{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:18:32Z","timestamp":1777601912935,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.intimp.2024.113003","type":"journal-article","created":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T12:01:35Z","timestamp":1724587295000},"page":"113003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Association between IL and 6 gene polymorphisms and circulating IL-6 levels in Behcet\u2019s disease: A meta-analysis"],"prefix":"10.1016","volume":"141","author":[{"given":"Young Ho","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwan Gyu","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.7861\/clinmedicine.17-1-71","article-title":"Behcet's disease","volume":"17","author":"Nair","year":"2017","journal-title":"Clinical Medicine."},{"issue":"10","key":"10.1016\/j.intimp.2024.113003_b0010","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.autrev.2011.11.026","article-title":"New insights into the pathogenesis of Behcet's disease","volume":"11","author":"de Chambrun","year":"2012","journal-title":"Autoimmunity Reviews."},{"issue":"10","key":"10.1016\/j.intimp.2024.113003_b0015","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harbor Perspectives in Biology."},{"key":"10.1016\/j.intimp.2024.113003_b0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar1916","article-title":"Interleukin-6: discovery of a pleiotropic cytokine","volume":"8","author":"Kishimoto","year":"2006","journal-title":"Arthritis Research & Therapy."},{"key":"10.1016\/j.intimp.2024.113003_b0025","series-title":"Inflammatory cytokines and their promoter polymorphisms","author":"Kilpinen","year":"2003"},{"key":"10.1016\/j.intimp.2024.113003_b0030","article-title":"Genetic polymorphisms in transforming growth factor-\u03b2, interferon-\u03b3 and interleukin-6 genes and susceptibility to behcet\u2019s disease in saudi population","volume":"253\u20139","author":"Al Okaily","year":"2020","journal-title":"Pharmacogenomics and Personalized Medicine."},{"issue":"8","key":"10.1016\/j.intimp.2024.113003_b0035","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.imbio.2014.03.004","article-title":"Polymorphisms of interleukin 6 and interleukin 10 in Egyptian people with Behcet's disease","volume":"219","author":"Talaat","year":"2014","journal-title":"Immunobiology."},{"issue":"2","key":"10.1016\/j.intimp.2024.113003_b0040","first-page":"S73","article-title":"Cytokine gene polymorphisms in Beh\u00e7et's disease and their association with clinical and laboratory findings","volume":"27","author":"Dilek","year":"2009","journal-title":"Clinical and Experimental Rheumatology-including Supplements."},{"issue":"4","key":"10.1016\/j.intimp.2024.113003_b0045","first-page":"292","article-title":"Proinflammatory cytokine gene polymorphisms in Behcet's disease","volume":"21","author":"Amirzargar","year":"2010","journal-title":"European Cytokine Network."},{"issue":"2","key":"10.1016\/j.intimp.2024.113003_b0050","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/ard.2004.024208","article-title":"Association between interleukin 6 gene polymorphisms and Beh\u00e7et\u2019s disease in Korean people","volume":"64","author":"Chang","year":"2005","journal-title":"Annals of the Rheumatic Diseases."},{"key":"10.1016\/j.intimp.2024.113003_b0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.imlet.2016.12.001","article-title":"An elevated pro-inflammatory cytokines profile in Behcet\u2019s disease: a multiplex analysis","volume":"186","author":"Gholijani","year":"2017","journal-title":"Immunology Letters."},{"issue":"42","key":"10.1016\/j.intimp.2024.113003_b0060","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000001858","article-title":"Putative role of serum amyloid-A and proinflammatory cytokines as biomarkers for Behcet's disease","volume":"94","author":"Lopalco","year":"2015","journal-title":"Medicine."},{"issue":"12","key":"10.1016\/j.intimp.2024.113003_b0065","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1111\/j.1468-3083.2011.04318.x","article-title":"Adiponectin levels, insulin resistance and their relationship with serum levels of inflammatory cytokines in patients with Behcet\u2019s disease","volume":"26","author":"Sahin","year":"2012","journal-title":"J Eur Acad Dermatol Venereol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0070","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1600-0714.2011.01061.x","article-title":"Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Beh\u00e7et\u2019s disease and recurrent aphthous ulcerations","volume":"41","author":"Pekiner","year":"2012","journal-title":"Journal of Oral Pathology & Medicine."},{"key":"10.1016\/j.intimp.2024.113003_b0075","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s10067-010-1649-2","article-title":"Visfatin levels and intima-media thicknesses in rheumatic diseases","volume":"30","author":"Ozgen","year":"2011","journal-title":"Clinical Rheumatology."},{"issue":"5","key":"10.1016\/j.intimp.2024.113003_b0080","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1600-0714.2009.00774.x","article-title":"Treatment with levamisole and colchicine can result in a significant reduction of IL-6, IL-8 or TNF-\u03b1 level in patients with mucocutaneous type of Behcet\u2019s disease","volume":"38","author":"Sun","year":"2009","journal-title":"Journal of Oral Pathology & Medicine."