{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T18:03:20Z","timestamp":1792519400724,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T00:00:00Z","timestamp":1726790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113210","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:36:21Z","timestamp":1727454981000},"page":"113210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"PB","title":["Treadmill exercise improves cerebral ischemia injury by regulating microglia polarization via downregulation of MMP12"],"prefix":"10.1016","volume":"142","author":[{"given":"Song","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanteng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunchu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113210_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2022.105432","article-title":"MMP-12 knockdown prevents secondary brain damage after ischemic stroke in mice","volume":"161","author":"Arruri","year":"2022","journal-title":"Neurochem Int."},{"key":"10.1016\/j.intimp.2024.113210_b0010","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1007\/s12975-021-00887-4","article-title":"Immune Cell Infiltration into the Brain After Ischemic Stroke in Humans Compared to Mice and Rats: a Systematic Review and Meta-Analysis","volume":"12","author":"Beuker","year":"2021","journal-title":"Transl Stroke Res."},{"key":"10.1016\/j.intimp.2024.113210_b0015","doi-asserted-by":"crossref","first-page":"e316","DOI":"10.1161\/STROKEAHA.120.033041","article-title":"Causal Effect of MMP-1 (Matrix Metalloproteinase-1), MMP-8, and MMP-12 Levels on Ischemic Stroke: A Mendelian Randomization Study","volume":"52","author":"C\u00e1rcel-M\u00e1rquez","year":"2021","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0020","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s12035-013-8538-z","article-title":"Mmp-9 inhibition: a therapeutic strategy in ischemic stroke","volume":"49","author":"Chaturvedi","year":"2014","journal-title":"Mol Neurobiol."},{"key":"10.1016\/j.intimp.2024.113210_b0025","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1161\/STROKEAHA.115.011031","article-title":"Matrix Metalloproteinase-12 Induces Blood-Brain Barrier Damage After Focal Cerebral Ischemia","volume":"46","author":"Chelluboina","year":"2015","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0030","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s12035-017-0418-5","article-title":"MMP-12, a Promising Therapeutic Target for Neurological Diseases","volume":"55","author":"Chelluboina","year":"2018","journal-title":"Mol Neurobiol."},{"key":"10.1016\/j.intimp.2024.113210_b0035","doi-asserted-by":"crossref","first-page":"9504","DOI":"10.1038\/srep09504","article-title":"Post-transcriptional inactivation of matrix metalloproteinase-12 after focal cerebral ischemia attenuates brain damage","volume":"5","author":"Chelluboina","year":"2015","journal-title":"Sci Rep."},{"key":"10.1016\/j.intimp.2024.113210_b0040","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22189999","article-title":"Intranasal Delivery of RGD-Containing Osteopontin Heptamer Peptide Confers Neuroprotection in the Ischemic Brain and Augments Microglia M2 Polarization","volume":"22","author":"Davaanyam","year":"2021","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.intimp.2024.113210_b0050","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1007\/s12035-021-02329-6","article-title":"Remote Ischemic Postconditioning vs. Physical Exercise After Stroke: an Alternative Rehabilitation Strategy?","volume":"58","author":"Geng","year":"2021","journal-title":"Mol Neurobiol."},{"key":"10.1016\/j.intimp.2024.113210_b0055","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1161\/01.STR.0000032302.91894.0F","article-title":"Behavioral tests after intracerebral hemorrhage in the rat","volume":"33","author":"Hua","year":"2002","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0060","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1161\/STROKEAHA.110.607879","article-title":"Improved cerebral vasomotor reactivity after exercise training in hemiparetic stroke survivors","volume":"42","author":"Ivey","year":"2011","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102135","article-title":"Microglia and Monocytes\/Macrophages Polarization Reveal Novel Therapeutic Mechanism against Stroke","volume":"18","author":"Kanazawa","year":"2017","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.intimp.2024.113210_b0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00401-018-1930-z","article-title":"Post-stroke inflammation-target or tool for therapy?","volume":"137","author":"Lambertsen","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.intimp.2024.113210_b0075","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3389\/fncel.2020.00186","article-title":"In Search of a Dose: The Functional and Molecular Effects of Exercise on Post-stroke Rehabilitation in Rats","volume":"14","author":"Li","year":"2020","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.intimp.2024.113210_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113854","article-title":"PLXNA2 knockdown promotes M2 microglia polarization through mTOR\/STAT3 signaling to improve functional recovery in rats after cerebral ischemia\/reperfusion injury","volume":"346","author":"Li","year":"2021","journal-title":"Exp Neurol."},{"key":"10.1016\/j.intimp.2024.113210_b0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.735485","article-title":"Treadmill Exercise Attenuates Cerebral Ischemia-Reperfusion Injury by Promoting Activation of M2 Microglia via Upregulation of Interleukin-4","volume":"8","author":"Lu","year":"2021","journal-title":"Front Cardiovasc Med."},{"key":"10.1016\/j.intimp.2024.113210_b0095","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/j.apmr.2016.06.007","article-title":"Plasma Matrix Metalloproteinases in Patients With Stroke During Intensive Rehabilitation Therapy","volume":"97","author":"Ma","year":"2016","journal-title":"Arch Phys Med Rehabil."},{"key":"10.1016\/j.intimp.2024.113210_b0100","doi-asserted-by":"crossref","first-page":"e897","DOI":"10.1016\/S2468-2667(21)00228-0","article-title":"Temporal trend and attributable risk factors of stroke burden in China, 1990\u20132019: an analysis for the Global Burden of Disease Study 2019","volume":"6","author":"Ma","year":"2021","journal-title":"Lancet Public Health."