{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T12:41:43Z","timestamp":1793191303793,"version":"4.5.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113206","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T06:44:23Z","timestamp":1727678663000},"page":"113206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"P1","title":["COX-2 targeted therapy for diabetic foot ulcers using T7-enhanced CS-PVA membranes"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0864-4818","authenticated-orcid":false,"given":"Raghul","family":"Murugan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Ashok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Ramya Ranjan Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priya","family":"Deivasigamani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhlid H.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bader O.","family":"Almutairi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8583-9352","authenticated-orcid":false,"given":"Ajay","family":"Guru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathiravan","family":"Muthu Kumaradoss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesu","family":"Arockiaraj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113206_b0005","doi-asserted-by":"crossref","unstructured":"M. Jalilian, P. Ahmadi Sarbarzeh, S. Oubari, Factors related to severity of diabetic foot ulcer: a systematic review, diabetes, Metab. Syndr. Obes. Targets Ther. Volume 13 (2020) 1835\u20131842. DOI: 10.2147\/DMSO.S256243.","DOI":"10.2147\/DMSO.S256243"},{"issue":"4","key":"10.1016\/j.intimp.2024.113206_b0010","doi-asserted-by":"crossref","first-page":"e1143","DOI":"10.1111\/hsc.13522","article-title":"Diabetes-related avoidable hospitalisations and its relationship with primary healthcare resourcing in China: A cross-sectional study from Sichuan Province","volume":"30","author":"Zhao","year":"2022","journal-title":"Health & Social Care in the Community"},{"key":"10.1016\/j.intimp.2024.113206_b0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0090-6980(02)00029-1","article-title":"Distinct functions of COX-1 and COX-2","volume":"68\u201369","author":"Morita","year":"2002","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.intimp.2024.113206_b0020","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(98)12154-2","article-title":"COX-2 inhibitors","volume":"353","author":"Hawkey","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.113206_b0025","doi-asserted-by":"crossref","first-page":"176356","DOI":"10.1016\/j.ejphar.2024.176356","article-title":"Catalpol ameliorates fructose-induced renal inflammation by inhibiting TLR4\/MyD88 signaling and uric acid reabsorption","volume":"967","author":"Chen","year":"2024","journal-title":"European Journal of Pharmacology"},{"issue":"32","key":"10.1016\/j.intimp.2024.113206_b0030","doi-asserted-by":"crossref","first-page":"2401369","DOI":"10.1002\/adma.202401369","article-title":"Stem Cell-Derived Nanovesicles Embedded in Dual-Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing","volume":"36","author":"Zhao","year":"2024","journal-title":"Advanced Materials"},{"key":"10.1016\/j.intimp.2024.113206_b0035","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/jhet.3118","article-title":"Anti-inflammatory exploration of sulfonamide containing diaryl pyrazoles with promising COX-2 selectivity and enhanced gastric safety profile","volume":"55","author":"Pavase","year":"2018","journal-title":"J. Heterocycl. Chem."},{"key":"10.1016\/j.intimp.2024.113206_b0040","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0090-6980(94)90074-4","article-title":"NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G\/H synthase\/cyclooxygenase (COX-2) activity in vitro","volume":"47","author":"Futaki","year":"1994","journal-title":"Prostaglandins"},{"key":"10.1016\/j.intimp.2024.113206_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120110","article-title":"Polyvinyl alcohol\/chitosan wound dressings loaded with antiseptics","volume":"593","author":"Massarelli","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.intimp.2024.113206_b0050","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.carbpol.2016.03.002","article-title":"Preparation and characterization of chitosan\/gelatin\/PVA hydrogel for wound dressings","volume":"146","author":"Fan","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2024.113206_b0055","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.carbpol.2015.08.021","article-title":"Antibacterial activity and in vitro evaluation of the biocompatibility of chitosan-based polysaccharide\/polyester membranes","volume":"134","author":"Wu","year":"2015","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.intimp.2024.113206_b0060","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1080\/03602559.2016.1275684","article-title":"PVA, PVA blends, and their nanocomposites for biodegradable packaging application","volume":"56","author":"Abdullah","year":"2017","journal-title":"Polym. Plast. Technol. Eng."