{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:24:36Z","timestamp":1792027476449,"version":"4.4.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.intimp.2024.112871","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T07:59:49Z","timestamp":1722931189000},"page":"112871","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Docosahexaenoic acid eliminates endoplasmic reticulum stress and inflammatory pathways in diabetic rat keratopathy"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1658-2098","authenticated-orcid":false,"given":"Arzu","family":"Gezer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6359-6249","authenticated-orcid":false,"given":"Mustafa","family":"\u00d6zkaraca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3140-0755","authenticated-orcid":false,"given":"Hilal","family":"\u00dcst\u00fcnda\u011f","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-8895","authenticated-orcid":false,"given":"Menek\u015fe","family":"Soydan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6mer","family":"Alkano\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8859-7814","authenticated-orcid":false,"given":"G\u00fcrsel","family":"Bedir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl_1","key":"10.1016\/j.intimp.2024.112871_b0005","doi-asserted-by":"crossref","first-page":"s99","DOI":"10.2337\/diacare.26.2007.S99","article-title":"A.D. Association, Diabetic retinopathy","volume":"26","author":"Fong","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.intimp.2024.112871_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11892-016-0812-9","article-title":"Biomarkers of diabetic retinopathy","volume":"16","author":"Ting","year":"2016","journal-title":"Curr. Diab. Rep."},{"issue":"11","key":"10.1016\/j.intimp.2024.112871_b0015","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.ophtha.2021.04.027","article-title":"Global prevalence of diabetic retinopathy and projection of burden through 2045: systematic review and meta-analysis","volume":"128","author":"Teo","year":"2021","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.tem.2013.09.005","article-title":"Neurodegeneration in the diabetic eye: new insights and therapeutic perspectives","volume":"25","author":"Simo","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.112871_b0025","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.preteyeres.2015.08.001","article-title":"The progress in understanding and treatment of diabetic retinopathy","volume":"51","author":"Stitt","year":"2016","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.intimp.2024.112871_b0030","doi-asserted-by":"crossref","unstructured":"M. Brownlee, The pathobiology of diabetic complications: a unifying mechanism, diabetes 54(6) (2005) 1615-1625.","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"10.1016\/j.intimp.2024.112871_b0035","doi-asserted-by":"crossref","unstructured":"X.-L. Du, D. Edelstein, L. Rossetti, I.G. Fantus, H. Goldberg, F. Ziyadeh, J. Wu, M. Brownlee, Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation, Proc. Natl. Acad. Sci. 97(22) (2000) 12222-12226.","DOI":"10.1073\/pnas.97.22.12222"},{"issue":"4","key":"10.1016\/j.intimp.2024.112871_b0040","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2337\/diab.40.4.405","article-title":"Role of oxidative stress in development of complications in diabetes","volume":"40","author":"Baynes","year":"1991","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.intimp.2024.112871_b0045","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1096\/fj.01-0707fje","article-title":"Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-\u03b1 suppression","volume":"16","author":"Joussen","year":"2002","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.intimp.2024.112871_b0050","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1016\/j.febslet.2009.04.007","article-title":"Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy","volume":"583","author":"Li","year":"2009","journal-title":"FEBS Lett."},{"issue":"5","key":"10.1016\/j.intimp.2024.112871_b0055","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.preteyeres.2011.05.002","article-title":"Inflammation in diabetic retinopathy","volume":"30","author":"Tang","year":"2011","journal-title":"Prog. Retin. Eye Res."},{"issue":"7","key":"10.1016\/j.intimp.2024.112871_b0060","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1755-3768.2009.01545.x","article-title":"on behalf of the Protein Kinase C Diabetic Retinopathy Study (PKC-DRS2) Study Group, Diabetic macular oedema and visual loss: relationship to location, severity and duration","volume":"87","author":"Gardner","year":"2009","journal-title":"Acta Ophthalmol."