{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T23:38:12Z","timestamp":1788392292499,"version":"build-2803163510"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"am","delay-in-days":346,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2020QH305"],"award-info":[{"award-number":["ZR2020QH305"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82004276"],"award-info":[{"award-number":["82004276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274471"],"award-info":[{"award-number":["82274471"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019446","name":"Medical and Health Science and Technology Development Project of Shandong Province","doi-asserted-by":"publisher","award":["2019WS552"],"award-info":[{"award-number":["2019WS552"]}],"id":[{"id":"10.13039\/501100019446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113574","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T01:05:43Z","timestamp":1731373543000},"page":"113574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"P3","title":["Notoginsenoside R1-Protocatechuic aldehyde reduces vascular inflammation and calcification through increasing the release of nitric oxide to inhibit TGF\u03b2R1-YAP\/TAZ pathway in vascular smooth muscle cells"],"prefix":"10.1016","volume":"143","author":[{"given":"Xinhai","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengkai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuya","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.113574_b0005","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s11906-012-0265-8","article-title":"Vascular calcification: pathophysiology and risk factors","volume":"14","author":"Chen","year":"2012","journal-title":"Curr. Hypertens. Rep."},{"issue":"4","key":"10.1016\/j.intimp.2024.113574_b0010","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/ATVBAHA.113.302642","article-title":"Has our understanding of calcification in human coronary atherosclerosis progressed?","volume":"34","author":"Otsuka","year":"2014","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113574_b0015","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/j.molmed.2019.08.006","article-title":"The Vicious Cycle of Arterial Stiffness and Arterial Media Calcification","volume":"25","author":"Van den Bergh","year":"2019","journal-title":"Trends Mol. Med."},{"issue":"26","key":"10.1016\/j.intimp.2024.113574_b0020","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1073\/pnas.1308814110","article-title":"Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries","volume":"110","author":"Kelly-Arnold","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"4","key":"10.1016\/j.intimp.2024.113574_b0025","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00223-013-9712-z","article-title":"Vascular calcification: an update on mechanisms and challenges in treatment","volume":"93","author":"Wu","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.intimp.2024.113574_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2020.102265","article-title":"A novel role of FKN\/CX3CR1 in promoting osteogenic transformation of VSMCs and atherosclerotic calcification","volume":"91","author":"Yang","year":"2020","journal-title":"Cell Calcium"},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0035","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/01.CIR.102.1.126","article-title":"American College of Cardiology\/American Heart Association Expert Consensus document on electron-beam computed tomography for the diagnosis and prognosis of coronary artery disease","volume":"102","author":"O'Rourke","year":"2000","journal-title":"Circulation"},{"issue":"8","key":"10.1016\/j.intimp.2024.113574_b0040","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1038\/s41401-023-01077-8","article-title":"Transcription factor 21 accelerates vascular calcification in mice by activating the IL-6\/STAT3 signaling pathway and the interplay between VSMCs and ECs","volume":"44","author":"Zhao","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.intimp.2024.113574_b0045","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/bs.ircmb.2020.02.007","article-title":"The biology of vascular calcification","volume":"354","author":"Quaglino","year":"2020","journal-title":"Int. Rev. Cell Mol. Biol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113574_b0050","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/nm.2252","article-title":"Conversion of vascular endothelial cells into multipotent stem-like cells","volume":"16","author":"Medici","year":"2010","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1096\/fj.14-249706","article-title":"Endothelial microparticles mediate inflammation-induced vascular calcification","volume":"29","author":"Buend\u00eda","year":"2015","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.intimp.2024.113574_b0060","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12980","article-title":"Role of crosstalk between endothelial cells and smooth muscle cells in vascular calcification in chronic kidney disease","volume":"54","author":"Zhang","year":"2021","journal-title":"Cell Prolif."},{"issue":"2","key":"10.1016\/j.intimp.2024.113574_b0065","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ajpath.2020.10.012","article-title":"Lack of endothelial nitric oxide synthase accelerates ectopic calcification in uremic mice fed an adenine and high phosphorus diet","volume":"191","author":"Oe","year":"2021","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113574_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9070804","article-title":"Vascular calcification mechanisms: updates and renewed insight into signaling pathways involved in high phosphate-mediated vascular smooth muscle cell calcification","volume":"9","author":"Abbasian","year":"2021","journal-title":"Biomedicines"},{"issue":"11","key":"10.1016\/j.intimp.2024.113574_b0075","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20112767","article-title":"TGF-\u03b2-mediated epithelial-mesenchymal transition and cancer metastasis","volume":"20","author":"Hao","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"570","key":"10.1016\/j.intimp.2024.113574_b0080","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aav5183","article-title":"Specificity, versatility, and control of TGF-\u03b2 family signaling","volume":"12","author":"Derynck","year":"2019","journal-title":"Sci. Signal."