{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:22:31Z","timestamp":1788481351545,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T00:00:00Z","timestamp":1724716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012899","name":"Lanzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012899","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100022817","name":"Lanzhou University Second Clinical Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100022817","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113043","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T20:22:16Z","timestamp":1725049336000},"page":"113043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"PA","title":["DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K\/AKT and ERK\/MAPK signaling through GRB2"],"prefix":"10.1016","volume":"142","author":[{"given":"Zheng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei-Lin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-Qing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-Rong","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Lin","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ming","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-Rong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.intimp.2024.113043_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2022.166557","article-title":"Small-cell lung cancer brain metastasis: from molecular mechanisms to diagnosis and treatment","volume":"1868","author":"Zhu","year":"2022","journal-title":"Biochim. Biophys. Acta. Mol. Basis. Dis."},{"key":"10.1016\/j.intimp.2024.113043_b0010","unstructured":"World Health Organization, Global cancer burden growing amidst mounting need for services. https:\/\/www.who.int\/news\/item\/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services, 2024 (accessed 13 March 2023)."},{"issue":"1","key":"10.1016\/j.intimp.2024.113043_b0015","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12943-022-01505-z","article-title":"Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring","volume":"21","author":"Li","year":"2022","journal-title":"Mol. Cancer."},{"issue":"1","key":"10.1016\/j.intimp.2024.113043_b0020","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12967-021-02985-1","article-title":"The role of exosomes in lung cancer metastasis and clinical applications: an updated review","volume":"19","author":"Yin","year":"2021","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.113043_b0025","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1038\/s41467-024-46284-x","article-title":"Drug-resistant EGFR mutations promote lung cancer by stabilizing interfaces in ligand-free kinase-active EGFR oligomers","volume":"15","author":"Iyer","year":"2024","journal-title":"Nat. Commun."},{"issue":"19","key":"10.1016\/j.intimp.2024.113043_b0030","doi-asserted-by":"crossref","first-page":"6033","DOI":"10.1073\/pnas.1500161112","article-title":"Major reorientation of tRNA substrates defines specificity of dihydrouridine synthases","volume":"112","author":"Byrne","year":"2015","journal-title":"Proc. Natl. Acad Sci. U S A."},{"issue":"13","key":"10.1016\/j.intimp.2024.113043_b0035","doi-asserted-by":"crossref","first-page":"5638","DOI":"10.1158\/0008-5472.CAN-05-0600","article-title":"A novel human tRNA-dihydrouridine synthase involved in pulmonary carcinogenesis","volume":"65","author":"Kato","year":"2005","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.intimp.2024.113043_b0040","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1093\/nar\/gkm1129","article-title":"Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR","volume":"36","author":"Mittelstadt","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2024.113043_b0045","doi-asserted-by":"crossref","first-page":"9905","DOI":"10.2147\/CMAR.S265671","article-title":"DUS4L silencing suppresses cell proliferation and promotes apoptosis in human lung adenocarcinoma cell line A549","volume":"12","author":"Li","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113043_b0050","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1186\/s12967-023-04483-y","article-title":"Cantharidin induces apoptosis of human triple negative breast cancer cells through mir-607-mediated downregulation of EGFR","volume":"21","author":"Yang","year":"2023","journal-title":"J. Transl. Med."},{"issue":"12","key":"10.1016\/j.intimp.2024.113043_b0055","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2174\/0929866525666171123213148","article-title":"The role of Grb2 in cancer and peptides as Grb2 antagonists","volume":"24","author":"Ijaz","year":"2018","journal-title":"Protein Pept. Lett."},{"issue":"10","key":"10.1016\/j.intimp.2024.113043_b0060","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1158\/1541-7786.MCR-12-0352","article-title":"GAB2\u2013a scaffolding protein in cancer","volume":"10","author":"Adams","year":"2012","journal-title":"Mol. Cancer Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.113043_b0065","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1093\/jb\/mvy047","article-title":"Involvement of partial EMT in cancer progression","volume":"164","author":"Saitoh","year":"2018","journal-title":"J. Biochem."