{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:18:20Z","timestamp":1793085500627,"version":"4.5.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.intimp.2024.112811","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T08:54:16Z","timestamp":1722070456000},"page":"112811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["A multistage protein subunit vaccine as BCG-booster confers protection against Mycobacterium tuberculosis infection in murine models"],"prefix":"10.1016","volume":"139","author":[{"given":"Zhenyan","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinchuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhidong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.112811_b0005","unstructured":"WHO, Global Tuberculosis Report 2023, (2023)."},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0010","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJMra1200894","article-title":"Tuberculosis","volume":"368","author":"Zumla","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.112811_b0015","first-page":"308","article-title":"Tuberculosis: common questions and answers","volume":"106","author":"Hartman-Adams","year":"2022","journal-title":"Am. Fam. Physician"},{"key":"10.1016\/j.intimp.2024.112811_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117594","article-title":"Tuberculosis vaccine: a journey from BCG to present","volume":"252","author":"Fatima","year":"2020","journal-title":"Life Sci."},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0025","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1586\/14760584.2016.1170599","article-title":"Why don't we have an effective tuberculosis vaccine yet?","volume":"15","author":"Davenne","year":"2016","journal-title":"Expert Rev. Vaccines"},{"issue":"9","key":"10.1016\/j.intimp.2024.112811_b0030","first-page":"698","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis","volume":"271","author":"Colditz","year":"1994","journal-title":"Meta-Anal. Published Literature, Jama"},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0035","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrmicro1211","article-title":"The success and failure of BCG - implications for a novel tuberculosis vaccine","volume":"3","author":"Andersen","year":"2005","journal-title":"Nat. Rev. Microbiol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0040","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/resp.13245","article-title":"Tuberculosis vaccines: opportunities and challenges","volume":"23","author":"Zhu","year":"2018","journal-title":"Respirology"},{"issue":"11","key":"10.1016\/j.intimp.2024.112811_b0045","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1093\/aje\/kws167","article-title":"Underestimating the safety benefits of a new vaccine: the impact of acellular pertussis vaccine versus whole-cell pertussis vaccine on health services utilization","volume":"176","author":"Hawken","year":"2012","journal-title":"Am. J. Epidemiol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/14760584.2018.1406309","article-title":"Multi-stage subunit vaccines against Mycobacterium tuberculosis: an alternative to the BCG vaccine or a BCG-prime boost?","volume":"17","author":"Khademi","year":"2018","journal-title":"Expert Rev. Vaccines"},{"issue":"9","key":"10.1016\/j.intimp.2024.112811_b0055","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20220846","article-title":"Perfecting antigen prediction","volume":"219","author":"Hoyos","year":"2022","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.112811_b0060","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1238649","article-title":"Recent advance in the development of tuberculosis vaccines in clinical trials and virus-like particle-based vaccine candidates","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0065","first-page":"373","article-title":"Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial, Lancet","volume":"9","author":"Day","year":"2021","journal-title":"Respir. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.112811_b0070","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1164\/rccm.201802-0366OC","article-title":"Dose optimization of H56:IC31 vaccine for tuberculosis-endemic populations. A double-blind, placebo-controlled, dose-selection trial","volume":"199","author":"Suliman","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0075","doi-asserted-by":"crossref","first-page":"2300463","DOI":"10.1080\/22221751.2023.2300463","article-title":"A multistage Sendai virus vaccine incorporating latency-associated antigens induces protection against acute and latent tuberculosis","volume":"13","author":"Hu","year":"2024","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.intimp.2024.112811_b0080","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.virol.2021.11.011","article-title":"A two-dose optimum for recombinant S1 protein-based COVID-19 vaccination","volume":"566","author":"Hu","year":"2022","journal-title":"Virology"},{"issue":"10","key":"10.1016\/j.intimp.2024.112811_b0085","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.vaccine.2007.12.038","article-title":"Vaccine adjuvant systems containing monophosphoryl lipid A and QS21 induce strong and persistent humoral and T cell responses