{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:41:55Z","timestamp":1770280915259,"version":"3.49.0"},"reference-count":156,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["2022.13327"],"award-info":[{"award-number":["2022.13327"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.112969","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:04:53Z","timestamp":1725642293000},"page":"112969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"PA","title":["Could P2X7 receptor be a potencial target in neonatal sepsis?"],"prefix":"10.1016","volume":"142","author":[{"given":"Sales","family":"Fialho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Trieu-Cuot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0005","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/0884533617695243","article-title":"Sepsis: current definition, pathophysiology, diagnosis, and management","volume":"32","author":"Taeb","year":"2017","journal-title":"Nutr. Clin. Pract."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0010","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S1473-3099(15)70112-X","article-title":"Sepsis: a roadmap for future research","volume":"15","author":"Cohen","year":"2015","journal-title":"Lancet Infect. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0015","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0020","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1089\/sur.2017.316","article-title":"Pediatric sepsis update: how are children different?","volume":"19","author":"Emr","year":"2018","journal-title":"Surg. Infect. (Larchmt)"},{"issue":"10219","key":"10.1016\/j.intimp.2024.112969_b0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990\u20132017: analysis for the Global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0030","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S2213-2600(18)30063-8","article-title":"The global burden of paediatric and neonatal sepsis: a systematic review","volume":"6","author":"Fleischmann-Struzek","year":"2018","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.intimp.2024.112969_b0035","unstructured":"WH Organization. Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions. Geneva, 2020."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0040","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMp1707170","article-title":"Recognizing sepsis as a global health priority \u2014 a WHO resolution","volume":"377","author":"Reinhart","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.112969_b0045","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1016\/j.ebiom.2022.104363","article-title":"Immunopathophysiology of human sepsis","volume":"86","author":"Wiersinga","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/j.intimp.2024.112969_b0050","doi-asserted-by":"crossref","unstructured":"Wynn Jl Fau - Wong HR, Wong HR. Pathophysiology of Neonatal Sepsis. Fetal and Neonatal Physiology. 2017.","DOI":"10.1016\/B978-0-323-35214-7.00152-9"},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0055","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharmthera.2005.04.013","article-title":"Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation","volume":"112","author":"Bours","year":"2006","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0060","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11302-014-9427-2","article-title":"Purinergic signalling and immune cells","volume":"10","author":"Burnstock","year":"2014","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.intimp.2024.112969_b0065","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bcp.2017.12.021","article-title":"The P2X7 receptor: A main player in inflammation","volume":"151","author":"Adinolfi","year":"2018","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0070","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.immuni.2017.06.020","article-title":"The P2X7 Receptor in Infection and Inflammation","volume":"47","author":"Di Virgilio","year":"2017","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0075","first-page":"1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis","volume":"101","author":"Bone","year":"1992","journal-title":"Crit. Care Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0080","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.chest.2016.10.057","article-title":"Systemic inflammatory response syndrome, quick sequential organ function assessment, and organ dysfunction: insights from a prospective database of ED patients with infection","volume":"151","author":"Williams","year":"2017","journal-title":"Chest"},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0085","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/PCC.0000000000000157","article-title":"Time for a neonatal-specific consensus definition for sepsis","volume":"15","author":"Wynn","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41390-020-0785-x","article-title":"Challenges in developing a consensus definition of neonatal sepsis","volume":"88","author":"McGovern","year":"2020","journal-title":"Pediatr. Res."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184159","article-title":"Unique transcriptomic response to sepsis is observed among patients of different age groups","volume":"12","author":"Raymond","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0100","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.intimp.2024.112969_b0105","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"J. Am. Med. Assoc."