{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:31:47Z","timestamp":1792801907683,"version":"4.5.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T00:00:00Z","timestamp":1721174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273530"],"award-info":[{"award-number":["82273530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.intimp.2024.112704","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T15:22:54Z","timestamp":1721402574000},"page":"112704","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["Role of glucose metabolism reprogramming in keratinocytes in the link between psoriasis and metabolic syndrome"],"prefix":"10.1016","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0624-5573","authenticated-orcid":false,"given":"Liang","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5938-9545","authenticated-orcid":false,"given":"Yuxin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7347-6814","authenticated-orcid":false,"given":"Chengxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0005","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-022-04523-3","article-title":"Advances in the pathogenesis of psoriasis: from keratinocyte perspective","volume":"13","author":"Zhou","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.112704_b0010","unstructured":"I.M. Michalek, B. Loring, S.M. John, O. World Health. Global report on psoriasis. Geneva: World Health Organization, 2016."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/bjd.16885","article-title":"Metabolic syndrome and risk of incident psoriasis: prospective data from the HUNT Study, Norway","volume":"180","author":"Snekvik","year":"2019","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0020","doi-asserted-by":"crossref","first-page":"24043","DOI":"10.1038\/s41598-021-03174-2","article-title":"Changes in metabolic syndrome and risk of psoriasis: a nationwide population-based study","volume":"11","author":"Lee","year":"2021","journal-title":"Sci. Rep."},{"issue":"3 Pt 1","key":"10.1016\/j.intimp.2024.112704_b0025","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/jid.2011.365","article-title":"Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom","volume":"132","author":"Langan","year":"2012","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112704_b0030","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/ijd.12879","article-title":"Comorbidity as a predictor for drug survival of biologic therapy in patients with psoriasis","volume":"55","author":"Jacobi","year":"2016","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2024.112704_b0035","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.omtn.2021.04.022","article-title":"lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1","volume":"25","author":"Luo","year":"2021","journal-title":"Mol. Ther. Nucl. Acids"},{"issue":"3","key":"10.1016\/j.intimp.2024.112704_b0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tibs.2015.12.001","article-title":"The warburg effect: how does it benefit cancer cells?","volume":"41","author":"Liberti","year":"2016","journal-title":"Trends Biochem. Sci"},{"key":"10.1016\/j.intimp.2024.112704_b0045","article-title":"Glycolysis in innate immune cells contributes to autoimmunity","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112704_b0050","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-immunol-032712-095956","article-title":"Metabolic regulation of T lymphocytes","volume":"31","author":"MacIver","year":"2013","journal-title":"Annu. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112704_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/genes13030549","article-title":"Expression of HK2, PKM2, and PFKM is associated with metastasis and late disease onset in breast cancer patients","volume":"13","author":"Ishfaq","year":"2022","journal-title":"Genes (Basel)"},{"issue":"3","key":"10.1016\/j.intimp.2024.112704_b0060","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3164\/jcbn.19-110","article-title":"Sirtuin 6 and metabolic genes interplay in Warburg effect in cancers","volume":"66","author":"Al-Azzam","year":"2020","journal-title":"J. Clin. Biochem. Nutr."},{"key":"10.1016\/j.intimp.2024.112704_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112612","article-title":"PFKFB3 inhibitors as potential anticancer agents: mechanisms of action, current developments, and structure-activity relationships","volume":"203","author":"Wang","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2024.112704_b0070","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.780839","article-title":"Modulation of macrophage immunometabolism: a new approach to fight infections","volume":"13","author":"Gauthier","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.112704_b0075","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.jid.2016.12.020","article-title":"PFKFB3, a direct target of p63, is required for proliferation and inhibits differentiation in epidermal keratinocytes","volume":"137","author":"Hamanaka","year":"2017","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.intimp.2024.112704_b0080","article-title":"Pyruvate kinase M2 mediates glycolysis contributes to psoriasis by promoting keratinocyte proliferation","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2024.112704_b0085","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/aps.2016.47","article-title":"Anticancer strategies based on the metabolic profile of tumor cells: therapeutic targeting of the