{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:55:49Z","timestamp":1792133749477,"version":"4.4.0"},"reference-count":117,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003347","name":"Fudan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023\\u202FM730674"],"award-info":[{"award-number":["2023\\u202FM730674"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.intimp.2024.112788","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T22:48:34Z","timestamp":1722293314000},"page":"112788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Neutrophils\u2019 dual role in cancer: from tumor progression to immunotherapeutic potential"],"prefix":"10.1016","volume":"140","author":[{"given":"Gujie","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binyang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haochun","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanjun","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengnan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weigang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112788_b0005","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Can. Cell"},{"key":"10.1016\/j.intimp.2024.112788_b0010","article-title":"Overcoming acquired resistance to cancer immune checkpoint therapy: potential strategies based on molecular mechanisms","volume":"13(1):120","author":"Wang","year":"2023","journal-title":"Cell Biosci."},{"issue":"18","key":"10.1016\/j.intimp.2024.112788_b0015","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1056\/NEJMoa1807315","article-title":"CD47 blockade by Hu5F9-G4 and Rituximab in non-Hodgkin's lymphoma","volume":"379","author":"Advani","year":"2018","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.112788_b0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ccr.2009.06.017","article-title":"Polarization of tumor-associated neutrophil phenotype by TGF-beta: \u201cN1\u201d versus \u201cN2\u201d TAN","volume":"16","author":"Fridlender","year":"2009","journal-title":"Cancer Cell"},{"issue":"7","key":"10.1016\/j.intimp.2024.112788_b0025","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1053\/j.gastro.2015.08.054","article-title":"Recent advances from basic and clinical studies of esophageal squamous cell carcinoma","volume":"149","author":"Ohashi","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112788_b0030","doi-asserted-by":"crossref","unstructured":"T.X. Huang, L. Fu, The immune landscape of esophageal cancer.Cancer Commun (Lond). 2019;39(1):79. Published 2019 Nov 26. doi:10.1186\/s40880-019-0427-z.","DOI":"10.1186\/s40880-019-0427-z"},{"issue":"13","key":"10.1016\/j.intimp.2024.112788_b0035","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1245\/s10434-013-3227-8","article-title":"Elevated preoperative neutrophil-to-lymphocyte ratio as a predictor of survival after gastroenterostomy in patients with advanced pancreatic adenocarcinoma","volume":"20","author":"Sugiura","year":"2013","journal-title":"Ann. Surg. Oncol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0040","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/SLA.0b013e318297ad6b","article-title":"Preoperative neutrophil-to-lymphocyte ratio is a predictor of survival after hepatectomy for hepatocellular carcinoma: a retrospective analysis","volume":"258","author":"Mano","year":"2013","journal-title":"Ann. Surg."},{"issue":"7","key":"10.1016\/j.intimp.2024.112788_b0045","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.4049\/jimmunol.175.7.4583","article-title":"Tumor-associated CD8+ T cell tolerance induced by bone marrow-derived immature myeloid cells","volume":"175","author":"Kusmartsev","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0050","doi-asserted-by":"crossref","first-page":"e31524","DOI":"10.1371\/journal.pone.0031524","article-title":"Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils","volume":"7","author":"Fridlender","year":"2012","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.intimp.2024.112788_b0055","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/s41571-019-0222-4","article-title":"Tumour-associated neutrophils in patients with cancer","volume":"16","author":"Shaul","year":"2019","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112788_b0060","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.21037\/jtd.2019.07.30","article-title":"Neutrophil-to-lymphocyte ratio as prognostic marker in esophageal cancer: a systematic review and meta-analysis","volume":"11","author":"Pirozzolo","year":"2019","journal-title":"J. Thorac. