{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T11:16:24Z","timestamp":1784805384652,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.intimp.2024.112810","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T17:58:01Z","timestamp":1723744681000},"page":"112810","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Network pharmacology and experimental verification revealing valnemulin alleviates DSS-induced ulcerative colitis by inhibiting intestinal senescence"],"prefix":"10.1016","volume":"141","author":[{"given":"Zhiwei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianlong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112810_b0005","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.aimed.2021.03.001","article-title":"Therapeutic effect of Plantago major on active severe pancolitis: A case report","volume":"9","author":"Tafazoli","year":"2022","journal-title":"Advances in Integrative Medicine"},{"key":"10.1016\/j.intimp.2024.112810_b0010","volume":"6","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.intimp.2024.112810_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153743","article-title":"Shaoyao decoction attenuates DSS-induced ulcerative colitis, macrophage and NLRP3 inflammasome activation through the MKP1\/NF-\u03baB pathway","volume":"92","author":"Wei","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.112810_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101596","article-title":"The role of nutrition in inflammaging","volume":"77","author":"Di Giosia","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.intimp.2024.112810_b0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.intimp.2024.112810_b0030","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10522-022-09976-9","article-title":"Green tea EGCG effectively alleviates experimental colitis in middle-aged male mice by attenuating multiple aspects of oxi-inflammatory stress and cell cycle deregulation","volume":"23","author":"Diwan","year":"2022","journal-title":"Biogerontology"},{"key":"10.1016\/j.intimp.2024.112810_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110205","article-title":"Artesunate ameliorates irinotecan-induced intestinal injury by suppressing cellular senescence and significantly enhances anti-tumor activity","volume":"119","author":"Jia","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112810_b0040","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1053\/j.gastro.2016.10.020","article-title":"Understanding and Preventing the Global Increase of Inflammatory Bowel Disease","volume":"152","author":"Kaplan","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112810_b0045","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1994835","article-title":"Effects of anti-aging interventions on intestinal microbiota","volume":"13","author":"Du","year":"2021","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2024.112810_b0050","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12602-021-09903-3","article-title":"Emerging Interrelationship Between the Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: Perspectives and Therapeutic Opportunities","volume":"14","author":"Sharma","year":"2022","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.intimp.2024.112810_b0055","article-title":"Atorvastatin calcium alleviates 5-fluorouracil-induced intestinal damage by inhibiting cellular senescence and significantly enhances its antitumor efficacy","volume":"121","author":"Xia","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112810_b0060","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00071-6","article-title":"Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK\/SIRT1\/NF-\u03baB signaling pathway and gut microbiota","volume":"11","author":"Zhao","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.112810_b0065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biochi.2021.11.008","article-title":"Role of AMPK mediated pathways in autophagy and aging","volume":"195","author":"Ge","year":"2022","journal-title":"Biochimie"},{"key":"10.1016\/j.intimp.2024.112810_b0070","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1039\/D1FO03969E","article-title":"Platycodon grandiflorum root fermentation broth reduces inflammation in a mouse IBD model through the AMPK\/NF-\u03baB\/NLRP3 pathway","volume":"13","author":"Wang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.intimp.2024.112810_b0075","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.bbrc.2022.11.035","article-title":"Anti-inflammation and anti-aging mechanisms of mercaptopurine in vivo and in vitro","volume":"638","author":"Jia","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.112810_b0080","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2885.2010.01230.x","article-title":"A physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs","volume":"34","author":"Yuan","year":"2011","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.intimp.2024.112810_b0085","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1128\/AAC.50.4.1458-1462.2006","article-title":"Interaction of Pleuromutilin Derivatives with the Ribosomal Peptidyl Transferase Center","volume":"50","author":"Long","year":"2006","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.intimp.2024.112810_b0090","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/s10753-010-9186-3","article-title":"Preventive Effects of Valnemulin on Lipopolysaccharide-Induced Acute Lung Injury in Mice","volume":"33","author":"Chen","year":"2010","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.112810_b0095","doi-asserted-by":"crossref","unstructured":"Yang, Q., Zhang, X., Wang, Q., Zhong, Y. & Liu, W. UPLC-MS\/MS Method for Simultaneous Determination of Valnemulin and Its Metabolites in Crucian Carp: In Vivo Metabolism and Tissue Distribution Analyses. Molecules 28, doi:10.3390\/molecules28145430 (2023).","DOI":"10.3390\/molecules28145430"},{"key":"10.1016\/j.intimp.2024.112810_b0100","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/jac\/dkm019","article-title":"In vitro activity against anaerobes of retapamulin, a new topical antibiotic for treatment of skin infections","volume":"59","author":"Odou","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.intimp.2024.112810_b0105","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.anaerobe.2016.04.005","article-title":"Ex vivo pharmacokinetic\/pharmacodynamic relationship of valnemulin against Clostridium perfringens in plasma, the small intestinal and caecal contents of rabbits","volume":"39","author":"Zhou","year":"2016","journal-title":"Anaerobe"},{"key":"10.1016\/j.intimp.2024.112810_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2022.106298","article-title":"Dissecting the molecular mechanism of cepharanthine against COVID-19, based on a network pharmacology strategy combined with RNA-sequencing analysis, molecular docking, and molecular dynamics simulation","volume":"151","author":"Liu","year":"2022","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.intimp.2024.112810_b0115","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s12967-022-03623-0","article-title":"Integrated lipidomics and network pharmacology analysis to reveal the mechanisms of berberine in the treatment of hyperlipidemia","volume":"20","author":"Chen","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2024.112810_b0120","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1038\/nprot.2017.044","article-title":"Chemically induced mouse models of acute and chronic intestinal inflammation","volume":"12","author":"Wirtz","year":"2017","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.intimp.2024.112810_b0125","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/ibd.20951","article-title":"Role of TNF receptors, TNFR1 and TNFR2, in dextran sodium sulfate-induced colitis","volume":"15","author":"Stillie","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2024.112810_b0130","doi-asserted-by":"crossref","first-page":"7292","DOI":"10.1039\/D0SC01234C","article-title":"First-generation species-selective chemical probes for fluorescence imaging of human senescence-associated beta-galactosidase","volume":"11","author":"Li","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.intimp.2024.112810_b0135","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1172\/JCI64098","article-title":"Cellular senescence and the senescent secretory phenotype: therapeutic opportunities","volume":"123","author":"Tchkonia","year":"2013","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.intimp.2024.112810_b0140","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/j.molcel.2021.03.018","article-title":"Physiological hypoxia restrains the senescence-associated secretory phenotype via AMPK-mediated mTOR suppression","volume":"81","author":"van Vliet","year":"2021","journal-title":"Mol. Cell"},{"key":"10.1016\/j.intimp.2024.112810_b0145","doi-asserted-by":"crossref","first-page":"e13483","DOI":"10.1111\/acel.13483","article-title":"Identification of a small molecule SR9009 that activates NRF2 to counteract cellular senescence","volume":"20","author":"Gao","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2024.112810_b0150","doi-asserted-by":"crossref","first-page":"2240035","DOI":"10.1080\/19490976.2023.2240035","article-title":"Exosomal-miR-129-2-3p derived from Fusobacterium nucleatum-infected intestinal epithelial cells promotes experimental colitis through regulating TIMELESS-mediated cellular senescence pathway","volume":"15","author":"Wei","year":"2023","journal-title":"Gut Microbes"},{"key":"10.1016\/j.intimp.2024.112810_b0155","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1158\/0008-5472.CAN-10-1966","article-title":"Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation","volume":"71","author":"Risques","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.intimp.2024.112810_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112286","article-title":"Tedizolid phosphate alleviates DSS-induced ulcerative colitis by inhibiting senescence of cell and colon tissue through activating AMPK signaling pathway","volume":"135","author":"Zhou","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112810_b0165","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.nutres.2023.10.001","article-title":"Lactoferrin improves symptoms of dextran sulfate sodium-induced colitis in mice through modulation of cellular senescence","volume":"120","author":"Sienkiewicz","year":"2023","journal-title":"Nutr. Res."},{"key":"10.1016\/j.intimp.2024.112810_b0170","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-35487-9","article-title":"Senescent cells perturb intestinal stem cell differentiation through Ptk7 induced noncanonical Wnt and YAP signaling","volume":"14","author":"Yun","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112810_b0175","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108952","article-title":"PPAR-Gamma Orchestrates EMT, AGE, and Cellular Senescence Pathways in Colonic Epithelium and Restrains the Progression of IBDs","volume":"24","author":"Pompili","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112810_b0180","doi-asserted-by":"crossref","first-page":"32081","DOI":"10.1074\/jbc.M502876200","article-title":"Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity","volume":"280","author":"Hahn-Windgassen","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.112810_b0185","first-page":"H2472","article-title":"Activation of cardiac AMP-activated protein kinase by LKB1 expression or chemical hypoxia is blunted by increased Akt activity","volume":"290","author":"Soltys","year":"2006","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"key":"10.1016\/j.intimp.2024.112810_b0190","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cmet.2014.03.002","article-title":"AMPK