},{"issue":"7","key":"10.1016\/j.intimp.2024.112969_b0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.it.2014.04.007","article-title":"Ontogeny of early life immunity","volume":"35","author":"Dowling","year":"2014","journal-title":"Trends Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0115","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nri2075","article-title":"Innate immunity of the newborn: basic mechanisms and clinical correlates","volume":"7","author":"Levy","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2024.112969_b0120","article-title":"Targeting purinergic signaling in the dynamics of disease progression in sepsis","volume":"11","author":"Leite-Aguiar","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112969_b0125","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.3389\/fimmu.2019.02536","article-title":"DAMPs and NETs in Sepsis","volume":"10","author":"Denning","year":"2019","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0130","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3109\/1040841X.2012.706249","article-title":"Recognition of bacterial infection by innate immune sensors","volume":"39","author":"Kumar","year":"2013","journal-title":"Crit. Rev. Microbiol."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0135","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/jcmm.13112","article-title":"Neutrophil dysregulation during sepsis: an overview and update","volume":"21","author":"Shen","year":"2017","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0140","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4161\/viru.25436","article-title":"Host innate immune responses to sepsis","volume":"5","author":"Wiersinga","year":"2014","journal-title":"Virulence"},{"issue":"12","key":"10.1016\/j.intimp.2024.112969_b0145","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2024.112969_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-016-1233-5","article-title":"Sepsis-induced long-term immune paralysis\u2013results of a descriptive, explorative study","volume":"20","author":"Arens","year":"2016","journal-title":"Critical Care"},{"key":"10.1016\/j.intimp.2024.112969_b0155","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3389\/fped.2018.00357","article-title":"Sepsis-Induced Immunosuppression in Neonates","volume":"6","author":"Hibbert","year":"2018","journal-title":"Front. Pediatr"},{"key":"10.1016\/j.intimp.2024.112969_b0160","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/PL00008445","article-title":"Plasma levels of interleukin-6 and interleukin-10 in preterm neonates evaluated for sepsis","volume":"160","author":"Romagnoli","year":"2001","journal-title":"European J. Pediat."},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0165","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1203\/PDR.0b013e3181f90810","article-title":"Human neonatal peripheral blood leukocytes demonstrate pathogen-specific coordinate expression of TLR2, TLR4\/MD2, and MyD88 during bacterial infection in vivo","volume":"68","author":"Zhang","year":"2010","journal-title":"Pediatr. Res."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0170","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.immuni.2012.10.014","article-title":"Innate immune function by Toll-like receptors: distinct responses in newborns and the elderly","volume":"37","author":"Kollmann","year":"2012","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0175","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1086\/509892","article-title":"Immaturity of infection control in preterm and term newborns is associated with impaired toll-like receptor signaling","volume":"195","author":"Sadeghi","year":"2007","journal-title":"J. Inf. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0180","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.tim.2004.09.004","article-title":"Toll-like receptors as an escape mechanism from the host defense","volume":"12","author":"Netea","year":"2004","journal-title":"Trends Microbiol."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0185","doi-asserted-by":"crossref","first-page":"4759","DOI":"10.4049\/jimmunol.1301752","article-title":"TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis","volume":"191","author":"Andrade","year":"2013","journal-title":"J. Immunol."},{"issue":"3\u20134","key":"10.1016\/j.intimp.2024.112969_b0190","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1159\/000241541","article-title":"Supply and release of storage neutrophils: a developmental study","volume":"41","author":"Erdman","year":"1982","journal-title":"Neonatology"},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0195","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0095-5108(18)30277-X","article-title":"Neutropenia in the neonate","volume":"22","author":"Al-Mulla","year":"1995","journal-title":"Clin. Perinatol."},{"issue":"1821","key":"10.1016\/j.intimp.2024.112969_b0200","first-page":"20143085","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"Simon","year":"2015","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.intimp.2024.112969_b0205","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.3389\/fimmu.2018.01759","article-title":"Innate Immunity of Neonates and Infants","volume":"9","author":"Yu","year":"2018","journal-title":"Front. Immunol."},{"issue":"25","key":"10.1016\/j.intimp.2024.112969_b0210","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1182\/blood-2008-07-171629","article-title":"Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates","volume":"113","author":"Yost","year":"2009","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0215","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1189\/jlb.4A0415-168RR","article-title":"Marked alterations of neutrophil functions during sepsis-induced immunosuppression","volume":"98","author":"Demaret","year":"2015","journal-title":"J. Leukoc. Biol."