{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:23:46Z","timestamp":1783110226391,"version":"3.54.6"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113485","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T08:28:33Z","timestamp":1730449713000},"page":"113485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"P3","title":["ATP citrate lyase ablation hampers exocrine regeneration via TLR4\/NF-kappaB signaling after acute pancreatitis in mice"],"prefix":"10.1016","volume":"143","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2007-1258","authenticated-orcid":false,"given":"Yu-pu","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-zhu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10252","key":"10.1016\/j.intimp.2024.113485_b0005","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S0140-6736(20)31310-6","article-title":"Acute pancreatitis","volume":"396","author":"Boxhoorn","year":"2020","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.intimp.2024.113485_b0010","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gutjnl-2022-327448","article-title":"Activated regulatory T-cells promote duodenal bacterial translocation into necrotic areas in severe acute pancreatitis","volume":"72","author":"Glaubitz","year":"2023","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.intimp.2024.113485_b0015","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1042\/CS20211031","article-title":"Inhibition of Notch activity suppresses hyperglycemia-augmented polarization of macrophages to the M1 phenotype and alleviates acute pancreatitis","volume":"136","author":"Hu","year":"2022","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"10.1016\/j.intimp.2024.113485_b0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41419-023-05655-w","article-title":"MLKL signaling regulates macrophage polarization in acute pancreatitis through CXCL10","volume":"14","author":"Peng","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.113485_b0025","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1053\/j.gastro.2021.09.029","article-title":"miR-802 Suppresses Acinar-to-Ductal Reprogramming During Early Pancreatitis and Pancreatic Carcinogenesis","volume":"162","author":"Ge","year":"2022","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.intimp.2024.113485_b0030","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/path.4595","article-title":"Serotonin promotes acinar dedifferentiation following pancreatitis-induced regeneration in the adult pancreas","volume":"237","author":"Saponara","year":"2015","journal-title":"J. Pathol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113485_b0035","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1002\/path.4440","article-title":"p21WAF1\/Cip1limits senescence and acinar-to-ductal metaplasia formation during pancreatitis","volume":"235","author":"Grabliauskaite","year":"2015","journal-title":"J. Pathol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113485_b0040","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1053\/j.gastro.2015.08.026","article-title":"Neutrophil Extracellular Traps Induce Trypsin Activation, Inflammation, and Tissue Damage in Mice With Severe Acute Pancreatitis","volume":"149","author":"Merza","year":"2015","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.intimp.2024.113485_b0045","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1083\/jcb.201301001","article-title":"Macrophage-secreted cytokines drive pancreatic acinar-to-ductal metaplasia through NF-kappaB and MMPs","volume":"202","author":"Liou","year":"2013","journal-title":"J. Cell Biol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113485_b0050","doi-asserted-by":"crossref","first-page":"534","DOI":"10.7150\/ijms.51618","article-title":"The Role of Pancreatic Infiltrating Innate Immune Cells in Acute Pancreatitis","volume":"18","author":"Peng","year":"2021","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.intimp.2024.113485_b0055","doi-asserted-by":"crossref","first-page":"1362727","DOI":"10.3389\/fimmu.2024.1362727","article-title":"Toll-like receptor 4 in pancreatic damage and immune infiltration in acute pancreatitis","volume":"15","author":"Mattke","year":"2024","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.intimp.2024.113485_b0060","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jcmgh.2022.07.013","article-title":"USP25 Deficiency Exacerbates Acute Pancreatitis via Up-Regulating TBK1-NF-kappaB Signaling in Macrophages","volume":"14","author":"Liu","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"18","key":"10.1016\/j.intimp.2024.113485_b0065","doi-asserted-by":"crossref","first-page":"7259","DOI":"10.1074\/jbc.RA118.006685","article-title":"ATP-citrate lyase multimerization is required for coenzyme-A substrate binding and catalysis","volume":"294","author":"Bazilevsky","year":"2019","journal-title":"J. Biol. Chem."