{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:50:57Z","timestamp":1792525857308,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113435","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T03:54:58Z","timestamp":1730692498000},"page":"113435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"P3","title":["Procyanidin B2 targeted CCR7 expression to inhibit the senescence-associated secretory phenotype through the NF-\u03baB pathway to promote osteogenic differentiation of periodontal ligament stem cells in periodontitis"],"prefix":"10.1016","volume":"143","author":[{"given":"Junwei","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilan","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuemeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.intimp.2024.113435_b0005","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1177\/0022034519846113","article-title":"Periodontal Medicine: 100 Years of Progress","volume":"98","author":"Beck","year":"2019","journal-title":"J. Dent. Res."},{"issue":"17","key":"10.1016\/j.intimp.2024.113435_b0010","doi-asserted-by":"crossref","first-page":"9312","DOI":"10.3390\/ijerph18179312","article-title":"Analysis the Link between Periodontal Diseases and Alzheimer's Disease: A Systematic Review","volume":"18","author":"Borsa","year":"2021","journal-title":"Int J Env Res Pub He"},{"issue":"4","key":"10.1016\/j.intimp.2024.113435_b0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1754-4505.2009.00082.x","article-title":"Effects of human aging on periodontal tissues","volume":"29","author":"Huttner","year":"2009","journal-title":"Spec. Care Dentist."},{"issue":"1","key":"10.1016\/j.intimp.2024.113435_b0020","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/prd.12135","article-title":"Aging, inflammation, immunity and periodontal disease","volume":"72","author":"Ebersole","year":"2000","journal-title":"Periodontol"},{"issue":"1","key":"10.1016\/j.intimp.2024.113435_b0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.job.2013.09.001","article-title":"Aging and its impact on innate immunity and inflammation: Implications for periodontitis","volume":"56","author":"Hajishengallis","year":"2014","journal-title":"J. Oral Biosci."},{"issue":"10","key":"10.1016\/j.intimp.2024.113435_b0030","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3390\/biology11101419","article-title":"Cellular Senescence and Periodontitis: Mechanisms and Therapeutics","volume":"11","author":"Chen","year":"2022","journal-title":"Biology-Basel"},{"key":"10.1016\/j.intimp.2024.113435_b0035","doi-asserted-by":"crossref","unstructured":"M.Y. Kuniko Ikegami, Mio Suzuki, Tomomi Nakamura, Koki Hashimoto, Jirouta Kitagaki, Manabu Yanagita, Masahiro Kitamura, Shinya Murakami Cellular senescence with SASP in periodontal ligament cells triggers inflammation in aging periodontal tissue, Aging (Albany NY) 15(5) (2023) 1279-1305.","DOI":"10.18632\/aging.204569"},{"key":"10.1016\/j.intimp.2024.113435_b0040","doi-asserted-by":"crossref","unstructured":"B.M. Seo, M. Miura, S. Gronthos, Investigation of multipotent postnatal stem cells from human periodontal ligament. (vol 364, pg 149, 2004), Lancet 364(9447) (2004) 1756-1756.","DOI":"10.1016\/S0140-6736(04)17397-2"},{"issue":"2","key":"10.1016\/j.intimp.2024.113435_b0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00441-014-1799-7","article-title":"Repeated lipopolysaccharide stimulation promotes cellular senescence in human dental pulp stem cells (DPSCs)","volume":"356","author":"Feng","year":"2014","journal-title":"Cell Tissue Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113435_b0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1089\/scd.2010.0040","article-title":"Markers Distinguishing Mesenchymal Stem Cells from Fibroblasts Are Downregulated with Passaging","volume":"20","author":"Halfon","year":"2011","journal-title":"Stem Cells Dev."},{"issue":"1","key":"10.1016\/j.intimp.2024.113435_b0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s13287-022-03093-7","article-title":"Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543\/PTEN\/PI3K\/AKT\/mTOR signaling pathway in the inflammatory microenvironment","volume":"13","author":"Zhao","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.intimp.2024.113435_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2023.137359","article-title":"Procyanidin B2: A promising multi-functional food-derived pigment for human diseases","volume":"433","author":"Chen","year":"2024","journal-title":"Food Chem."},{"issue":"9","key":"10.1016\/j.intimp.2024.113435_b0065","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.3390\/ijms24097930","article-title":"Procyanidin B2 Attenuates Sepsis-Induced Acute Lung Injury via Regulating Hippo\/Rho\/PI3K\/NF-\u03baB Signaling Pathway","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7","key":"10.1016\/j.intimp.2024.113435_b0070","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1002\/jor.25492","article-title":"Procyanidin B2 alleviates oxidative stress-induced nucleus pulposus cells apoptosis through upregulating Nrf2 via PI3K-Akt pathway","volume":"41","author":"Zou","year":"2023","journal-title":"J. Orthop. Res."