{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T19:01:20Z","timestamp":1774638080422,"version":"3.50.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.intimp.2024.112721","type":"journal-article","created":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T17:23:39Z","timestamp":1721496219000},"page":"112721","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia"],"prefix":"10.1016","volume":"139","author":[{"given":"Tianyue","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingwei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhao","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengmeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuaijie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangbing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongrui","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10141","key":"10.1016\/j.intimp.2024.112721_b0005","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.intimp.2024.112721_b0010","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41423-021-00806-5","article-title":"The transcription factor KLF14 regulates macrophage glycolysis and immune function by inhibiting HK2 in sepsis","volume":"19","author":"Yuan","year":"2022","journal-title":"Cell. Mol. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112721_b0015","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2024.112721_b0020","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1164\/rccm.202111-2484OC","article-title":"Association between Type of Fluid Received Prior to Enrollment, Type of Admission, and Effect of Balanced Crystalloid in Critically Ill Adults: A Secondary Exploratory Analysis of the BaSICS Clinical Trial","volume":"205","author":"Zampieri","year":"2022","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"12","key":"10.1016\/j.intimp.2024.112721_b0025","first-page":"1487","article-title":"Balanced Crystalloids versus Saline in Sepsis","volume":"200","author":"Brown","year":"2019","journal-title":"A Secondary Analysis of the SMART Clinical Trial, American Journal of Respiratory and Critical Care Medicine"},{"issue":"15","key":"10.1016\/j.intimp.2024.112721_b0030","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1001\/jama.2012.13356","article-title":"Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults","volume":"308","author":"Yunos","year":"2012","journal-title":"J. Am. Med. Assoc."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0035","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1186\/s13054-016-1499-7","article-title":"Hyperchloremia and moderate increase in serum chloride are associated with acute kidney injury in severe sepsis and septic shock patients","volume":"20","author":"Suetrong","year":"2016","journal-title":"Crit. Care"},{"issue":"12","key":"10.1016\/j.intimp.2024.112721_b0040","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.jchf.2021.07.006","article-title":"Chloride in Heart Failure: The Neglected Electrolyte","volume":"9","author":"Zandijk","year":"2021","journal-title":"JACC. Heart Failure"},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0045","doi-asserted-by":"crossref","first-page":"15883","DOI":"10.1038\/s41598-017-16238-z","article-title":"An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock","volume":"7","author":"Oh","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2024.112721_b0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/emermed-2019-209239","article-title":"Hypochloraemia is associated with 28-day mortality in patients with septic shock: a retrospective analysis of a multicentre prospective registry","volume":"38","author":"Lee","year":"2021","journal-title":"Emerg. Med. J."},{"issue":"4","key":"10.1016\/j.intimp.2024.112721_b0055","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1152\/physrev.00004.2021","article-title":"Physiology and pathophysiology of human airway mucus","volume":"102","author":"Hill","year":"2022","journal-title":"Physiol. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2024.112721_b0060","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/brv.12536","article-title":"The chloride anion as a signalling effector","volume":"94","author":"Valdivieso","year":"2019","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"issue":"12","key":"10.1016\/j.intimp.2024.112721_b0065","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1038\/s41556-019-0431-1","article-title":"Interpreting an apoptotic corpse as anti-inflammatory involves a chloride sensing pathway","volume":"21","author":"Perry","year":"2019","journal-title":"Nat. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.immuni.2014.06.013","article-title":"Origin and functions of tissue macrophages","volume":"41","author":"Epelman","year":"2014","journal-title":"Immunity"},{"issue":"23","key":"10.1016\/j.intimp.2024.112721_b0075","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1016\/j.cell.2022.10.007","article-title":"Macrophages in health and disease","volume":"185","author":"Park","year":"2022","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.intimp.2024.112721_b0080","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"issue":"40","key":"10.1016\/j.intimp.2024.112721_b0085","doi-asserted-by":"crossref","first-page":"E9371","DOI":"10.1073\/pnas.1812744115","article-title":"Chloride regulates dynamic NLRP3-dependent ASC oligomerization and inflammasome priming","volume":"115","author":"Green","year":"2018","journal-title":"PNAS"},{"key":"10.1016\/j.intimp.2024.112721_b0090","doi-asserted-by":"crossref","unstructured":"V. Riazanski, G. Mauleon, A.M. Zimnicka, S. Chen, D.J. Nelson, Phagosomal chloride dynamics in the alveolar macrophage, iScience 25(1) (2022) 103636.","DOI":"10.1016\/j.isci.2021.103636"},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1161\/CIRCRESAHA.121.320239","article-title":"Tubular IL-1\u03b2 Induces Salt Sensitivity in Diabetes by Activating Renal Macrophages","volume":"131","author":"Veiras","year":"2022","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.112721_b0100","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/cvr\/cvy252","article-title":"Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension","volume":"115","author":"Krishnan","year":"2019","journal-title":"Cardiovasc. Res."},{"issue":"5","key":"10.1016\/j.intimp.2024.112721_b0105","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/brv.12536","article-title":"The chloride anion as a signalling effector","volume":"94","author":"Valdivieso","year":"2019","journal-title":"Biol. Rev. Camb. Philos. Soc."},{"key":"10.1016\/j.intimp.2024.112721_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173997","article-title":"SGK1 mediates hypotonic challenge-induced proliferation in basilar artery smooth muscle cells via promoting CREB signaling pathway","volume":"898","author":"Chen","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112721_b0115","doi-asserted-by":"crossref","first-page":"1036844","DOI":"10.3389\/fphar.2022.1036844","article-title":"Serum and glucocorticoid-regulated kinase 1: Structure, biological functions, and its inhibitors","volume":"13","author":"Jang","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112721_b0120","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-023-01857-8","article-title":"Role of Serum\/Glucocorticoid-Regulated Kinase 1 (SGK1) in Immune and Inflammatory Diseases","author":"Bian","year":"2023","journal-title":"Inflammation"},{"issue":"324","key":"10.1016\/j.intimp.2024.112721_b0125","doi-asserted-by":"crossref","first-page":"ra41","DOI":"10.1126\/scisignal.2005050","article-title":"Chloride sensing by WNK1 involves inhibition of autophosphorylation","volume":"7","author":"Piala","year":"2014","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0130","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/ki.2015.289","article-title":"Unique chloride-sensing properties of WNK4 permit the distal nephron to modulate potassium homeostasis","volume":"89","author":"Terker","year":"2016","journal-title":"Kidney Int."},{"issue":"2","key":"10.1016\/j.intimp.2024.112721_b0135","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cmet.2017.01.007","article-title":"WNK Kinase Signaling in Ion Homeostasis and Human Disease","volume":"25","author":"Shekarabi","year":"2017","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0140","doi-asserted-by":"crossref","first-page":"4546","DOI":"10.1038\/s41467-021-24784-4","article-title":"Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis","volume":"12","author":"Mayes-Hopfinger","year":"2021","journal-title":"Nat. Commun."},{"issue":"22","key":"10.1016\/j.intimp.2024.112721_b0145","doi-asserted-by":"crossref","first-page":"9283","DOI":"10.1074\/jbc.M116.773739","article-title":"Akt3 kinase suppresses pinocytosis of low-density lipoprotein by macrophages via a novel WNK\/SGK1\/Cdc42 protein pathway","volume":"292","author":"Ding","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.intimp.2024.112721_b0150","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1681\/ASN.2010060681","article-title":"Activation of PI3-kinase stimulates endocytosis of ROMK via Akt1\/SGK1-dependent phosphorylation of WNK1","volume":"22","author":"Cheng","year":"2011","journal-title":"J Am Soc Nephrol"},{"issue":"24","key":"10.1016\/j.intimp.2024.112721_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.09.042","article-title":"WNK kinases sense molecular crowding and rescue cell volume via phase separation","volume":"185","author":"Boyd-Shiwarski","year":"2022","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.intimp.2024.112721_b0160","doi-asserted-by":"crossref","DOI":"10.1172\/JCI164222","article-title":"WNK1 promotes water homeostasis by acting as a central osmolality sensor for arginine vasopressin release","volume":"133","author":"Jin","year":"2023","journal-title":"J. Clin. Invest."