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2024.112788_b0065","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1007\/s00262-013-1476-9","article-title":"Tumor-associated neutrophils (TAN) develop pro-tumorigenic properties during tumor progression","volume":"62","author":"Mishalian","year":"2013","journal-title":"Cancer Immunol. Immunother."},{"issue":"7","key":"10.1016\/j.intimp.2024.112788_b0070","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1053\/j.gastro.2016.02.040","article-title":"Tumor-associated neutrophils recruit macrophages and T-regulatory cells to promote progression of hepatocellular carcinoma and resistance to sorafenib","volume":"150","author":"Zhou","year":"2016","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.intimp.2024.112788_b0075","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1084\/jem.141.6.1442","article-title":"Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system","volume":"141","author":"Clark","year":"1975","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.112788_b0080","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.it.2016.03.005","article-title":"Aging: A temporal dimension for neutrophils","volume":"37","author":"Adrover","year":"2016","journal-title":"Trends Immunol."},{"issue":"47","key":"10.1016\/j.intimp.2024.112788_b0085","doi-asserted-by":"crossref","first-page":"28364","DOI":"10.18632\/oncotarget.25342","article-title":"Tumor-derived granzyme B-expressing neutrophils acquire antitumor potential after lipid A treatment","volume":"9","author":"Martin","year":"2018","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/j.intimp.2024.112788_b0090","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1182\/blood-2003-08-2806","article-title":"IFNalpha-stimulated neutrophils and monocytes release a soluble form of TNF-related apoptosis-inducing ligand (TRAIL\/Apo-2 ligand) displaying apoptotic activity on leukemic cells","volume":"103","author":"Tecchio","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.0019-2805.2003.01794.x","article-title":"Regulation of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) and TRAIL receptor expression in human neutrophils","volume":"111","author":"Kamohara","year":"2004","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2024.112788_b0100","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/701067","article-title":"Distinct functions of neutrophil in cancer and its regulation","volume":"2015","author":"Granot","year":"2015","journal-title":"Mediators Inflamm."},{"issue":"9","key":"10.1016\/j.intimp.2024.112788_b0105","doi-asserted-by":"crossref","first-page":"5472","DOI":"10.4049\/jimmunol.174.9.5472","article-title":"Immature neutrophils mediate tumor cell killing via IgA but not IgG Fc receptors","volume":"174","author":"Otten","year":"2005","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112788_b0110","first-page":"200","article-title":"Targeted therapy: leveraging ADCC to enhance anti-HER2 therapy","volume":"14","author":"Killock","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"16 Pt 1","key":"10.1016\/j.intimp.2024.112788_b0115","first-page":"5866","article-title":"Neutrophils contribute to the biological antitumor activity of rituximab in a non-Hodgkin's lymphoma severe combined immunodeficiency mouse model","volume":"9","author":"Hernandez-Ilizaliturri","year":"2003","journal-title":"Clin. Can. Res."},{"issue":"12","key":"10.1016\/j.intimp.2024.112788_b0120","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1172\/JCI77053","article-title":"Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer","volume":"124","author":"Eruslanov","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"20","key":"10.1016\/j.intimp.2024.112788_b0125","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1182\/blood-2018-11-844548","article-title":"Neutrophil plasticity in the tumor microenvironment","volume":"133","author":"Giese","year":"2019","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.intimp.2024.112788_b0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2567.2008.02950.x","article-title":"Neutrophil mobilization and clearance in the bone marrow","volume":"125","author":"Furze","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.intimp.2024.112788_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136744","article-title":"Neutrophils in tumorigenesis: missing targets for successful next generation cancer