{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T09:39:08Z","timestamp":1791279548358,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T00:00:00Z","timestamp":1762300800000},"content-version":"am","delay-in-days":339,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871463"],"award-info":[{"award-number":["81871463"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113534","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T08:43:54Z","timestamp":1730796234000},"page":"113534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"P3","title":["HSYA ameliorates venous thromboembolism by depleting the formation of TLR4\/NF-\u03baB pathway-dependent neutrophil extracellular traps"],"prefix":"10.1016","volume":"143","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longcheng","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"20 Suppl","key":"10.1016\/j.intimp.2024.113534_b0005","first-page":"S376","article-title":"Overview of venous thromboembolism","volume":"23","author":"Phillippe","year":"2017","journal-title":"Am J Manag Care"},{"key":"10.1016\/j.intimp.2024.113534_b0010","doi-asserted-by":"crossref","DOI":"10.5402\/2011\/124610","article-title":"Venous thromboembolism: classification, risk factors, diagnosis, and management","volume":"2011","author":"Moheimani","year":"2011","journal-title":"ISRN Hematol"},{"issue":"2","key":"10.1016\/j.intimp.2024.113534_b0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1634\/theoncologist.2016-0214","article-title":"Cancer and Venous Thromboembolic Disease: A Review","volume":"22","author":"Donnellan","year":"2017","journal-title":"Oncologist"},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.113534_b0020","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/j.thromres.2018.01.028","article-title":"Morbidity, mortality and costs associated with venous thromboembolism in hospitalized patients with cancer","volume":"164","author":"Lyman","year":"2018","journal-title":"Thromb Res"},{"key":"10.1016\/j.intimp.2024.113534_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2022.103782","article-title":"Venous thromboembolism in cancer and cancer immunotherapy","volume":"178","author":"Kacimi","year":"2022","journal-title":"Crit Rev Oncol Hematol"},{"issue":"8","key":"10.1016\/j.intimp.2024.113534_b0030","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","article-title":"Epidemiology of venous thromboembolism","volume":"12","author":"Heit","year":"2015","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"10.1016\/j.intimp.2024.113534_b0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21072602","article-title":"Role of microRNAs in Venous Thromboembolism","volume":"21","author":"Morelli","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0040","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s12943-019-1033-z","article-title":"The role of m(6)A RNA methylation in human cancer","volume":"18","author":"Chen","year":"2019","journal-title":"Mol Cancer"},{"issue":"6","key":"10.1016\/j.intimp.2024.113534_b0045","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3892\/ijmm.2020.4746","article-title":"Role of m6A RNA methylation in cardiovascular disease (Review)","volume":"46","author":"Qin","year":"2020","journal-title":"Int J Mol Med"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0050","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1186\/s12864-024-10294-2","article-title":"RNA methylation patterns, immune characteristics, and autophagy-related mechanisms mediated by N6-methyladenosine (m6A) regulatory factors in venous thromboembolism","volume":"25","author":"Zhang","year":"2024","journal-title":"BMC Genomics"},{"issue":"2","key":"10.1016\/j.intimp.2024.113534_b0055","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.intimp.2024.113534_b0060","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/nm.4294","article-title":"An emerging role for neutrophil extracellular traps in noninfectious disease","volume":"23","author":"Jorch","year":"2017","journal-title":"Nat Med"},{"issue":"8","key":"10.1016\/j.intimp.2024.113534_b0065","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1182\/blood.2020005861","article-title":"Neutrophil extracellular traps promote fibrous vascular occlusions in chronic thrombosis","volume":"137","author":"Sharma","year":"2021","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.intimp.2024.113534_b0070","doi-asserted-by":"crossref","first-page":"e0270865","DOI":"10.1371\/journal.pone.0270865","article-title":"Markers of neutrophil activation and neutrophil extracellular traps in diagnosing patients with acute venous thromboembolism: A feasibility study based on two VTE cohorts","volume":"17","author":"Smith","year":"2022","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.intimp.2024.113534_b0075","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.7150\/ijbs.69141","article-title":"Neutrophil extracellular traps mediate m(6)A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells","volume":"18","author":"Zhang","year":"2022","journal-title":"Int J Biol Sci"},{"issue":"3","key":"10.1016\/j.intimp.2024.113534_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112259","article-title":"METTL3-mediated m6A mRNA methylation regulates neutrophil activation through targeting TLR4 signaling","volume":"42","author":"Luo","year":"2023","journal-title":"Cell