{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:57:51Z","timestamp":1787767071336,"version":"build-2784847793"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002325"],"award-info":[{"award-number":["82002325"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009108","name":"Shandong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2023MH159"],"award-info":[{"award-number":["ZR2023MH159"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2022LZY001"],"award-info":[{"award-number":["ZR2022LZY001"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH167"],"award-info":[{"award-number":["ZR2021MH167"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021LZY004"],"award-info":[{"award-number":["ZR2021LZY004"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2020QH075"],"award-info":[{"award-number":["ZR2020QH075"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.intimp.2024.112801","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T15:21:32Z","timestamp":1723130492000},"page":"112801","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy"],"prefix":"10.1016","volume":"140","author":[{"given":"Jinjin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingzhi","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feifei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongpeng","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.112801_b0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1529-9430(01)00021-3","article-title":"Biochemistry of intervertebral disc degeneration and the potential for gene therapy applications[J]","volume":"1","author":"Cassinelli","year":"2001","journal-title":"Spine J"},{"issue":"1","key":"10.1016\/j.intimp.2024.112801_b0010","article-title":"Discogenic Low Back Pain: Anatomy, Pathophysiology and Treatments of Intervertebral Disc Degeneration[J]","volume":"24","author":"Mohd","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.intimp.2024.112801_b0015","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/NHH.0000000000001212","article-title":"Treating Discogenic Low Back Pain in the Home Care Setting[J]","volume":"41","author":"Creighton","year":"2023","journal-title":"Home Healthc Now"},{"key":"10.1016\/j.intimp.2024.112801_b0020","doi-asserted-by":"crossref","first-page":"115","DOI":"10.22203\/eCM.v040a07","article-title":"The tissue-renin-angiotensin-system of the human intervertebral disc[J]","volume":"40","author":"Li","year":"2020","journal-title":"Eur Cell Mater"},{"key":"10.1016\/j.intimp.2024.112801_b0025","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.wneu.2021.09.066","article-title":"Fundamentals of Intervertebral Disc Degeneration[J]","volume":"157","author":"Kirnaz","year":"2022","journal-title":"World Neurosurg"},{"key":"10.1016\/j.intimp.2024.112801_b0030","doi-asserted-by":"crossref","first-page":"2166817","DOI":"10.1155\/2022\/2166817","article-title":"The Role of Oxidative Stress in Intervertebral Disc Degeneration[J]","volume":"2022","author":"Cao","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"5","key":"10.1016\/j.intimp.2024.112801_b0035","first-page":"4163","article-title":"Roles of endoplasmic reticulum stress and autophagy on H2O2-induced oxidative stress injury in HepG2 cells[J]","volume":"18","author":"Wu","year":"2018","journal-title":"Mol Med Rep"},{"issue":"8","key":"10.1016\/j.intimp.2024.112801_b0040","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/os.13302","article-title":"Mitochondrial Dysfunction in Oxidative Stress-Mediated Intervertebral Disc Degeneration[J]","volume":"14","author":"Wang","year":"2022","journal-title":"Orthop Surg"},{"issue":"11\u201312","key":"10.1016\/j.intimp.2024.112801_b0045","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s10495-022-01770-9","article-title":"Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK\/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo[J]","volume":"27","author":"Zhang","year":"2022","journal-title":"Apoptosis"},{"issue":"3","key":"10.1016\/j.intimp.2024.112801_b0050","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1111\/jcmm.14125","article-title":"Melatonin ameliorates intervertebral disc degeneration via the potential mechanisms of mitophagy induction and apoptosis inhibition[J]","volume":"23","author":"Chen","year":"2019","journal-title":"J Cell Mol Med"},{"issue":"3\u20134","key":"10.1016\/j.intimp.2024.112801_b0055","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1080\/10715762.2022.2094791","article-title":"VDR promotes nucleus pulposus cell mitophagy as a protective mechanism against oxidative stress injury[J]","volume":"56","author":"Lan","year":"2022","journal-title":"Free Radic