},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0220","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1097\/INF.0000000000000297","article-title":"Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns: Use of the I\/T: 2","volume":"33","author":"Newman","year":"2014","journal-title":"Pediatr Infect Dis J."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0225","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.epag.2017.12.002","article-title":"Can we rely on the neutrophil left shift for the diagnosis of neonatal sepsis? Need for re-evaluation","volume":"66","author":"Saied","year":"2018","journal-title":"Egyptian Pediat. Assoc. Gazette."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0230","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1097\/CCM.0000000000000344","article-title":"Circulating immature granulocytes with T-cell killing functions predict sepsis deterioration","volume":"42","author":"Gu\u00e9rin","year":"2014","journal-title":"Crit Care Med."},{"key":"10.1016\/j.intimp.2024.112969_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.940930","article-title":"The neonatal innate immune response to sepsis: checkpoint proteins as novel mediators of this response and as possible therapeutic\/diagnostic levers","volume":"13","author":"Hensler","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0240","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.immuni.2017.03.009","article-title":"Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny","volume":"46","author":"Kollmann","year":"2017","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0245","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/pr.2015.164","article-title":"Monocyte HLA-DR expression and neutrophil CD64 expression as biomarkers of infection in critically ill neonates and infants","volume":"78","author":"Juskewitch","year":"2015","journal-title":"Pediatr Res."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0250","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1203\/00006450-199905010-00151","article-title":"The monocyte HLA-DR expression of healthy and infected premature neonates","volume":"45","author":"Fotopoulos","year":"1999","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.intimp.2024.112969_b0255","article-title":"Understanding Early-life adaptive immunity to guide interventions for pediatric health","volume":"11","author":"Semmes","year":"2020","journal-title":"Front. Immunol."},{"issue":"6491","key":"10.1016\/j.intimp.2024.112969_b0260","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.aaz9330","article-title":"Prenatal development of human immunity","volume":"368","author":"Park","year":"2020","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0265","first-page":"2745","article-title":"Slow, programmed maturation of the immunoglobulin HCDR3 repertoire during the third trimester of fetal life","volume":"98","author":"Schroeder","year":"2001","journal-title":"Blood, The Journal of the American Society of Hematology"},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/imm.12454","article-title":"Is the developmentally immature immune response in paediatric sepsis a recapitulation of immune tolerance?","volume":"145","author":"Maddux","year":"2015","journal-title":"Immunology"},{"issue":"12","key":"10.1016\/j.intimp.2024.112969_b0275","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.3390\/microorganisms10122398","article-title":"Updates on Group B Streptococcus infection in the field of obstetrics and gynecology","volume":"10","author":"Choi","year":"2022","journal-title":"Microorganisms"},{"issue":"7","key":"10.1016\/j.intimp.2024.112969_b0280","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S1473-3099(20)30602-2","article-title":"To give or not to give antibiotics is not the only question","volume":"21","author":"Magalhaes","year":"2021","journal-title":"Lancet Infect. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0285","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1586\/14787210.2015.1079126","article-title":"Group B streptococcal infections in the newborn infant and the potential value of maternal vaccination","volume":"13","author":"Berardi","year":"2015","journal-title":"Expert Rev. Anti Infect. Ther."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1002363","article-title":"Inhibition of IL-10 production by maternal antibodies against Group B Streptococcus GAPDH confers immunity to offspring by favoring neutrophil recruitment","volume":"7","author":"Madureira","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.intimp.2024.112969_b0295","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2022.04.004","article-title":"Maternal vaccination against group B Streptococcus glyceraldehyde-3-phosphate dehydrogenase leads to gut dysbiosis in the offspring","volume":"103","author":"Bonifacio Andrade","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.intimp.2024.112969_b0300","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fped.2018.00199","article-title":"Immunomodulation to prevent or treat neonatal sepsis: past, present, and future","volume":"6","author":"Schuller","year":"2018","journal-title":"Front. Pediatr."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0305","first-page":"189","article-title":"Human milk for the premature infant","volume":"60","author":"Underwood","year":"2013","journal-title":"Pediatric Clinics"},{"issue":"13","key":"10.1016\/j.intimp.2024.112969_b0310","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1001\/jama.2009.1403","article-title":"Bovine lactoferrin supplementation for prevention of late-onset sepsis in very low-birth-weight neonates: a randomized trial","volume":"302","author":"Manzoni","year":"2009","journal-title":"Jama"},{"issue":"7","key":"10.1016\/j.intimp.2024.112969_b0315","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1080\/14767058.2017.1402001","article-title":"Efficacy of zinc supplementation for neonatal sepsis: a systematic review and meta-analysis","volume":"32","author":"Tang","year":"2019","journal-title":"J. Matern. Fetal. Neonatal Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0320","article-title":"Pentoxifylline for treatment of sepsis and necrotizing enterocolitis in neonates","author":"Pammi","year":"2015","journal-title":"Cochrane Database Syst. Rev."