Rep"},{"issue":"6","key":"10.1016\/j.intimp.2024.113534_b0085","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201293","article-title":"Cotinine inhibits TLR4\/NF-\u03baB signaling pathway and improves deep vein thrombosis in rats","volume":"40","author":"Cheng","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.intimp.2024.113534_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2021.12.262","article-title":"Hydroxysafflor yellow A and anhydrosafflor yellow B alleviate ferroptosis and parthanatos in PC12 cells injured by OGD\/R","volume":"179","author":"Chen","year":"2022","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"10.1016\/j.intimp.2024.113534_b0095","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1007\/s10753-020-01297-8","article-title":"Hydroxysafflor Yellow A Inhibits Staphylococcus aureus-Induced Mouse Endometrial Inflammation via TLR2-Mediated NF-kB and MAPK Pathway","volume":"44","author":"He","year":"2021","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.113534_b0100","doi-asserted-by":"crossref","first-page":"6643615","DOI":"10.1155\/2021\/6643615","article-title":"Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia\/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis","volume":"2021","author":"Ye","year":"2021","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"10.1016\/j.intimp.2024.113534_b0105","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.jep.2011.11.016","article-title":"Taoren-Honghua herb pair and its main components promoting blood circulation through influencing on hemorheology, plasma coagulation and platelet aggregation","volume":"139","author":"Liu","year":"2012","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.intimp.2024.113534_b0110","doi-asserted-by":"crossref","first-page":"2720369","DOI":"10.1155\/2020\/2720369","article-title":"Three Ingredients of Safflower Alleviate Acute Lung Injury and Inhibit NET Release Induced by Lipopolysaccharide","volume":"2020","author":"Wang","year":"2020","journal-title":"Mediators Inflamm"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0115","doi-asserted-by":"crossref","first-page":"9173","DOI":"10.1038\/s41598-018-27217-3","article-title":"Protective effect of hydroxysafflor yellow A against acute kidney injury via the TLR4\/NF-\u03baB signaling pathway","volume":"8","author":"Bai","year":"2018","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.intimp.2024.113534_b0120","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1007\/s11064-021-03484-x","article-title":"Hydroxysafflor Yellow A Inhibits A\u03b2(1\u201342)-Induced Neuroinflammation by Modulating the Phenotypic Transformation of Microglia via TREM2\/TLR4\/NF-\u03baB Pathway in BV-2 Cells","volume":"47","author":"Ren","year":"2022","journal-title":"Neurochem Res"},{"issue":"6","key":"10.1016\/j.intimp.2024.113534_b0125","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/cbdd.14045","article-title":"Hydroxysafflor yellow A protects against ulcerative colitis via suppressing TLR4\/NF-\u03baB signaling pathway","volume":"99","author":"Feng","year":"2022","journal-title":"Chem Biol Drug Des"},{"issue":"13","key":"10.1016\/j.intimp.2024.113534_b0130","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa023153","article-title":"Evaluation of D-dimer in the diagnosis of suspected deep-vein thrombosis","volume":"349","author":"Wells","year":"2003","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.intimp.2024.113534_b0135","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1161\/ATVBAHA.110.221721","article-title":"Overexpression of the cell cycle inhibitor p16INK4a promotes a prothrombotic phenotype following vascular injury in mice","volume":"31","author":"Cardenas","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"10.1016\/j.intimp.2024.113534_b0140","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1364\/BOE.2.001470","article-title":"Real-time full field laser Doppler imaging","volume":"2","author":"Leutenegger","year":"2011","journal-title":"Biomed Opt Express"},{"issue":"3","key":"10.1016\/j.intimp.2024.113534_b0145","first-page":"74","article-title":"Validity of Laser Doppler Flowmetry in Predicting Outcome in Murine Intraluminal Middle Cerebral Artery Occlusion Stroke","volume":"8","author":"Hedna","year":"2015","journal-title":"J Vasc Interv Neurol"},{"key":"10.1016\/j.intimp.2024.113534_b0150","article-title":"Using Laser Doppler Imaging and Monitoring to Analyze Spinal Cord Microcirculation in Rat","volume":"135","author":"Jing","year":"2018","journal-title":"J vis Exp"},{"issue":"3","key":"10.1016\/j.intimp.2024.113534_b0155","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.4049\/jimmunol.1600954","article-title":"Deficiency of Phosphatidylinositol 3-Kinase \u03b4 Signaling Leads to Diminished Numbers of Regulatory T Cells and Increased Neutrophil Activity Resulting in Mortality Due to Endotoxic Shock","volume":"199","author":"Okeke","year":"2017","journal-title":"J Immunol"},{"key":"10.1016\/j.intimp.2024.113534_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102906","article-title":"Neutrophil extracellular traps drive intestinal microvascular endothelial ferroptosis by impairing Fundc1-dependent mitophagy","volume":"67","author":"Chu","year":"2023","journal-title":"Redox Biol"},{"key":"10.1016\/j.intimp.2024.113534_b0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fimmu.2016.00236","article-title":"The