{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T11:34:03Z","timestamp":1785843243174,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T00:00:00Z","timestamp":1728604800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113374","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T20:40:01Z","timestamp":1729284001000},"page":"113374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"P2","title":["Diammonium glycyrrhizinate ameliorates alcohol-induced liver injury by reducing oxidative stress, steatosis, and inflammation"],"prefix":"10.1016","volume":"143","author":[{"given":"Xiaomei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2024.113374_b0005","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2022.05.031","article-title":"Natural history of alcohol-associated liver disease: understanding the changing landscape of pathophysiology and patient care","volume":"163","author":"Bajaj","year":"2022","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.intimp.2024.113374_b0010","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3727\/105221620X15952664091823","article-title":"Epidemiological realities of alcoholic liver disease: global burden, research trends, and therapeutic promise","volume":"20","author":"Xiao","year":"2020","journal-title":"Gene Expr."},{"issue":"9","key":"10.1016\/j.intimp.2024.113374_b0015","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1111\/liv.15312","article-title":"Epidemic characteristics of alcohol-related liver disease in Asia from 2000 to 2020: a systematic review and meta-analysis","volume":"42","author":"Xu","year":"2022","journal-title":"Liver Int."},{"issue":"5","key":"10.1016\/j.intimp.2024.113374_b0020","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1053\/j.gastro.2011.09.002","article-title":"Alcoholic liver disease: pathogenesis and new therapeutic targets","volume":"141","author":"Gao","year":"2011","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2024.113374_b0025","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/s12967-023-04166-8","article-title":"Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease","volume":"21","author":"Yan","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2024.113374_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107963","article-title":"Telmisartan alleviates alcohol-induced liver injury by activation of PPAR-gamma\/Nrf-2 crosstalk in mice","volume":"99","author":"Abdelhamid","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113374_b0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ejphar.2017.04.025","article-title":"Diammonium glycyrrhizinate alleviates hepatopulmonary syndrome via restoring superoxide dismutase 3 activity in rats","volume":"807","author":"Zhao","year":"2017","journal-title":"Eur. J. Pharmacol."},{"issue":"25","key":"10.1016\/j.intimp.2024.113374_b0040","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.2174\/1381612828666220421134910","article-title":"Diammonium glycyrrhizinate preparation for liver function recovery in chronic hepatitis B in China: a meta-analysis with trial sequential analysis","volume":"28","author":"Liu","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.intimp.2024.113374_b0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.fct.2014.08.009","article-title":"Role of Nrf2 activation and NF-kappaB inhibition in valproic acid induced hepatotoxicity and in diammonium glycyrrhizinate induced protection in mice","volume":"73","author":"Jin","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113374_b0050","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.1021\/acs.molpharmaceut.8b00347","article-title":"Diammonium glycyrrhizinate protects against nonalcoholic fatty liver disease in mice through modulation of gut microbiota and restoration of intestinal barrier","volume":"15","author":"Li","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.intimp.2024.113374_b0055","doi-asserted-by":"crossref","first-page":"8491742","DOI":"10.1155\/2017\/8491742","article-title":"Metformin and diammonium glycyrrhizinate enteric-coated capsule versus metformin alone versus diammonium glycyrrhizinate enteric-coated capsule alone in patients with nonalcoholic fatty liver disease and type 2 diabetes mellitus","volume":"2017","author":"Zhang","year":"2017","journal-title":"Gastroenterol. Res. Pract."},{"issue":"3","key":"10.1016\/j.intimp.2024.113374_b0060","doi-asserted-by":"crossref","first-page":"693","DOI":"10.20892\/j.issn.2095-3941.2020.0262","article-title":"Heat shock protein 90 promotes RNA helicase DDX5 accumulation and exacerbates hepatocellular carcinoma by inhibiting autophagy","volume":"18","author":"Zhang","year":"2021","journal-title":"Cancer Biol. Med."