},{"key":"10.1016\/j.intimp.2024.113043_b0070","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ceb.2016.06.002","article-title":"Epithelial-mesenchymal transition (EMT) and metastasis: yes, no, maybe?","volume":"43","author":"Diepenbruck","year":"2016","journal-title":"Curr. Opin Cell Biol."},{"issue":"7702","key":"10.1016\/j.intimp.2024.113043_b0075","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41586-018-0040-3","article-title":"Identification of the tumour transition states occurring during EMT","volume":"556","author":"Pastushenko","year":"2018","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.intimp.2024.113043_b0080","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1038\/s41589-021-00874-8","article-title":"Activity-based RNA-modifying enzyme probing reveals DUS3L-mediated dihydrouridylation","volume":"17","author":"Dai","year":"2021","journal-title":"Nat. Chem. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113043_b0085","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41568-023-00611-4","article-title":"Transfer RNAs as dynamic and critical regulators of cancer progression","volume":"23","author":"Pinzaru","year":"2023","journal-title":"Nat. Rev Cancer."},{"issue":"6","key":"10.1016\/j.intimp.2024.113043_b0090","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1093\/nar\/gky1302","article-title":"Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2","volume":"47","author":"Bou-Nader","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"12","key":"10.1016\/j.intimp.2024.113043_b0095","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/biom12121760","article-title":"Evolutionary diversity of dus2 enzymes reveals novel structural and functional features among members of the RNA dihydrouridine synthases family","volume":"12","author":"Lombard","year":"2022","journal-title":"Biomolecules"},{"issue":"19","key":"10.1016\/j.intimp.2024.113043_b0100","doi-asserted-by":"crossref","first-page":"9446","DOI":"10.1093\/nar\/gkv989","article-title":"An extended dsRBD is required for post-transcriptional modification in human tRNAs","volume":"43","author":"Bou-Nader","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113043_b0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0014-5793(95)00578-W","article-title":"The Grb2 adaptor","volume":"369","author":"Chardin","year":"1995","journal-title":"FEBS Lett."},{"issue":"249","key":"10.1016\/j.intimp.2024.113043_b0110","doi-asserted-by":"crossref","first-page":"pe49","DOI":"10.1126\/scisignal.2003576","article-title":"Grb2, a double-edged sword of receptor tyrosine kinase signaling","volume":"5","author":"Belov","year":"2012","journal-title":"Sci. Signal."},{"issue":"3","key":"10.1016\/j.intimp.2024.113043_b0115","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/1097-0215(20001101)88:3<363::AID-IJC7>3.0.CO;2-4","article-title":"Up-regulation of the protein tyrosine phosphatase SHP-1 in human breast cancer and correlation with GRB2 expression","volume":"88","author":"Yip","year":"2000","journal-title":"Int. J. Cancer."},{"key":"10.1016\/j.intimp.2024.113043_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106441","article-title":"Progesterone receptor-Grb2 interaction is associated with better outcomes in breast cancer","volume":"237","author":"Wittayavimol","year":"2024","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113043_b0125","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12964-023-01241-x","article-title":"RNF173 suppresses RAF\/MEK\/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in hepatocellular carcinoma","volume":"21","author":"Zhou","year":"2023","journal-title":"Cell Commun. Signal."},{"issue":"4","key":"10.1016\/j.intimp.2024.113043_b0130","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1080\/15216540050033195","article-title":"Significance of the Grb2 and son of sevenless (Sos) proteins in human bladder cancer cell lines","volume":"49","author":"Watanabe","year":"2000","journal-title":"IUBMB Life"},{"issue":"8","key":"10.1016\/j.intimp.2024.113043_b0135","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/cells7080097","article-title":"Overexpression of GRB2 enhances epithelial to mesenchymal transition of A549 cells by upregulating SNAIL expression","volume":"7","author":"Mitra","year":"2018","journal-title":"Cells"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924015649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924015649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,4]],"date-time":"2024-10-04T02:53:21Z","timestamp":1728010401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924015649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":27,"alternative-id":["S1567576924015649"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113043","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K\/AKT and ERK\/MAPK signaling through GRB2","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113043"}}