{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:02:36Z","timestamp":1790791356334,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.intimp.2024.112685","type":"journal-article","created":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T20:16:13Z","timestamp":1721765773000},"page":"112685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Baicalein upregulates macrophage TREM2 expression via TrKB-CREB1 pathway to attenuate acute inflammatory injury in acute-on-chronic liver failure"],"prefix":"10.1016","volume":"139","author":[{"given":"Jia","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiongchi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiumin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2024.112685_b0005","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1053\/j.gastro.2013.02.042","article-title":"Acute-on-chronic liver failure is a distinct syndrome that develops in patients with acute decompensation of cirrhosis","volume":"144","author":"Moreau","year":"2013","journal-title":"Gastroenterology"},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.112685_b0010","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1016\/j.jhep.2020.11.047","article-title":"Acute-on-chronic liver failure: A distinct clinical syndrome","volume":"75","author":"Moreau","year":"2021","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0015","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/gutjnl-2020-322161","article-title":"Global burden of disease: acute-on-chronic liver failure, a systematic review and meta-analysis","volume":"71","author":"Mezzano","year":"2022","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2024.112685_b0020","doi-asserted-by":"crossref","first-page":"16041","DOI":"10.1038\/nrdp.2016.41","article-title":"Acute-on-chronic liver failure in cirrhosis","volume":"2","author":"Arroyo","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"3","key":"10.1016\/j.intimp.2024.112685_b0025","doi-asserted-by":"crossref","first-page":"670","DOI":"10.3350\/cmh.2022.0103","article-title":"Acute-on-chronic liver failure: Terminology, mechanisms and management","volume":"29","author":"Br","year":"2023","journal-title":"Clin Mol Hepatol"},{"issue":"3","key":"10.1016\/j.intimp.2024.112685_b0030","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrgastro.2015.219","article-title":"Acute-on-chronic liver failure: terminology, mechanisms and management","volume":"13","author":"Sarin","year":"2016","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.intimp.2024.112685_b0035","doi-asserted-by":"crossref","DOI":"10.1111\/liv.15733","article-title":"Mechanisms and treatment approaches for ACLF","author":"Piano","year":"2023","journal-title":"Liver Int"},{"key":"10.1016\/j.intimp.2024.112685_b0040","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.3389\/fimmu.2018.02948","article-title":"The role of monocytes and macrophages in acute and acute-on-chronic liver failure","volume":"9","author":"Triantafyllou","year":"2018","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.intimp.2024.112685_b0045","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.jhep.2022.07.006","article-title":"Combination of G-CSF and a TLR4 inhibitor reduce inflammation and promote regeneration in a mouse model of ACLF","volume":"77","author":"Engelmann","year":"2022","journal-title":"J Hepatol"},{"issue":"4","key":"10.1016\/j.intimp.2024.112685_b0050","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.jhep.2015.11.021","article-title":"Macrophage activation markers predict mortality in patients with liver cirrhosis without or with acute-on-chronic liver failure (ACLF)","volume":"64","author":"Gr\u00f8nb\u00e6k","year":"2016","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0055","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jhep.2020.03.027","article-title":"Innate immune cells in cirrhosis","volume":"73","author":"Bernsmeier","year":"2020","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41419-020-03378-w","article-title":"M2-like macrophages exert hepatoprotection in acute-on-chronic liver failure through inhibiting necroptosis-S100A9-necroinflammation axis","volume":"12","author":"Bai","year":"2021","journal-title":"Cell Death Dis"},{"issue":"9","key":"10.1016\/j.intimp.2024.112685_b0065","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/s41419-022-05181-1","article-title":"Galectin-3 critically mediates the hepatoprotection conferred by M2-like macrophages in ACLF by inhibiting pyroptosis but not necroptosis signalling","volume":"13","author":"Bai","year":"2022","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2022.11.013","article-title":"Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.112685_b0075","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ejmech.2017.03.004","article-title":"Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders","volume":"131","author":"Dinda","year":"2017","journal-title":"Eur J Med Chem"},{"key":"10.1016\/j.intimp.2024.112685_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2023.115629","article-title":"An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: Insights into molecular mechanisms","volume":"258","author":"Dinda","year":"2023","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0085","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ctrv.2008.09.005","article-title":"New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin","volume":"35","author":"Li-Weber","year":"2009","journal-title":"Baicalein and Baicalin, Cancer Treat Rev"},{"key":"10.1016\/j.intimp.2024.112685_b0090","doi-asserted-by":"crossref","first-page":"1113810","DOI":"10.3389\/fphar.2023.1113810","article-title":"The mechanism of action of paeoniae radix rubra-angelicae sinensis radix drug pair in the treatment of rheumatoid arthritis through PI3K\/AKT\/NF-\u03baB signaling pathway","volume":"14","author":"Li","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.intimp.2024.112685_b0095","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.freeradbiomed.2023.01.006","article-title":"Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis","volume":"196","author":"Wan","year":"2023","journal-title":"Free Radic Biol Med"},{"issue":"Pt B","key":"10.1016\/j.intimp.2024.112685_b0100","article-title":"Baicalein alleviates pyroptosis and inflammation in hyperlipidemic pancreatitis by inhibiting NLRP3\/Caspase-1 pathway through the miR-192-5p\/TXNIP axis","volume":"101","author":"Wang","year":"2021","journal-title":"Int Immunopharmacol"},{"issue":"6","key":"10.1016\/j.intimp.2024.112685_b0105","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/s41401-021-00781-7","article-title":"Baicalein ameliorates ulcerative colitis by improving intestinal epithelial barrier via AhR\/IL-22 pathway in ILC3s","volume":"43","author":"Li","year":"2022","journal-title":"Acta Pharmacol