{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:56:09Z","timestamp":1792605369505,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100021780","name":"Weill Cornell Department of Anesthesiology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100021780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Anhui Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2008085\\u202FJ34"],"award-info":[{"award-number":["2008085\\u202FJ34"]}],"id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005492","name":"Stanford University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH010034"],"award-info":[{"award-number":["2023AH010034"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009558","name":"University Natural Science Research Project of Anhui Province","doi-asserted-by":"publisher","award":["2023AH053320"],"award-info":[{"award-number":["2023AH053320"]}],"id":[{"id":"10.13039\/501100009558","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.intimp.2024.112852","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T02:32:53Z","timestamp":1722825173000},"page":"112852","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Dietary capsaicin attenuates cardiac injury after myocardial infarction in type 2 diabetic mice by inhibiting ferroptosis through activation of TRPV1 and Nrf2\/HMOX1 pathway"],"prefix":"10.1016","volume":"140","author":[{"given":"Chen","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruilin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.112852_b0005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12933-016-0491-5","article-title":"Dapagliflozin decreases small dense low-density lipoprotein-cholesterol and increases high-density lipoprotein 2-cholesterol in patients with type 2 diabetes: comparison with sitagliptin","volume":"16","author":"Hayashi","year":"2017","journal-title":"Cardiovasc Diabetol."},{"issue":"12","key":"10.1016\/j.intimp.2024.112852_b0010","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1016\/j.ajpath.2017.08.023","article-title":"Aggravated postinfarct heart failure in type 2 diabetes is associated with impaired mitophagy and exaggerated inflammasome activation","volume":"187","author":"Durga","year":"2017","journal-title":"Am J Pathol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112852_b0015","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12933-023-01746-2","article-title":"Deletion of Tbc1d4\/As160 abrogates cardiac glucose uptake and increases myocardial damage after ischemia\/reperfusion","volume":"22","author":"Binsch","year":"2023","journal-title":"Cardiovasc Diabetol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0020","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1089\/dna.2019.5097","article-title":"Ferroptosis is involved in diabetes myocardial ischemia\/reperfusion injury through endoplasmic reticulum stress","volume":"39","author":"Li","year":"2020","journal-title":"DNA Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112852_b0025","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","article-title":"The NLRP3 inflammasome in acute myocardial infarction","volume":"15","author":"Toldo","year":"2018","journal-title":"Nat Rev Cardiol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112852_b0030","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112852_b0035","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics."},{"key":"10.1016\/j.intimp.2024.112852_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154999","article-title":"EGCG attenuated acute myocardial infarction by inhibiting ferroptosis via miR-450b-5p\/ACSL4 axis","volume":"119","author":"Yu","year":"2023","journal-title":"Phytomedicine."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0045","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1161\/ATVBAHA.122.318161","article-title":"Platelet internalization mediates ferroptosis in myocardial infarction","volume":"43","author":"Miao","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0050","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.molcel.2015.06.011","article-title":"Glutaminolysis and transferrin regulate ferroptosis","volume":"59","author":"Gao","year":"2015","journal-title":"Mol Cell."},{"issue":"19","key":"10.1016\/j.intimp.2024.112852_b0055","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1161\/CIRCULATIONAHA.122.060257","article-title":"Alox15\/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis","volume":"147","author":"Cai","year":"2023","journal-title":"Circulation."},{"issue":"1","key":"10.1016\/j.intimp.2024.112852_b0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat Rev Cardiol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0065","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.apsb.2021.10.005","article-title":"Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK\/NRF2 pathways","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm Sin B."},{"issue":"11","key":"10.1016\/j.intimp.2024.112852_b0070","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/s41419-019-2061-8","article-title":"Quantitative proteomic analyses reveal that GPX4 downregulation during myocardial infarction contributes to ferroptosis in cardiomyocytes","volume":"10","author":"Park","year":"2019","journal-title":"Cell Death Dis."},{"issue":"9","key":"10.1016\/j.intimp.2024.112852_b0075","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1111\/obr.12703","article-title":"Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy","volume":"19","author":"Bishnoi","year":"2018","journal-title":"Obes Rev."},{"issue":"6","key":"10.1016\/j.intimp.2024.112852_b0080","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.trsl.2013.02.003","article-title":"Targeting TRPV1 and TRPV2 for potential therapeutic interventions in cardiovascular disease","volume":"161","author":"Robbins","year":"2013","journal-title":"Transl Res."},{"issue":"9","key":"10.1016\/j.intimp.2024.112852_b0085","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.003774","article-title":"Transient receptor potential vanilloid 1 regulates mitochondrial membrane potential and myocardial reperfusion injury","volume":"5","author":"Hurt","year":"2016","journal-title":"J Am Heart Assoc."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0090","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1161\/HYPERTENSIONAHA.108.118349","article-title":"Transient receptor potential vanilloid gene deletion exacerbates inflammation and atypical cardiac remodeling after myocardial infarction","volume":"53","author":"Huang","year":"2009","journal-title":"Hypertension."