{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:09:17Z","timestamp":1787497757462,"version":"build-2736575974"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113259","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T21:09:18Z","timestamp":1727384958000},"page":"113259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"PB","title":["Effect of intranasal administration of Granulocyte-Macrophage Colony-Stimulating Factor on pulmonary Cryptococcus gattii infection"],"prefix":"10.1016","volume":"142","author":[{"given":"Adithap","family":"Hansakon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rungwadee","family":"Khampoongern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-5908-9480","authenticated-orcid":false,"given":"Lauritz","family":"Schiller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siranart","family":"Jeerawattanawart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0303-9544","authenticated-orcid":false,"given":"Pornpimon","family":"Angkasekwinai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113259_b0005","unstructured":"Coordination G, Alastruey-Izquierdo A, Organization WH, Organization WH. WHO fungal priority pathogens list to guide research, development and public health action. Organizaci\u00f3n Mundial de la Salud (OMS); 2022. Report No.: 9240060251."},{"issue":"7","key":"10.1016\/j.intimp.2024.113259_b0010","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019760","article-title":"Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis","volume":"4","author":"Kwon-Chung","year":"2014","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.intimp.2024.113259_b0015","first-page":"00103","article-title":"The primary target organ of Cryptococcus gattii is different from that of Cryptococcus neoformans in a murine model","volume":"3(3):10.1128\/mbio","author":"Ngamskulrungroj","year":"2012","journal-title":"MBio"},{"issue":"4","key":"10.1016\/j.intimp.2024.113259_b0020","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1128\/CMR.00126-13","article-title":"Cryptococcus gattii infections","volume":"27","author":"Chen","year":"2014","journal-title":"Clin. Microbiol. Rev."},{"issue":"1","key":"10.1016\/j.intimp.2024.113259_b0025","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.wem.2019.10.004","article-title":"The disease ecology, epidemiology, clinical manifestations, and management of emerging Cryptococcus gattii complex infections","volume":"31","author":"Diaz","year":"2020","journal-title":"Wilderness Environ. Med."},{"key":"10.1016\/j.intimp.2024.113259_b0030","article-title":"What makes Cryptococcus gattii a pathogen?","volume":"16(1):fov106","author":"Bielska","year":"2016","journal-title":"FEMS Yeast Res."},{"issue":"10","key":"10.1016\/j.intimp.2024.113259_b0035","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1128\/IAI.00628-09","article-title":"Cryptococcus gattii isolates from the British Columbia cryptococcosis outbreak induce less protective inflammation in a murine model of infection than Cryptococcus neoformans","volume":"77","author":"Cheng","year":"2009","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.intimp.2024.113259_b0040","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4049\/jimmunol.1202707","article-title":"Cryptococcus gattii is killed by dendritic cells, but evades adaptive immunity by failing to induce dendritic cell maturation","volume":"191","author":"Huston","year":"2013","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113259_b0045","doi-asserted-by":"crossref","first-page":"3880","DOI":"10.1128\/IAI.01773-14","article-title":"Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts","volume":"82","author":"Angkasekwinai","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.intimp.2024.113259_b0050","doi-asserted-by":"crossref","unstructured":"A. Hansakon P. Ngamskulrungroj P. Angkasekwinai Contribution of laccase expression to immune response against Cryptococcus gattii infection Infect. Immun. 88(3), 10.1128\/iai 2020 00712 0079.","DOI":"10.1128\/IAI.00712-19"},{"issue":"7","key":"10.1016\/j.intimp.2024.113259_b0055","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1128\/iai.63.7.2632-2644.1995","article-title":"Effects of the two varieties of Cryptococcus neoformans cells and culture filtrate antigens on neutrophil locomotion","volume":"63","author":"Dong","year":"1995","journal-title":"Infect. Immun."},{"issue":"10","key":"10.1016\/j.intimp.2024.113259_b0060","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1136\/thoraxjnl-2017-211323","article-title":"Randomised controlled trial of GM-CSF in critically ill patients with impaired neutrophil phagocytosis","volume":"73","author":"Pinder","year":"2018","journal-title":"Thorax"},{"key":"10.1016\/j.intimp.2024.113259_b0065","doi-asserted-by":"crossref","unstructured":"Chen TK, Batra JS, Michalik DE, Casillas J, Patel R, Ruiz ME, et al., editors. Recombinant human granulocyte-macrophage colony-stimulating factor (rhu GM-CSF) as adjuvant therapy for invasive fungal diseases. Open Forum Infectious Diseases; 2022: Oxford University Press US.","DOI":"10.1093\/ofid\/ofac535"},{"issue":"4","key":"10.1016\/j.intimp.2024.113259_b0070","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.4049\/jimmunol.1501512","article-title":"Local GM-CSF\u2013dependent differentiation and activation of pulmonary dendritic cells and macrophages protect against progressive cryptococcal lung infection in mice","volume":"196","author":"Chen","year":"2016","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113259_b0075","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.2353\/ajpath.2007.060595","article-title":"Role of granulocyte macrophage colony-stimulating factor in host defense against pulmonary Cryptococcus neoformans infection during murine allergic bronchopulmonary mycosis","volume":"170","author":"Chen","year":"2007","journal-title":"Am. J. Pathol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113259_b0080","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1258\/0956462971920226","article-title":"Liposomal amphotericin B and recombinant human granulocyte-macrophage colony-stimulating factor (rHuGM-CSF) in the treatment of paediatric AIDS-related cryptococcosis","volume":"8","author":"Manfredi","year":"1997","journal-title":"Int J STD AIDS."