therapies?","volume":"22","author":"Tolle","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2024.112788_b0140","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.3390\/ijms23063218","article-title":"Tumor-mediated neutrophil polarization and therapeutic implications","volume":"23","author":"Raftopoulou","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.112788_b0145","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1074-7613(03)00263-2","article-title":"Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescence","volume":"19","author":"Martin","year":"2003","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.intimp.2024.112788_b0150","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4110\/in.2017.17.5.298","article-title":"Current understanding in neutrophil differentiation and heterogeneity","volume":"17","author":"Hong","year":"2017","journal-title":"Immune Netw."},{"key":"10.1016\/j.intimp.2024.112788_b0155","article-title":"Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin","volume":"20(1):62","author":"Cheng","year":"2021","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2024.112788_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115277","article-title":"Feiyanning downregulating CXCLs\/CXCR2 axis to suppress TANs infiltration in the prevention of lung cancer metastasis","volume":"295","author":"Wu","year":"2022","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0165","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s12032-013-0809-z","article-title":"High expression of CXCR-2 correlates with lymph node metastasis and predicts unfavorable prognosis in resected esophageal carcinoma","volume":"31","author":"Sui","year":"2014","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cell.2012.04.042","article-title":"A CXCL1 paracrine network links cancer chemoresistance and metastasis","volume":"150","author":"Acharyya","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.intimp.2024.112788_b0175","doi-asserted-by":"crossref","first-page":"E566","DOI":"10.1073\/pnas.1424927112","article-title":"Invasive breast cancer reprograms early myeloid differentiation in the bone marrow to generate immunosuppressive neutrophils","volume":"112","author":"Casbon","year":"2015","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.intimp.2024.112788_b0180","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.immuni.2019.03.021","article-title":"The IL-17 family of cytokines in health and disease","volume":"50","author":"McGeachy","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.112788_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11040564","article-title":"Tumor-associated neutrophils in cancer: going Pro","volume":"11","author":"Wu","year":"2019","journal-title":"Cancers (basel)."},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0190","doi-asserted-by":"crossref","first-page":"e001895","DOI":"10.1136\/jitc-2020-001895","article-title":"Blocking IL-17A enhances tumor response to anti-PD-1 immunotherapy in microsatellite stable colorectal cancer","volume":"9","author":"Liu","year":"2021","journal-title":"J. Immunother. Cancer"},{"issue":"5","key":"10.1016\/j.intimp.2024.112788_b0195","first-page":"399","article-title":"HIF-1\u03b1 contributes to hypoxia-induced invasion and metastasis of esophageal carcinoma via inhibiting E-cadherin and promoting MMP-2 expression","volume":"66","author":"Jing","year":"2012","journal-title":"Acta Med. Okayama"},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0200","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1172\/JCI130952","article-title":"Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils","volume":"130","author":"Mahiddine","year":"2020","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0205","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13045-024-01559-0","article-title":"Deciphering the performance of macrophages in tumour microenvironment: a call for precision immunotherapy","volume":"17","author":"Toledo","year":"2024","journal-title":"J. Hematol. Oncol."},{"issue":"8","key":"10.1016\/j.intimp.2024.112788_b0210","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.1182\/blood-2006-12-063826","article-title":"Neutrophils efficiently cross-prime naive T cells in vivo","volume":"110","author":"Beauvillain","year":"2007","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.intimp.2024.112788_b0215","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.it.2005.09.007","article-title":"Close encounters of neutrophils and DCs","volume":"26","author":"van Gisbergen","year":"2005","journal-title":"Trends Immunol."