},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0325","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s000110050341","article-title":"Increased release of ATP from endothelial cells during acute inflammation","volume":"47","author":"Bodin","year":"1998","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2024.112969_b0330","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.mam.2017.01.002","article-title":"Extracellular ATP and adenosine: The Yin and Yang in immune responses?","volume":"55","author":"Faas","year":"2017","journal-title":"Mol. Aspects Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0335","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nri.2016.4","article-title":"Purinergic regulation of the immune system","volume":"16","author":"Cekic","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0340","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/physrev.00043.2006","article-title":"Physiology and pathophysiology of purinergic neurotransmission","volume":"87","author":"Burnstock","year":"2007","journal-title":"Physiol. Rev."},{"issue":"10","key":"10.1016\/j.intimp.2024.112969_b0345","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1161\/01.RES.0000250174.31269.70","article-title":"ATP release from activated neutrophils occurs via connexin 43 and modulates adenosine-dependent endothelial cell function","volume":"99","author":"Eltzschig","year":"2006","journal-title":"Circ. Res."},{"issue":"31","key":"10.1016\/j.intimp.2024.112969_b0350","doi-asserted-by":"crossref","first-page":"22650","DOI":"10.1074\/jbc.M113.476283","article-title":"Pannexin 1 channels link chemoattractant receptor signaling to local excitation and global inhibition responses at the front and back of polarized neutrophils","volume":"288","author":"Bao","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0355","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00424-006-0061-x","article-title":"Vesicular release of ATP at central synapses","volume":"452","author":"Pankratov","year":"2006","journal-title":"Pflugers Arch."},{"issue":"Pt 19","key":"10.1016\/j.intimp.2024.112969_b0360","first-page":"4567","article-title":"Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes","volume":"125","author":"Sivaramakrishnan","year":"2012","journal-title":"J. Cell Sci."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0365","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1096\/fj.15-272450","article-title":"Extracellular ATP protects against sepsis through macrophage P2X7 purinergic receptors by enhancing intracellular bacterial killing","volume":"29","author":"Csoka","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2024.112969_b0370","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.42670","article-title":"Connexin-43-dependent ATP release mediates macrophage activation during sepsis","volume":"8","author":"Dosch","year":"2019","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0375","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41598-018-37232-z","article-title":"Enhanced macrophage pannexin 1 expression and hemichannel activation exacerbates lethal experimental sepsis","volume":"9","author":"Chen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.112969_b0380","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s12264-015-1561-5","article-title":"Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis","volume":"31","author":"Zhou","year":"2015","journal-title":"Neurosci. Bull."},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0385","doi-asserted-by":"crossref","first-page":"302","DOI":"10.21037\/atm-22-371","article-title":"The relationship between soluble CD73 and the incidence of septic shock in severe sepsis patients: a cross-sectional analysis of data from a prospective FINNAKI study","volume":"10","author":"Gao","year":"2022","journal-title":"Ann. Transl. Med."},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0390","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.jhep.2017.05.021","article-title":"CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury","volume":"67","author":"Savio","year":"2017","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0395","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.4049\/jimmunol.1003379","article-title":"Ecto-5'-nucleotidase (CD73) decreases mortality and organ injury in sepsis","volume":"187","author":"Hasko","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.112969_b0400","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fimmu.2013.00085","article-title":"Regulation of inflammation by adenosine","volume":"4","author":"Hasko","year":"2013","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0405","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-200009000-00014","article-title":"High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock","volume":"28","author":"Martin","year":"2000","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.intimp.2024.112969_b0410","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijid.2014.11.006","article-title":"High circulating CD39(+) regulatory T cells predict poor survival for sepsis patients","volume":"30","author":"Huang","year":"2015","journal-title":"Int. J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0415","first-page":"1935","article-title":"TLR