{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T22:26:23Z","timestamp":1783635983729,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010040","name":"Taishan Scholar Project of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010029","name":"Taishan Scholar Foundation of Shandong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.intimp.2024.112592","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:43:04Z","timestamp":1719880984000},"page":"112592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK\/NF-\u03baB signaling and NLRP3 inflammasome activation"],"prefix":"10.1016","volume":"138","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7093-4931","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenghua","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112592_b0005","doi-asserted-by":"crossref","first-page":"159","DOI":"10.5853\/jos.2019.02978","article-title":"Beyond the brain: the systemic pathophysiological response to acute ischemic stroke","volume":"22","author":"Balch","year":"2020","journal-title":"J. Stroke."},{"key":"10.1016\/j.intimp.2024.112592_b0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.4103\/bc.bc_32_18","article-title":"Brain-gut axis after stroke","volume":"4","author":"Arya","year":"2018","journal-title":"Brain Circ."},{"key":"10.1016\/j.intimp.2024.112592_b0015","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.gtc.2018.07.002","article-title":"Brain-gut axis: clinical implications","volume":"47","author":"Khlevner","year":"2018","journal-title":"Gastroenterol. Clin. North. Am."},{"key":"10.1016\/j.intimp.2024.112592_b0020","doi-asserted-by":"crossref","first-page":"400","DOI":"10.3109\/15376516.2010.550337","article-title":"Escin attenuates cerebral edema induced by acute omethoate poisoning","volume":"21","author":"Wang","year":"2011","journal-title":"Toxicol. Mech. Methods."},{"key":"10.1016\/j.intimp.2024.112592_b0025","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neuint.2010.05.001","article-title":"Escin attenuates cognitive deficits and hippocampal injury after transient global cerebral ischemia in mice via regulating certain inflammatory genes","volume":"57","author":"Zhang","year":"2010","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.intimp.2024.112592_b0030","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1055\/s-0029-1185838","article-title":"Escin, a natural mixture of triterpene saponins, exhibits antitumor activity against hepatocellular carcinoma","volume":"75","author":"Zhou","year":"2009","journal-title":"Planta. Med."},{"key":"10.1016\/j.intimp.2024.112592_b0035","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1007\/s00268-005-7870-5","article-title":"Escin: inhibiting inflammation and promoting gastrointestinal transit to attenuate formation of postoperative adhesions","volume":"29","author":"Fu","year":"2005","journal-title":"World J Surg"},{"key":"10.1016\/j.intimp.2024.112592_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115627","article-title":"Integrated systematic pharmacology analysis and experimental validation to reveal the mechanism of action of Semen aesculi on inflammatory bowel diseases","volume":"298","author":"Li","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.112592_b0045","doi-asserted-by":"crossref","first-page":"699","DOI":"10.2147\/DDDT.S297501","article-title":"Glucocorticoid-like activity of Escin: a new mechanism for an old drug","volume":"15","author":"Gallelli","year":"2021","journal-title":"Drug. Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2024.112592_b0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.phymed.2010.08.013","article-title":"Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro","volume":"18","author":"Xin","year":"2011","journal-title":"Phytomedicine."},{"key":"10.1016\/j.intimp.2024.112592_b0055","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.fitote.2011.04.004","article-title":"The potent anti-inflammatory agent escin does not increase corticosterone secretion and immune cell apoptosis in mice","volume":"82","author":"Zhang","year":"2011","journal-title":"Fitoterapia."},{"key":"10.1016\/j.intimp.2024.112592_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109659","article-title":"Escin alleviates stress-induced intestinal dysfunction to protect brain injury by regulating the gut-brain axis in ischemic stroke rats","volume":"115","author":"Li","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112592_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113554","article-title":"Escin ameliorates the impairments of neurological function and blood brain barrier by inhibiting systemic inflammation in intracerebral hemorrhagic mice","volume":"337","author":"Ding","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2024.112592_b0070","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146852","article-title":"NLRP3\/caspase-1\/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression","volume":"6","author":"Li","year":"2021","journal-title":"JCI. Insight."