},{"issue":"4","key":"10.1016\/j.intimp.2024.113003_b0085","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3129\/i08-081","article-title":"Evaluation of serum resistin levels in patients with ocular and non-ocular Beh\u00e7et\u2019s disease","volume":"43","author":"Yal\u00e7indag","year":"2008","journal-title":"Canadian Journal of Ophthalmology."},{"key":"10.1016\/j.intimp.2024.113003_b0090","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s10753-008-9082-2","article-title":"Ghrelin and obestatin levels in rheumatoid arthritis","volume":"31","author":"Koca","year":"2008","journal-title":"Inflammation."},{"issue":"5","key":"10.1016\/j.intimp.2024.113003_b0095","doi-asserted-by":"crossref","first-page":"596","DOI":"10.47102\/annals-acadmedsg.V33N5p596","article-title":"Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behcet's disease","volume":"33","author":"Akdeniz","year":"2004","journal-title":"Annals-Academy of Medicine Singapore."},{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0100","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1076\/ocii.12.1.53.28062","article-title":"The demonstration of serum interleukin 6\u20138, tumor necrosis factor-alpha, complement, and immunoglobulin levels in Beh\u00e7et\u2019s disease with ocular involvement","volume":"12","author":"Bardak","year":"2004","journal-title":"Ocular Immunology and Inflammation."},{"issue":"3","key":"10.1016\/j.intimp.2024.113003_b0105","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1468-3083.2004.00907.x","article-title":"Serum interleukin-6, procalcitonin and C-reactive protein levels in subjects with active Beh\u00e7et's disease","volume":"18","author":"Adam","year":"2004","journal-title":"Journal of the European Academy of Dermatology and Venereology."},{"key":"10.1016\/j.intimp.2024.113003_b0110","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/09629350220131935","article-title":"Serum levels of TNF-\u03b1, sIL-2R, IL-6, and IL-8 are increased and associated with elevated lipid peroxidation in patients with Beh\u00e7et's disease","volume":"11","author":"Evereklioglu","year":"2002","journal-title":"Mediators of Inflammation."},{"key":"10.1016\/j.intimp.2024.113003_b0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1155\/S0962935192000437","article-title":"Interleukin-6 in peripheral blood and inflammatory sites in Behcet's disease","volume":"1","author":"Hamzaoui","year":"1992","journal-title":"Mediators of Inflammation."},{"issue":"9","key":"10.1016\/j.intimp.2024.113003_b0120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.medcli.2015.09.017","article-title":"The impact of the IL-1\u03b2, IL-1Ra, IL-2, IL-6 and IL-10 gene polymorphisms on the development of Behcet's disease and their association with the phenotype","volume":"146","author":"Bar\u0131\u015f","year":"2016","journal-title":"Medicina Cl\u00ednica."},{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0125","first-page":"11","article-title":"Diagnostic accuracy of lung ultrasound for interstitial lung disease in patients with connective tissue diseases: a meta-analysis","volume":"34","author":"Song","year":"2016","journal-title":"Clin Exp Rheumatol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113003_b0130","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1177\/0961203315624557","article-title":"Association between interferon-\u03b3 +874 T\/A polymorphism and susceptibility to autoimmune diseases: a meta-analysis","volume":"25","author":"Lee","year":"2016","journal-title":"Lupus."},{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0135","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.humimm.2013.09.012","article-title":"Meta-analysis of differentially expressed genes in primary Sjogren's syndrome by using microarray","volume":"75","author":"Song","year":"2014","journal-title":"Hum Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113003_b0140","doi-asserted-by":"crossref","first-page":"116","DOI":"10.4078\/jrd.2023.0005","article-title":"Circulating leptin and its correlation with rheumatoid arthritis activity: a meta-analysis","volume":"30","author":"Lee","year":"2023","journal-title":"Journal of Rheumatic Diseases."},{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4078\/jrd.2022.29.1.46","article-title":"Mendelian randomization research on the relationship between rheumatoid arthritis and systemic lupus erythematosus and the risk of autistic spectrum disorder","volume":"29","author":"Lee","year":"2022","journal-title":"Journal of Rheumatic Diseases."},{"issue":"12","key":"10.1016\/j.intimp.2024.113003_b0150","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1111\/1756-185X.13404","article-title":"Neutrophil-to-lymphocyte ratio, mean platelet volume and platelet-to-lymphocyte ratio in Beh\u00e7et\u2019s disease and their correlation with disease activity: A meta-analysis","volume":"21","author":"Lee","year":"2018","journal-title":"International Journal of Rheumatic Diseases."},{"key":"10.1016\/j.intimp.2024.113003_b0155","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med Res Methodol."