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2024.112871_b0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mrfmmm.2004.06.056","article-title":"ER stress and the unfolded protein response","volume":"569","author":"Schr\u00f6der","year":"2005","journal-title":"Mutation Res.\/Fundamental Mol. Mech. Mutagenesis"},{"issue":"3","key":"10.1016\/j.intimp.2024.112871_b0070","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/j.1365-2125.2012.04374.x","article-title":"Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?","volume":"75","author":"Calder","year":"2013","journal-title":"Br. J. Clin. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.112871_b0075","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nm1591","article-title":"Increased dietary intake of \u03c9-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis","volume":"13","author":"Connor","year":"2007","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.112871_b0080","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ophtha.2023.11.030","article-title":"ASCEND-Eye: effects of Omega-3 fatty acids on diabetic retinopathy","volume":"131","author":"Sammons","year":"2024","journal-title":"Ophthalmology"},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0085","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/antiox13010120","article-title":"Diabetic keratopathy: redox signaling pathways and therapeutic prospects","volume":"13","author":"Buonfiglio","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.intimp.2024.112871_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118789","article-title":"Sirt1 attenuates diabetic keratopathy by regulating the endoplasmic reticulum stress pathway","volume":"265","author":"Wei","year":"2021","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.112871_b0095","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1080\/09273948.2022.2027464","article-title":"Lactucaxanthin regulates the cascade of retinal oxidative stress, endoplasmic reticulum stress and inflammatory signaling in diabetic rats","volume":"31","author":"Rani","year":"2023","journal-title":"Ocul. Immunol. Inflamm."},{"issue":"5","key":"10.1016\/j.intimp.2024.112871_b0100","doi-asserted-by":"crossref","first-page":"942e","DOI":"10.1097\/PRS.0000000000006739","article-title":"Docosahexaenoic acid improves diabetic wound healing in a rat model by restoring impaired plasticity of macrophage progenitor cells","volume":"145","author":"Jia","year":"2020","journal-title":"Plast. Reconstr. Surg."},{"issue":"4","key":"10.1016\/j.intimp.2024.112871_b0105","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/fcp.12892","article-title":"Induction of a single dose of streptozotocin (50 mg) in rat model causes insulin resistance with type 2 diabetes mellitus","volume":"37","author":"Sharma","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112871_b0110","first-page":"276","article-title":"Investigation of apoptotic and autophagic effects of chronic roflumilast use on testicular tissue in rats by immunohistochemical and immunofluorescence methods","volume":"26","author":"Gezer","year":"2023","journal-title":"Iran. J. Basic Med. Sci."},{"key":"10.1016\/j.intimp.2024.112871_b0115","doi-asserted-by":"crossref","unstructured":"K.J. Livak, T.D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method, methods 25(4) (2001) 402-408.","DOI":"10.1006\/meth.2001.1262"},{"issue":"3","key":"10.1016\/j.intimp.2024.112871_b0120","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1007\/s10753-019-01172-1","article-title":"Evidence on n-3 fatty acids and oleic acid role in retinal inflammation and microvascular integrity: insight from a hyperlipidemic rat model","volume":"43","author":"Bettadahalli","year":"2020","journal-title":"Inflammation"},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0125","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/antiox11010116","article-title":"Supplementation with a highly concentrated docosahexaenoic acid (DHA) in non-proliferative diabetic retinopathy: A 2-year randomized double-blind placebo-controlled study","volume":"11","author":"Pi\u00f1as Garc\u00eda","year":"2022","journal-title":"Antioxidants"},{"issue":"22","key":"10.1016\/j.intimp.2024.112871_b0130","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1056\/NEJM199412013312203","article-title":"Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders","volume":"331","author":"Aiello","year":"1994","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0135","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1001\/archopht.1996.01100130062010","article-title":"Inhibition of vascular endothelial growth factor prevents retinal ischemia\u2014associated iris neovascularization in a nonhuman primate","volume":"114","author":"Adamis","year":"1996","journal-title":"Arch. Ophthalmol."