stimulation initiates a CD39-based autoregulatory mechanism that limits macrophage inflammatory responses","volume":"122","author":"Cohen","year":"2013","journal-title":"Blood, The Journal of the American Society of Hematology"},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0420","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1016\/j.immuni.2021.08.005","article-title":"Sepsis expands a CD39+ plasmablast population that promotes immunosuppression via adenosine-mediated inhibition of macrophage antimicrobial activity","volume":"54","author":"Nascimento","year":"2021","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0425","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1111\/j.1574-6968.2011.02216.x","article-title":"Biochemical properties of Candida parapsilosis ecto-5'-nucleotidase and the possible role of adenosine in macrophage interaction","volume":"317","author":"Russo-Abrahao","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0430","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1084\/jem.20090097","article-title":"Staphylococcus aureus synthesizes adenosine to escape host immune responses","volume":"206","author":"Thammavongsa","year":"2009","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.intimp.2024.112969_b0435","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1074\/jbc.M113.545632","article-title":"Extracellular nucleotide catabolism by the Group B Streptococcus ectonucleotidase NudP increases bacterial survival in blood","volume":"289","author":"Firon","year":"2014","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0440","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1017\/S0031182011001879","article-title":"NTPDase activity in lymphocytes of rats infected by Trypanosoma evansi","volume":"139","author":"Oliveira","year":"2012","journal-title":"Parasitology"},{"key":"10.1016\/j.intimp.2024.112969_b0445","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/650874","article-title":"Adenosine and immune imbalance in visceral leishmaniasis: the possible role of ectonucleotidases","volume":"2012","author":"Paletta-Silva","year":"2012","journal-title":"J. Trop. Med."},{"key":"10.1016\/j.intimp.2024.112969_b0450","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3389\/fphar.2018.00052","article-title":"The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?","volume":"9","author":"Savio","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.112969_b0455","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/B978-0-12-385526-8.00011-4","article-title":"P2X receptors in health and disease","volume":"61","author":"Burnstock","year":"2011","journal-title":"Adv. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0460","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.tcb.2018.01.005","article-title":"The elusive P2X7 macropore","volume":"28","author":"Di Virgilio","year":"2018","journal-title":"Trends Cell Biol."},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0465","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1096\/fj.09-150862","article-title":"Two haplotypes of the P2X7 receptor containing the Ala-348 to Thr polymorphism exhibit a gain-of-function effect and enhanced interleukin-1\u03b2 secretion","volume":"24","author":"Stokes","year":"2010","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0470","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010232","article-title":"Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases","volume":"23","author":"Ren","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112969_b0475","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3389\/fimmu.2018.00399","article-title":"Purinergic Regulation of Neutrophil Function","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0480","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.imbio.2012.07.010","article-title":"High glucose concentration impairs ATP outflow and immunoglobulin production by human peripheral B lymphocytes: involvement of P2X7 receptor","volume":"218","author":"Sakowicz-Burkiewicz","year":"2013","journal-title":"Immunobiology"},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0485","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1002\/eji.202249932","article-title":"P2X7 is expressed on human innate-like T lymphocytes and mediates susceptibility to ATP-induced cell death","volume":"52","author":"Winzer","year":"2022","journal-title":"Eur. J. Immunol."},{"issue":"14","key":"10.1016\/j.intimp.2024.112969_b0490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21144937","article-title":"P2X7 Receptor at the Crossroads of T Cell Fate","volume":"21","author":"Rivas-Yanez","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112969_b0495","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.112.3.297","article-title":"Human primary fibroblasts in vitro express a purinergic P2X7 receptor coupled to ion fluxes, microvesicle formation and IL-6 release","volume":"112","author":"Solini","year":"1999","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.intimp.2024.112969_b0500","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1038\/ncomms2023","article-title":"Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors","volume":"3","author":"Kurashima","year":"2012","journal-title":"Nat. Commun."},{"issue":"15","key":"10.1016\/j.intimp.2024.112969_b0505","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1096\/fj.00-0031com","article-title":"The P2 purinergic receptors of human dendritic cells: identification and coupling to cytokine release","volume":"14","author":"Ferrari","year":"2000","journal-title":"FASEB J."