Res"},{"issue":"13","key":"10.1016\/j.intimp.2024.112801_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation[J]","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.intimp.2024.112801_b0065","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s10787-022-01098-5","article-title":"Maltol ameliorates intervertebral disc degeneration through inhibiting PI3K\/AKT\/NF-kappaB pathway and regulating NLRP3 inflammasome-mediated pyroptosis[J]","volume":"31","author":"Gong","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.intimp.2024.112801_b0070","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.joca.2021.02.204","article-title":"Roles of NLRP3 inflammasome in intervertebral disc degeneration[J]","volume":"29","author":"Chao-Yang","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"9","key":"10.1016\/j.intimp.2024.112801_b0075","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death[J]","volume":"18","author":"Huang","year":"2021","journal-title":"Cell Mol Immunol"},{"issue":"18","key":"10.1016\/j.intimp.2024.112801_b0080","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.7150\/thno.45922","article-title":"Mitochondrial Sirtuin 3: New emerging biological function and therapeutic target[J]","volume":"10","author":"Zhang","year":"2020","journal-title":"Theranostics"},{"issue":"11","key":"10.1016\/j.intimp.2024.112801_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0173-3","article-title":"Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration[J]","volume":"50","author":"Wang","year":"2018","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.intimp.2024.112801_b0090","doi-asserted-by":"crossref","first-page":"3319056","DOI":"10.1155\/2022\/3319056","article-title":"Irisin Promotes Osteogenesis by Modulating Oxidative Stress and Mitophagy through SIRT3 Signaling under Diabetic Conditions[J]","volume":"2022","author":"Li","year":"2022","journal-title":"Oxid Med Cell Longev"},{"issue":"10","key":"10.1016\/j.intimp.2024.112801_b0095","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1111\/cns.14222","article-title":"Zinc defends against Parthanatos and promotes functional recovery after spinal cord injury through SIRT3-mediated anti-oxidative stress and mitophagy[J]","volume":"29","author":"Jiang","year":"2023","journal-title":"CNS Neurosci Ther"},{"issue":"12","key":"10.1016\/j.intimp.2024.112801_b0100","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1080\/13880209.2016.1216131","article-title":"Therapeutic potential of naringin: an overview[J]","volume":"54","author":"Chen","year":"2016","journal-title":"Pharm Biol"},{"issue":"3","key":"10.1016\/j.intimp.2024.112801_b0105","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20193431","article-title":"Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway[J]","volume":"40","author":"Zhao","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.intimp.2024.112801_b0110","article-title":"Naringenin and naringin in cardiovascular disease prevention: A preclinical review[J]","volume":"887","author":"Heidary","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.intimp.2024.112801_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113035","article-title":"Naringin suppressed airway inflammation and ameliorated pulmonary endothelial hyperpermeability by upregulating Aquaporin1 in lipopolysaccharide\/cigarette smoke-induced mice[J]","volume":"150","author":"Zhang","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"50","key":"10.1016\/j.intimp.2024.112801_b0120","doi-asserted-by":"crossref","first-page":"13133","DOI":"10.1021\/acs.jafc.8b03942","article-title":"Protective Effect of Naringin on DSS-Induced Ulcerative Colitis in Mice[J]","volume":"66","author":"Cao","year":"2018","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.intimp.2024.112801_b0125","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.lfs.2018.07.031","article-title":"Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress[J]","volume":"216","author":"Zhou","year":"2019","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.intimp.2024.112801_b0130","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.molmed.2014.11.008","article-title":"Mitochondria: diversity in the regulation of the NLRP3 inflammasome[J]","volume":"21","author":"Gurung","year":"2015","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.intimp.2024.112801_b0135","doi-asserted-by":"crossref","unstructured":"OICHI T, TANIGUCHI Y, SOMA K, et al. A Mouse Intervertebral Disc Degeneration Model by Surgically Induced Instability[J]. Spine (Phila Pa 1976), 