Emerging Role of NETs in Venous Thrombosis and Immunothrombosis","volume":"7","author":"Kimball","year":"2016","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.intimp.2024.113534_b0170","doi-asserted-by":"crossref","first-page":"e22946","DOI":"10.4161\/onci.22946","article-title":"Neutrophil extracellular traps: A new link to cancer-associated thrombosis and potential implications for tumor progression","volume":"2","author":"Demers","year":"2013","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.intimp.2024.113534_b0175","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3389\/fimmu.2012.00333","article-title":"Abundant neutrophil extracellular traps in thrombus of patient with microscopic polyangiitis","volume":"3","author":"Nakazawa","year":"2012","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.intimp.2024.113534_b0180","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/all.12111","article-title":"Extracellular DNA traps in allergic, infectious, and autoimmune diseases","volume":"68","author":"Simon","year":"2013","journal-title":"Allergy"},{"issue":"4","key":"10.1016\/j.intimp.2024.113534_b0185","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1160\/TH15-09-0710","article-title":"Phosphotidylserine exposure and neutrophil extracellular traps enhance procoagulant activity in patients with inflammatory bowel disease","volume":"115","author":"He","year":"2016","journal-title":"Thromb Haemost"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0190","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.1100450","article-title":"Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus","volume":"187","author":"Villanueva","year":"2011","journal-title":"J Immunol"},{"issue":"12","key":"10.1016\/j.intimp.2024.113534_b0195","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1055\/s-0041-1728763","article-title":"Linking Neutrophil Extracellular Traps and Platelet Activation: A Composite Biomarker Score for Predicting Outcomes after Acute Myocardial Infarction","volume":"121","author":"Hally","year":"2021","journal-title":"Thromb Haemost"},{"issue":"22","key":"10.1016\/j.intimp.2024.113534_b0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232214477","article-title":"Platelet-Neutrophil Association in NETs-Rich Areas in the Retrieved AIS Patient Thrombi","volume":"23","author":"Pir","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2 Suppl","key":"10.1016\/j.intimp.2024.113534_b0205","doi-asserted-by":"crossref","first-page":"e419S","DOI":"10.1378\/chest.11-2301","article-title":"Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines","volume":"141","author":"Kearon","year":"2012","journal-title":"Chest"},{"issue":"21","key":"10.1016\/j.intimp.2024.113534_b0210","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1056\/NEJMoa1114238","article-title":"Aspirin for preventing the recurrence of venous thromboembolism","volume":"366","author":"Becattini","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.intimp.2024.113534_b0215","doi-asserted-by":"crossref","DOI":"10.1177\/2040620719841735","article-title":"Optimal use of thrombopoietin receptor agonists in immune thrombocytopenia","volume":"10","author":"Al-Samkari","year":"2019","journal-title":"Ther Adv Hematol"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0220","doi-asserted-by":"crossref","first-page":"e24051","DOI":"10.1016\/j.heliyon.2024.e24051","article-title":"Knowledge map of thrombopoietin receptor agonists: A bibliometric analysis","volume":"10","author":"Hu","year":"2024","journal-title":"Heliyon"},{"issue":"5","key":"10.1016\/j.intimp.2024.113534_b0225","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1172\/JCI84538","article-title":"Neutrophil extracellular traps - the dark side of neutrophils","volume":"126","author":"S\u00f8rensen","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.intimp.2024.113534_b0230","article-title":"Ferric Chloride-induced Murine Thrombosis Models","volume":"115","author":"Li","year":"2016","journal-title":"J vis Exp"},{"issue":"4","key":"10.1016\/j.intimp.2024.113534_b0235","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/j.1538-7836.2011.04218.x","article-title":"Mechanisms underlying FeCl3-induced arterial thrombosis","volume":"9","author":"Eckly","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"5","key":"10.1016\/j.intimp.2024.113534_b0240","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.intimp.2024.113534_b0245","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"10.1016\/j.intimp.2024.113534_b0250","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/s41422-020-00441-1","article-title":"Ferroptosis: molecular mechanisms and health implications","volume":"31","author":"Tang","year":"2021","journal-title":"Cell Res"},{"key":"10.1016\/j.intimp.2024.113534_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116621","article-title":"NETs induce ferroptosis of endothelial cells in LPS-ALI through SDC-1\/HS and downstream pathways","volume":"175","author":"Fei","year":"2024","journal-title":"Biomed Pharmacother"},{"issue":"20","key":"10.1016\/j.intimp.2024.113534_b0260","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1111\/bph.15583","article-title":"Neutrophil elastase promotes neointimal hyperplasia by targeting toll-like receptor 4 (TLR4)-NF-\u03baB