},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0510","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1002\/glia.22628","article-title":"P2X7-dependent, but differentially regulated release of IL-6, CCL2, and TNF-alpha in cultured mouse microglia","volume":"62","author":"Shieh","year":"2014","journal-title":"Glia"},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0515","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s11302-012-9308-5","article-title":"A new role for the P2X7 receptor: a scavenger receptor for bacteria and apoptotic cells in the absence of serum and extracellular ATP","volume":"8","author":"Wiley","year":"2012","journal-title":"Purinergic Signal"},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0520","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11302-011-9255-6","article-title":"Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view","volume":"7","author":"Costa-Junior","year":"2011","journal-title":"Purinergic Signal"},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0525","doi-asserted-by":"crossref","first-page":"8926","DOI":"10.1038\/s41598-018-27281-9","article-title":"The P2X7 receptor and pannexin-1 are involved in glucose-induced autocrine regulation in beta-cells","volume":"8","author":"Tozzi","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0530","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1038\/s41598-017-03813-7","article-title":"Neuronal P2X7 receptor-induced reactive oxygen species production contributes to nociceptive behavior in mice","volume":"7","author":"Munoz","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.intimp.2024.112969_b0535","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1182\/blood-2005-07-2994","article-title":"Rapid ATP-induced release of matrix metalloproteinase 9 is mediated by the P2X7 receptor","volume":"107","author":"Gu","year":"2006","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0540","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.immuni.2014.10.010","article-title":"ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer's patches to promote host-microbiota mutualism","volume":"41","author":"Proietti","year":"2014","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0545","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s10384-018-0587-4","article-title":"Crucial role of P2X7 receptor for effector T cell activation in experimental autoimmune uveitis","volume":"62","author":"Takeda","year":"2018","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.intimp.2024.112969_b0550","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.3389\/fimmu.2020.01179","article-title":"The P2X7 Receptor as Regulator of T Cell Development and Function","volume":"11","author":"Grassi","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0555","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.cyto.2011.05.003","article-title":"P2X7 receptor positively regulates MyD88-dependent NF-kappaB activation","volume":"55","author":"Liu","year":"2011","journal-title":"Cytokine"},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0560","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1159\/000371388","article-title":"The P2X7 receptor contributes to the development of the exacerbated inflammatory response associated with sepsis","volume":"7","author":"Santana","year":"2015","journal-title":"J. Innate Immun."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0565","doi-asserted-by":"crossref","first-page":"4364","DOI":"10.1038\/s41598-017-04231-5","article-title":"Systemic blockade of P2X7 receptor protects against sepsis-induced intestinal barrier disruption","volume":"7","author":"Wu","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0570","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s11302-020-09746-7","article-title":"P2X7 receptor deletion attenuates oxidative stress and liver damage in sepsis","volume":"16","author":"Larrouyet-Sarto","year":"2020","journal-title":"Purinergic Signal"},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0575","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/cr.2015.61","article-title":"P2RX7 sensitizes Mac-1\/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy","volume":"25","author":"Wang","year":"2015","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.112969_b0580","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/s11302-023-09936-z","article-title":"P2X7 receptor antagonist A-438079 alleviates oxidative stress of lung in LPS-induced septic rats","volume":"19","author":"Ozkanlar","year":"2023","journal-title":"Purinergic Signal"},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0585","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1007\/s12035-016-0168-9","article-title":"P2X7 receptor signaling contributes to sepsis-associated brain dysfunction","volume":"54","author":"Savio","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.intimp.2024.112969_b0590","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/3777351","article-title":"The improvement of sepsis-associated encephalopathy by P2X7R inhibitor through inhibiting the Omi\/HtrA2 apoptotic signaling pathway","volume":"2022","author":"Wang","year":"2022","journal-title":"Behav. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0595","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1038\/s41467-019-10626-x","article-title":"P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis","volume":"10","author":"Martinez-Garcia","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.112969_b0600","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fcimb.2017.00113","article-title":"P2X1, P2X4, and P2X7 receptor knock out mice expose differential outcome of sepsis induced by alpha-haemolysin producing Escherichia coli","volume":"7","author":"Greve","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2024.112969_b0605","first-page":"9","article-title":"CD14 release induced by P2X7 receptor restricts inflammation and increases survival during sepsis","author":"Alarcon-Vila","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.intimp.2024.112969_b0610","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cytogfr.2019.06.003","article-title":"CD14: Biology and role in the pathogenesis of disease","volume":"48","author":"Wu","year":"2019","journal-title":"Cytokine Growth Factor Rev."