{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T04:40:56Z","timestamp":1740112856584,"version":"3.37.3"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002412","name":"Xi'an Jiaotong University","doi-asserted-by":"publisher","award":["TX5J021"],"award-info":[{"award-number":["TX5J021"]}],"id":[{"id":"10.13039\/501100002412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113494","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T11:59:35Z","timestamp":1730289575000},"page":"113494","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"P2","title":["Nicorandil restores endothelial cell Kir6.2 expression to alleviate neuropathic pain in mice after chronic constriction injury"],"prefix":"10.1016","volume":"143","author":[{"given":"Minghao","family":"Du","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiani","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichen","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0005","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physrev.00045.2019","article-title":"Neuropathic pain: from mechanisms to treatment","volume":"101","author":"Finnerup","year":"2021","journal-title":"Physiol. Rev."},{"issue":"4","key":"10.1016\/j.intimp.2024.113494_b0010","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.mayocp.2015.01.018","article-title":"Neuropathic pain: principles of diagnosis and treatment","volume":"90","author":"Gilron","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.intimp.2024.113494_b0015","doi-asserted-by":"crossref","unstructured":"R.A. Moore, C.C. Chi, P.J. Wiffen et al., Oral nonsteroidal anti-inflammatory drugs for neuropathic pain. The Cochrane database of systematic reviews 2015(10) (2015) Cd010902.","DOI":"10.1002\/14651858.CD010902.pub2"},{"issue":"5","key":"10.1016\/j.intimp.2024.113494_b0020","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/WCO.0000000000000980","article-title":"Advances in the treatment of neuropathic pain","volume":"34","author":"Attal","year":"2021","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.intimp.2024.113494_b0025","doi-asserted-by":"crossref","DOI":"10.1177\/2058738419838383","article-title":"The neuropathic pain: An overview of the current treatment and future therapeutic approaches","volume":"33","author":"Cavalli","year":"2019","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113494_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113385","article-title":"Targeting the blood-nerve barrier for the management of immune-mediated peripheral neuropathies","volume":"331","author":"Stubbs","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2024.113494_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113244","article-title":"Characteristics of the nerve barrier and the blood dorsal root ganglion barrier in health and disease","volume":"327","author":"Reinhold","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2024.113494_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113272","article-title":"Biology of the human blood-nerve barrier in health and disease","volume":"328","author":"Ubogu","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.intimp.2024.113494_b0045","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/bs.irn.2017.08.004","article-title":"Impact of inflammation on the blood-neural barrier and blood-nerve interface: from review to therapeutic preview","volume":"137","author":"Skaper","year":"2017","journal-title":"Int. Rev. Neurobiol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113494_b0050","first-page":"521","article-title":"HIF-1: structure, biology and natural modulators","volume":"19","author":"Yang","year":"2021","journal-title":"Chin. J. Nat. Med."},{"issue":"4","key":"10.1016\/j.intimp.2024.113494_b0055","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.immuni.2014.09.008","article-title":"HIF transcription factors, inflammation, and immunity","volume":"41","author":"Palazon","year":"2014","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.intimp.2024.113494_b0060","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cmet.2020.08.002","article-title":"The role of HIF in immunity and inflammation","volume":"32","author":"McGettrick","year":"2020","journal-title":"Cell Metab."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0065","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mcn.2006.09.009","article-title":"Evidence of HIF-1 functional binding activity to caspase-3 promoter after photothrombotic cerebral ischemia","volume":"34","author":"van Hoecke","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"issue":"13","key":"10.1016\/j.intimp.2024.113494_b0070","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1002\/cne.23072","article-title":"Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1\u03b1 (HIF-1\u03b1)","volume":"520","author":"Hsieh","year":"2012","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0075","doi-asserted-by":"crossref","DOI":"10.1085\/jgp.202113046","article-title":"Mechanistic insights on KATP channel regulation from cryo-EM structures","volume":"155","author":"Driggers","year":"2023","journal-title":"J. Gen. Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0080","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1152\/physrev.00003.2015","article-title":"KATP channels in the cardiovascular system","volume":"96","author":"Foster","year":"2016","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.intimp.2024.113494_b0085","doi-asserted-by":"crossref","first-page":"C1230","DOI":"10.1152\/ajpcell.00099.2022","article-title":"Subcellular trafficking and endocytic recycling of K(ATP) channels","volume":"322","author":"Yang","year":"2022","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0090","doi-asserted-by":"crossref","first-page":"e0246019","DOI":"10.1371\/journal.pone.0246019","article-title":"The KATP channel opener, nicorandil, ameliorates brain damage by modulating synaptogenesis after ischemic stroke","volume":"16","author":"Zhao","year":"2021","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2024.113494_b0095","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2174\/1871527320666210119095626","article-title":"ATP-sensitive potassium channel subunits in neuroinflammation: novel drug targets in neurodegenerative disorders","volume":"21","author":"Maqoud","year":"2022","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"727","key":"10.1016\/j.intimp.2024.113494_b0100","doi-asserted-by":"crossref","first-page":"eabl5405","DOI":"10.1126\/scisignal.abl5405","article-title":"Adenosine signaling activates ATP-sensitive K(+) channels in endothelial cells and pericytes in CNS capillaries","volume":"15","author":"Sancho","year":"2022","journal-title":"Sci. Signal."},{"key":"10.1016\/j.intimp.2024.113494_b0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1744-8069-6-6","article-title":"KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy","volume":"6","author":"Zoga","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.intimp.2024.113494_b0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1744-8069-10-73","article-title":"Characteristics of dorsal root ganglia neurons sensitive to Substance P","volume":"10","author":"Moraes","year":"2014","journal-title":"Mol. Pain"},{"key":"10.1016\/j.intimp.2024.113494_b0115","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1744-8069-7-35","article-title":"Activation of ATP-sensitive potassium channels antagonize nociceptive behavior and hyperexcitability of DRG neurons from rats","volume":"7","author":"Du","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.intimp.2024.113494_b0120","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1744-8069-5-12","article-title":"Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation","volume":"5","author":"Kawano","year":"2009","journal-title":"Mol. Pain"},{"key":"10.1016\/j.intimp.2024.113494_b0125","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pbb.2013.10.019","article-title":"Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: Participation of the \u03ba-opioid receptor and KATP","volume":"114\u2013115","author":"Ming-Tatt","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"3","key":"10.1016\/j.intimp.2024.113494_b0130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5455\/javar.2022.i603","article-title":"Effects of Azadirachta indica on neuropathic pain induced by chronic constriction injury to sciatic nerve of Wistar rat","volume":"9","author":"Biswas","year":"2022","journal-title":"J. Adv. Veterinary Animal Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.intimp.2024.113494_b0140","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.neuroscience.2006.08.007","article-title":"Effect of spinal cord stimulation in an animal model of neuropathic pain relates to degree of tactile \u201callodynia\u201d","volume":"143","author":"Smits","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.intimp.2024.113494_b0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ejphar.2018.02.014","article-title":"Nicorandil inhibits mechanical allodynia induced by paclitaxel by activating opioidergic and serotonergic mechanisms","volume":"824","author":"Morais","year":"2018","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0150","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/s41392-023-01543-z","article-title":"Extracellular RNAs-TLR3 signaling contributes to cognitive impairment after chronic neuropathic pain in mice","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0155","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12974-022-02489-9","article-title":"Activation of locus coeruleus-spinal cord noradrenergic neurons alleviates neuropathic pain in mice via reducing neuroinflammation from astrocytes and microglia in spinal dorsal horn","volume":"19","author":"Li","year":"2022","journal-title":"J. Neuroinflam."