{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:28:46Z","timestamp":1791491326877,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204741"],"award-info":[{"award-number":["82204741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113396","type":"journal-article","created":{"date-parts":[[2024,10,17]],"date-time":"2024-10-17T20:35:17Z","timestamp":1729197317000},"page":"113396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"P2","title":["Palmatine alleviates inflammation and modulates ferroptosis against dextran sulfate sodium (DSS)-induced ulcerative colitis"],"prefix":"10.1016","volume":"143","author":[{"given":"Wanli","family":"Ji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113396_b0005","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s10875-007-9110-2","article-title":"Apoptosis inhibitor expressed by macrophages tempers autoimmune colitis and the risk of colitis-based carcinogenesis in TCR\u03b1\/Mice","volume":"27","author":"Haruta","year":"2007","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.intimp.2024.113396_b0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.25122\/jml-2018-0075","article-title":"A review of the diagnosis, prevention, and treatment methods of inflammatory bowel disease","volume":"12","author":"Seyedian","year":"2019","journal-title":"J. Med. Life"},{"key":"10.1016\/j.intimp.2024.113396_b0015","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-pathol-012615-044152","article-title":"Genetics and pathogenesis of inflammatory bowel disease","volume":"11","author":"Liu","year":"2016","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.intimp.2024.113396_b0020","first-page":"20","article-title":"Ferruginol alleviates inflammation in dextran sulfate sodium-induced colitis in mice through inhibiting COX-2, MMP-9 and NF-\u03baB signaling","volume":"10","author":"Xiao-Yan","year":"2020","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"10.1016\/j.intimp.2024.113396_b0025","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/jmf.2017.3944","article-title":"Mangosteen extract prevents dextran sulfate sodium-induced colitis in mice by suppressing NF-\u03baB activation and inflammation","volume":"20","author":"Chae","year":"2017","journal-title":"J. Med. Food"},{"key":"10.1016\/j.intimp.2024.113396_b0030","doi-asserted-by":"crossref","unstructured":"N.A. Molodecky, I.S.S. \u00a7, D.M. Rabi, W.A. Ghali, M. Ferris, G.C., E.I. Benchimol, R. Panaccione, S. Ghosh, H.W. Barkema, Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review, Gastroenterology 142 (2012) 46\u201354.","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"10.1016\/j.intimp.2024.113396_b0035","first-page":"9","article-title":"Management of patients with inflammatory bowel disease: current and future treatments","author":"Wilhelm","year":"2017","journal-title":"Clin. Pharm."},{"key":"10.1016\/j.intimp.2024.113396_b0040","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S1567-7443(07)00218-9","article-title":"Glucocorticoid resistance in inflammatory diseases","volume":"7","author":"Franchimont","year":"2007","journal-title":"NeuroImmune Biol."},{"key":"10.1016\/j.intimp.2024.113396_b0045","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.113396_b0050","first-page":"165","article-title":"Ferroptosis: death by lipid peroxidation","author":"Wan","year":"2016","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.intimp.2024.113396_b0055","doi-asserted-by":"crossref","unstructured":"X. Yao, W. Li, Fang, C. Xiao, X. Wu, M. Li, Z. Luo, Emerging roles of energy metabolism in ferroptosis regulation of tumor cells, Adv. Sci. (Weinheim, Baden-Wurttemberg, Germany) 8 (2021) e2100997.","DOI":"10.1002\/advs.202100997"},{"key":"10.1016\/j.intimp.2024.113396_b0060","first-page":"162","article-title":"Ferrostatin-1 protects HT-22 cells from oxidative toxicity","volume":"15","author":"Jun","year":"2020","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2024.113396_b0065","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.pbiomolbio.2020.04.001","article-title":"Ferroptosis as an emerging target in inflammatory diseases","volume":"155","author":"Mao","year":"2020","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1016\/j.intimp.2024.113396_b0070","first-page":"H1170","article-title":"Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury","volume":"320","author":"Stamenkovic","year":"2021","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.intimp.2024.113396_b0075","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.dld.2021.02.011","article-title":"Furin inhibits epithelial cell injury and alleviates experimental colitis by activating the Nrf2-Gpx4 signaling pathway","volume":"53","author":"Dong","year":"2021","journal-title":"Dig. Liver Dis."},{"key":"10.1016\/j.intimp.2024.113396_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118356","article-title":"Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4","volume":"259","author":"Wang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113396_b0085","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2147\/DDDT.S356307","article-title":"Palmatine protects against MSU-induced gouty arthritis via regulating the NF-\u03baB\/NLRP3 and Nrf2 pathways","volume":"16","author":"Cheng","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2024.113396_b0090","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/09168451.2019.1659714","article-title":"Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells","volume":"84","author":"Shinji","year":"2020","journal-title":"Biosci. Biotech. Bioch."