Antagonizing peroxisome proliferator-activated receptor \u03b3 facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway","volume":"17","author":"Ji","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2024.112545_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102787","article-title":"Irisin inhibits neutrophil extracellular traps formation and protects against acute pancreatitis in mice","volume":"64","author":"Han","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0255","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/jcmm.14811","article-title":"Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin \u03b1V\u03b25 receptor","volume":"24","author":"Bi","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2024.112545_b0260","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yjmcc.2021.06.013","article-title":"FNDC5\/Irisin attenuates diabetic cardiomyopathy in a type 2 diabetes mouse model by activation of integrin \u03b1V\/\u03b25-AKT signaling and reduction of oxidative\/nitrosative stress","volume":"160","author":"Lin","year":"2021","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.intimp.2024.112545_b0265","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.preteyeres.2016.08.001","article-title":"Autophagy in the eye: development, degeneration, and aging","volume":"55","author":"Boya","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"issue":"9","key":"10.1016\/j.intimp.2024.112545_b0270","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.4161\/auto.21052","article-title":"An appetite for destruction: from self-eating to cell cannibalism as a neuronal survival strategy","volume":"8","author":"Poels","year":"2012","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.intimp.2024.112545_b0275","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0245-z","article-title":"Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1\/FOXO3a-mediated autophagy and mitochondrial biogenesis","volume":"51","author":"Dusabimana","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2024.112545_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102288","article-title":"Empagliflozin attenuates cardiac microvascular ischemia\/reperfusion through activating the AMPK\u03b11\/ULK1\/FUNDC1\/mitophagy pathway","volume":"52","author":"Cai","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.112545_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101671","article-title":"HIF-1\u03b1-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia\/reperfusion injury","volume":"36","author":"Fu","year":"2020","journal-title":"Redox Biol."},{"issue":"13","key":"10.1016\/j.intimp.2024.112545_b0290","doi-asserted-by":"crossref","first-page":"13187","DOI":"10.18632\/aging.103420","article-title":"Electroacupuncture ameliorates cerebral ischemia\/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway","volume":"12","author":"Mei","year":"2020","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.intimp.2024.112545_b0295","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41467-017-02280-y","article-title":"LncRNA CAIF inhibits autophagy and attenuates myocardial infarction by blocking p53-mediated myocardin transcription","volume":"9","author":"Liu","year":"2018","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.intimp.2024.112545_b0300","doi-asserted-by":"crossref","DOI":"10.3390\/cells12151969","article-title":"The role of mitophagy in glaucomatous neurodegeneration","volume":"12","author":"Stavropoulos","year":"2023","journal-title":"Cells"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692401066X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692401066X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:53:15Z","timestamp":1778820795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692401066X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":60,"alternative-id":["S156757692401066X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112545","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Irisin attenuates acute glaucoma-induced neuroinflammation by activating microglia-integrin \u03b1V\u03b25\/AMPK and promoting autophagy","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112545","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112545"}}