{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:08:17Z","timestamp":1792886897405,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018579","name":"Training Program for Excellent Young Innovators of Changsha","doi-asserted-by":"publisher","award":["SPROG2206"],"award-info":[{"award-number":["SPROG2206"]}],"id":[{"id":"10.13039\/501100018579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010012","name":"National Aerospace Science Foundation of China","doi-asserted-by":"publisher","award":["8207061128"],"award-info":[{"award-number":["8207061128"]}],"id":[{"id":"10.13039\/501100010012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010167","name":"Shanghai Shen Kang Hospital Development Center","doi-asserted-by":"publisher","award":["SHDC22020CR1013B"],"award-info":[{"award-number":["SHDC22020CR1013B"]}],"id":[{"id":"10.13039\/501100010167","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.112942","type":"journal-article","created":{"date-parts":[[2024,8,31]],"date-time":"2024-08-31T22:37:45Z","timestamp":1725143865000},"page":"112942","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"PA","title":["Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K\/Akt\/GSK-3\u03b2 pathway in gout"],"prefix":"10.1016","volume":"142","author":[{"given":"Fangfang","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguo","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hejian","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10287","key":"10.1016\/j.intimp.2024.112942_b0005","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.intimp.2024.112942_b0010","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/ar2952","article-title":"Mechanisms of inflammation in gout","volume":"12","author":"Busso","year":"2010","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0015","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/RHU.0b013e31827d8790","article-title":"Mechanistic aspects of inflammation and clinical management of inflammation in acute gouty arthritis","volume":"19","author":"Cronstein","year":"2013","journal-title":"J. Clin. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/eji.201445427","article-title":"Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal","volume":"46","author":"Mills","year":"2016","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2024.112942_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/bs.ai.2016.12.001","article-title":"Macrophages and mitochondria: a critical interplay between metabolism, signaling, and the functional activity","volume":"133","author":"Tur","year":"2017","journal-title":"Adv. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.112942_b0030","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/rheumatology\/kez165","article-title":"Sirt1 ameliorates monosodium urate crystal-induced inflammation by altering macrophage polarization via the PI3K\/Akt\/STAT6 pathway","volume":"58","author":"Liu","year":"2019","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.intimp.2024.112942_b0035","first-page":"647","article-title":"Cloning and mRNA expression analysis of a novel human protooncogene, c-mer","volume":"5","author":"Graham","year":"1994","journal-title":"Cell Growth Differ."},{"issue":"19","key":"10.1016\/j.intimp.2024.112942_b0040","doi-asserted-by":"crossref","first-page":"5275","DOI":"10.1158\/1078-0432.CCR-12-1451","article-title":"Molecular pathways: MERTK signaling in cancer","volume":"19","author":"Cummings","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.112942_b0045","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev-immunol-032414-112103","article-title":"TAM receptor signaling in immune homeostasis","volume":"33","author":"Rothlin","year":"2015","journal-title":"Annu. Rev. Immunol."},{"issue":"549","key":"10.1016\/j.intimp.2024.112942_b0050","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aar3721","article-title":"MerTK signaling in macrophages promotes the synthesis of inflammation resolution mediators by suppressing CaMKII activity","volume":"11","author":"Cai","year":"2018","journal-title":"Sci. Signal"},{"issue":"365","key":"10.1016\/j.intimp.2024.112942_b0055","doi-asserted-by":"crossref","first-page":"p. ra21","DOI":"10.1126\/scisignal.2005864","article-title":"Mer signaling increases the abundance of the transcription factor LXR to promote the resolution of acute sterile inflammation","volume":"8","author":"Choi","year":"2015","journal-title":"Sci. Signal"},{"issue":"6","key":"10.1016\/j.intimp.2024.112942_b0060","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1189\/jlb.0611289","article-title":"Inhibiting Mer receptor tyrosine kinase suppresses STAT1, SOCS1\/3, and NF-kappaB activation and enhances inflammatory responses in lipopolysaccharide-induced acute lung injury","volume":"91","author":"Lee","year":"2012","journal-title":"J. Leukoc. Biol."},{"issue":"23","key":"10.1016\/j.intimp.2024.112942_b0065","doi-asserted-by":"crossref","first-page":"6526","DOI":"10.1073\/pnas.1524292113","article-title":"MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation","volume":"113","author":"Cai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.intimp.2024.112942_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.107893","article-title":"Resolving inflammation by TAM receptor activation","volume":"227","author":"Vago","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0075","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s13075-016-1167-y","article-title":"Interleukin 37 limits monosodium urate crystal-induced innate immune responses in human and murine models of gout","volume":"18","author":"Liu","year":"2016","journal-title":"Arthritis Res. Ther."},{"issue":"8","key":"10.1016\/j.intimp.2024.112942_b0080","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1194\/jlr.M056689","article-title":"Macrophage SR-BI mediates efferocytosis via Src\/PI3K\/Rac1 signaling and reduces atherosclerotic lesion necrosis","volume":"56","author":"Tao","year":"2015","journal-title":"J. Lipid Res."},{"issue":"5","key":"10.1016\/j.intimp.2024.112942_b0085","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1172\/JCI67816","article-title":"MERTK receptor tyrosine kinase is a therapeutic target in melanoma","volume":"123","author":"Schlegel","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.112942_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102763","article-title":"NOX2 inhibition stabilizes vulnerable plaques by enhancing macrophage efferocytosis via MertK\/PI3K\/AKT pathway","volume":"64","author":"Wang","year":"2023","journal-title":"Redox Biol."