},{"key":"10.1016\/j.intimp.2024.113396_b0095","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phrs.2018.09.010","article-title":"Palmatine ameliorated murine colitis by suppressing tryptophan metabolism and regulating gut microbiota","volume":"137","author":"Zhang","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2024.113396_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113335","article-title":"8-Oxypalmatine, a novel oxidative metabolite of palmatine, exhibits superior anti-colitis effect via regulating Nrf2 and NLRP3 inflammasome","volume":"153","author":"Cheng","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113396_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173267","article-title":"Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17\/EGFR","volume":"882","author":"Chen","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113396_b0110","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molimm.2018.10.015","article-title":"Palmatine attenuated dextran sulfate sodium (DSS)-induced colitis via promoting mitophagy-mediated NLRP3 inflammasome inactivation","volume":"105","author":"Mai","year":"2019","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2024.113396_b0115","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jep.2018.06.001","article-title":"Ficus carica aqueous extract alleviates delayed gastric emptying and recovers ulcerative colitis-enhanced acute functional gastrointestinal disorders in rats","volume":"224","author":"Rtibi","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113396_b0120","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/ibd.20753","article-title":"Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis","volume":"15","author":"Alex","year":"2009","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.intimp.2024.113396_b0125","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.intimp.2024.113396_b0130","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41586-019-1705-2","article-title":"The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis","volume":"575","author":"Bersuker","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.113396_b0135","doi-asserted-by":"crossref","first-page":"1610251","DOI":"10.1155\/2021\/1610251","article-title":"Xi Lei San Attenuates dextran sulfate sodium-induced colitis in rats and TNF-\u03b1-stimulated colitis in CACO2 cells: involvement of the NLRP3 inflammasome and autophagy","volume":"2021","author":"Tao","year":"2021","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2024.113396_b0140","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.chom.2017.12.017","article-title":"Intestinal epithelial cell autophagy is required to protect against TNF-induced apoptosis during chronic colitis in mice","volume":"23","author":"Pott","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.intimp.2024.113396_b0145","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41419-020-2299-1","article-title":"Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis","volume":"11","author":"Xu","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.113396_b0150","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.immuni.2023.01.023","article-title":"Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes","volume":"56","author":"Panda","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.113396_b0155","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.113396_b0160","first-page":"91","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","author":"Doll","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2024.113396_b0165","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1021\/acschembio.5b00245","article-title":"Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death","volume":"10","author":"Dixon","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.intimp.2024.113396_b0170","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.bbrc.2016.08.124","article-title":"Identification of ACSL4 as a biomarker and contributor of ferroptosis","volume":"478","author":"Yuan","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.113396_b0175","doi-asserted-by":"crossref","unstructured":"B.C. A, Z.C. A, M.L. A, X.G. A, Y.C. A, Y.W. A, Z.W. A, D.C. B, H.S. A, Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects, Brain Res. Bull. 153 (2019) 122\u2013132.","DOI":"10.1016\/j.brainresbull.2019.08.013"},{"key":"10.1016\/j.intimp.2024.113396_b0180","unstructured":"P.W.-J.Z.-Y.Y.J.-W.J.-F.C.F. Rong-biao, N2L,a novel lipoic acid-niacin dimer,attenuates ferroptosis and decreases lipid peroxidation in HT22 cells, Chin. J. Pharm. Toxicol. 35 (2021) 654\u2013655."},{"key":"10.1016\/j.intimp.2024.113396_b0185","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41569-022-00735-4","article-title":"The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease","volume":"20","author":"Fang","year":"2023","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.intimp.2024.113396_b0190","doi-asserted-by":"crossref","first-page":"153551","DOI":"10.1016\/j.phymed.2021.153551","article-title":"Shuganning injection, a traditional Chinese patent medicine, induces ferroptosis and suppresses tumor growth in triple-negative breast cancer cells","author":"Du","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.113396_b0195","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1136\/gutjnl-2014-307720","article-title":"Iron fortification adversely affects the gut microbiome, increases pathogen abundance and induces intestinal inflammation in Kenyan infants","volume":"64","author":"Jaeggi","year":"2015","journal-title":"Gut"},{"key":"10.1016\/j.intimp.2024.113396_b0200","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s12276-022-00829-6","article-title":"The Nrf2 antioxidant defense system in intervertebral disc degeneration: molecular insights","volume":"54","author":"Xiang","year":"2022","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2024.113396_b0205","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2020.06.005","article-title":"Ferroptosis mediated DSS-induced ulcerative colitis associated with Nrf2\/HO-1 signaling pathway","author":"Chen","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.intimp.2024.113396_b0210","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1089\/ars.2010.3400","article-title":"Thiol-based redox switches and gene regulation","volume":"14","author":"Helmann","year":"2011","journal-title":"Antioxidants Redox Signalling"},{"key":"10.1016\/j.intimp.2024.113396_b0215","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13020-022-00652-1","article-title":"Therapeutic material basis and underling mechanisms of Shaoyao Decoction-exerted alleviation effects of colitis based on GPX4-regulated ferroptosis in epithelial cells","volume":"17","author":"Li","year":"2022","journal-title":"Chin. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924019180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924019180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T02:31:52Z","timestamp":1736303512000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924019180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":43,"alternative-id":["S1567576924019180"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113396","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Palmatine alleviates inflammation and modulates ferroptosis against dextran sulfate sodium (DSS)-induced ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113396"}}