against hepatitis B surface antigen in healthy adult volunteers","volume":"26","author":"Vandepapeli\u00e8re","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2024.112811_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.585359","article-title":"Rescuing ESAT-6 Specific CD4 T cells from terminal differentiation is critical for long-term control of murine Mtb infection","volume":"11","author":"Clemmensen","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112811_b0095","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/infdis\/jiw141","article-title":"Association of human antibodies to arabinomannan with enhanced mycobacterial opsonophagocytosis and intracellular growth reduction","volume":"214","author":"Chen","year":"2016","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0100","doi-asserted-by":"crossref","first-page":"6658","DOI":"10.1038\/s41467-021-26934-0","article-title":"A Mycobacterium tuberculosis-specific subunit vaccine that provides synergistic immunity upon co-administration with Bacillus Calmette-Gu\u00e9rin","volume":"12","author":"Woodworth","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112811_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.micpath.2016.01.006","article-title":"Recombinant BCG prime and PPE protein boost provides potent protection against acute Mycobacterium tuberculosis infection in mice","volume":"93","author":"Yang","year":"2016","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.intimp.2024.112811_b0110","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1080\/08830185.2021.1922685","article-title":"Tuberculosis vaccine BCG: the magical effect of the old vaccine in the fight against the COVID-19 pandemic","volume":"41","author":"Aspatwar","year":"2022","journal-title":"Int. Rev. Immunol."},{"issue":"39","key":"10.1016\/j.intimp.2024.112811_b0115","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1016\/j.vaccine.2015.08.033","article-title":"Prospects in Mycobacterium bovis Bacille Calmette et Gu\u00e9rin (BCG) vaccine diversity and delivery: why does BCG fail to protect against tuberculosis?","volume":"33","author":"Moliva","year":"2015","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.intimp.2024.112811_b0120","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.smim.2013.04.006","article-title":"Tuberculosis vaccines: time to think about the next generation","volume":"25","author":"Kaufmann","year":"2013","journal-title":"Semin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112811_b0125","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1556\/030.65.2018.019","article-title":"Specific immune responses induced by multi-epitope DNA derived from Mycobacterium tuberculosis DosR antigens","volume":"65","author":"Moradi","year":"2018","journal-title":"Acta Microbiol. Immunol. Hung."},{"issue":"6","key":"10.1016\/j.intimp.2024.112811_b0130","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/sji.12556","article-title":"Subunit vaccines consisting of antigens from dormant and replicating bacteria show promising therapeutic effect against mycobacterium bovis BCG latent infection","volume":"85","author":"Li","year":"2017","journal-title":"Scand. J. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112811_b0135","article-title":"Therapeutic effect of subunit vaccine AEC\/BC02 on mycobacterium tuberculosis post-chemotherapy relapse using a latent infection murine model","volume":"10","author":"Lu","year":"2022","journal-title":"Vaccines (basel)"},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0140","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1172\/JCI46252","article-title":"The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection","volume":"122","author":"Lin","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"9","key":"10.1016\/j.intimp.2024.112811_b0145","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41577-019-0174-z","article-title":"Moving tuberculosis vaccines from theory to practice","volume":"19","author":"Andersen","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2024.112811_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/cells9122673","article-title":"Recent advances in the development of protein- and peptide-based subunit vaccines against tuberculosis","volume":"9","author":"Bellini","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.112811_b0155","doi-asserted-by":"crossref","first-page":"1238586","DOI":"10.3389\/fimmu.2023.1238586","article-title":"Advances in protein subunit vaccines against tuberculosis","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112811_b0160","doi-asserted-by":"crossref","unstructured":"D.R. Tait, M. Hatherill, O. Van Der Meeren, A.M. Ginsberg, E. Van Brakel, B. Salaun, T.J. Scriba, E.J. Akite, H.M. Ayles, A. Bollaerts, M.A. Demoiti\u00e9, A. Diacon, T.G. Evans, P. Gillard, E. Hellstr\u00f6m, J.C. Innes, M. Lempicki, M. Malahleha, N. Martinson, D. Mesia Vela, M. Muyoyeta, V. Nduba, T.G. Pascal, M. Tameris, F. Thienemann, R.J. Wilkinson, F. Roman, Final Analysis of a Trial of M72\/AS01(E) Vaccine to Prevent Tuberculosis, N Engl J Med 381(25) (2019) 2429-2439.","DOI":"10.1056\/NEJMoa1909953"},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0165","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S2213-2600(18)30077-8","article-title":"Safety and immunogenicity of the novel tuberculosis vaccine ID93 + GLA-SE in BCG-vaccinated healthy adults in South Africa: a randomised, double-blind, placebo-controlled phase 1 trial","volume":"6","author":"Penn-Nicholson","year":"2018","journal-title":"Lancet Respir. Med."