Warburg effect","volume":"37","author":"Chen","year":"2016","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0090","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12964-023-01455-z","article-title":"The immune checkpoint TIGIT\/CD155 promotes the exhaustion of CD8 + T cells in TNBC through glucose metabolic reprogramming mediated by PI3K\/AKT\/mTOR signaling","volume":"22","author":"Huang","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"Pt B","key":"10.1016\/j.intimp.2024.112704_b0095","article-title":"LPA\/LPAR1 signaling induces PGAM1 expression via AKT\/mTOR\/HIF-1alpha pathway and increases aerobic glycolysis, contributing to keratinocyte proliferation","volume":"311","author":"Kim","year":"2022","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.intimp.2024.112704_b0100","first-page":"854","article-title":"Upregulation of PI3K\/AKT\/mTOR, FABP5 and PPARbeta\/delta in human psoriasis and imiquimod-induced murine psoriasiform dermatitis model","volume":"96","author":"Chamcheu","year":"2016","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.intimp.2024.112704_b0105","doi-asserted-by":"crossref","first-page":"2786","DOI":"10.3389\/fimmu.2018.02786","article-title":"Epidermal mTORC1 signaling contributes to the pathogenesis of psoriasis and could serve as a therapeutic target","volume":"9","author":"Buerger","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/biom13010010","article-title":"Encouraging tactics with genetically modified probiotics to improve immunity for the prevention of immune-related diseases including cardio-metabolic disorders","volume":"13","author":"Asai","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.intimp.2024.112704_b0115","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.2147\/CCID.S422355","article-title":"Higher IL-9 level is associated with psoriasis vulgaris complicated by metabolic syndrome","volume":"16","author":"Yan","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"10","key":"10.1016\/j.intimp.2024.112704_b0120","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-002451","article-title":"MET overexpression contributes to STAT4-PD-L1 signaling activation associated with tumor-associated, macrophages-mediated immunosuppression in primary glioblastomas","volume":"9","author":"Wang","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"9","key":"10.1016\/j.intimp.2024.112704_b0125","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.4049\/jimmunol.0902464","article-title":"Skin inflammation induced by the synergistic action of IL-17A, IL-22, oncostatin M, IL-1{alpha}, and TNF-{alpha} recapitulates some features of psoriasis","volume":"184","author":"Guilloteau","year":"2010","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112704_b0130","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/bjd.14481","article-title":"Zinc finger protein A20 is involved in the antipsoriatic effect of calcipotriol","volume":"175","author":"Liu","year":"2016","journal-title":"Br. J. Dermatol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112704_b0135","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1002\/mnfr.201500635","article-title":"Fructose and glucose combined with free fatty acids induce metabolic disorders in HepG2 cell: a new model to study the impacts of high-fructose\/sucrose and high-fat diets in vitro","volume":"60","author":"Zhao","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.112704_b0140","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.jaad.2017.04.1133","article-title":"Systematic review and meta-analysis of the association between psoriasis and metabolic syndrome","volume":"77","author":"Rodr\u00edguez-Z\u00fa\u00f1iga","year":"2017","journal-title":"J. Am. Acad. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/jdi.12663","article-title":"Prevalence of metabolic syndrome in Chinese psoriasis patients: a hospital-based cross-sectional study","volume":"9","author":"Gui","year":"2018","journal-title":"J Diabetes Investig."},{"issue":"16","key":"10.1016\/j.intimp.2024.112704_b0150","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1111\/febs.14577","article-title":"Glucose transporters in cancer - from tumor cells to the tumor microenvironment","volume":"285","author":"Ancey","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.intimp.2024.112704_b0155","doi-asserted-by":"crossref","DOI":"10.1002\/cac2.12549","article-title":"The regulatory roles and clinical significance of glycolysis in tumor","author":"Qiao","year":"2024","journal-title":"Cancer Commun (Lond)"},{"issue":"8","key":"10.1016\/j.intimp.2024.112704_b0160","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/ijd.14037","article-title":"Glucose transporter-1 (GLUT-1) expression in psoriasis: correlation with disease severity","volume":"57","author":"Hodeib","year":"2018","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.intimp.2024.112704_b0165","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.2147\/CCID.S435624","article-title":"Inhibition of key glycolytic enzyme hexokinase 2 ameliorates psoriasiform inflammation in vitro and in vivo","volume":"16","author":"Zhuang","year":"2023","journal-title":"Clin. Cosmet. Investig. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112704_b0170","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1111\/bjd.15008","article-title":"Exploration of candidate biomarkers for human psoriasis based on gas chromatography-mass spectrometry serum metabolomics","volume":"176","author":"Kang","year":"2017","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.intimp.2024.112704_b0175","doi-asserted-by":"crossref","first-page":"1188745","DOI":"10.3389\/fimmu.2023.1188745","article-title":"A prediction model identifying glycolysis signature as therapeutic target for psoriasis","volume":"14","author":"Shou","year":"2023","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0180","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jid.2018.06.184","article-title":"Cornulin is induced in psoriasis lesions and promotes keratinocyte proliferation via phosphoinositide 3-kinase\/Akt pathways","volume":"139","author":"Li","year":"2019","journal-title":"J. Invest. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0185","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jdermsci.2024.02.007","article-title":"Rh family C glycoprotein contributes to psoriatic inflammation through regulating the dysdifferentiation and cytokine secretion of keratinocytes","volume":"114","author":"Liu","year":"2024","journal-title":"J. Dermatol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.112704_b0190","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/15548627.2020.1725381","article-title":"Autophagy-based unconventional secretion of HMGB1 by keratinocytes plays a pivotal role in psoriatic skin in fl ammation","volume":"17","author":"Wang","year":"2021","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.intimp.2024.112704_b0195","doi-asserted-by":"crossref","first-page":"e334","DOI":"10.1038\/cddis.2012.69","article-title":"Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis","volume":"3","author":"Madonna","year":"2012","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0200","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/bjd.12271","article-title":"Mammalian target of rapamycin and its downstream signalling components are activated in psoriatic skin","volume":"169","author":"Buerger","year":"2013","journal-title":"Br. J. Dermatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0205","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cyto.2012.06.316","article-title":"IL-22 induced cell proliferation is regulated by PI3K\/Akt\/mTOR signaling cascade","volume":"60","author":"Mitra","year":"2012","journal-title":"Cytokine"},{"issue":"7","key":"10.1016\/j.intimp.2024.112704_b0210","doi-asserted-by":"crossref","first-page":"e0180853","DOI":"10.1371\/journal.pone.0180853","article-title":"Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation","volume":"12","author":"Buerger","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.112704_b0215","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.774808","article-title":"Cardiometabolic comorbidities in patients with psoriasis: focusing on risk, biological therapy, and pathogenesis","volume":"12","author":"Cai","year":"2021","journal-title":"Front Pharmacol."},{"issue":"6","key":"10.1016\/j.intimp.2024.112704_b0220","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/jdv.18044","article-title":"Psoriasis and metabolic syndrome: implications for the management and treatment of psoriasis","volume":"36","author":"Wu","year":"2022","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112704_b0225","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1038\/s41598-017-04175-w","article-title":"Palmitic Acid-BSA enhances Amyloid-\u03b2 production through GPR40-mediated dual pathways in neuronal cells: involvement of the Akt\/mTOR\/HIF-1\u03b1 and Akt\/NF-\u03baB pathways","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.intimp.2024.112704_b0230","doi-asserted-by":"crossref","first-page":"18861","DOI":"10.3390\/ijms140918861","article-title":"Oleic acid increases synthesis and secretion of VEGF in rat vascular smooth muscle cells: role of oxidative stress and impairment in obesity","volume":"14","author":"Doronzo","year":"2013","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/j.intimp.2024.112704_b0235","doi-asserted-by":"crossref","first-page":"e79708","DOI":"10.1371\/journal.pone.0079708","article-title":"Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin\/IGF1R signaling and activation of AKT\/mTOR","volume":"8","author":"Lopez","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.112704_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102026","article-title":"Increased glycolysis is an early consequence of palmitate lipotoxicity mediated by redox signaling","volume":"45","author":"Kakimoto","year":"2021","journal-title":"Redox Biol."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2024.113384","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T00:00:00Z","timestamp":1735084800000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924012256?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924012256?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T08:07:19Z","timestamp":1732954039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924012256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":48,"alternative-id":["S1567576924012256"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112704","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.intimp.2024.113384","asserted-by":"object"}]},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of glucose metabolism reprogramming in keratinocytes in the link between psoriasis and metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112704","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112704"}}