},{"issue":"24","key":"10.1016\/j.intimp.2024.112942_b0095","doi-asserted-by":"crossref","first-page":"9517","DOI":"10.1073\/pnas.1119038109","article-title":"Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization","volume":"109","author":"Arranz","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0100","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.151819","article-title":"Gsk3beta regulates the resolution of liver ischemia\/reperfusion injury via MerTK","volume":"8","author":"Zhang","year":"2023","journal-title":"JCI Insight"},{"issue":"10","key":"10.1016\/j.intimp.2024.112942_b0105","first-page":"2557","article-title":"2015 Gout classification criteria: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"67","author":"Neogi","year":"2015","journal-title":"ArthritisRheumatol"},{"issue":"3","key":"10.1016\/j.intimp.2024.112942_b0110","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/art.1780200320","article-title":"Preliminary criteria for the classification of the acute arthritis of primary gout","volume":"20","author":"Wallace","year":"1977","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.intimp.2024.112942_b0115","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.cbi.2006.09.011","article-title":"Suppressive effect of Withania somnifera root powder on experimental gouty arthritis: An in vivo and in vitro study","volume":"164","author":"Rasool","year":"2006","journal-title":"Chem. Biol. Interact"},{"issue":"5","key":"10.1016\/j.intimp.2024.112942_b0120","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/art.30249","article-title":"Monosodium urate monohydrate crystal-recruited noninflammatory monocytes differentiate into M1-like proinflammatory macrophages in a peritoneal murine model of gout","volume":"63","author":"Martin","year":"2011","journal-title":"Arthritis Rheum."},{"issue":"10","key":"10.1016\/j.intimp.2024.112942_b0125","first-page":"1359","article-title":"Imaging cell death with radiolabeled annexin V in an experimental model of rheumatoid arthritis","volume":"43","author":"Post","year":"2002","journal-title":"J. Nucl. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.112942_b0130","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nm.3547","article-title":"Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines","volume":"20","author":"Schauer","year":"2014","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0135","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/art.24185","article-title":"Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout","volume":"60","author":"Martin","year":"2009","journal-title":"Arthritis Rheum."},{"issue":"9","key":"10.1016\/j.intimp.2024.112942_b0140","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1111\/bph.14967","article-title":"Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis","volume":"177","author":"Yin","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112942_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120155","article-title":"A multifunctional anti-inflammatory drug that can specifically target activated macrophages, massively deplete intracellular H2O2, and produce large amounts CO for a highly efficient treatment of osteoarthritis","volume":"255","author":"Yang","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.intimp.2024.112942_b0150","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.2147\/DDDT.S210220","article-title":"Aucubin protects chondrocytes against IL-1beta-Induced apoptosis in vitro and inhibits osteoarthritis in mice model","volume":"13","author":"Wang","year":"2019","journal-title":"Drug Des. Devel. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2024.112942_b0155","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1124\/jpet.108.148122","article-title":"Glycogen synthase kinase-3beta mediates endoplasmic reticulum stress-induced lysosomal apoptosis in leukemia","volume":"329","author":"Huang","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2024.112942_b0160","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1136\/annrheumdis-2020-217342","article-title":"Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1beta activation on macrophages","volume":"79","author":"Renaudin","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.112942_b0165","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fimmu.2018.00103","article-title":"Macrophage Recognition of Crystals and Nanoparticles","volume":"9","author":"Nakayama","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0170","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12943-019-1022-2","article-title":"Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment","volume":"18","author":"Myers","year":"2019","journal-title":"Mol. Cancer"},{"issue":"11","key":"10.1016\/j.intimp.2024.112942_b0175","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/s41571-023-00813-7","article-title":"TAM family kinases as therapeutic targets at the interface of cancer and immunity","volume":"20","author":"DeRyckere","year":"2023","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"9","key":"10.1016\/j.intimp.2024.112942_b0180","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/s41577-019-0167-y","article-title":"How macrophages deal with death","volume":"19","author":"Lemke","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0952-7915(02)00016-X","article-title":"Macrophage regulation by Tyro 3 family receptors","volume":"15","author":"Lemke","year":"2003","journal-title":"Curr. Opin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112942_b0190","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.cell.2020.08.031","article-title":"A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart","volume":"183","author":"Nicolas-Avila","year":"2020","journal-title":"Cell"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924014632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924014632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T02:49:15Z","timestamp":1728010155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924014632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":38,"alternative-id":["S1567576924014632"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112942","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K\/Akt\/GSK-3\u03b2 pathway in gout","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112942","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112942"}}