{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T21:11:54Z","timestamp":1793481114660,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113394","type":"journal-article","created":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T23:03:10Z","timestamp":1729465390000},"page":"113394","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"P2","title":["Urolithin A improves myocardial ischemia\u2013reperfusion injury by attenuating oxidative stress and ferroptosis through Nrf2 pathway"],"prefix":"10.1016","volume":"143","author":[{"given":"Zhe","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113394_b0005","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41569-019-0218-x","article-title":"RNA-based diagnostic and therapeutic strategies for cardiovascular disease","volume":"16","author":"Lu","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2024.113394_b0010","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/6267720","article-title":"Protective effect of sufentanil on myocardial ischemia-reperfusion injury in rats by inhibiting endoplasmic reticulum stress","volume":"2022","author":"Qiu","year":"2022","journal-title":"Comput. Math. Methods Med."},{"key":"10.1016\/j.intimp.2024.113394_b0015","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.tcm.2022.02.005","article-title":"Myocardial ischemia-reperfusion injury and the influence of inflammation","volume":"33","author":"Algoet","year":"2023","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.intimp.2024.113394_b0020","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.7150\/ijms.59411","article-title":"A novel danshensu\/tetramethylpyrazine protects against myocardial ischemia reperfusion injury in rats","volume":"18","author":"Wang","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.intimp.2024.113394_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165768","article-title":"Mitochondrial ROS in myocardial ischemia reperfusion and remodeling","volume":"1866","author":"Bugger","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.intimp.2024.113394_b0030","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.113394_b0035","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2024.113394_b0040","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1111\/febs.16059","article-title":"Signaling pathways and defense mechanisms of ferroptosis","volume":"289","author":"Liu","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.intimp.2024.113394_b0045","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/s41571-020-00462-0","article-title":"Broadening horizons: the role of ferroptosis in cancer","volume":"18","author":"Chen","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.intimp.2024.113394_b0050","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.7150\/thno.54113","article-title":"Ferroptosis as a novel therapeutic target for cardiovascular disease","volume":"11","author":"Wu","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.intimp.2024.113394_b0055","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/s41573-023-00749-8","article-title":"The therapeutic potential of targeting regulated non-apoptotic cell death","volume":"22","author":"Hadian","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.intimp.2024.113394_b0060","article-title":"Ferroptosis: opportunities and challenges in myocardial ischemia-reperfusion injury","volume":"2021","author":"Zhao","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2024.113394_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2021.145968","article-title":"Resveratrol protects against myocardial ischemia-reperfusion injury via attenuating ferroptosis","volume":"808","author":"Li","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2024.113394_b0070","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41418-020-0593-1","article-title":"Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis","volume":"28","author":"Lee","year":"2021","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.intimp.2024.113394_b0075","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.7150\/ijbs.69116","article-title":"Urolithin A protects against acetaminophen-induced liver injury in mice via sustained activation of Nrf2","volume":"18","author":"Gao","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2024.113394_b0080","doi-asserted-by":"crossref","first-page":"e13662","DOI":"10.1111\/acel.13662","article-title":"Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis","volume":"21","author":"D'Amico","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2024.113394_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105967","article-title":"Urolithin A suppresses RANKL-induced osteoclastogenesis and postmenopausal osteoporosis by, suppresses inflammation and downstream NF-kappaB activated pyroptosis pathways","volume":"174","author":"Tao","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2024.113394_b0090","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/ptr.7370","article-title":"Urolithin A alleviates acute kidney injury induced by renal ischemia reperfusion through the p62-Keap1-Nrf2 signaling pathway","volume":"36","author":"Zhang","year":"2022","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2024.113394_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1067402","article-title":"Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2\/HO-1 signaling pathway","volume":"14","author":"Lou","year":"2023","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113394_b0100","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.bbrc.2017.03.119","article-title":"Urolithin A alleviates myocardial ischemia\/reperfusion injury via PI3K\/Akt pathway","volume":"486","author":"Tang","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.113394_b0105","doi-asserted-by":"crossref","DOI":"10.3791\/1438-v","article-title":"LAD-ligation: a murine model of myocardial infarction","author":"Kolk","year":"2009","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.intimp.2024.113394_b0110","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jjcc.2022.07.003","article-title":"Treatment strategies of acute myocardial infarction: updates on revascularization, pharmacological therapy, and beyond","volume":"81","author":"Saito","year":"2023","journal-title":"J. Cardiol."