},{"issue":"7753","key":"10.1016\/j.intimp.2024.113485_b0070","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41586-019-1095-5","article-title":"Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle","volume":"568","author":"Verschueren","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.intimp.2024.113485_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.632526","article-title":"Exploring the Role of ATP-Citrate Lyase in the Immune System","volume":"12","author":"Dominguez","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.intimp.2024.113485_b0080","doi-asserted-by":"crossref","first-page":"9602","DOI":"10.1096\/fj.201900213R","article-title":"ATP-citrate lyase is an epigenetic regulator to promote obesity-related kidney injury","volume":"33","author":"Chen","year":"2019","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.intimp.2024.113485_b0085","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1158\/2159-8290.CD-18-0567","article-title":"Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis","volume":"9","author":"Carrer","year":"2019","journal-title":"Cancer Discov"},{"issue":"46","key":"10.1016\/j.intimp.2024.113485_b0090","doi-asserted-by":"crossref","first-page":"24534","DOI":"10.1002\/anie.202107223","article-title":"High-Throughput Single-Cell Mass Spectrometry Reveals Abnormal Lipid Metabolism in Pancreatic Ductal Adenocarcinoma","volume":"60","author":"Liu","year":"2021","journal-title":"Angew Chem Int Ed Engl"},{"issue":"1","key":"10.1016\/j.intimp.2024.113485_b0095","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbrc.2018.01.008","article-title":"beta cells can be generated from cytokeratin 5-positive cells after cerulein-induced pancreatitis in adult mice","volume":"496","author":"Shi","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.intimp.2024.113485_b0100","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/s41419-021-04160-2","article-title":"Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2024.113485_b0105","doi-asserted-by":"crossref","first-page":"G838","DOI":"10.1152\/ajpgi.00102.2018","article-title":"Inhibition of endoplasmic reticulum stress by 4-phenylbutyric acid prevents vital organ injury in rat acute pancreatitis","volume":"315","author":"Hong","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113485_b0110","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1053\/gast.1996.v110.pm8566606","article-title":"Transforming growth factor beta promotes development of fibrosis after repeated courses of acute pancreatitis in mice","volume":"110","author":"Van Laethem","year":"1996","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.intimp.2024.113485_b0115","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1136\/gut.2006.105833","article-title":"Suppression of transforming growth factor beta signalling aborts caerulein induced pancreatitis and eliminates restricted stimulation at high caerulein concentrations","volume":"56","author":"Wildi","year":"2007","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.intimp.2024.113485_b0120","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1053\/j.gastro.2021.08.033","article-title":"Novel Circulating and Tissue Monocytes as Well as Macrophages in Pancreatitis and Recovery","volume":"161","author":"Manohar","year":"2021","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.intimp.2024.113485_b0125","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1053\/j.gastro.2023.05.028","article-title":"Detailed Characteristics of Post-discharge Mortality in Acute Pancreatitis","volume":"165","author":"Czapari","year":"2023","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.intimp.2024.113485_b0130","doi-asserted-by":"crossref","first-page":"e109463","DOI":"10.15252\/embj.2021109463","article-title":"ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration","volume":"41","author":"Umemoto","year":"2022","journal-title":"EMBO J."},{"issue":"11","key":"10.1016\/j.intimp.2024.113485_b0135","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1016\/j.celrep.2017.11.038","article-title":"ATP Citrate Lyase Regulates Myofiber Differentiation and Increases Regeneration by Altering Histone Acetylation","volume":"21","author":"Das","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.intimp.2024.113485_b0140","article-title":"Nuclear Acly protects the liver from ischemia-reperfusion injury","author":"Gao","year":"2023","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.intimp.2024.113485_b0145","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41419-023-05932-8","article-title":"ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.113485_b0150","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12967-023-04431-w","article-title":"ACLY as a modulator of liver cell functions and its role in Metabolic Dysfunction-Associated