},{"issue":"8","key":"10.1016\/j.intimp.2024.113259_b0085","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.4049\/jimmunol.1202526","article-title":"Anti\u2013GM-CSF autoantibodies in patients with cryptococcal meningitis","volume":"190","author":"Rosen","year":"2013","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113259_b0090","doi-asserted-by":"crossref","first-page":"00912-14","DOI":"10.1128\/mBio.00912-14","article-title":"Anti-granulocyte-macrophage colony-stimulating factor autoantibodies are a risk factor for central nervous system infection by Cryptococcus gattii in otherwise immunocompetent patients","volume":"5","author":"Saijo","year":"2014","journal-title":"MBio."},{"key":"10.1016\/j.intimp.2024.113259_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmi.2024.01.018","article-title":"Anti-GM-CSF autoantibodies predict outcome of cryptococcal meningitis in patients not infected with HIV: A cohort study","author":"Jiang","year":"2024","journal-title":"Clin. Microbiol. Infect."},{"issue":"5","key":"10.1016\/j.intimp.2024.113259_b0100","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10875-023-01451-5","article-title":"Anti-GM-CSF neutralizing autoantibodies in Colombian patients with disseminated cryptococcosis","volume":"43","author":"Arango-Franco","year":"2023","journal-title":"J. Clin. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113259_b0105","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1007\/s10875-022-01341-2","article-title":"Cryptococcus gattii infection as the major clinical manifestation in patients with autoantibodies against granulocyte\u2013macrophage colony-stimulating factor","volume":"42","author":"Wang","year":"2022","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.intimp.2024.113259_b0110","doi-asserted-by":"crossref","unstructured":"Crum-Cianflone NF, Lam PV, Ross-Walker S, Rosen LB, Holland SM, editors. Autoantibodies to granulocyte-macrophage colony-stimulating factor associated with severe and unusual manifestations of Cryptococcus gattii infections. Open Forum Infectious Diseases; 2017: Oxford University Press US.","DOI":"10.1093\/ofid\/ofx211"},{"issue":"3","key":"10.1016\/j.intimp.2024.113259_b0115","doi-asserted-by":"crossref","first-page":"e1001","DOI":"10.1002\/cpz1.1001","article-title":"Murine Models of Cryptococcus Infection","volume":"4","author":"Hansakon","year":"2024","journal-title":"Current Protocols."},{"issue":"1","key":"10.1016\/j.intimp.2024.113259_b0120","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1080\/21505594.2018.1556150","article-title":"Cryptococcus neoformans and Cryptococcus gattii clinical isolates from Thailand display diverse phenotypic interactions with macrophages","volume":"10","author":"Hansakon","year":"2019","journal-title":"Virulence"},{"key":"10.1016\/j.intimp.2024.113259_b0125","doi-asserted-by":"crossref","unstructured":"J.A. Reed M. Ikegami E.R. Cianciolo W. Lu P.S. Cho W. Hull et al. Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice American Journal of Physiology-Lung Cellular and Molecular Physiology. 276 4 1999 L556 L63.","DOI":"10.1152\/ajplung.1999.276.4.L556"},{"issue":"5","key":"10.1016\/j.intimp.2024.113259_b0130","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.4049\/jimmunol.1300426","article-title":"IL-33 signaling regulates innate and adaptive immunity to Cryptococcus neoformans","volume":"191","author":"Flaczyk","year":"2013","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113259_b0135","doi-asserted-by":"crossref","first-page":"674","DOI":"10.4049\/jimmunol.2000073","article-title":"IL-25 receptor signaling modulates host defense against Cryptococcus neoformans infection","volume":"205","author":"Hansakon","year":"2020","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113259_b0140","doi-asserted-by":"crossref","first-page":"e0193015","DOI":"10.1371\/journal.pone.0193015","article-title":"Selective targeting of tumor associated macrophages in different tumor models","volume":"13","author":"Kakoschky","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113259_b0145","doi-asserted-by":"crossref","first-page":"e20190073","DOI":"10.1590\/1678-9199-jvatitd-2019-0073","article-title":"Neutrophils activated by BJcuL, a C-type lectin isolated from Bothrops jararacussu venom, decrease the invasion potential of neuroblastoma SK-N-SH cells in vitro","volume":"26","author":"Carneiro-Goetten","year":"2020","journal-title":"J. Venomous Anim. Toxins Incl. Trop. Dis."},{"key":"10.1016\/j.intimp.2024.113259_b0150","doi-asserted-by":"crossref","unstructured":"Chen B, Clark CR, Chou T. Granulocyte\/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor. 1988.","DOI":"10.1182\/blood.V71.4.997.bloodjournal714997"},{"issue":"1","key":"10.1016\/j.intimp.2024.113259_b0155","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1080\/mmy.40.1.21.26","article-title":"Effect of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor on polymorphonuclear neutrophils, monocytes or monocyte-derived macrophages combined with voriconazole against Cryptococcus neoformans","volume":"40","author":"Chiller","year":"2002","journal-title":"Med. Mycol."