},{"issue":"12","key":"10.1016\/j.intimp.2024.112871_b0140","doi-asserted-by":"crossref","first-page":"6815","DOI":"10.1167\/iovs.10-5339","article-title":"Docosahexaenoic acid improves the nitroso-redox balance and reduces VEGF-mediated angiogenic signaling in microvascular endothelial cells","volume":"51","author":"Matesanz","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.112871_b0145","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2174\/157340109788185562","article-title":"Polyunsaturated fatty acids in pathological retinal angiogenesis","volume":"5","author":"Das","year":"2009","journal-title":"Curr. Nutr. Food Sci."},{"issue":"11","key":"10.1016\/j.intimp.2024.112871_b0150","first-page":"12747","article-title":"The role of \u03c9-3 PUFAs in affecting retinal neovascularization by regulating microglia phenotype","volume":"12","author":"Ji","year":"2019","journal-title":"Int. J. Clin. Experiment. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0155","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2147\/vhrm.2008.04.01.115","article-title":"Endoplasmic reticulum stress and diabetic retinopathy","volume":"4","author":"Oshitari","year":"2008","journal-title":"Vasc. Health Risk Manag."},{"issue":"6","key":"10.1016\/j.intimp.2024.112871_b0160","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1210\/er.2007-0015","article-title":"The role for endoplasmic reticulum stress in diabetes mellitus","volume":"29","author":"Eizirik","year":"2008","journal-title":"Endocr. Rev."},{"issue":"11","key":"10.1016\/j.intimp.2024.112871_b0170","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1080\/02713680600966785","article-title":"Induction of endoplasmic reticulum stress in retinal pericytes by glucose deprivation","volume":"31","author":"Ikesugi","year":"2006","journal-title":"Curr. Eye Res."},{"issue":"8","key":"10.1016\/j.intimp.2024.112871_b0175","first-page":"2791","article-title":"Response of VEGF expression to amino acid deprivation and inducers of endoplasmic reticulum stress","volume":"43","author":"Abcouwer","year":"2002","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.intimp.2024.112871_b0180","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00592-009-0170-z","article-title":"The role of endoplasmic reticulum stress in the early stage of diabetic retinopathy","volume":"48","author":"Li","year":"2011","journal-title":"Acta Diabetol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112871_b0185","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/1389203719666180928123449","article-title":"Pathological perturbations in diabetic retinopathy: hyperglycemia, AGEs, oxidative stress and inflammatory pathways","volume":"20","author":"Sahajpal","year":"2019","journal-title":"Curr. Protein Pept. Sci."},{"key":"10.1016\/j.intimp.2024.112871_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2021.108901","article-title":"Omega-3 fatty acids promote neuroprotection, decreased apoptosis and reduced glial cell activation in the retina of a mouse model of OPA1-related autosomal dominant optic atrophy","volume":"215","author":"Kalogerou","year":"2022","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.intimp.2024.112871_b0195","article-title":"DHA-promoted repair of human corneal epithelial cells in high-glucose environment","author":"Huang","year":"2021","journal-title":"Food Sci. Technol."},{"key":"10.1016\/j.intimp.2024.112871_b0200","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.nutr.012809.104635","article-title":"Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases","volume":"31","author":"Bazan","year":"2011","journal-title":"Ann. Rev. Nutrit."},{"issue":"9","key":"10.1016\/j.intimp.2024.112871_b0205","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1167\/iovs.05-0241","article-title":"Topical combination of NGF and DHA increases rabbit corneal nerve regeneration after photorefractive keratectomy","volume":"46","author":"Esquenazi","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013924?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924013924?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T12:01:52Z","timestamp":1786363312000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924013924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":41,"alternative-id":["S1567576924013924"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112871","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Docosahexaenoic acid eliminates endoplasmic reticulum stress and inflammatory pathways in diabetic rat keratopathy","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112871","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112871"}}