},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0170","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1093\/infdis\/jis425","article-title":"Therapeutic immunization against Mycobacterium tuberculosis is an effective adjunct to antibiotic treatment","volume":"207","author":"Coler","year":"2013","journal-title":"J. Infect. Dis."},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0175","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.tube.2009.06.001","article-title":"The DosR regulon of M. tuberculosis and antibacterial tolerance","volume":"89","author":"Bartek","year":"2009","journal-title":"Tuberculosis (Edinb.)"},{"issue":"5","key":"10.1016\/j.intimp.2024.112811_b0180","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1084\/jem.20030205","article-title":"Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program","volume":"198","author":"Voskuil","year":"2003","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0185","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.micinf.2006.03.018","article-title":"Human T-cell responses to 25 novel antigens encoded by genes of the dormancy regulon of Mycobacterium tuberculosis","volume":"8","author":"Leyten","year":"2006","journal-title":"Microbes Infect."},{"issue":"2","key":"10.1016\/j.intimp.2024.112811_b0190","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tube.2011.12.005","article-title":"T cell responses to DosR and Rpf proteins in actively and latently infected individuals from Colombia","volume":"92","author":"Ria\u00f1o","year":"2012","journal-title":"Tuberculosis (Edinb.)"},{"issue":"6","key":"10.1016\/j.intimp.2024.112811_b0195","doi-asserted-by":"crossref","first-page":"818","DOI":"10.5588\/ijtld.12.0695","article-title":"Immunogenicity of dormancy-related antigens in individuals infected with Mycobacterium tuberculosis in Japan","volume":"17","author":"Hozumi","year":"2013","journal-title":"Int. J. Tuberc. Lung Dis."},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0200","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jinf.2018.10.016","article-title":"Differential T cell responses against DosR-associated antigen Rv2028c in BCG-vaccinated populations with tuberculosis infection","volume":"78","author":"Zhao","year":"2019","journal-title":"J. Infect."},{"issue":"30","key":"10.1016\/j.intimp.2024.112811_b0205","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1016\/j.vaccine.2009.04.033","article-title":"Pulmonary delivery of DNA encoding Mycobacterium tuberculosis latency antigen Rv1733c associated to PLGA-PEI nanoparticles enhances T cell responses in a DNA prime\/protein boost vaccination regimen in mice","volume":"27","author":"Bivas-Benita","year":"2009","journal-title":"Vaccine"},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0210","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1128\/CVI.00111-09","article-title":"Immunogenicity of novel DosR regulon-encoded candidate antigens of Mycobacterium tuberculosis in three high-burden populations in Africa","volume":"16","author":"Black","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112811_b0215","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/j.1365-2958.2010.07399.x","article-title":"Carbon flux rerouting during Mycobacterium tuberculosis growth arrest","volume":"78","author":"Shi","year":"2010","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.intimp.2024.112811_b0220","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-017-0008-6","article-title":"Comprehensive definition of human immunodominant CD8 antigens in tuberculosis","volume":"2","author":"Lewinsohn","year":"2017","journal-title":"npj Vaccines"},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0225","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri2274","article-title":"T-cell quality in memory and protection: implications for vaccine design","volume":"8","author":"Seder","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0230","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1128\/CVI.00368-09","article-title":"Phenotypic definition of effector and memory T-lymphocyte subsets in mice chronically infected with Mycobacterium tuberculosis","volume":"17","author":"Henao-Tamayo","year":"2010","journal-title":"Clin. Vaccine Immunol."