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2024.112969_b0615","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cca.2011.05.023","article-title":"P2RX7 genotype association in severe sepsis identified by a novel Multi-Individual Array for rapid screening and replication of risk SNPs","volume":"413","author":"Geistlinger","year":"2012","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.intimp.2024.112969_b0620","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1352789","article-title":"Loss-of-function\/gain-of-function polymorphisms of the ATP sensitive P2X7R influence sepsis, septic shock, pneumonia, and survival outcomes","volume":"15","author":"Guggemos","year":"2024","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0625","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99431","article-title":"Macrophage P2X4 receptors augment bacterial killing and protect against sepsis","volume":"3","author":"Csoka","year":"2018","journal-title":"JCI Insight."},{"key":"10.1016\/j.intimp.2024.112969_b0630","first-page":"13","article-title":"LPS-induced systemic neonatal inflammation: blockage of P2X7R by BBG decreases mortality on rat pups and oxidative stress in hippocampus of adult rats","author":"Silva","year":"2019","journal-title":"Front. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0635","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101485R","article-title":"Nucleotide receptors mediate protection against neonatal sepsis and meningitis caused by alpha-hemolysin expressing Escherichia coli K1","volume":"36","author":"Chambers","year":"2022","journal-title":"FASEB J."},{"key":"10.1016\/j.intimp.2024.112969_b0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.nsa.2024.104010","article-title":"Modulation of P2X7 receptor prevents neurological sequalae in a mouse model of perinatal group b streptococcus infection","volume":"3","author":"Fialho","year":"2024","journal-title":"Neurosci. Appl."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0645","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s11302-022-09870-6","article-title":"P2X receptors in the balance between inflammation and pathogen control in sepsis","volume":"18","author":"Savio","year":"2022","journal-title":"Purinergic Signall."},{"issue":"125","key":"10.1016\/j.intimp.2024.112969_b0650","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2000549","article-title":"Purinergic signaling: a fundamental mechanism in neutrophil activation","volume":"3","author":"Chen","year":"2010","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0655","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1365-2567.2008.02950.x","article-title":"Neutrophil mobilization and clearance in the bone marrow","volume":"125","author":"Furze","year":"2008","journal-title":"Immunology"},{"issue":"7","key":"10.1016\/j.intimp.2024.112969_b0660","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/BF03401797","article-title":"CD39 modulates endothelial cell activation and apoptosis","volume":"6","author":"Goepfert","year":"2000","journal-title":"Mol. Med."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0665","doi-asserted-by":"crossref","first-page":"6754","DOI":"10.4049\/jimmunol.166.11.6754","article-title":"P2X7 nucleotide receptor mediation of membrane pore formation and superoxide generation in human promyelocytes and neutrophils1","volume":"166","author":"Suh","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.112969_b0670","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fimmu.2017.00435","article-title":"P2X7 receptor in bone marrow-derived cells aggravates tuberculosis caused by hypervirulent mycobacterium bovis","volume":"8","author":"Bomfim","year":"2017","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0675","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jpain.2016.10.008","article-title":"Intra-articular blockade of P2X7 receptor reduces the articular hyperalgesia and inflammation in the knee joint synovitis especially in female rats","volume":"18","author":"Teixeira","year":"2017","journal-title":"J. Pain"},{"issue":"12","key":"10.1016\/j.intimp.2024.112969_b0680","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1016\/j.jid.2018.05.018","article-title":"Extracellular ATP and IL-23 form a local inflammatory circuit leading to the development of a neutrophil-dependent psoriasiform dermatitis","volume":"138","author":"Diaz-Perez","year":"2018","journal-title":"J. Invest. Dermatol."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0685","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/exd.12094","article-title":"P2X7 receptor is required for neutrophil accumulation in a mouse model of irritant contact dermatitis","volume":"22","author":"da Silva","year":"2013","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.intimp.2024.112969_b0690","first-page":"7","article-title":"Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1\u03b2 secretion in response to ATP","author":"Karmakar","year":"2016","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0695","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.immuni.2010.05.007","article-title":"Alternative activation of macrophages: mechanism and functions","volume":"32","author":"Gordon","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.112969_b0700","doi-asserted-by":"crossref","first-page":"22586","DOI":"10.1038\/srep22586","article-title":"Macrophage activation and polarization modify P2X7 receptor secretome influencing the inflammatory process","volume":"6","author":"de Torre-Minguela","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.intimp.2024.112969_b0705","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.4049\/jimmunol.179.3.1913","article-title":"Nonclassical IL-1 beta secretion stimulated by P2X7 receptors is dependent on inflammasome activation and correlated with exosome release in murine macrophages","volume":"179","author":"Qu","year":"2007","journal-title":"J. Immunol."