},{"key":"10.1016\/j.intimp.2024.113394_b0115","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.ahj.2015.08.005","article-title":"Reperfusion therapy for acute myocardial infarction: concepts and controversies from inception to acceptance","volume":"170","author":"Rentrop","year":"2015","journal-title":"Am. Heart J."},{"key":"10.1016\/j.intimp.2024.113394_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153169","article-title":"Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation","volume":"68","author":"Xu","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.113394_b0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1142\/S0192415X17500057","article-title":"Punicalagin pretreatment attenuates myocardial ischemia-reperfusion injury via activation of AMPK","volume":"45","author":"Ding","year":"2017","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.intimp.2024.113394_b0130","first-page":"641","article-title":"Crocetin alleviates myocardial ischemia\/reperfusion injury by regulating inflammation and the unfolded protein response","volume":"21","author":"Yang","year":"2020","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.113394_b0135","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.molmed.2021.04.009","article-title":"Impact of the natural compound Urolithin A on health, disease, and aging","volume":"27","author":"D'Amico","year":"2021","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.intimp.2024.113394_b0140","article-title":"Urolithin A as a potential agent for prevention of age-related disease: a scoping review","volume":"15","author":"Kothe","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.intimp.2024.113394_b0145","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s13311-019-00753-0","article-title":"Activation of the miR-34a-mediated SIRT1\/mTOR signaling pathway by Urolithin A attenuates D-galactose-induced brain aging in mice","volume":"16","author":"Chen","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.intimp.2024.113394_b0150","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/cns.13136","article-title":"Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo","volume":"25","author":"Ahsan","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.intimp.2024.113394_b0155","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.neuroscience.2020.09.027","article-title":"Urolithin A prevents focal cerebral ischemic injury via attenuating apoptosis and neuroinflammation in mice","volume":"448","author":"Lin","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2024.113394_b0160","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.redox.2015.01.002","article-title":"Oxidative stress: a concept in redox biology and medicine","volume":"4","author":"Sies","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.113394_b0165","article-title":"Targeting ferroptosis as a promising therapeutic strategy for ischemia-reperfusion injury","volume":"11","author":"Pan","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2024.113394_b0170","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41392-023-01606-1","article-title":"Targeting ferroptosis opens new avenues for the development of novel therapeutics","volume":"8","author":"Sun","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2024.113394_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.628988","article-title":"Baicalin prevents myocardial ischemia\/reperfusion injury through inhibiting ACSL4 mediated ferroptosis","volume":"12","author":"Fan","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113394_b0180","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.2147\/DDDT.S409232","article-title":"Galangin attenuates myocardial ischemic reperfusion-induced ferroptosis by targeting Nrf2\/Gpx4 signaling pathway","volume":"17","author":"Yang","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2024.113394_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.590226","article-title":"Iron metabolism in ferroptosis","volume":"8","author":"Chen","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.intimp.2024.113394_b0190","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070680","article-title":"Mitochondria in health and disease","volume":"8","author":"Annesley","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.113394_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101777","article-title":"Phosphoglycerate mutase 5 exacerbates cardiac ischemia-reperfusion injury through disrupting mitochondrial quality control","volume":"38","author":"Zhu","year":"2021","journal-title":"Redox Biol."},{"key":"10.1016\/j.intimp.2024.113394_b0200","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.freeradbiomed.2022.01.012","article-title":"Mitochondrial oxidative stress mediated Fe-induced ferroptosis via the NRF2-ARE pathway","volume":"180","author":"Chen","year":"2022","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.intimp.2024.113394_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113572","article-title":"Dexmedetomidine attenuates myocardial ischemia\/reperfusion-induced ferroptosis via AMPK\/GSK-3beta\/Nrf2 axis","volume":"154","author":"Wang","year":"2022","journal-title":"Biomed. Pharmacother."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924019167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924019167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T21:31:46Z","timestamp":1736285506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924019167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":41,"alternative-id":["S1567576924019167"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113394","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urolithin A improves myocardial ischemia\u2013reperfusion injury by attenuating oxidative stress and ferroptosis through Nrf2 pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113394","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113394"}}