},{"issue":"11","key":"10.1016\/j.intimp.2024.113435_b0075","doi-asserted-by":"crossref","first-page":"e21309","DOI":"10.1016\/j.heliyon.2023.e21309","article-title":"Protective effect and mechanism of procyanidin B2 against hypoxic injury of cardiomyocytes","volume":"9","author":"Xue","year":"2023","journal-title":"Heliyon"},{"issue":"14","key":"10.1016\/j.intimp.2024.113435_b0080","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.3390\/ijms23147769","article-title":"Procyanidin B2 Alleviates Heat-Induced Oxidative Stress through the Nrf2 Pathway in Bovine Mammary Epithelial Cells","volume":"23","author":"Wang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.intimp.2024.113435_b0085","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.jid.2020.02.032","article-title":"Research Techniques Made Simple: Whole-Transcriptome Sequencing by RNA-Seq for Diagnosis of Monogenic Disorders","volume":"140","author":"Saeidian","year":"2020","journal-title":"J, Invest. Dermatol."},{"key":"10.1016\/j.intimp.2024.113435_b0090","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.807574","article-title":"Transcriptome Analysis Reveals the Anti-cancerous Mechanism of Licochalcone A on Human Hepatoma Cell HepG2","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.intimp.2024.113435_b0095","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.csbj.2024.02.002","article-title":"Comprehensive integration of single-cell RNA and transcriptome RNA sequencing to establish a pyroptosis-related signature for improving prognostic prediction of gastric cancer","volume":"23","author":"Li","year":"2024","journal-title":"Comput Struct Biotec"},{"key":"10.1016\/j.intimp.2024.113435_b0100","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbrc.2020.11.081","article-title":"Assessing the effect and related mechanism of naringenin on the proliferation, osteogenic differentiation and endothelial differentiation of human periodontal ligament stem cells","volume":"534","author":"Zhang","year":"2021","journal-title":"Biochem Bioph Res Co"},{"issue":"8","key":"10.1016\/j.intimp.2024.113435_b0105","doi-asserted-by":"crossref","first-page":"7133","DOI":"10.3390\/ijms24087133","article-title":"Osteogenic Differentiation Effect of Human Periodontal Ligament Stem-Cell Initial Cell Density on Autologous Cells and Human Bone Marrow Stromal Cells","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"15","key":"10.1016\/j.intimp.2024.113435_b0110","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.3390\/foods11152374","article-title":"Comparison of Maillard-Type Glycated Collagen with Alginate Oligosaccharide and Glucose: Its Characterization, Antioxidant Activity, and Cytoprotective Activity on H2O2-Induced Cell Oxidative Damage","volume":"11","author":"Yang","year":"2022","journal-title":"Foods"},{"issue":"3","key":"10.1016\/j.intimp.2024.113435_b0115","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1080\/21655979.2022.2036915","article-title":"Kruppel-like factor 5-mediated Sirtuin6 promotes osteogenic differentiation and inhibits inflammatory injury of lipopolysaccharide-induced periodontal membrane stem cells by inhibiting nuclear factor kappa-B pathway","volume":"13","author":"Li","year":"2022","journal-title":"Bioengineered"},{"issue":"3","key":"10.1016\/j.intimp.2024.113435_b0120","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1007\/s12253-018-0464-y","article-title":"Ki67 and P53 in Relation to Disease Progression in Metastatic Pancreatic Cancer: a Single Institution Analysis","volume":"25","author":"Temraz","year":"2019","journal-title":"Pathol. Oncol. Res."},{"key":"10.1016\/j.intimp.2024.113435_b0125","doi-asserted-by":"crossref","first-page":"e13722","DOI":"10.7554\/eLife.13722","article-title":"The cell proliferation antigen Ki-67 organises heterochromatin","volume":"5","author":"Sobecki","year":"2016","journal-title":"Elife"},{"issue":"17","key":"10.1016\/j.intimp.2024.113435_b0130","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1158\/1078-0432.CCR-12-3630","article-title":"Lamin B1 Is a Novel Therapeutic Target of Betulinic Acid in Pancreatic Cancer","volume":"19","author":"Li","year":"2013","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.intimp.2024.113435_b0135","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/615486","article-title":"Mechanisms of Bone Resorption in Periodontitis","volume":"2015","author":"Hienz","year":"2015","journal-title":"J. Immunol. Res."},{"issue":"7","key":"10.1016\/j.intimp.2024.113435_b0140","first-page":"787","article-title":"Staging and grading of periodontitis: Framework and proposal of a new classification and case definition (vol 45, pg S149, 2018)","volume":"46","author":"Tonetti","year":"2019","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.intimp.2024.113435_b0145","first-page":"1","article-title":"Global Prevalence of Periodontal Disease and Lack of Its Surveillance","volume":"2020","author":"Nazir","year":"2020","journal-title":"Scientific World Journal"},{"issue":"6","key":"10.1016\/j.intimp.2024.113435_b0150","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/jre.12785","article-title":"Prevalence and severity of periodontal disease in a historical Austrian population","volume":"55","author":"Bertl","year":"2020","journal-title":"J. Periodontal Res."