signalling","volume":"178","author":"Yang","year":"2021","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.intimp.2024.113534_b0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2018.08.014","article-title":"Suppression of TLR4 activation by resveratrol is associated with STAT3 and Akt inhibition in oxidized low-density lipoprotein-activated platelets","volume":"836","author":"Sun","year":"2018","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.intimp.2024.113534_b0270","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021010","article-title":"Toll-like Receptors and Thrombopoiesis","volume":"24","author":"Tang","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1016\/j.intimp.2024.113534_b0275","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180598","article-title":"Effect of miR-495 on lower extremity deep vein thrombosis through the TLR4 signaling pathway by regulation of IL1R1","volume":"38","author":"Tang","year":"2018","journal-title":"Biosci Rep"},{"issue":"11","key":"10.1016\/j.intimp.2024.113534_b0280","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1016\/j.drudis.2021.06.004","article-title":"m6A RNA methylation and beyond - The epigenetic machinery and potential treatment options","volume":"26","author":"Garbo","year":"2021","journal-title":"Drug Discov Today"},{"issue":"20","key":"10.1016\/j.intimp.2024.113534_b0285","doi-asserted-by":"crossref","first-page":"11619","DOI":"10.1093\/nar\/gkac1027","article-title":"METTL3-mediated m6A modification stabilizes TERRA and maintains telomere stability","volume":"50","author":"Chen","year":"2022","journal-title":"Nucleic Acids Res"},{"issue":"12","key":"10.1016\/j.intimp.2024.113534_b0290","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1161\/ATVBAHA.121.316414","article-title":"Endothelial METTL3 (Methyltransferase-Like 3) Inhibits Fibrinolysis by Promoting PAI-1 (Plasminogen Activator Inhibitor-1) Expression Through Enhancing Jun Proto-Oncogene N6-Methyladenosine Modification","volume":"41","author":"Bai","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.intimp.2024.113534_b0295","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153579","article-title":"Hydroxysafflor yellows alleviate thrombosis and acetaminophen-induced toxicity in vivo by enhancing blood circulation and poison excretion","volume":"87","author":"Wang","year":"2021","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0300","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s12974-017-0870-1","article-title":"HSYA alleviates secondary neuronal death through attenuating oxidative stress, inflammatory response, and neural apoptosis in SD rat spinal cord compression injury","volume":"14","author":"Pei","year":"2017","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.intimp.2024.113534_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153694","article-title":"Hydroxysafflor yellow A, a natural compound from Carthamus tinctorius L with good effect of alleviating atherosclerosis","volume":"91","author":"Xue","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.113534_b0310","doi-asserted-by":"crossref","unstructured":"Bacchetti, T., et al., Antioxidant and Pro-Oxidant Properties of Carthamus Tinctorius, Hydroxy Safflor Yellow A, and Safflor Yellow A. Antioxidants (Basel), 2020. 9(2).","DOI":"10.3390\/antiox9020119"},{"issue":"20","key":"10.1016\/j.intimp.2024.113534_b0315","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1182\/blood-2018-11-844530","article-title":"Neutrophils and NETs in modulating acute and chronic inflammation","volume":"133","author":"Castanheira","year":"2019","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0320","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/physrev.00062.2021","article-title":"Neutrophil extracellular traps in the pathology of cancer and other inflammatory diseases","volume":"103","author":"Herre","year":"2023","journal-title":"Physiol Rev"},{"issue":"11","key":"10.1016\/j.intimp.2024.113534_b0325","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.autrev.2017.09.012","article-title":"Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review","volume":"16","author":"Lee","year":"2017","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10.1016\/j.intimp.2024.113534_b0330","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/imr.13277","article-title":"NETosis: Sculpting tumor metastasis and immunotherapy","volume":"321","author":"Hu","year":"2024","journal-title":"Immunol Rev"},{"issue":"8","key":"10.1016\/j.intimp.2024.113534_b0335","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1097\/JS9.0000000000001479","article-title":"Comparative investigation of neoadjuvant immunotherapy versus adjuvant immunotherapy in perioperative patients with cancer: a global-scale, cross-sectional, and large-sample informatics study","volume":"110","author":"Guo","year":"2024","journal-title":"Int J Surg"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:44:21Z","timestamp":1762551861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924020563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":67,"alternative-id":["S1567576924020563"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113534","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HSYA ameliorates venous thromboembolism by depleting the formation of TLR4\/NF-\u03baB pathway-dependent neutrophil extracellular traps","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113534"}}