},{"issue":"19","key":"10.1016\/j.intimp.2024.112788_b0220","first-page":"4755","article-title":"Tumor-associated neutrophils in colorectal cancer development","volume":"14","author":"Zheng","year":"2022","journal-title":"Progress. Immunother. Can."},{"issue":"27","key":"10.1016\/j.intimp.2024.112788_b0225","doi-asserted-by":"crossref","first-page":"11091","DOI":"10.1073\/pnas.1222251110","article-title":"CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer","volume":"110","author":"Loi","year":"2013","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.intimp.2024.112788_b0230","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1182\/blood.2018892752","article-title":"Deficiency of adenosine deaminase 2 triggers adenosine-mediated NETosis and TNF production in patients with DADA2","volume":"134","author":"Carmona-Rivera","year":"2019","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.112788_b0235","doi-asserted-by":"crossref","unstructured":"S. Xiong, L. Dong, L. Cheng, Neutrophils in cancer carcinogenesis and metastasis, J. Hematol. Oncol. 2021;14(1):173. Published 2021 Oct 21. doi:10.1186\/s13045-021-01187-y.","DOI":"10.1186\/s13045-021-01187-y"},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0240","first-page":"117","article-title":"The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer","volume":"1825","author":"Verbeke","year":"2012","journal-title":"Biochimica et Biophysica Acta, Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.intimp.2024.112788_b0245","doi-asserted-by":"crossref","unstructured":"M. Hosono, Y.I. Koma, N. Takase, et al., CXCL8 derived from tumor-associated macrophages and esophageal squamous cell carcinomas contributes to tumor progression by promoting migration and invasion of cancer cells, Oncotarget. 8(62) (2017) 106071\u2013106088. Published 2017 Nov 20. doi:10.18632\/oncotarget.22526.","DOI":"10.18632\/oncotarget.22526"},{"issue":"4","key":"10.1016\/j.intimp.2024.112788_b0250","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1158\/0008-5472.CAN-08-1921","article-title":"Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes","volume":"69","author":"Rodriguez","year":"2009","journal-title":"Can. Res."},{"issue":"6\u20137","key":"10.1016\/j.intimp.2024.112788_b0255","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3109\/08820139.2012.680634","article-title":"Metabolism of L-arginine by myeloid-derived suppressor cells in cancer: mechanisms of T cell suppression and therapeutic perspectives","volume":"41","author":"Raber","year":"2012","journal-title":"Immunol. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2024.112788_b0260","first-page":"545","article-title":"Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration","volume":"2","author":"McDowell","year":"2021","journal-title":"Nat Can."},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0265","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1172\/JCI122085","article-title":"Neutrophil-induced genomic instability impedes resolution of inflammation and wound healing","volume":"129","author":"Butin-Israeli","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.112788_b0270","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10020431","article-title":"Neutrophil extracellular traps, angiogenesis and cancer","volume":"10","author":"Poto","year":"2022","journal-title":"Biomedicines."},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0275","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nm.2084","article-title":"Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth","volume":"16","author":"Houghton","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2024.112788_b0280","doi-asserted-by":"crossref","unstructured":"S. Xiong, L. Dong, L. Cheng, Neutrophils in cancer carcinogenesis and metastasis, J. Hematol. Oncol. 14(1) (2021) 173. Published 2021 Oct 21. doi:10.1186\/s13045-021-01187-y.","DOI":"10.1186\/s13045-021-01187-y"},{"issue":"8","key":"10.1016\/j.intimp.2024.112788_b0285","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1158\/2159-8290.CD-12-0527","article-title":"TGF-\u03b2 signaling in myeloid cells is required for tumor metastasis","volume":"3","author":"Pang","year":"2013","journal-title":"Can. Discov."