},{"key":"10.1016\/j.intimp.2024.112592_b0075","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/ijnp\/pyaa060","article-title":"Baicalein Attenuates neuroinflammation by inhibiting NLRP3\/caspase-1\/GSDMD Pathway in MPTP induced mice model of parkinson's disease","volume":"23","author":"Rui","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.intimp.2024.112592_b0080","article-title":"Enteric fungi protect against intestinal ischemia\u2013reperfusion injury via inhibiting the SAA1-GSDMD pathway","author":"Chen","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.intimp.2024.112592_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101534","article-title":"Metformin protects against intestinal ischemia-reperfusion injury and cell pyroptosis via TXNIP-NLRP3-GSDMD pathway","volume":"32","author":"Jia","year":"2020","journal-title":"Redox. Biol."},{"key":"10.1016\/j.intimp.2024.112592_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110677","article-title":"Aucubin improves chronic unpredictable mild stress-induced depressive behavior in mice via the GR\/NF-\u03baB\/NLRP3 axis","volume":"123","author":"Liu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112592_b0095","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.7150\/thno.71086","article-title":"Pyroptosis in inflammatory diseases and cancer","volume":"12","author":"Rao","year":"2022","journal-title":"Theranostics."},{"key":"10.1016\/j.intimp.2024.112592_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110990","article-title":"Uric acid aggravates myocardial ischemia-reperfusion injury via ROS\/NLRP3 pyroptosis pathway","volume":"133","author":"Shen","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.112592_b0105","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1080\/19490976.2020.1756690","article-title":"Glycated milk protein fermented with Lactobacillus rhamnosus ameliorates the cognitive health of mice under mild-stress condition","volume":"11","author":"Oh","year":"2020","journal-title":"Gut. Microbes."},{"key":"10.1016\/j.intimp.2024.112592_b0110","first-page":"53250","article-title":"Ex vivo intestinal sacs to assess mucosal permeability in models of gastrointestinal disease","author":"Mateer","year":"2016","journal-title":"J. Vis. Exp"},{"key":"10.1016\/j.intimp.2024.112592_b0115","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1152\/ajpendo.00122.2005","article-title":"Comparative analysis of ACTH and corticosterone sampling methods in rats","volume":"289","author":"Vahl","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.112592_b0120","doi-asserted-by":"crossref","first-page":"7171","DOI":"10.1039\/D1FO01164B","article-title":"Bifidobacterium dentium N8 with potential probiotic characteristics prevents LPS-induced intestinal barrier injury by alleviating the inflammatory response and regulating the tight junction in Caco-2 cell monolayers","volume":"12","author":"Zhao","year":"2021","journal-title":"Food. Funct."},{"key":"10.1016\/j.intimp.2024.112592_b0125","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1042\/BCJ20160679","article-title":"Calcium-mediated oxidative stress: a common mechanism in tight junction disruption by different types of cellular stress","volume":"474","author":"Gangwar","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.intimp.2024.112592_b0130","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1038\/s41598-020-80637-y","article-title":"Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis","volume":"11","author":"Shukla","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.112592_b0135","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1212\/WNL.0000000000012781","article-title":"Global epidemiology of stroke and access to acute ischemic stroke interventions","volume":"97","author":"Saini","year":"2021","journal-title":"Neurology."},{"key":"10.1016\/j.intimp.2024.112592_b0140","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2016.00592","article-title":"Endothelial response to glucocorticoids in inflammatory diseases","volume":"7","author":"Zieli\u0144ska","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112592_b0145","article-title":"Repression of the glucocorticoid receptor aggravates acute ischemic brain injuries in adult mice","volume":"19","author":"Li","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112592_b0150","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.cell.2021.12.024","article-title":"GSDMB is increased in IBD and regulates epithelial restitution\/repair independent of pyroptosis","volume":"185","author":"Rana","year":"2022","journal-title":"Cell."},{"key":"10.1016\/j.intimp.2024.112592_b0155","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158057","article-title":"Dieckol Attenuated Glucocorticoid-Induced Muscle Atrophy by Decreasing NLRP3 Inflammasome and Pyroptosis","volume":"22","author":"Oh","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112592_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153743","article-title":"Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-kappaB pathway","volume":"92","author":"Wei","year":"2021","journal-title":"Phytomedicine."