2018,43(10): E557-E564.","DOI":"10.1097\/BRS.0000000000002427"},{"issue":"10","key":"10.1016\/j.intimp.2024.112801_b0140","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/j.spinee.2016.05.007","article-title":"Therapeutic effects of naringin on degenerative human nucleus pulposus cells for discogenic low back pain[J]","volume":"16","author":"Li","year":"2016","journal-title":"Spine J"},{"key":"10.1016\/j.intimp.2024.112801_b0145","doi-asserted-by":"crossref","first-page":"9963","DOI":"10.12659\/MSM.918597","article-title":"Naringin Protects Against Interleukin 1beta (IL-1beta)-Induced Human Nucleus Pulposus Cells Degeneration via Downregulation Nuclear Factor kappa B (NF-kappaB) Pathway and p53 Expression[J]","volume":"25","author":"Gao","year":"2019","journal-title":"Med Sci Monit"},{"issue":"6","key":"10.1016\/j.intimp.2024.112801_b0150","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1080\/03008207.2019.1631299","article-title":"Naringin alleviates H(2)O(2)-induced apoptosis via the PI3K\/Akt pathway in rat nucleus pulposus-derived mesenchymal stem cells[J]","volume":"61","author":"Nan","year":"2020","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.intimp.2024.112801_b0155","doi-asserted-by":"crossref","first-page":"6179444","DOI":"10.1155\/2022\/6179444","article-title":"Naringin Inhibits Apoptosis Induced by Cyclic Stretch in Rat Annular Cells and Partially Attenuates Disc Degeneration by Inhibiting the ROS\/NF-kappaB Pathway[J]","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.intimp.2024.112801_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.956355","article-title":"Targeting Oxidative Stress and Inflammation in Intervertebral Disc Degeneration: Therapeutic Perspectives of Phytochemicals[J]","volume":"13","author":"Kang","year":"2022","journal-title":"Front Pharmacol"},{"issue":"5","key":"10.1016\/j.intimp.2024.112801_b0165","doi-asserted-by":"crossref","first-page":"589","DOI":"10.3171\/spi.2005.2.5.0589","article-title":"Positive feedback loop of interleukin-1beta upregulating production of inflammatory mediators in human intervertebral disc cells in vitro[J]","volume":"2","author":"Jimbo","year":"2005","journal-title":"J Neurosurg Spine"},{"issue":"4","key":"10.1016\/j.intimp.2024.112801_b0170","doi-asserted-by":"crossref","first-page":"R732","DOI":"10.1186\/ar1732","article-title":"The role of interleukin-1 in the pathogenesis of human intervertebral disc degeneration[J]","volume":"7","author":"le Maitre","year":"2005","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.intimp.2024.112801_b0175","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1080\/08820139.2023.2205884","article-title":"Ginkgetin Alleviates Intervertebral Disc Degeneration by Inhibiting Apoptosis, Inflammation, and Disturbance of Extracellular Matrix Synthesis and Catabolism via Inactivation of NLRP3 Inflammasome[J]","volume":"52","author":"Hu","year":"2023","journal-title":"Immunol Invest"},{"key":"10.1016\/j.intimp.2024.112801_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113968","article-title":"Insight into the regulation of NLRP3 inflammasome activation by mitochondria in liver injury and the protective role of natural products[J]","volume":"156","author":"Liu","year":"2022","journal-title":"Biomed Pharmacother"},{"issue":"21","key":"10.1016\/j.intimp.2024.112801_b0185","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222111338","article-title":"Mitochondria as a Cellular Hub in Infection and Inflammation[J]","volume":"22","author":"Andrieux","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.intimp.2024.112801_b0190","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cca.2020.04.016","article-title":"Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function[J]","volume":"508","author":"Zhang","year":"2020","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.intimp.2024.112801_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115354","article-title":"SIRT3 attenuates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome via autophagy[J]","volume":"207","author":"Sun","year":"2023","journal-title":"Biochem Pharmacol"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:57:41Z","timestamp":1786363061000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924013225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":39,"alternative-id":["S1567576924013225"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112801","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naringin safeguards vertebral endplate chondrocytes from apoptosis and NLRP3 inflammasome activation through SIRT3-mediated mitophagy","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112801","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112801"}}