},{"key":"10.1016\/j.intimp.2024.113259_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.752856","article-title":"The role of GM-CSF autoantibodies in infection and autoimmune pulmonary alveolar proteinosis: a concise review","volume":"12","author":"Ataya","year":"2021","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113259_b0165","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1172\/JCI5212","article-title":"GM-CSF\u2013deficient mice are susceptible to pulmonary group B streptococcal infection","volume":"103","author":"LeVine","year":"1999","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.intimp.2024.113259_b0170","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.164.5.2602","article-title":"Granulocyte-macrophage colony-stimulating factor in the innate immune response to Pneumocystis carinii pneumonia in mice","volume":"164","author":"Paine","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.113259_b0175","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1111\/j.1440-1843.2006.00801.x","article-title":"Extra-pulmonary aspects of acquired pulmonary alveolar proteinosis as predicted by granulocyte-macrophage colony-stimulating factor-deficient mice","volume":"11","author":"Seymour","year":"2006","journal-title":"Respirology"},{"key":"10.1016\/j.intimp.2024.113259_b0180","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fcimb.2017.00373","article-title":"Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance","volume":"7","author":"Nguyen","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2024.113259_b0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.micpath.2019.04.026","article-title":"Staphylococcus aureus versus neutrophil: Scrutiny of ancient combat","volume":"131","author":"Nasser","year":"2019","journal-title":"Microb. Pathog."},{"issue":"5","key":"10.1016\/j.intimp.2024.113259_b0190","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/mi.2014.65","article-title":"Classical versus alternative macrophage activation: the Ying and the Yang in host defense against pulmonary fungal infections","volume":"7","author":"Wager","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.intimp.2024.113259_b0195","doi-asserted-by":"crossref","unstructured":"M.J. Davis T.M. Tsang Y. Qiu J.K. Dayrit J.B. Freij G.B. Huffnagle et al. Macrophage M1\/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection MBio 2013;4(3):10.1128\/mbio. 00264 00213.","DOI":"10.1128\/mBio.00264-13"},{"issue":"1","key":"10.1016\/j.intimp.2024.113259_b0200","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s12931-023-02557-5","article-title":"Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma","volume":"24","author":"Chang","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113259_b0205","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01514-17","article-title":"Role of granulocyte-macrophage colony-stimulating factor production by T cells during Mycobacterium tuberculosis infection","author":"Rothchild","year":"2017","journal-title":"MBio."},{"key":"10.1016\/j.intimp.2024.113259_b0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1742-2094-9-268","article-title":"GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia","volume":"9","author":"Parajuli","year":"2012","journal-title":"Journal of neuroinflammation."},{"key":"10.1016\/j.intimp.2024.113259_b0215","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3389\/fimmu.2019.01265","article-title":"Roles of GM-CSF in the pathogenesis of autoimmune diseases: an update","volume":"10","author":"Lotfi","year":"2019","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113259_b0220","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/mmy\/myy153","article-title":"Neutrophil-mediated antifungal activity against highly virulent Cryptococcus gattii strain R265","volume":"57","author":"Ueno","year":"2019","journal-title":"Med. Mycol."},{"key":"10.1016\/j.intimp.2024.113259_b0225","volume":"10","author":"Hamilton","year":"2019","journal-title":"GM-CSF-Dependent Inflammatory Pathways. Frontiers in Immunology."},{"issue":"6","key":"10.1016\/j.intimp.2024.113259_b0230","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.cytogfr.2010.10.002","article-title":"IL-17 family member cytokines: regulation and function in innate immunity","volume":"21","author":"Reynolds","year":"2010","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.intimp.2024.113259_b0235","doi-asserted-by":"crossref","DOI":"10.1172\/JCI176142","article-title":"BTK drives neutrophil activation for sterilizing antifungal immunity","author":"Desai","year":"2024","journal-title":"J. Clin. Invest."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924017818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924017818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T01:02:36Z","timestamp":1734051756000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924017818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":47,"alternative-id":["S1567576924017818"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113259","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of intranasal administration of Granulocyte-Macrophage Colony-Stimulating Factor on pulmonary Cryptococcus gattii infection","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113259"}}