},{"key":"10.1016\/j.intimp.2024.113206_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2021.105302","article-title":"Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2\/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects","volume":"116","author":"Hendawy","year":"2021","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.intimp.2024.113206_b0070","doi-asserted-by":"crossref","unstructured":"R. Murugan, S.P. Ramya Ranjan Nayak, B. Haridevamuthu, D. Priya, V. Chitra, B.O. Almutairi, S. Arokiyaraj, M. Saravanan, M.K. Kathiravan, J. Arockiaraj, Neuroprotective potential of pyrazole benzenesulfonamide derivative T1 in targeted intervention against PTZ-induced epilepsy-like condition in in vivo zebrafish model, Int. Immunopharmacol. 131 (2024) 111859. DOI: 10.1016\/j.intimp.2024.111859.","DOI":"10.1016\/j.intimp.2024.111859"},{"key":"10.1016\/j.intimp.2024.113206_b0075","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1016\/j.ejmech.2011.08.014","article-title":"Synthesis and biological evaluation of novel pyrazole derivatives with anticancer activity","volume":"46","author":"Balbi","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.intimp.2024.113206_b0080","doi-asserted-by":"crossref","unstructured":"R. Murugan, R. Rajesh, A. Guru, B. Haridevamuthu, B.O. Almutairi, M.H. Almutairi, A. Juliet, S. Renganayagi, P. Gopinath, J. Arockiaraj, Deacetylepoxyazadiradione Derived from Epoxyazadiradione of Neem (Azadirachta indica A. Juss) Fruits Mitigates LPS\u2010Induced Oxidative Stress and Inflammation in Zebrafish Larvae, Chem. Biodivers. 19 (2022). DOI: 10.1002\/cbdv.202200041.","DOI":"10.1002\/cbdv.202200041"},{"key":"10.1016\/j.intimp.2024.113206_b0085","doi-asserted-by":"crossref","unstructured":"G. Sudhakaran, D. Kesavan, S.P.R. Ranjan Nayak, S. Madesh, R. Meenatchi, R. Pachaiappan, M.H. Almutairi, B.O. Almutairi, J. Arockiaraj, Bisphenol A-induced ovarian damage countered by luteolin: experiments in in vitro CHO cells and in vivo PCOS phenotype zebrafish, Tissue Cell (2024) 102532. DOI: 10.1016\/j.tice.2024.102532.","DOI":"10.1016\/j.tice.2024.102532"},{"key":"10.1016\/j.intimp.2024.113206_b0090","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s10695-024-01371-0","article-title":"Textile azo dye, Sudan Black B, inducing hepatotoxicity demonstrated in in vivo zebrafish larval model","volume":"50","author":"Ramamurthy","year":"2024","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.intimp.2024.113206_b0095","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1021\/acsfoodscitech.3c00352","article-title":"Electrospun nanofibrous mat-on-film bilayered halochromic freshness marker-enabled intelligent food packaging film based on red cabbage anthocyanins","volume":"3","author":"Thakur","year":"2023","journal-title":"ACS Food Sci. Technol."},{"key":"10.1016\/j.intimp.2024.113206_b0100","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/molecules24010127","article-title":"Edible chitosan films and their nanosized counterparts exhibit antimicrobial activity and enhanced mechanical and barrier properties","volume":"24","author":"Gomes","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2024.113206_b0105","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1007\/s00125-023-05992-7","article-title":"Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice","volume":"66","author":"Li","year":"2023","journal-title":"Diabetologia"},{"key":"10.1016\/j.intimp.2024.113206_b0110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/0003-9861(61)90291-0","article-title":"The determination of hydroxyproline in tissue and protein samples containing small proportions of this imino acid","volume":"93","author":"Woessner","year":"1961","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.intimp.2024.113206_b0115","doi-asserted-by":"crossref","unstructured":"M. Lund, M. Krudtaa Dahle, G. Timmerhaus, M. Alarcon, M. Powell, V. Aspehaug, E. Rimstad, S.M. J\u00f8rgensen, Hypoxia tolerance and responses to hypoxic stress during heart and skeletal muscle inflammation in Atlantic salmon (Salmo salar), PLoS One 12 (2017) e0181109. DOI: 10.1371\/journal.pone.0181109.","DOI":"10.1371\/journal.pone.0181109"},{"key":"10.1016\/j.intimp.2024.113206_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.116917","article-title":"Indole-3 acetic acid induced cardiac hypertrophy in Wistar albino rats","volume":"486","author":"Nayak","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113206_b0125","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/php.12914","article-title":"Improved