},{"key":"10.1016\/j.intimp.2024.112788_b0290","doi-asserted-by":"crossref","unstructured":"M. Sano, H. Ijichi, R. Takahashi, et al., Blocking CXCLs-CXCR2 axis in tumor-stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion\/migration and a shift of immune-inflammatory microenvironment, Oncogenesis 8(2) (2019) 8. Published 2019 Jan 18. doi:10.1038\/s41389-018-0117-8.","DOI":"10.1038\/s41389-018-0117-8"},{"issue":"9","key":"10.1016\/j.intimp.2024.112788_b0295","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1172\/JCI61067","article-title":"Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis","volume":"122","author":"Jamieson","year":"2012","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.112788_b0300","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3389\/fimmu.2020.01749","article-title":"The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis","volume":"11","author":"Masucci","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112788_b0305","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cyto.2018.12.021","article-title":"IL-17 and colorectal cancer: from carcinogenesis to treatment","volume":"116","author":"Razi","year":"2019","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0310","first-page":"161","article-title":"Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines","volume":"17","author":"Wada","year":"2007","journal-title":"Oncol. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2024.112788_b0315","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1002\/hep.29088","article-title":"Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice","volume":"65","author":"Gordon-Weeks","year":"2017","journal-title":"Hepatology"},{"issue":"51","key":"10.1016\/j.intimp.2024.112788_b0320","doi-asserted-by":"crossref","first-page":"20262","DOI":"10.1073\/pnas.0706438104","article-title":"Human neutrophils uniquely release TIMP-free MMP-9 to provide a potent catalytic stimulator of angiogenesis","volume":"104","author":"Ardi","year":"2007","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.intimp.2024.112788_b0325","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s10456-011-9207-3","article-title":"Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma","volume":"14","author":"Bausch","year":"2011","journal-title":"Angiogenesis"},{"issue":"12","key":"10.1016\/j.intimp.2024.112788_b0330","doi-asserted-by":"crossref","first-page":"e20190354","DOI":"10.1084\/jem.20190354","article-title":"Interleukin-17-induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer","volume":"217","author":"Zhang","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.112788_b0335","doi-asserted-by":"crossref","unstructured":"M. Gordon-Alonso, T. Hirsch, C. Wildmann, P. van der Bruggen, Galectin-3 captures interferon-gamma in the tumor matrix reducing chemokine gradient production and T-cell tumor infiltration, Nat. Commun. 8(1) (2017) 793. Published 2017 Oct 6. doi:10.1038\/s41467-017-00925-6.","DOI":"10.1038\/s41467-017-00925-6"},{"issue":"7754","key":"10.1016\/j.intimp.2024.112788_b0340","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41586-019-1118-2","article-title":"Fatty acid transport protein 2 reprograms neutrophils in cancer","volume":"569","author":"Veglia","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.112788_b0345","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/bs.mie.2019.07.022","article-title":"Detection and functional evaluation of arginase-1 isolated from human PMNs and murine MDSC","volume":"632","author":"Can\u00e8","year":"2020","journal-title":"Methods Enzymol."},{"issue":"12","key":"10.1016\/j.intimp.2024.112788_b0350","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1002\/ijc.28622","article-title":"Subpopulations of myeloid-derived suppressor cells impair T cell responses through independent nitric oxide-related pathways","volume":"134","author":"Raber","year":"2014","journal-title":"Int. J. Can."},{"issue":"8","key":"10.1016\/j.intimp.2024.112788_b0355","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.trecan.2021.04.007","article-title":"Metabolic plasticity of neutrophils: relevance to pathogen responses and cancer","volume":"7","author":"Rogers","year":"2021","journal-title":"Trends Can."},{"key":"10.1016\/j.intimp.2024.112788_b0360","doi-asserted-by":"crossref","unstructured":"ayes, R.F., Mouhanna, J.G., Nicolau, I., et al., 2019. Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects. JCI Insight. 