{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:25:04Z","timestamp":1786991104310,"version":"build-2736575974"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113409","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:48:53Z","timestamp":1729212533000},"page":"113409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"P2","title":["Apigenin alleviates Sj\u00f6gren\u2019s syndrome-induced salivary gland epithelial cell ferroptosis via ER\u03b1 signaling-mediated regulation of the ATF3\/SLC7A1l axis"],"prefix":"10.1016","volume":"143","author":[{"given":"Qianwen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janak L.","family":"Pathak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9482","key":"10.1016\/j.intimp.2024.113409_b0005","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren's syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.intimp.2024.113409_b0010","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1093\/rheumatology\/kez027","article-title":"Pain and fatigue in primary Sj\u00f6gren's syndrome","volume":"60","author":"Omdal","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2024.113409_b0015","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2023.05.027","article-title":"Interferon-\u03b3 induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK\/STAT1-mediated inhibition of system Xc","volume":"205","author":"Cao","year":"2023","journal-title":"Free Radic. Biol. Med."},{"issue":"10","key":"10.1016\/j.intimp.2024.113409_b0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1167\/iovs.63.10.3","article-title":"AKR1C1 protects corneal epithelial cells against oxidative stress-mediated ferroptosis in dry eye","volume":"63","author":"Zuo","year":"2022","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2024.113409_b0025","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jaut.2012.01.004","article-title":"Sex steroids in Sj\u00f6gren's syndrome","volume":"39","author":"Konttinen","year":"2012","journal-title":"J. Autoimmun."},{"issue":"4","key":"10.1016\/j.intimp.2024.113409_b0030","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0002-9440(10)63505-5","article-title":"Development of autoimmune exocrinopathy resembling Sj\u00f6gren's syndrome in estrogen-deficient mice of healthy background","volume":"163","author":"Ishimaru","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2024.113409_b0035","article-title":"Apigenin, a single active component of herbal extract, alleviates xerostomia via ER\u03b1-mediated upregulation of AQP5 activation","volume":"13","author":"Wei","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"19","key":"10.1016\/j.intimp.2024.113409_b0040","doi-asserted-by":"crossref","first-page":"10155","DOI":"10.1073\/pnas.1917946117","article-title":"Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis","volume":"117","author":"Shao","year":"2020","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.intimp.2024.113409_b0045","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00395-018-0698-6","article-title":"Activating transcription factor 3 in cardiovascular diseases: a potential therapeutic target","volume":"113","author":"Zhou","year":"2018","journal-title":"Basic Res. Cardiol."},{"issue":"2_suppl","key":"10.1016\/j.intimp.2024.113409_b0050","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/0271678X231171999","article-title":"The multifaceted roles of activating transcription factor 3 (ATF3) in inflammatory responses - potential target to regulate neuroinflammation in acute brain injury","volume":"43","author":"Li","year":"2023","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"10","key":"10.1016\/j.intimp.2024.113409_b0055","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/s41419-023-06182-4","article-title":"Macrophages originated IL-33\/ST2 inhibits ferroptosis in endometriosis via the ATF3\/SLC7A11 axis","volume":"14","author":"Wu","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.intimp.2024.113409_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176009","article-title":"Butyrate enhances erastin-induced ferroptosis of osteosarcoma cells via regulating ATF3\/SLC7A11 pathway","volume":"957","author":"Nie","year":"2023","journal-title":"Eur. J. Pharmacol."},{"issue":"7915","key":"10.1016\/j.intimp.2024.113409_b0065","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41586-022-04754-6","article-title":"Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes","volume":"606","author":"Maschalidi","year":"2022","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.intimp.2024.113409_b0070","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1002\/cpph.65","article-title":"Spontaneous model of Sj\u00f6gren's syndrome in NOD mice","volume":"86","author":"Scuron","year":"2019","journal-title":"Curr. Protoc. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113409_b0075","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.archoralbio.2018.11.001","article-title":"Hyperoxia reduces salivary secretion by inducing oxidative stress in mice","volume":"98","author":"Tajiri","year":"2019","journal-title":"Arch. Oral Biol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113409_b0080","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"issue":"7873","key":"10.1016\/j.intimp.2024.113409_b0085","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.intimp.2024.113409_b0090","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1002\/pro.3902","article-title":"PyXlinkViewer: a flexible tool for visualization of protein chemical crosslinking data within the PyMOL molecular graphics system","volume":"29","author":"Schiffrin","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.intimp.2024.113409_b0095","doi-asserted-by":"crossref","first-page":"e07454","DOI":"10.7554\/eLife.07454","article-title":"Contacts-based prediction of binding affinity in protein-protein complexes","volume":"4","author":"Vangone","year":"2015","journal-title":"Elife"},{"issue":"23","key":"10.1016\/j.intimp.2024.113409_b0100","doi-asserted-by":"crossref","first-page":"3676","DOI":"10.1093\/bioinformatics\/btw514","article-title":"PRODIGY: a web server for predicting the binding affinity of protein-protein complexes","volume":"32","author":"Xue","year":"2016","journal-title":"Bioinformatics"},{"issue":"14","key":"10.1016\/j.intimp.2024.113409_b0105","doi-asserted-by":"crossref","first-page":"2632","DOI":"10.1016\/j.jmb.2014.04.017","article-title":"Proteins feel more than they see: fine-tuning of binding affinity by properties of the non-interacting surface","volume":"426","author":"Kastritis","year":"2014","journal-title":"J. Mol. Biol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113409_b0110","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.jmb.2016.12.004","article-title":"Arpeggio: a web server for calculating and visualising interatomic interactions in protein structures","volume":"429","author":"Jubb","year":"2017","journal-title":"J. Mol. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113409_b0115","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1080\/17460441.2022.2002298","article-title":"The prediction of protein-ligand unbinding for modern drug discovery","volume":"17","author":"Zhang","year":"2022","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.intimp.2024.113409_b0120","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sj\u00f6gren syndrome","volume":"2","author":"Brito-Zer\u00f3n","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"10","key":"10.1016\/j.intimp.2024.113409_b0125","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.autrev.2018.05.005","article-title":"Clinical and immunological parameters of Sj\u00f6gren's syndrome","volume":"17","author":"Psianou","year":"2018","journal-title":"Autoimmun. Rev."},{"issue":"8","key":"10.1016\/j.intimp.2024.113409_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19082369","article-title":"Modulation of apoptosis by cytotoxic mediators and cell-survival molecules in Sj\u00f6gren's syndrome","volume":"19","author":"Nakamura","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.113409_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167121","article-title":"CD4 T cell-secreted IFN-\u03b3 in Sj\u00f6gren's syndrome induces salivary gland epithelial cell ferroptosis","volume":"1870","author":"Zhou","year":"2024","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.intimp.2024.113409_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2024.04.003","article-title":"Downregulated GPX4 in salivary gland epithelial cells contributes to salivary secretion dysfunction in Sjogren's syndrome via lipid ROS\/pSTAT4\/AQP5 axis","volume":"218","author":"Zhou","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.113409_b0145","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12988","article-title":"Interplay of anti-SSA\/SSB status and hypertension in determining cardiovascular risk in primary Sj\u00f6gren's syndrome","volume":"287","author":"Bartoloni","year":"2020","journal-title":"J. Intern. Med."},{"issue":"6","key":"10.1016\/j.intimp.2024.113409_b0150","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/ard.2009.110619","article-title":"EULAR Sjogren's syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjogren's syndrome","volume":"69","author":"Seror","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.intimp.2024.113409_b0155","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1002\/ddr.21964","article-title":"Quercetin ameliorates salivary gland apoptosis and inflammation in primary Sj\u00f6gren's syndrome through regulation of the leptin\/OB-R signaling","volume":"83","author":"Chang","year":"2022","journal-title":"Drug Dev. Res."},{"issue":"2","key":"10.1016\/j.intimp.2024.113409_b0160","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/08923973.2017.1418881","article-title":"Cardamonin inhibits pro-inflammatory cytokine production and suppresses NO pathway in PBMCs from patients with primary Sj\u00f6gren's syndrome","volume":"40","author":"Benchabane","year":"2018","journal-title":"Immunopharmacol. Immunotoxicol."},{"issue":"13","key":"10.1016\/j.intimp.2024.113409_b0165","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311179","article-title":"Outline of salivary gland pathogenesis of Sj\u00f6gren's syndrome and current therapeutic approaches","volume":"24","author":"Yura","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2024.113409_b0170","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s12016-007-8007-4","article-title":"The role of epithelial cells in the pathogenesis of Sj\u00f6gren's syndrome","volume":"32","author":"Manoussakis","year":"2007","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113409_b0175","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/s41590-021-00993-3","article-title":"Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity","volume":"22","author":"Li","year":"2021","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113409_b0180","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.immuni.2024.03.019","article-title":"Ironing out the role of ferroptosis in immunity","volume":"57","author":"Bell","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2024.113409_b0185","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.916664","article-title":"Ferroptosis and autoimmune diseases","volume":"13","author":"Lai","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113409_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121331","article-title":"Formononetin ameliorates ferroptosis-associated fibrosis in renal tubular epithelial cells and in mice with chronic kidney disease by suppressing the Smad3\/ATF3\/SLC7A11 signaling","volume":"315","author":"Zhu","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113409_b0195","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jare.2020.07.007","article-title":"Quercetin alleviates acute kidney injury by inhibiting ferroptosis","volume":"28","author":"Wang","year":"2021","journal-title":"J. Adv. Res."},{"issue":"6","key":"10.1016\/j.intimp.2024.113409_b0200","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","article-title":"Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification","volume":"102","author":"Ye","year":"2022","journal-title":"Kidney Int."},{"issue":"35","key":"10.1016\/j.intimp.2024.113409_b0205","doi-asserted-by":"crossref","first-page":"32899","DOI":"10.1074\/jbc.M305456200","article-title":"Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element\/ATF site of the proglucagon gene promoter","volume":"278","author":"Wang","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"16","key":"10.1016\/j.intimp.2024.113409_b0210","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1128\/MCB.00159-12","article-title":"The stress response mediator ATF3 represses androgen signaling by binding the androgen receptor","volume":"32","author":"Wang","year":"2012","journal-title":"Mol. Cell Biol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924019313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924019313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T21:32:19Z","timestamp":1736285539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924019313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"alternative-id":["S1567576924019313"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113409","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apigenin alleviates Sj\u00f6gren\u2019s syndrome-induced salivary gland epithelial cell ferroptosis via ER\u03b1 signaling-mediated regulation of the ATF3\/SLC7A1l axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113409"}}