},{"key":"10.1016\/j.intimp.2024.113210_b0105","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2522\/ptj.20130053","article-title":"Promoting neuroplasticity for motor rehabilitation after stroke: considering the effects of aerobic exercise and genetic variation on brain-derived neurotrophic factor","volume":"93","author":"Mang","year":"2013","journal-title":"Phys Ther."},{"key":"10.1016\/j.intimp.2024.113210_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070691","article-title":"Physical Exercise Inhibits Inflammation and Microglial Activation","volume":"8","author":"Mee-Inta","year":"2019","journal-title":"Cells."},{"key":"10.1016\/j.intimp.2024.113210_b0115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1136\/svn-2018-000142","article-title":"Post-stroke mRNA expression profile of MMPs: effect of genetic deletion of MMP-12","volume":"3","author":"Nalamolu","year":"2018","journal-title":"Stroke Vasc Neurol."},{"key":"10.1016\/j.intimp.2024.113210_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/608581","article-title":"Physical Exercise as a Diagnostic, Rehabilitation, and Preventive Tool: Influence on Neuroplasticity and Motor Recovery after Stroke","volume":"2015","author":"Pin-Barre","year":"2015","journal-title":"Neural Plast."},{"key":"10.1016\/j.intimp.2024.113210_b0125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S1836-9553(13)70159-0","article-title":"Treadmill training is effective for ambulatory adults with stroke: a systematic review","volume":"59","author":"Polese","year":"2013","journal-title":"J Physiother."},{"key":"10.1016\/j.intimp.2024.113210_b0130","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STROKEAHA.118.022606","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0135","doi-asserted-by":"crossref","first-page":"e52121","DOI":"10.1371\/journal.pone.0052121","article-title":"Spatial and temporal gene expression differences in core and periinfarct areas in experimental stroke: a microarray analysis","volume":"7","author":"Ramos-Cejudo","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.intimp.2024.113210_b0140","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fimmu.2012.00132","article-title":"Post-ischemic inflammation in the brain","volume":"3","author":"Shichita","year":"2012","journal-title":"Front Immunol."},{"key":"10.1016\/j.intimp.2024.113210_b0145","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbi.2019.09.005","article-title":"Neurogenesis promoted by the CD200\/CD200R signaling pathway following treadmill exercise enhances post-stroke functional recovery in rats","volume":"82","author":"Sun","year":"2019","journal-title":"Brain Behav Immun."},{"key":"10.1016\/j.intimp.2024.113210_b0150","series-title":"Implications of MMP-12 in the pathophysiology of ischaemic stroke","author":"Veeravalli","year":"2023"},{"key":"10.1016\/j.intimp.2024.113210_b0155","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1161\/STR.0000000000000098","article-title":"Guidelines for Adult Stroke Rehabilitation and Recovery: A Guideline for Healthcare Professionals From the American Heart Association\/American Stroke Association","volume":"47","author":"Winstein","year":"2016","journal-title":"Stroke."},{"key":"10.1016\/j.intimp.2024.113210_b0160","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.expneurol.2018.12.005","article-title":"Treadmill exercise ameliorates focal cerebral ischemia\/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1\/VEGF signaling pathways","volume":"313","author":"Xie","year":"2019","journal-title":"Exp Neurol."},{"key":"10.1016\/j.intimp.2024.113210_b0165","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13041-020-00598-1","article-title":"Temporal expression profiling of DAMPs-related genes revealed the biphasic post-ischemic inflammation in the experimental stroke model","volume":"13","author":"Yamaguchi","year":"2020","journal-title":"Mol Brain."},{"key":"10.1016\/j.intimp.2024.113210_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105290","article-title":"Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system","volume":"152","author":"Yang","year":"2021","journal-title":"Neurobiol Dis."},{"key":"10.1016\/j.intimp.2024.113210_b0175","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12974-022-02433-x","article-title":"Macrophage elastase (MMP12) critically contributes to the development of subretinal fibrosis","volume":"19","author":"Yi","year":"2022","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.intimp.2024.113210_b0180","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s12974-017-0993-4","article-title":"EZH2 suppression in glioblastoma shifts microglia toward M1 phenotype in tumor microenvironment","volume":"14","author":"Yin","year":"2017","journal-title":"J Neuroinflammation."},{"key":"10.1016\/j.intimp.2024.113210_b0185","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/cns.13899","article-title":"Phagocytic microglia and macrophages in brain injury and repair","volume":"28","author":"Yu","year":"2022","journal-title":"CNS Neurosci Ther."},{"key":"10.1016\/j.intimp.2024.113210_b0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2202-14-46","article-title":"Physical exercise improves functional recovery through mitigation of autophagy, attenuation of apoptosis and enhancement of neurogenesis after MCAO in rats","volume":"14","author":"Zhang","year":"2013","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.intimp.2024.113210_b0195","doi-asserted-by":"crossref","first-page":"6074","DOI":"10.3390\/ijms14036074","article-title":"Early Exercise Protects against Cerebral Ischemic Injury through Inhibiting Neuron Apoptosis in Cortex in Rats","volume":"14","author":"Zhang","year":"2013","journal-title":"Int J Mol Sci."},{"key":"10.1016\/j.intimp.2024.113210_b0200","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s13105-021-00848-3","article-title":"Inhibition of HDAC3 and ATXN3 by miR-25 prevents neuronal loss and ameliorates neurological recovery in cerebral stroke experimental rats","volume":"78","author":"Zhou","year":"2022","journal-title":"J Physiol Biochem."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924017326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924017326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:00:46Z","timestamp":1734051646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924017326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":39,"alternative-id":["S1567576924017326"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113210","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Treadmill exercise improves cerebral ischemia injury by regulating microglia polarization via downregulation of MMP12","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113210"}}