},{"issue":"37","key":"10.1016\/j.intimp.2024.112811_b0235","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.1016\/j.vaccine.2018.07.035","article-title":"Induction and maintenance of a phenotypically heterogeneous lung tissue-resident CD4(+) T cell population following BCG immunisation","volume":"36","author":"Bull","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2024.112811_b0240","doi-asserted-by":"crossref","unstructured":"I.V. Lyadova, A.V. Panteleev, Th1 and Th17 Cells in Tuberculosis: Protection, Pathology, and Biomarkers, Mediators Inflamm 2015 (2015) 854507.","DOI":"10.1155\/2015\/854507"},{"issue":"7","key":"10.1016\/j.intimp.2024.112811_b0245","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.it.2010.05.002","article-title":"Airway luminal T cells: a newcomer on the stage of TB vaccination strategies","volume":"31","author":"Jeyanathan","year":"2010","journal-title":"Trends Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112811_b0250","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007643","article-title":"A comparison of antigen-specific T cell responses induced by six novel tuberculosis vaccine candidates","volume":"15","author":"Rodo","year":"2019","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.intimp.2024.112811_b0255","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/mi.2013.86","article-title":"tuberculosis infection delays Th1 immunity via immunoadaptor DAP12-regulated IRAK-M and IL-10 expression in antigen-presenting cells","volume":"7","author":"Jeyanathan","year":"2014","journal-title":"Mucosal Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112811_b0260","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.4049\/jimmunol.1300527","article-title":"Mycobacteria-infected dendritic cells attract neutrophils that produce IL-10 and specifically shut down Th17 CD4 T cells through their IL-10 receptor","volume":"191","author":"Doz","year":"2013","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0265","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1165\/rcmb.2010-0319OC","article-title":"IL-10 blocks phagosome maturation in mycobacterium tuberculosis-infected human macrophages","volume":"45","author":"O'Leary","year":"2011","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112811_b0270","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.bbrc.2016.04.045","article-title":"Mycobacterium tuberculosis EIS gene inhibits macrophage autophagy through up-regulation of IL-10 by increasing the acetylation of histone H3","volume":"473","author":"Duan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2024.112811_b0275","doi-asserted-by":"crossref","first-page":"6343","DOI":"10.4049\/jimmunol.169.11.6343","article-title":"In vivo IL-10 production reactivates chronic pulmonary tuberculosis in C57BL\/6 mice","volume":"169","author":"Turner","year":"2002","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2024.112811_b0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005809","article-title":"The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent","volume":"12","author":"Wiens","year":"2016","journal-title":"PLoS Pathog."},{"issue":"5","key":"10.1016\/j.intimp.2024.112811_b0285","doi-asserted-by":"crossref","first-page":"788","DOI":"10.3390\/clinpract12050082","article-title":"Role of Interferons in Mycobacterium tuberculosis Infection","volume":"12","author":"Shanmuganathan","year":"2022","journal-title":"Clin Pract"},{"issue":"7507","key":"10.1016\/j.intimp.2024.112811_b0290","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature13489","article-title":"Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk","volume":"511","author":"Mayer-Barber","year":"2014","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2024.112811_b0295","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1038\/s41590-021-01066-1","article-title":"Robust IgM responses following intravenous vaccination with Bacille Calmette-Gu\u00e9rin associate with prevention of Mycobacterium tuberculosis infection in macaques","volume":"22","author":"Irvine","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.112811_b0300","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.3389\/fimmu.2019.01317","article-title":"The Humoral Immune Response to BCG Vaccination","volume":"10","author":"Tanner","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0305","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imr.12270","article-title":"Tuberculosis vaccines: barriers and prospects on the quest for a transformative tool","volume":"264","author":"Karp","year":"2015","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2024.112811_b0310","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.ymthe.2017.02.018","article-title":"Sendai virus mucosal vaccination establishes lung-resident memory CD8 T Cell immunity and boosts BCG-primed protection against TB in Mice","volume":"25","author":"Hu","year":"2017","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.112811_b0315","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1080\/21505594.2022.2080342","article-title":"Intranasal bovine \u03b2-defensin-5 enhances antituberculosis immunity in a mouse model by a novel protein-based respiratory mucosal vaccine","volume":"13","author":"Liang","year":"2022","journal-title":"Virulence"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,30]],"date-time":"2024-11-30T08:09:33Z","timestamp":1732954173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924013328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":63,"alternative-id":["S1567576924013328"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112811","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multistage protein subunit vaccine as BCG-booster confers protection against Mycobacterium tuberculosis infection in murine models","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112811"}}