},{"key":"10.1016\/j.intimp.2024.112852_b0095","article-title":"Consumption of spicy foods and total and cause specific mortality: population based cohort study","volume":"351","author":"Lv","year":"2015","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.intimp.2024.112852_b0100","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1161\/HYPERTENSIONAHA.118.11035","article-title":"Potential protective mechanism in the cardiac microvascular injury","volume":"72","author":"Li","year":"2018","journal-title":"Hypertension."},{"issue":"1","key":"10.1016\/j.intimp.2024.112852_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1902719","article-title":"The gut microbiota metabolite capsiate promotes Gpx4 expression by activating TRPV1 to inhibit intestinal ischemia reperfusion-induced ferroptosis","volume":"13","author":"Deng","year":"2021","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.intimp.2024.112852_b0110","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/10408399109527536","article-title":"Capsicum\u2013production, technology, chemistry, and quality. Part V. Impact on physiology, pharmacology, nutrition, and metabolism; structure, pungency, pain, and desensitization sequences","volume":"29","author":"Govindarajan","year":"1991","journal-title":"Crit Rev Food Sci Nutr."},{"key":"10.1016\/j.intimp.2024.112852_b0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-1-4939-3661-8_10","article-title":"Mouse models of type 2 diabetes mellitus in drug discovery","volume":"1438","author":"Baribault","year":"2016","journal-title":"Methods Mol Biol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112852_b0120","doi-asserted-by":"crossref","DOI":"10.3390\/nu8050174","article-title":"Dietary capsaicin protects cardiometabolic organs from dysfunction","volume":"8","author":"Sun","year":"2016","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2024.112852_b0125","article-title":"Beyond neuronal heat sensing: diversity of TRPV1 heat-capsaicin receptor-channel functions","volume":"14","author":"Shuba","year":"2020","journal-title":"Front Cell Neurosci."},{"issue":"19","key":"10.1016\/j.intimp.2024.112852_b0130","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1080\/10408398.2021.1991883","article-title":"Modulating effects of capsaicin on glucose homeostasis and the underlying mechanism","volume":"63","author":"Liang","year":"2023","journal-title":"Crit Rev Food Sci Nutr."},{"key":"10.1016\/j.intimp.2024.112852_b0135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/nu10050630","article-title":"Capsaicin in metabolic syndrome","volume":"10","author":"Panchal","year":"2018","journal-title":"Nutrients."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0140","doi-asserted-by":"crossref","first-page":"393","DOI":"10.32604\/biocell.2023.024944","article-title":"Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice","volume":"47","author":"Lu","year":"2023","journal-title":"Biocell."},{"key":"10.1016\/j.intimp.2024.112852_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111858","article-title":"Interleukin-1beta polarization in M1 macrophage mediates myocardial fibrosis in diabetes","volume":"131","author":"Guo","year":"2024","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112852_b0150","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell."},{"issue":"21","key":"10.1016\/j.intimp.2024.112852_b0155","doi-asserted-by":"crossref","first-page":"9995","DOI":"10.1111\/jcmm.16890","article-title":"Inhibition of the long non-coding RNA ZFAS1 attenuates ferroptosis by sponging miR-150-5p and activates CCND2 against diabetic cardiomyopathy","volume":"25","author":"Ni","year":"2021","journal-title":"J Cell Mol Med."},{"key":"10.1016\/j.intimp.2024.112852_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101107","article-title":"NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis","volume":"23","author":"Dodson","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.112852_b0165","doi-asserted-by":"crossref","first-page":"9067610","DOI":"10.1155\/2020\/9067610","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 diabetic osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid Med Cell Longev."},{"issue":"13","key":"10.1016\/j.intimp.2024.112852_b0170","doi-asserted-by":"crossref","first-page":"12943","DOI":"10.18632\/aging.103378","article-title":"Nrf2 inhibits ferroptosis and protects against acute lung injury due to intestinal ischemia reperfusion via regulating SLC7A11 and HO-1","volume":"12","author":"Dong","year":"2020","journal-title":"Aging (Albany NY)"},{"issue":"38","key":"10.1016\/j.intimp.2024.112852_b0175","doi-asserted-by":"crossref","first-page":"42887","DOI":"10.1021\/acsami.2c10506","article-title":"Astaxanthin activated the Nrf2\/HO-1 pathway to enhance autophagy and inhibit ferroptosis, ameliorating acetaminophen-induced liver injury","volume":"14","author":"Cai","year":"2022","journal-title":"ACS Appl Mater Interfaces."},{"key":"10.1016\/j.intimp.2024.112852_b0180","article-title":"Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2\/HO-1\/GPX4 activation","volume":"13","author":"Yang","year":"2022","journal-title":"Front Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112852_b0185","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s12967-021-02745-1","article-title":"Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2\/HO-1 pathway","volume":"19","author":"Li","year":"2021","journal-title":"J Transl Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.112852_b0190","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s13238-016-0353-7","article-title":"Understand spiciness: mechanism of TRPV1 channel activation by capsaicin","volume":"8","author":"Yang","year":"2017","journal-title":"Protein Cell."},{"issue":"6","key":"10.1016\/j.intimp.2024.112852_b0195","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/s41419-021-03792-8","article-title":"TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca(2+)\/CaMKII\/Nrf2 signaling pathway","volume":"12","author":"Lv","year":"2021","journal-title":"Cell Death Dis."},{"issue":"2","key":"10.1016\/j.intimp.2024.112852_b0200","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death DIS."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T11:55:55Z","timestamp":1786362955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924013730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":40,"alternative-id":["S1567576924013730"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112852","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary capsaicin attenuates cardiac injury after myocardial infarction in type 2 diabetic mice by inhibiting ferroptosis through activation of TRPV1 and Nrf2\/HMOX1 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112852","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112852"}}