},{"issue":"383","key":"10.1016\/j.intimp.2024.112721_b0165","doi-asserted-by":"crossref","first-page":"ra65","DOI":"10.1126\/scisignal.aaa0354","article-title":"WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons","volume":"8","author":"Friedel","year":"2015","journal-title":"Sci. Signal."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0170","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2021.010502","article-title":"Sample size, power and effect size revisited: simplified and practical approaches in pre-clinical, clinical and laboratory studies","volume":"31","author":"Serdar","year":"2021","journal-title":"Biochem Med (zagreb)"},{"key":"10.1016\/j.intimp.2024.112721_b0175","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.bbi.2022.05.005","article-title":"Distinct post-sepsis induced neurochemical alterations in two mouse strains","volume":"104","author":"Browne","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0180","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s41467-017-00227-x","article-title":"CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation","volume":"8","author":"Tang","year":"2017","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.intimp.2024.112721_b0185","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1213\/01.ANE.0000086896.90343.13","article-title":"ONO-1714, a nitric oxide synthase inhibitor, attenuates endotoxin-induced acute lung injury in rabbits","volume":"97","author":"Mikawa","year":"2003","journal-title":"Anesth. Analg."},{"issue":"3","key":"10.1016\/j.intimp.2024.112721_b0190","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.ejim.2011.11.013","article-title":"Chloride: The queen of electrolytes?","volume":"23","author":"Berend","year":"2012","journal-title":"Eur. J. Intern. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0195","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1113\/expphysiol.2005.031823","article-title":"CFTR, chloride concentration and cell volume: could mammalian protein histidine phosphorylation play a latent role?","volume":"91","author":"Treharne","year":"2006","journal-title":"Exp. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0200","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1254\/jphs.10026SC","article-title":"Contribution of Chloride Channel Conductance to the Regulation of Resting Membrane Potential in Chondrocytes","volume":"113","author":"Funabashi","year":"2010","journal-title":"J. Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.112721_b0205","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0022-2836(02)00702-7","article-title":"The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding","volume":"322","author":"B\u00e4ckstr\u00f6m","year":"2002","journal-title":"J. Mol. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112721_b0210","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/s41385-018-0013-8","article-title":"Increased intracellular Cl- concentration promotes ongoing inflammation in airway epithelium","volume":"11","author":"Zhang","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.intimp.2024.112721_b0215","doi-asserted-by":"crossref","unstructured":"J.-C. Chen, Y.-F. Lo, Y.-W. Lin, S.-H. Lin, C.-L. Huang, C.-J. Cheng, WNK4 kinase is a physiological intracellular chloride sensor, Proceedings of the National Academy of Sciences of the United States of America 116(10) (2019) 4502-4507.","DOI":"10.1073\/pnas.1817220116"},{"issue":"17","key":"10.1016\/j.intimp.2024.112721_b0220","doi-asserted-by":"crossref","first-page":"17404","DOI":"10.1021\/acsomega.9b02187","article-title":"Investigating Phosphorylation-Induced Conformational Changes in WNK1 Kinase by Molecular Dynamics Simulations","volume":"4","author":"Jonniya","year":"2019","journal-title":"ACS Omega"},{"key":"10.1016\/j.intimp.2024.112721_b0225","doi-asserted-by":"crossref","unstructured":"A. Lee, M. Shirley, Remimazolam: A Review in Procedural Sedation, Drugs 81(10) (2021) 1193-1201.","DOI":"10.1007\/s40265-021-01544-8"},{"key":"10.1016\/j.intimp.2024.112721_b0230","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2147\/DDDT.S344240","article-title":"Protective Effects of Remimazolam on Cerebral Ischemia\/Reperfusion Injury in Rats by Inhibiting of NLRP3 Inflammasome-Dependent Pyroptosis","volume":"16","author":"Shi","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2024.112721_b0235","article-title":"Remimazolam Protects Against LPS-Induced Endotoxicity Improving Survival of Endotoxemia Mice","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2024.112721_b0240","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"van der Poll","year":"2021","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0245","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/s13046-023-02798-8","article-title":"Electrolyte imbalance causes suppression of NK and T cell effector function in malignant ascites","volume":"42","author":"Hrvat","year":"2023","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.112721_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2022.104658","article-title":"High extracellular sodium chloride concentrations induce resistance to LPS signal in human dendritic cells","volume":"384","author":"Al-Hajj","year":"2023","journal-title":"Cell. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0255","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41392-023-01520-6","article-title":"RUNX1 promotes mitophagy and alleviates pulmonary inflammation during acute lung injury","volume":"8","author":"Tang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"6","key":"10.1016\/j.intimp.2024.112721_b0260","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1097\/HEP.0000000000000041","article-title":"Runt-related transcription factor-1 ameliorates bile acid-induced hepatic inflammation in cholestasis through JAK\/STAT3 signaling","volume":"77","author":"Zhang","year":"2023","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.intimp.2024.112721_b0265","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41392-022-01048-1","article-title":"SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl- accumulation in respiratory epithelium","volume":"7","author":"Chen","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2024.112721_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113738","article-title":"WNK4-SPAK modulates lipopolysaccharide-induced macrophage activation","volume":"171","author":"Hung","year":"2020","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112721_b0275","doi-asserted-by":"crossref","unstructured":"A.B. Jaykumar, S. Plumber, D.M. Barry, D. Binns, C. Wichaidit, M. Grzemska, S. Earnest, E.J. Goldsmith, O. Cleaver, M.H. Cobb, WNK1 collaborates with TGF-\u03b2 in endothelial cell junction turnover and angiogenesis, Proceedings of the National Academy of Sciences of the United States of America 119(30) (2022) e2203743119.","DOI":"10.1073\/pnas.2203743119"},{"issue":"12","key":"10.1016\/j.intimp.2024.112721_b0280","doi-asserted-by":"crossref","first-page":"6379","DOI":"10.1172\/JCI94171","article-title":"Mutation affecting the conserved acidic WNK1 motif causes inherited hyperkalemic hyperchloremic acidosis","volume":"130","author":"Louis-Dit-Picard","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.intimp.2024.112721_b0285","doi-asserted-by":"crossref","first-page":"e1217","DOI":"10.1002\/ctm2.1217","article-title":"The WNK1-ERK5 route plays a pathophysiological role in ovarian cancer and limits therapeutic efficacy of trametinib","volume":"13","author":"S\u00e1nchez-Fdez","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"11","key":"10.1016\/j.intimp.2024.112721_b0290","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1038\/nchembio.2168","article-title":"Small-molecule WNK inhibition regulates cardiovascular and renal function","volume":"12","author":"Yamada","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2024.112721_b0295","doi-asserted-by":"crossref","unstructured":"J. Seok, H.S. Warren, A.G. Cuenca, M.N. Mindrinos, H.V. Baker, W. Xu, D.R. Richards, G.P. McDonald-Smith, H. Gao, L. Hennessy, C.C. Finnerty, C.M. L\u00f3pez, S. Honari, E.E. Moore, J.P. Minei, J. Cuschieri, P.E. Bankey, J.L. Johnson, J. Sperry, A.B. Nathens, T.R. Billiar, M.A. West, M.G. Jeschke, M.B. Klein, R.L. Gamelli, N.S. Gibran, B.H. Brownstein, C. Miller-Graziano, S.E. Calvano, P.H. Mason, J.P. Cobb, L.G. Rahme, S.F. Lowry, R.V. Maier, L.L. Moldawer, D.N. Herndon, R.W. Davis, W. Xiao, R.G. Tompkins, Genomic responses in mouse models poorly mimic human inflammatory diseases, Proceedings of the National Academy of Sciences of the United States of America 110(9) (2013) 3507-12.","DOI":"10.1073\/pnas.1222878110"},{"key":"10.1016\/j.intimp.2024.112721_b0300","first-page":"463","volume":"41","author":"Osuchowski","year":"2014","journal-title":"Y.M"},{"key":"10.1016\/j.intimp.2024.112721_b0305","doi-asserted-by":"crossref","unstructured":"K. Takao, T. Miyakawa, Genomic responses in mouse models greatly mimic human inflammatory diseases, Proceedings of the National Academy of Sciences of the United States of America 112(4) (2015) 1167-72.","DOI":"10.1073\/pnas.1401965111"},{"key":"10.1016\/j.intimp.2024.112721_b0310","first-page":"53","volume":"30","author":"Poli-de-Figueiredo","year":"2008","journal-title":"Experimental Models of Sepsis and Their Clinical Relevance, Shock"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924012426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924012426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T08:08:04Z","timestamp":1732954084000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924012426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":62,"alternative-id":["S1567576924012426"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112721","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Macrophage WNK1 senses intracellular hypo-chlorine to regulate vulnerability to sepsis attack during hypochloremia","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112721","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112721"}}