2019;5(16):e128008. doi: 10.1172\/jci.insight.128008.","DOI":"10.1172\/jci.insight.128008"},{"key":"10.1016\/j.intimp.2024.112788_b0365","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.intimp.2024.112788_b0370","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jlb.59.2.229","article-title":"Rapid killing of human neutrophils by the potent activator phorbol 12-myristate 13-acetate (PMA) accompanied by changes different from typical apoptosis or necrosis","volume":"59","author":"Takei","year":"1996","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2024.112788_b0375","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","article-title":"NETosis: how vital is it?","volume":"122","author":"Yipp","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0380","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s13046-021-02036-z","article-title":"Neutrophil extracellular traps in cancer: not only catching microbes","volume":"40","author":"Ronchetti","year":"2021","journal-title":"J. Exp. Clin. Can. Res."},{"issue":"38","key":"10.1016\/j.intimp.2024.112788_b0385","first-page":"20","article-title":"Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release","volume":"4","author":"Neeli","year":"2013","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112788_b0390","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"Li","year":"2010","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.112788_b0395","doi-asserted-by":"crossref","unstructured":"S.R. lark, et al., Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood.Nat. Med.13, 463\u2013469 (2007).","DOI":"10.1038\/nm1565"},{"key":"10.1016\/j.intimp.2024.112788_b0400","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-3-030-44518-8_2","article-title":"Neutrophil elastase and neutrophil extracellular traps in the tumor microenvironment","volume":"1263","author":"Huang","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.intimp.2024.112788_b0405","doi-asserted-by":"crossref","unstructured":"H. Zuo, M. Yang, Q. Ji, et al., Targeting neutrophil extracellular traps: a novel antitumor strategy, J. Immunol. Res. 2023 (2023) 5599660. Published 2023 Nov 9. doi:10.1155\/2023\/5599660.","DOI":"10.1155\/2023\/5599660"},{"issue":"21","key":"10.1016\/j.intimp.2024.112788_b0410","doi-asserted-by":"crossref","first-page":"5626","DOI":"10.1158\/0008-5472.CAN-19-0800","article-title":"Neutrophil extracellular traps drive mitochondrial homeostasis in tumors to augment growth","volume":"79","author":"Yazdani","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2024.112788_b0415","doi-asserted-by":"crossref","first-page":"6252138","DOI":"10.1155\/2019\/6252138","article-title":"Influence of Interleukin-8 and neutrophil extracellular trap (NET) formation in the tumor microenvironment: is there a pathogenic role?","volume":"2019","author":"Gonzalez-Aparicio","year":"2019","journal-title":"J. Immunol. Res."},{"issue":"9","key":"10.1016\/j.intimp.2024.112788_b0420","first-page":"2717","article-title":"HMGB1 overexpression promotes a malignant phenotype and radioresistance in ESCC","volume":"13","author":"Dong","year":"2022","journal-title":"J. Can."},{"key":"10.1016\/j.intimp.2024.112788_b0425","doi-asserted-by":"crossref","first-page":"1326031","DOI":"10.3389\/fimmu.2023.1326031","article-title":"m6A methylation modification and immune cell infiltration: implications for targeting the catalytic subunit m6A-METTL complex in gastrointestinal cancer immunotherapy","volume":"14","author":"Peng","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112788_b0430","doi-asserted-by":"crossref","first-page":"1075260","DOI":"10.3389\/fimmu.2022.1075260","article-title":"No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment","volume":"13","author":"Fang","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112788_b0435","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ccell.2023.02.001","article-title":"NETworking with cancer: the bidirectional interplay between cancer and neutrophil extracellular traps","volume":"41","author":"Adrover","year":"2023","journal-title":"Can. Cell"},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0440","doi-asserted-by":"crossref","first-page":"e23559","DOI":"10.1016\/j.heliyon.2023.e23559","article-title":"Neutrophil extracellular traps in adult diseases and neonatal bacterial infectious diseases: a review","volume":"10","author":"Li","year":"2023","journal-title":"Heliyon."