at the nexus of energetics and aging","volume":"20","author":"Burkewitz","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2024.112810_b0195","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1007\/s00109-011-0748-0","article-title":"AMP-activated protein kinase inhibits NF-\u03baB signaling and inflammation: impact on healthspan and lifespan","volume":"89","author":"Salminen","year":"2011","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.intimp.2024.112810_b0200","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1053\/j.gastro.2009.06.049","article-title":"FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation","volume":"137","author":"Zhou","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112810_b0205","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s00125-006-0447-5","article-title":"Prostaglandin E2 regulates Foxo activity via the Akt pathway: implications for pancreatic islet beta cell dysfunction","volume":"49","author":"Meng","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.intimp.2024.112810_b0210","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/03602532.2023.2197178","article-title":"Interaction of drugs with gut microbiota modulators","volume":"55","author":"Kim","year":"2023","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.intimp.2024.112810_b0215","doi-asserted-by":"crossref","first-page":"1326339","DOI":"10.3389\/fmicb.2024.1326339","article-title":"Mendelian randomization analysis reveals an independent causal relationship between four gut microbes and acne vulgaris","volume":"15","author":"Wu","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2024.112810_b0220","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/1751-2980.12849","article-title":"Gut microbiota in ulcerative colitis: insights on pathogenesis and treatment","volume":"21","author":"Guo","year":"2020","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.intimp.2024.112810_b0225","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2020.09.060","article-title":"Aging, Frailty, and the Microbiome\u2014How Dysbiosis Influences Human Aging and Disease","volume":"160","author":"Haran","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.112810_b0230","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tvjl.2014.05.010","article-title":"Integration of pharmacokinetic and pharmacodynamic indices of valnemulin in broiler chickens after a single intravenous and intramuscular administration","volume":"201","author":"Zhao","year":"2014","journal-title":"Vet. J."},{"key":"10.1016\/j.intimp.2024.112810_b0235","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.intimp.2009.02.018","article-title":"Valnemulin downregulates nitric oxide, prostaglandin E2, and cytokine production via inhibition of NF-kappaB and MAPK activity","volume":"9","author":"Zhang","year":"2009","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.112810_b0240","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02388-17","article-title":"Unraveling the Metabolic Routes of Retapamulin: Insights into Drug Development of Pleuromutilins","volume":"62","author":"Sun","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.intimp.2024.112810_b0245","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1007\/s10620-007-9760-1","article-title":"A Meta-Analysis of Antibiotic Therapy for Active Ulcerative Colitis","volume":"52","author":"Rahimi","year":"2007","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.intimp.2024.112810_b0250","article-title":"Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety","volume":"8","author":"Schlievert","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.112810_b0255","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fphar.2017.00553","article-title":"Synergistic Effect of Pleuromutilins with Other Antimicrobial Agents against Staphylococcus aureus In Vitro and in an Experimental Galleria mellonella Model","volume":"8","author":"Dong","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112810_b0260","doi-asserted-by":"crossref","first-page":"9121","DOI":"10.1002\/jcp.26956","article-title":"Cellular senescence: Molecular mechanisms and pathogenicity","volume":"233","author":"Wei","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2024.112810_b0265","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.112810_b0270","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/joim.13141","article-title":"Senolytic drugs: from discovery to translation","volume":"288","author":"Kirkland","year":"2020","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.intimp.2024.112810_b0275","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1038\/s41591-022-01923-y","article-title":"Cellular senescence and senolytics: the path to the clinic","volume":"28","author":"Chaib","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2024.112810_b0280","article-title":"Senolytic Treatment Improve Small Intestine Regeneration in Aging","author":"Luo","year":"2023","journal-title":"Aging Dis."},{"key":"10.1016\/j.intimp.2024.112810_b0285","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.ijbiomac.2020.10.259","article-title":"Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota","volume":"166","author":"Cui","year":"2021","journal-title":"Int. J. Biol. Macromol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T17:34:16Z","timestamp":1731087256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924013316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":57,"alternative-id":["S1567576924013316"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112810","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network pharmacology and experimental verification revealing valnemulin alleviates DSS-induced ulcerative colitis by inhibiting intestinal senescence","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112810","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112810"}}