wound remodeling correlates with modulated TGF -beta expression in skin diabetic wounds following combined red and infrared photobiomodulation treatments","volume":"94","author":"Fekrazad","year":"2018","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.intimp.2024.113206_b0130","doi-asserted-by":"crossref","unstructured":"B. Haridevamuthu, T. Manjunathan, A. Guru, C. Ranjith Wilson Alphonse, S. Boopathi, R. Murugan, M.K. Gatasheh, A. Atef Hatamleh, A. Juliet, P. Gopinath, J. Arockiaraj, Amelioration of acrylamide induced neurotoxicity by benzo[b]thiophene analogs via glutathione redox dynamics in zebrafish larvae, Brain Res. 1788 (2022) 147941. DOI: 10.1016\/j.brainres.2022.147941.","DOI":"10.1016\/j.brainres.2022.147941"},{"key":"10.1016\/j.intimp.2024.113206_b0135","doi-asserted-by":"crossref","unstructured":"J.B. Acosta, D. Garcia del Barco, D. Cibrian Vera, W. Savigne, P. Lopez\u2010Saura, G. Guillen Nieto, G.S. Schultz, The pro\u2010inflammatory environment in recalcitrant diabetic foot wounds, Int. Wound J. 5 (2008) 530\u2013539. DOI: 10.1111\/j.1742-481X.2008.00457.x.","DOI":"10.1111\/j.1742-481X.2008.00457.x"},{"issue":"4","key":"10.1016\/j.intimp.2024.113206_b0140","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.3892\/etm.2021.10607","article-title":"Piperazine ferulate prevents high\u2011glucose\u2011induced filtration barrier injury of glomerular endothelial cells","volume":"22","author":"Yang","year":"2021","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.intimp.2024.113206_b0145","doi-asserted-by":"crossref","DOI":"10.1115\/1.4055693","article-title":"Preparation and characterization of red mud modified chitosan-PVA composite membrane for direct methanol fuel cell","volume":"20","author":"Murmu","year":"2023","journal-title":"J. Electrochem. Energy Convers. Storage"},{"key":"10.1016\/j.intimp.2024.113206_b0150","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/wrr.12125","article-title":"The effects of pH on wound healing, biofilms, and antimicrobial efficacy","volume":"22","author":"Percival","year":"2014","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.intimp.2024.113206_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpb.2022.100238","article-title":"Copigmentation and stabilization of anthocyanins using organic molecules and encapsulation techniques","volume":"29","author":"Gen\u00e7da\u011f","year":"2022","journal-title":"Curr. Plant Biol."},{"key":"10.1016\/j.intimp.2024.113206_b0160","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0039-6109(05)70572-7","article-title":"WOUND INFECTION: a failure of wound healing caused by an imbalance of bacteria","volume":"77","author":"Robson","year":"1997","journal-title":"Surg. Clin. North Am."},{"key":"10.1016\/j.intimp.2024.113206_b0165","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.3945\/jn.117.256404","article-title":"Proline precursors and collagen synthesis: biochemical challenges of nutrient supplementation and wound healing","volume":"147","author":"Albaugh","year":"2017","journal-title":"J. Nutr."},{"key":"10.1016\/j.intimp.2024.113206_b0170","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/02844319409071186","article-title":"Growth factors and wound healing","volume":"28","author":"Steenfos","year":"1994","journal-title":"Scand. J. Plast. Reconstr. Surg Hand Surg."},{"key":"10.1016\/j.intimp.2024.113206_b0175","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.lfs.2016.04.017","article-title":"Selective inhibition of COX-2 improves cutaneous wound healing of pressure ulcers in mice through reduction of iNOS expression","volume":"153","author":"Romana-Souza","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113206_b0180","doi-asserted-by":"crossref","DOI":"10.4172\/2157-7099.1000481","article-title":"Inhibition of wound TGF beta-1 by celecoxib: a possible therapeutic route for scar free wound","volume":"08","author":"Abd El Aleem","year":"2017","journal-title":"J. Cytol. Histol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924017284?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924017284?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T07:40:49Z","timestamp":1729669249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924017284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":36,"alternative-id":["S1567576924017284"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113206","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"COX-2 targeted therapy for diabetic foot ulcers using T7-enhanced CS-PVA membranes","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113206","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113206"}}