},{"key":"10.1016\/j.intimp.2024.112788_b0445","doi-asserted-by":"crossref","first-page":"38738","DOI":"10.1038\/srep38738","article-title":"Neutrophil extracellular trap formation and circulating nucleosomes in patients with chronic myeloproliferative neoplasms","volume":"6","author":"Marin Oyarz\u00fan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.112788_b0450","doi-asserted-by":"crossref","unstructured":"A.C. Leal, D.M. Mizurini, T. Gomes, et al., Tumor-derived exosomes induce the formation of neutrophil extracellular traps: implications for the establishment of cancer-associated thrombosis, Sci. Rep. 7(1) (2017) 6438. Published 2017 Jul 25. doi:10.1038\/s41598-017-06893-7.","DOI":"10.1038\/s41598-017-06893-7"},{"key":"10.1016\/j.intimp.2024.112788_b0455","doi-asserted-by":"crossref","unstructured":"Y. Zhang, A. Wang, Onuma et al., Neutrophils extracellular traps inhibition improves PD-1 blockade immunotherapy in colorectal cancer, Can. 13(21) (2021) Article ID 5333.","DOI":"10.3390\/cancers13215333"},{"key":"10.1016\/j.intimp.2024.112788_b0460","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.785222","article-title":"Neutrophil extracellular traps promote T cell exhaustion in the tumor microenvironment","volume":"12","author":"Kaltenmeier","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112788_b0465","doi-asserted-by":"crossref","unstructured":"R.F. Rayes, J.G. Mouhanna, I. Nicolau, et al., Primary tumors induce neutrophil extracellular traps with targetable metastasis promoting effects, JCI Insight 5(16) (2019) e128008. Published 2019 Jul 25. doi:10.1172\/jci.insight.128008.","DOI":"10.1172\/jci.insight.128008"},{"key":"10.1016\/j.intimp.2024.112788_b0470","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3389\/fonc.2020.01036","article-title":"Diagnostic therapeutic predictive, and prognostic value of neutrophil extracellular traps in patients with gastric adenocarcinoma","volume":"10","author":"Zhang","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.intimp.2024.112788_b0475","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1158\/1078-0432.CCR-18-1226","article-title":"Neutrophil extracellular traps induced by IL8 promote diffuse large B-cell lymphoma progression via the TLR9 signaling","volume":"25","author":"Nie","year":"2019","journal-title":"Clin. Can. Res."},{"key":"10.1016\/j.intimp.2024.112788_b0480","doi-asserted-by":"crossref","first-page":"361ra138","DOI":"10.1126\/scitranslmed.aag1711","article-title":"Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps","volume":"8","author":"Park","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2024.112788_b0485","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.thromres.2019.06.005","article-title":"Neutrophil extracellular traps induced by activated platelets contribute to procoagulant activity in patients with colorectal cancer","volume":"180","author":"Zhang","year":"2019","journal-title":"Thromb. Res."},{"key":"10.1016\/j.intimp.2024.112788_b0490","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s00432-019-02922-2","article-title":"Neutrophil extracellular traps enhance procoagulant activity in patients with oral squamous cell carcinoma","volume":"145","author":"Li","year":"2019","journal-title":"J. Can. Res. Clin. Oncol."},{"key":"10.1016\/j.intimp.2024.112788_b0495","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1084\/jem.20181170","article-title":"Neutrophils facilitate ovarian cancer premetastatic niche formation in the omentum","volume":"216","author":"Lee","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.112788_b0500","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.immuni.2020.03.001","article-title":"CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity","volume":"52","author":"Teijeira","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.112788_b0505","first-page":"596","article-title":"Neutrophil extracellular traps promote liver micrometastasis in pancreatic ductal adenocarcinoma via the activation of cancer associated fibroblasts","volume":"56","author":"Takesue","year":"2020","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.intimp.2024.112788_b0510","doi-asserted-by":"crossref","first-page":"e1134073","DOI":"10.1080\/2162402X.2015.1134073","article-title":"Priming of neutrophils toward NETosis promotes tumor growth","volume":"5","author":"Demers","year":"2016","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2024.112788_b0515","doi-asserted-by":"crossref","first-page":"e0216055","DOI":"10.1371\/journal.pone.0216055","article-title":"Cancer cell-induced neutrophil extracellular traps promote both hypercoagulability and cancer progression","volume":"14","author":"Jung","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.112788_b0520","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1002\/hep.29914","article-title":"Neutrophil extracellular traps promote inflammation and development of hepatocellular carcinoma in nonalcoholic steatohepatitis","volume":"68","author":"Van der Windt","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2024.112788_b0525","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1158\/1535-7163.MCT-19-1020","article-title":"A novel peptidylarginine deiminase 4 (PAD4) inhibitor BMS-P5 blocks formation of neutrophil extracellular traps and delays progression of multiple myeloma","volume":"19","author":"Li","year":"2020","journal-title":"Mol. Cancer Ther."