},{"issue":"18","key":"10.1016\/j.intimp.2024.112969_b0710","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1007\/s00018-010-0609-y","article-title":"Novel macrophage polarization model: from gene expression to identification of new anti-inflammatory molecules","volume":"68","author":"Lopez-Castejon","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"issue":"40","key":"10.1016\/j.intimp.2024.112969_b0715","doi-asserted-by":"crossref","first-page":"33968","DOI":"10.1074\/jbc.M502705200","article-title":"Pseudoapoptosis induced by brief activation of ATP-gated P2X7 receptors","volume":"280","author":"Mackenzie","year":"2005","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.intimp.2024.112969_b0720","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins: linking Ca2+ signalling to membrane dynamics","volume":"6","author":"Gerke","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0725","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/eji.201243077","article-title":"Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection","volume":"43","author":"Zhang","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2024.112969_b0730","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1268804","article-title":"Dysregulated monocyte-derived macrophage response to Group B Streptococcus in newborns","volume":"14","author":"Ravi","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.112969_b0735","doi-asserted-by":"crossref","first-page":"491","DOI":"10.3389\/fimmu.2014.00491","article-title":"Macrophage cytokines: involvement in immunity and infectious diseases","volume":"5","author":"Arango Duque","year":"2014","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.112969_b0740","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12865-023-00546-3","article-title":"Prevention of M2 polarization and temporal limitation of differentiation in monocytes by extracellular ATP","volume":"24","author":"Scherr","year":"2023","journal-title":"BMC Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.112969_b0745","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25052495","article-title":"P2X7 receptor in dendritic cells and macrophages: implications in antigen presentation and T lymphocyte activation","volume":"25","author":"Acuna-Castillo","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.112969_b0750","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40635-016-0096-z","article-title":"Sepsis modeling in mice: ligation length is a major severity factor in cecal ligation and puncture","volume":"4","author":"Ruiz","year":"2016","journal-title":"Intensive Care Med Exp."},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.112969_b0755","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s40635-020-00309-z","article-title":"Role of the adaptive immune response in sepsis","volume":"8","author":"Brady","year":"2020","journal-title":"Intensive Care Med. Exp."},{"issue":"7","key":"10.1016\/j.intimp.2024.112969_b0760","doi-asserted-by":"crossref","DOI":"10.1097\/00003246-199907000-00002","article-title":"Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction","volume":"27","author":"Hotchkiss","year":"1999","journal-title":"Crit. Care Med."},{"issue":"8","key":"10.1016\/j.intimp.2024.112969_b0765","doi-asserted-by":"crossref","first-page":"5110","DOI":"10.4049\/jimmunol.174.8.5110","article-title":"Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways","volume":"174","author":"Hotchkiss","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.112969_b0770","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1084\/jem.20171976","article-title":"P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus","volume":"216","author":"Faliti","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.112969_b0775","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.3389\/fimmu.2020.01946","article-title":"CD4 T follicular helper cells prevent depletion of follicular B cells in response to cecal ligation and puncture","volume":"11","author":"Taylor","year":"2020","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.intimp.2024.112969_b0780","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.15290","article-title":"Blocking P2X7 receptor with AZ 10606120 exacerbates vascular hyperpermeability and inflammation in murine polymicrobial sepsis","volume":"10","author":"Meegan","year":"2022","journal-title":"Physiol. Rep."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924014905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924014905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T21:24:48Z","timestamp":1732742688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924014905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":156,"alternative-id":["S1567576924014905"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112969","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Could P2X7 receptor be a potencial target in neonatal sepsis?","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.112969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"112969"}}