},{"issue":"15","key":"10.1016\/j.intimp.2024.113374_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14153820","article-title":"DEAD-Box RNA helicases DDX3X and DDX5 as oncogenes or oncosuppressors: a network perspective","volume":"14","author":"Secchi","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.intimp.2024.113374_b0070","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/s41419-020-02759-5","article-title":"DDX5-targeting fully human monoclonal autoantibody inhibits proliferation and promotes differentiation of acute promyelocytic leukemia cells by increasing ROS production","volume":"11","author":"Wu","year":"2020","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2024.113374_b0075","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/hep.32651","article-title":"RNA helicase DEAD-box protein 5 alleviates nonalcoholic steatohepatitis progression via tethering TSC complex and suppressing mTORC1 signaling","volume":"77","author":"Zhang","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2024.113374_b0080","article-title":"The effect of STAT1, miR-99b, and MAP2K1 in alcoholic liver disease (ALD) mouse model and hepatocyte","volume":"16","author":"Du","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.intimp.2024.113374_b0085","doi-asserted-by":"crossref","unstructured":"M. Grohmann, F. Wiede, G.T. Dodd, E.N. Gurzov, G.J. Ooi, T. Butt, A.A. Rasmiena, S. Kaur, T. Gulati, P.K. Goh, A.E. Treloar, S. Archer, W.A. Brown, M. Muller, M.J. Watt, O. Ohara, C.A. McLean, T. Tiganis, Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC, Cell 175(5) (2018) 1289-1306 e20.","DOI":"10.1016\/j.cell.2018.09.053"},{"issue":"2","key":"10.1016\/j.intimp.2024.113374_b0090","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1053\/jhep.2002.31169","article-title":"Expression of interferon alfa signaling components in human alcoholic liver disease","volume":"35","author":"Nguyen","year":"2002","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.intimp.2024.113374_b0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3727\/105221617X695519","article-title":"Animal models of alcoholic liver disease: pathogenesis and clinical relevance","volume":"17","author":"Gao","year":"2017","journal-title":"Gene Expr."},{"issue":"40","key":"10.1016\/j.intimp.2024.113374_b0100","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1038\/sj.onc.1210387","article-title":"SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1","volume":"26","author":"Jacobs","year":"2007","journal-title":"Oncogene"},{"issue":"8","key":"10.1016\/j.intimp.2024.113374_b0105","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/j.cgh.2023.04.015","article-title":"The global burden of liver disease","volume":"21","author":"Younossi","year":"2023","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.intimp.2024.113374_b0110","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jnutbio.2016.08.011","article-title":"Evaluating the effects of refined carbohydrate and fat diets with acute ethanol consumption using a mouse model of alcoholic liver injury","volume":"39","author":"Goncalves","year":"2017","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.intimp.2024.113374_b0115","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.taap.2018.08.019","article-title":"Nrf2 in alcoholic liver disease","volume":"357","author":"Sun","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113374_b0120","article-title":"Autophagy, oxidative stress, and alcoholic liver disease: a systematic review and potential clinical applications","volume":"12","author":"Salete-Granado","year":"2023","journal-title":"Antioxidants (Basel)"},{"issue":"1","key":"10.1016\/j.intimp.2024.113374_b0125","first-page":"85","article-title":"Roles of DDX5 in the tumorigenesis, proliferation, differentiation, metastasis and pathway regulation of human malignancies","volume":"1871","author":"Nyamao","year":"2019","journal-title":"Biochim. Biophys. Acta"},{"issue":"2","key":"10.1016\/j.intimp.2024.113374_b0130","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1007\/s10753-019-01162-3","article-title":"Cordycepin attenuates IFN-gamma-induced macrophage IP-10 and mig expressions by inhibiting STAT1 activity in CFA-induced inflammation mice model","volume":"43","author":"Yang","year":"2020","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.113374_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106125","article-title":"DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-kappaB pathway","volume":"177","author":"Xu","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.113374_b0140","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2019.11.013","article-title":"Interleukin-22 ameliorates acute-on-chronic liver failure by reprogramming impaired regeneration pathways in mice","volume":"72","author":"Xiang","year":"2020","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113374_b0145","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1136\/gutjnl-2020-323126","article-title":"RNA helicase DDX5 enables STAT1 mRNA translation and interferon signalling in hepatitis B virus replicating hepatocytes","volume":"71","author":"Sun","year":"2022","journal-title":"Gut"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924018964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924018964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T02:31:17Z","timestamp":1736303477000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924018964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":29,"alternative-id":["S1567576924018964"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113374","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diammonium glycyrrhizinate ameliorates alcohol-induced liver injury by reducing oxidative stress, steatosis, and inflammation","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113374"}}