},{"issue":"11","key":"10.1016\/j.intimp.2024.112788_b0530","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1038\/s41590-020-0783-5","article-title":"Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis","volume":"21","author":"Li","year":"2020","journal-title":"Nat. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2024.112788_b0535","doi-asserted-by":"crossref","first-page":"e1344804","DOI":"10.1080\/2162402X.2017.1344804","article-title":"Exogenous lipid uptake induces metabolic and functional reprogramming of tumor-associated myeloid-derived suppressor cells","volume":"6","author":"Al-Khami","year":"2017","journal-title":"Oncoimmunology."},{"key":"10.1016\/j.intimp.2024.112788_b0540","article-title":"CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells","volume":"9(1):2399","author":"Tulotta","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0545","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1021\/acsnano.6b06477","article-title":"Nanoparticles coated with neutrophil membranes can effectively treat cancer metastasis","volume":"11","author":"Kang","year":"2017","journal-title":"ACS Nano"},{"issue":"22","key":"10.1016\/j.intimp.2024.112788_b0550","doi-asserted-by":"crossref","first-page":"e1706245","DOI":"10.1002\/adma.201706245","article-title":"Neutrophil-based drug delivery systems","volume":"30","author":"Chu","year":"2018","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.intimp.2024.112788_b0555","doi-asserted-by":"crossref","first-page":"32","DOI":"10.20892\/j.issn.2095-3941.2019.0372","article-title":"Targeting and exploitation of tumor-associated neutrophils to enhance immunotherapy and drug delivery for cancer treatment","volume":"17","author":"Zhang","year":"2020","journal-title":"Can. Biol. Med."},{"issue":"8","key":"10.1016\/j.intimp.2024.112788_b0560","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s00262-017-1988-9","article-title":"CCR5 in recruitment and activation of myeloid-derived suppressor cells in melanoma","volume":"66","author":"Umansky","year":"2017","journal-title":"Can. Immunol. Immunother."},{"issue":"7556","key":"10.1016\/j.intimp.2024.112788_b0565","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0570","doi-asserted-by":"crossref","first-page":"794","DOI":"10.4049\/jimmunol.1202088","article-title":"Increased myeloid-derived suppressor cells in gastric cancer correlate with cancer stage and plasma S100A8\/A9 proinflammatory proteins","volume":"190","author":"Wang","year":"2013","journal-title":"J. Immunol."},{"issue":"17","key":"10.1016\/j.intimp.2024.112788_b0575","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1158\/1078-0432.CCR-17-0741","article-title":"Entinostat neutralizes myeloid-derived suppressor cells and enhances the antitumor effect of PD-1 inhibition in murine models of lung and renal cell carcinoma","volume":"23","author":"Orillion","year":"2017","journal-title":"Clin. Can. Res."},{"key":"10.1016\/j.intimp.2024.112788_b0580","doi-asserted-by":"crossref","first-page":"16009","DOI":"10.1038\/npjbcancer.2016.9","article-title":"TNF is a key cytokine mediating neutrophil cytotoxic activity in breast cancer patients","volume":"2","author":"Comen","year":"2016","journal-title":"NPJ Breast Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2024.112788_b0585","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1158\/0008-5472.CAN-12-2325","article-title":"VEGFA-VEGFR pathway blockade inhibits tumor-induced regulatory T-cell proliferation in colorectal cancer","volume":"73","author":"Terme","year":"2013","journal-title":"Can. Res."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:04:06Z","timestamp":1786363446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924013092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":117,"alternative-id":["S1567576924013092"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112788","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophils\u2019 dual role in cancer: from tumor progression to immunotherapeutic potential","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112788"}}