Steatohepatitis","volume":"21","author":"Convertini","year":"2023","journal-title":"J Transl Med"},{"issue":"11","key":"10.1016\/j.intimp.2024.113485_b0155","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.3390\/cells10112962","article-title":"ACLY Nuclear Translocation in Human Macrophages Drives Proinflammatory Gene Expression by NF-kappaB Acetylation","volume":"10","author":"Santarsiero","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.intimp.2024.113485_b0160","first-page":"347","article-title":"Reduction in O-GlcNAcylation Mitigates the Severity of Inflammatory Response in Cerulein-Induced Acute Pancreatitis in a Mouse Model","volume":"11","author":"Moore","year":"2022","journal-title":"Biology (Basel)"},{"issue":"13","key":"10.1016\/j.intimp.2024.113485_b0165","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.3390\/ijms22136871","article-title":"Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-kappaB Signaling Pathway in Mice","volume":"22","author":"Zhou","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.intimp.2024.113485_b0170","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/j.gastro.2012.09.059","article-title":"Activation of nuclear factor-kappaB in acinar cells increases the severity of pancreatitis in mice","volume":"144","author":"Huang","year":"2013","journal-title":"Gastroenterology"},{"issue":"3","key":"10.1016\/j.intimp.2024.113485_b0175","doi-asserted-by":"crossref","first-page":"411","DOI":"10.5009\/gnl14050","article-title":"Pyrrolidine Dithiocarbamate Inhibits Nuclear Factor kappaB and Toll-Like Receptor 4 Expression in Rats with Acute Necrotizing Pancreatitis","volume":"9","author":"Xu","year":"2015","journal-title":"Gut Liver"},{"issue":"4","key":"10.1016\/j.intimp.2024.113485_b0180","doi-asserted-by":"crossref","first-page":"591","DOI":"10.3390\/biom11040591","article-title":"The Initial Course of IL1\u03b2, IL-6, IL-8, IL-10, IL-12, IFN-\u03b3 and TNF-\u03b1 with Regard to Severity Grade in Acute Pancreatitis","volume":"11","author":"Sternby","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.intimp.2024.113485_b0185","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ajpath.2015.09.022","article-title":"Loss of Periostin Results in Impaired Regeneration and Pancreatic Atrophy after Cerulein-Induced Pancreatitis","volume":"186","author":"Hausmann","year":"2016","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2024.113485_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106900","article-title":"Protective effects of Coenzyme Q10 against acute pancreatitis","volume":"88","author":"Shin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113485_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.109919","article-title":"Deletion of macrophage migration inhibitory factor ameliorates inflammation in mice model severe acute pancreatitis","volume":"125","author":"Zhu","year":"2020","journal-title":"Biomed Pharmacother"},{"issue":"6","key":"10.1016\/j.intimp.2024.113485_b0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3390\/antiox8060195","article-title":"Effect of Acute Ingestion of Green Tea Extract and Lemon Juice on Oxidative Stress and Lipid Profile in Pigs Fed a High-Fat Diet","volume":"8","author":"Fang","year":"2019","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.intimp.2024.113485_b0205","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.freeradbiomed.2018.12.034","article-title":"Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress","volume":"134","author":"Chenxu","year":"2019","journal-title":"Free Radic Biol. Med."},{"key":"10.1016\/j.intimp.2024.113485_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112082","article-title":"Geniposide ameliorates psoriatic skin inflammation by inhibiting the TLR4\/MyD88\/NF-\u03baB p65 signaling pathway and MMP9","volume":"133","author":"Liu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"Pt 2","key":"10.1016\/j.intimp.2024.113485_b0215","article-title":"Structural identification and immunostimulatory effect of Bacillus velezensis GV1 polysaccharides via TLR4\/NF-\u03baB signaling pathway in RAW264.7 macrophages","volume":"280","author":"Le","year":"2024","journal-title":"Int. J. Biol. Macromol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020071?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020071?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:19:50Z","timestamp":1733977190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924020071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":43,"alternative-id":["S1567576924020071"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113485","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ATP citrate lyase ablation hampers exocrine regeneration via TLR4\/NF-kappaB signaling after acute pancreatitis in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113485","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113485"}}