},{"key":"10.1016\/j.intimp.2024.112592_b0165","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1161\/STROKEAHA.110.607705","article-title":"Stress worsens endothelial function and ischemic stroke via glucocorticoids","volume":"42","author":"Balkaya","year":"2011","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.112592_b0170","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10571-018-0610-9","article-title":"Mineralocorticoid Receptors, Neuroinflammation and Hypertensive Encephalopathy","volume":"39","author":"Brocca","year":"2019","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2024.112592_b0175","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/acer.12093","article-title":"Mifepristone pretreatment reduces ethanol withdrawal severity in vivo","volume":"37","author":"Sharrett-Field","year":"2013","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.intimp.2024.112592_b0180","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0015-0282(97)00189-1","article-title":"Mifepristone (RU486): a review","volume":"68","author":"Mahajan","year":"1997","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.112592_b0185","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.yfrne.2006.05.001","article-title":"Effects of genetically altered brain glucocorticoid receptor action on behavior and adrenal axis regulation in mice","volume":"27","author":"Howell","year":"2006","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.intimp.2024.112592_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23063322","article-title":"Crosstalk between p38 MAPK and GR Signaling","volume":"23","author":"Zeyen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112592_b0195","first-page":"964","article-title":"Hypomethylation of NLRP3 gene promoter discriminates glucocorticoid-resistant from glucocorticoid-sensitive idiopathic nephrotic syndrome patients, Clinical and Translational","volume":"14","author":"Lucaf\u00f2","year":"2021","journal-title":"Science."},{"key":"10.1016\/j.intimp.2024.112592_b0200","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7150\/ijms.30424","article-title":"Glucocorticoid regulates NLRP3 in acute-on-chronic hepatitis B liver failure","volume":"16","author":"Zhao","year":"2019","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.intimp.2024.112592_b0205","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.freeradbiomed.2020.11.003","article-title":"Glucocorticoid receptors involved in melatonin inhibiting cell apoptosis and NLRP3 inflammasome activation caused by bacterial toxin pyocyanin in colon","volume":"162","author":"Cai","year":"2021","journal-title":"Free. Radical. Biology. and. Medicine."},{"key":"10.1016\/j.intimp.2024.112592_b0210","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12488","article-title":"Role of tumor necrosis factor receptor-associated factor 6 in pyroptosis during acute pancreatitis","volume":"24","author":"Wei","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.112592_b0215","doi-asserted-by":"crossref","first-page":"5414","DOI":"10.1111\/jcmm.17564","article-title":"Echinacoside inhibited cardiomyocyte pyroptosis and improved heart function of HF rats induced by isoproterenol via suppressing NADPH\/ROS\/ER stress","volume":"26","author":"Ni","year":"2022","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.intimp.2024.112592_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2019.00210","article-title":"Glucocorticoid-driven NLRP3 inflammasome activation in hippocampal microglia mediates chronic stress-induced depressive-like behaviors","volume":"12","author":"Feng","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.intimp.2024.112592_b0225","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41420-022-00906-9","article-title":"HDAC11 promotes both NLRP3\/caspase-1\/GSDMD and caspase-3\/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells","volume":"8","author":"Yao","year":"2022","journal-title":"Cell. Death. Discov."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924011135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924011135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T17:31:29Z","timestamp":1722360689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924011135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":45,"alternative-id":["S1567576924011135"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112592","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Escin alleviates cerebral ischemia-induced intestinal pyroptosis via the GR-dependent p38 MAPK\/NF-\u03baB signaling and NLRP3 inflammasome activation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112592","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112592"}}