},{"issue":"54","key":"10.1016\/j.intimp.2024.113435_b0155","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1600-0757.2009.00333.x","article-title":"Contribution of lipopolysaccharide to periodontitis","volume":"2000","author":"Jain","year":"2010","journal-title":"Periodontol"},{"issue":"4","key":"10.1016\/j.intimp.2024.113435_b0160","doi-asserted-by":"crossref","first-page":"665","DOI":"10.3233\/JAD-121918","article-title":"Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue","volume":"36","author":"Poole","year":"2013","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.intimp.2024.113435_b0165","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2147\/IJN.S150897","article-title":"Human \u03b2-defensin 3-combined gold nanoparticles for enhancement of osteogenic differentiation of human periodontal ligament cells in inflammatory microenvironments","volume":"13","author":"Zhou","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"41","key":"10.1016\/j.intimp.2024.113435_b0170","doi-asserted-by":"crossref","first-page":"15048","DOI":"10.1021\/acs.jafc.3c03119","article-title":"Vitisin A, as a Type of Pyranoanthocyanin, Suppresses Inflammation by Restricting Hematopoietic Stem Cell Differentiation toward Monocytes in Bone Marrow","volume":"71","author":"Li","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2024.113435_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115220","article-title":"LPS-induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis","volume":"132","author":"Aquino-Martinez","year":"2020","journal-title":"Bone"},{"issue":"10","key":"10.1016\/j.intimp.2024.113435_b0180","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/JPER.20-0529","article-title":"Senescent cells exacerbate chronic inflammation and contribute to periodontal disease progression in old mice","volume":"92","author":"Aquino-Martinez","year":"2021","journal-title":"J. Periodontol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113435_b0185","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/cells9010193","article-title":"Visfatin Induces Senescence of Human Dental Pulp Cells","volume":"9","author":"Ok","year":"2020","journal-title":"Cells-Basel"},{"issue":"5","key":"10.1016\/j.intimp.2024.113435_b0190","article-title":"High copper levels induce premature senescence in 3T3-L1 preadipocytes","volume":"1871","author":"de Oliveira","year":"2024","journal-title":"BBA-Mol. Cell. Res."},{"key":"10.1016\/j.intimp.2024.113435_b0195","first-page":"1","article-title":"MDM2 accelerated renal senescence via ubiquitination and degradation of HDAC1","author":"Xiang","year":"2024","journal-title":"Acta Pharmacol. Sin."},{"issue":"8","key":"10.1016\/j.intimp.2024.113435_b0200","first-page":"6673","article-title":"Senescent characteristics of human corneal endothelial cells upon ultraviolet-A exposure","volume":"16","author":"Numa","year":"2024","journal-title":"Aging-Us"},{"issue":"2","key":"10.1016\/j.intimp.2024.113435_b0205","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1474-9726.2012.00795.x","article-title":"A senescent cell bystander effect: senescence-induced senescence","volume":"11","author":"Nelson","year":"2012","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.intimp.2024.113435_b0210","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/CIRCRESAHA.111.261388","article-title":"Aging and Atherosclerosis Mechanisms, Functional Consequences, and Potential Therapeutics for Cellular Senescence","volume":"111","author":"Wang","year":"2012","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.intimp.2024.113435_b0215","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/pharmaceutics15020461","article-title":"CCR7 Mediates Dendritic-Cell-Derived Exosome Migration and Improves Cardiac Function after Myocardial Infarction","volume":"15","author":"Zhang","year":"2023","journal-title":"Pharmaceutics"},{"issue":"6","key":"10.1016\/j.intimp.2024.113435_b0220","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.3390\/antiox12061165","article-title":"Dietary Curcumin Attenuates Hepatic Cellular Senescence by Suppressing the MAPK\/NF-\u03baB Signaling Pathway in Aged Mice","volume":"12","author":"Lee","year":"2023","journal-title":"Antioxidants-Basel"},{"issue":"3","key":"10.1016\/j.intimp.2024.113435_b0225","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.3390\/ijms24032365","article-title":"Dendrobine Alleviates Cellular Senescence and Osteoarthritis via the ROS\/NF-\u03baB Axis","volume":"24","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113435_b0230","doi-asserted-by":"crossref","unstructured":"H.-D.F. Uta E H\u00f6pken, Dagmar Meyer, Michael Hinz, Korinna Leder, Harald Stein, Martin Lipp, Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs, Blood 99(4) (2002) 1109-1116.","DOI":"10.1182\/blood.V99.4.1109"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692401957X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692401957X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:19:28Z","timestamp":1733977168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692401957X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":46,"alternative-id":["S156757692401957X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113435","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Procyanidin B2 targeted CCR7 expression to inhibit the senescence-associated secretory phenotype through the NF-\u03baB pathway to promote osteogenic differentiation of periodontal ligament stem cells in periodontitis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113435"}}