Sin"},{"issue":"4","key":"10.1016\/j.intimp.2024.112685_b0110","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.jhep.2019.11.009","article-title":"Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF","volume":"72","author":"Moreau","year":"2020","journal-title":"J Hepatol"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0115","article-title":"Acute-on-chronic liver failure: Definitions, pathophysiology and principles of treatment","volume":"3","author":"Zaccherini","year":"2021","journal-title":"JHEP Rep"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0120","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jhep.2020.01.011","article-title":"Toll-like receptor 4 is a therapeutic target for prevention and treatment of liver failure","volume":"73","author":"Engelmann","year":"2020","journal-title":"J Hepatol"},{"issue":"3","key":"10.1016\/j.intimp.2024.112685_b0125","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1055\/s-0041-1723034","article-title":"The current status of granulocyte-colony stimulating factor to treat acute-on-chronic liver failure","volume":"41","author":"Engelmann","year":"2021","journal-title":"Semin Liver Dis"},{"issue":"7","key":"10.1016\/j.intimp.2024.112685_b0130","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1007\/s00011-013-0624-1","article-title":"Blockade of high-mobility group box-1 ameliorates acute on chronic liver failure in rats","volume":"62","author":"Li","year":"2013","journal-title":"Inflamm Res"},{"issue":"5","key":"10.1016\/j.intimp.2024.112685_b0135","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1083\/jcb.200805048","article-title":"CaMKII locally encodes L-type channel activity to signal to nuclear CREB in excitation-transcription coupling","volume":"183","author":"Wheeler","year":"2008","journal-title":"J Cell Biol"},{"issue":"10","key":"10.1016\/j.intimp.2024.112685_b0140","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1523\/JNEUROSCI.0893-19.2020","article-title":"Neuronal L-type calcium channel signaling to the nucleus requires a novel CaMKII\u03b1-shank3 interaction","volume":"40","author":"Perfitt","year":"2020","journal-title":"J Neurosci"},{"issue":"3","key":"10.1016\/j.intimp.2024.112685_b0145","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1172\/JCI59643","article-title":"Macrophage plasticity and polarization: in vivo veritas","volume":"122","author":"Sica","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2024.112685_b0150","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jconrel.2016.01.026","article-title":"Delivery strategies to control inflammatory response: Modulating M1\u2013M2 polarization in tissue engineering applications","volume":"240","author":"Alvarez","year":"2016","journal-title":"J Control Release"},{"issue":"9","key":"10.1016\/j.intimp.2024.112685_b0155","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"issue":"12","key":"10.1016\/j.intimp.2024.112685_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122626","article-title":"Function of TREM1 and TREM2 in liver-related diseases","volume":"9","author":"Sun","year":"2020","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0165","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1186\/s12967-023-04294-1","article-title":"Intrahepatic macrophage reprogramming associated with lipid metabolism in hepatitis B virus-related acute-on-chronic liver failure","volume":"21","author":"Peng","year":"2023","journal-title":"J Transl Med"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0170","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12974-021-02144-9","article-title":"High-salt diet downregulates TREM2 expression and blunts efferocytosis of macrophages after acute ischemic stroke","volume":"18","author":"Hu","year":"2021","journal-title":"J Neuroinflammation"},{"issue":"15","key":"10.1016\/j.intimp.2024.112685_b0175","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1111\/jcmm.17842","article-title":"TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum","volume":"27","author":"Zhu","year":"2023","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.intimp.2024.112685_b0180","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.bbi.2019.07.004","article-title":"Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2","volume":"81","author":"Xu","year":"2019","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.intimp.2024.112685_b0185","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.immuni.2022.11.013","article-title":"Prolonged hypernutrition impairs TREM2-dependent efferocytosis to license chronic liver inflammation and NASH development","volume":"56","author":"Wang","year":"2023","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.intimp.2024.112685_b0190","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/s41571-018-0113-0","article-title":"NTRK fusion-positive cancers and TRK inhibitor therapy","volume":"15","author":"Cocco","year":"2018","journal-title":"Nat Rev Clin Oncol"},{"issue":"5","key":"10.1016\/j.intimp.2024.112685_b0195","doi-asserted-by":"crossref","first-page":"10122","DOI":"10.3390\/ijms140510122","article-title":"TrkB receptor signalling: implications in neurodegenerative, psychiatric and proliferative disorders","volume":"14","author":"Gupta","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.intimp.2024.112685_b0200","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1523\/JNEUROSCI.0367-19.2019","article-title":"CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons","volume":"40","author":"Esvald","year":"2020","journal-title":"J Neurosci"},{"key":"10.1016\/j.intimp.2024.112685_b0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2019.01.004","article-title":"CREB signals as PBMC-based biomarkers of cognitive dysfunction: A novel perspective of the brain-immune axis","volume":"78","author":"Bartolotti","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.intimp.2024.112685_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111556","article-title":"Baicalein alleviates depression-like behavior in rotenone- induced Parkinson's disease model in mice through activating the BDNF\/TrkB\/CREB pathway","volume":"140","author":"Zhao","year":"2021","journal-title":"Biomed Pharmacother"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924012062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924012062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T07:22:15Z","timestamp":1732951335000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924012062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":42,"alternative-id":["S1567576924012062"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112685","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Baicalein upregulates macrophage TREM2 expression via TrKB-CREB1 pathway to attenuate acute inflammatory injury in acute-on-chronic liver failure","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112685","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112685"}}