},{"key":"10.1016\/j.intimp.2024.113003_b0160","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jad.2015.11.052","article-title":"Depression and telomere length: A meta-analysis","volume":"191","author":"Ridout","year":"2016","journal-title":"J Affect Disord."},{"key":"10.1016\/j.intimp.2024.113003_b0165","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2000."},{"issue":"7","key":"10.1016\/j.intimp.2024.113003_b0170","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med."},{"issue":"7121","key":"10.1016\/j.intimp.2024.113003_b0175","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1136\/bmj.315.7121.1533","article-title":"Meta-analysis: principles and procedures","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj."},{"issue":"3","key":"10.1016\/j.intimp.2024.113003_b0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials."},{"issue":"11","key":"10.1016\/j.intimp.2024.113003_b0185","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med."},{"issue":"7109","key":"10.1016\/j.intimp.2024.113003_b0190","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","article-title":"Bias in meta-analysis detected by a simple, graphical test","volume":"315","author":"Egger","year":"1997","journal-title":"Bmj."},{"key":"10.1016\/j.intimp.2024.113003_b0195","doi-asserted-by":"crossref","first-page":"2797","DOI":"10.1007\/s10067-018-4049-7","article-title":"Correlation between IL-17A\/F, IL-23, IL-35 and IL-12\/-23 (p40) levels in peripheral blood lymphocyte cultures and disease activity in Behcet\u2019s patients","volume":"37","author":"Sonmez","year":"2018","journal-title":"Clinical Rheumatology."},{"issue":"14","key":"10.1016\/j.intimp.2024.113003_b0200","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2174\/1381612824666180327165604","article-title":"Signaling pathways in inflammation and anti-inflammatory therapies","volume":"24","author":"Yeung","year":"2018","journal-title":"Current Pharmaceutical Design."},{"issue":"12","key":"10.1016\/j.intimp.2024.113003_b0205","doi-asserted-by":"crossref","first-page":"6287","DOI":"10.4049\/jimmunol.1200385","article-title":"IL-17 and TNF-\u03b1 sustain neutrophil recruitment during inflammation through synergistic effects on endothelial activation","volume":"188","author":"Griffin","year":"2012","journal-title":"The Journal of Immunology."},{"key":"10.1016\/j.intimp.2024.113003_b0210","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1902\/jop.2008.080172","article-title":"Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases","volume":"79","author":"Wilson","year":"2008","journal-title":"Journal of Periodontology."},{"issue":"3","key":"10.1016\/j.intimp.2024.113003_b0215","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.reuma.2018.06.006","article-title":"Methylation status of interleukin-6 gene promoter in patients with behcet's disease","volume":"16","author":"Alipour","year":"2020","journal-title":"Reumatologia Clinica."},{"issue":"1","key":"10.1016\/j.intimp.2024.113003_b0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.4078\/jrd.2023.0054","article-title":"Clinical and immunological responses to COVID-19 vaccination in rheumatoid arthritis patients on disease modifying antirheumatic drugs: a cross-sectional study","volume":"31","author":"Eerike","year":"2024","journal-title":"Journal of Rheumatic Diseases."},{"key":"10.1016\/j.intimp.2024.113003_b0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60740-3","article-title":"NF-IL6 and NF-\u03baB in cytokine gene regulation","volume":"65","author":"Akira","year":"1997","journal-title":"Advances in Immunology."},{"key":"10.1016\/j.intimp.2024.113003_b0230","doi-asserted-by":"crossref","unstructured":"Kestler DP, Agarwal S, Cobb J, Goldstein KM, Hall RE. Detection and analysis of an alternatively spliced isoform of interleukin-6 mRNA in peripheral blood mononuclear cells. 1995.","DOI":"10.1182\/blood.V86.12.4559.bloodjournal86124559"},{"issue":"6","key":"10.1016\/j.intimp.2024.113003_b0235","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1038\/ng.2653","article-title":"The genotype-tissue expression (GTEx) project","volume":"45","author":"Lonsdale","year":"2013","journal-title":"Nature Genetics."},{"key":"10.1016\/j.intimp.2024.113003_b0240","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s10753-013-9713-0","article-title":"MiR-146a regulates IL-6 production in lipopolysaccharide-induced RAW264. 7 macrophage cells by inhibiting Notch1","volume":"37","author":"He","year":"2014","journal-title":"Inflammation."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924015248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924015248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T17:37:21Z","timestamp":1731087441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924015248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":48,"alternative-id":["S1567576924015248"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113003","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between IL and 6 gene polymorphisms and circulating IL-6 levels in Behcet\u2019s disease: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113003"}}