},{"key":"10.1016\/j.intimp.2024.113494_b0160","doi-asserted-by":"crossref","DOI":"10.1177\/17590914231198983","article-title":"Therapeutic effect of nicotinamide mononucleotide for hypoxic-ischemic brain injury in neonatal mice","volume":"15","author":"Kawamura","year":"2023","journal-title":"ASN Neuro"},{"issue":"3","key":"10.1016\/j.intimp.2024.113494_b0165","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.nbd.2008.12.010","article-title":"Early inhibition of HIF-1alpha with small interfering RNA reduces ischemic-reperfused brain injury in rats","volume":"33","author":"Chen","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0170","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/kjm2.12139","article-title":"Aqueous extract of Dendrobium officinale confers neuroprotection against hypoxic-ischemic brain damage in neonatal rats","volume":"36","author":"Li","year":"2020","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2024.113494_b0175","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S0092-8674(03)00154-5","article-title":"HIF-1alpha is essential for myeloid cell-mediated inflammation","volume":"112","author":"Cramer","year":"2003","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0180","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00540-018-2579-4","article-title":"Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain","volume":"33","author":"Matsuda","year":"2019","journal-title":"J. Anesth."},{"issue":"4","key":"10.1016\/j.intimp.2024.113494_b0185","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1097\/j.pain.0000000000000444","article-title":"Early alterations of Hedgehog signaling pathway in vascular endothelial cells after peripheral nerve injury elicit blood-nerve barrier disruption, nerve inflammation, and neuropathic pain development","volume":"157","author":"Moreau","year":"2016","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0190","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/nyas.14816","article-title":"MicroRNA-21-5p functions via RECK\/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury","volume":"1515","author":"Reinhold","year":"2022","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2024.113494_b0195","doi-asserted-by":"crossref","first-page":"296","DOI":"10.4103\/ijp.IJP_298_19","article-title":"Nicorandil: a drug with ongoing benefits and different mechanisms in various diseased conditions","volume":"51","author":"Ahmed","year":"2019","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113494_b0200","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.pbb.2013.03.004","article-title":"Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice","volume":"106","author":"Dutra","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.intimp.2024.113494_b0205","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ejphar.2015.10.047","article-title":"Opioid pathways activation mediates the activity of nicorandil in experimental models of nociceptive and inflammatory pain","volume":"768","author":"Dutra","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113494_b0210","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.bmc.2014.03.011","article-title":"Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers","volume":"22","author":"C\u00e9sar","year":"2014","journal-title":"Bioorg. Med. Chem."},{"issue":"11","key":"10.1016\/j.intimp.2024.113494_b0215","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1016\/j.pain.2011.08.003","article-title":"Reopening of ATP-sensitive potassium channels reduces neuropathic pain and regulates astroglial gap junctions in the rat spinal cord","volume":"152","author":"Wu","year":"2011","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.intimp.2024.113494_b0220","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroscience.2009.04.076","article-title":"ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury","volume":"162","author":"Kawano","year":"2009","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0225","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000097003","article-title":"Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury","volume":"57","author":"Yin","year":"2007","journal-title":"Eur. Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113494_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103609","article-title":"Kir6.2-deficient mice develop somatosensory dysfunction and axonal loss in the peripheral nerves","volume":"25","author":"Nakai-Shimoda","year":"2022","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.intimp.2024.113494_b0235","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/jcmm.13006","article-title":"Activation of ATP-sensitive potassium channels facilitates the function of human endothelial colony-forming cells via Ca(2+)\/Akt\/eNOS pathway","volume":"21","author":"Wu","year":"2017","journal-title":"J. Cell Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020162?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020162?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T02:34:27Z","timestamp":1736303667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924020162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":47,"alternative-id":["S1567576924020162"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113494","relation":{},"ISSN":["1567-5769"],"issn-type":[{"type":"print","value":"1567-5769"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicorandil restores endothelial cell Kir6.2 expression to alleviate neuropathic pain in mice after chronic constriction injury","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113494","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113494"}}