},{"issue":"7","key":"10.1016\/j.intimp.2024.113574_b0085","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1167\/iovs.18-24258","article-title":"YAP\/TAZ Are essential for TGF-\u03b22-mediated conjunctival fibrosis","volume":"59","author":"Futakuchi","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0090","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-78056-0","article-title":"Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis","volume":"10","author":"Kim","year":"2020","journal-title":"Sci. Rep."},{"issue":"21","key":"10.1016\/j.intimp.2024.113574_b0095","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1016\/j.jmb.2015.04.015","article-title":"Crosstalk between Hippo and TGF\u03b2: Subcellular Localization of YAP\/TAZ\/Smad Complexes","volume":"427","author":"Grannas","year":"2015","journal-title":"J. Mol. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0100","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/cvr\/cvm049","article-title":"Nitric oxide regulates vascular calcification by interfering with TGF- signalling","volume":"77","author":"Kanno","year":"2008","journal-title":"Cardiovasc. Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0105","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s13577-021-00600-5","article-title":"Piezo1 mediates endothelial atherogenic inflammatory responses via regulation of YAP\/TAZ activation","volume":"35","author":"Yang","year":"2022","journal-title":"Hum. Cell"},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07022-2","article-title":"Reciprocal inhibition of YAP\/TAZ and NF-\u03baB regulates osteoarthritic cartilage degradation","volume":"9","author":"Deng","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.113574_b0115","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.587913","article-title":"Lactate suppresses macrophage pro-inflammatory response to LPS stimulation by inhibition of YAP and NF-\u03baB activation via GPR81-mediated signaling","volume":"11","author":"Yang","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0120","doi-asserted-by":"crossref","first-page":"e028358","DOI":"10.1161\/JAHA.122.028358","article-title":"A POTENTIAL NEW LINK BETWEEN INFLAMMATION AND VASCULAR CALCIFICATION","volume":"12","author":"Cai","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"4","key":"10.1016\/j.intimp.2024.113574_b0125","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1517\/13543784.2014.892582","article-title":"Saponins of Panax notoginseng: chemistry, cellular targets and therapeutic opportunities in cardiovascular diseases","volume":"23","author":"Liu","year":"2014","journal-title":"Expert Opin. Invest. Drugs"},{"issue":"5","key":"10.1016\/j.intimp.2024.113574_b0130","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/aps.2017.193","article-title":"Salvia miltiorrhizaBurge (Danshen): a golden herbal medicine in cardiovascular therapeutics","volume":"39","author":"Li","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0135","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.cjtee.2022.06.008","article-title":"Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury","volume":"26","author":"Zhu","year":"2023","journal-title":"Chin. J. Traumatol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113574_b0140","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.1016\/j.apsb.2021.03.021","article-title":"Protocatechuic aldehyde protects cardiomycoytes against ischemic injury via regulation of nuclear pyruvate kinase M2","volume":"11","author":"Wu","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0145","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbrc.2012.05.092","article-title":"Protocatechuic aldehyde inhibits migration and proliferation of vascular smooth muscle cells and intravascular thrombosis","volume":"423","author":"Moon","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2024.113574_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115742","article-title":"Protocatechuic aldehyde increases pericyte coverage and mitigates pericyte damage to enhance the atherosclerotic plaque stability","volume":"168","author":"Zhang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113574_b0155","article-title":"Ginsenoside Rg1-notoginsenoside R1-protocatechuic aldehyde reduces atherosclerosis and attenuates low-shear stress-induced vascular endothelial cell dysfunction","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113574_b0160","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.7150\/thno.49771","article-title":"ERK1\/2 inhibition reduces vascular calcification by activating miR-126-3p-DKK1\/LRP6 pathway","volume":"11","author":"Zeng","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0165","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s10020-023-00759-7","article-title":"PRMT3 methylates HIF-1\u03b1 to enhance the vascular calcification induced by chronic kidney disease","volume":"30","author":"Zhou","year":"2024","journal-title":"Mol. Med."},{"issue":"24","key":"10.1016\/j.intimp.2024.113574_b0170","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1161\/CIRCULATIONAHA.107.732867","article-title":"Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo","volume":"116","author":"Aikawa","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.intimp.2024.113574_b0175","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jep.2016.07.008","article-title":"Hydroalcoholic extract and pure compounds from Senecio nutans Sch. Bip (Compositae) induce vasodilation in rat aorta through endothelium-dependent and independent mechanisms","volume":"192","author":"Paredes","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113574_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.111847","article-title":"Marsdenia tenacissima extract dilated small mesenteric arteries via stimulating endothelial nitric oxide synthase and inhibiting calcium influx","volume":"238","author":"Hao","year":"2019","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113574_b0185","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.vph.2015.07.004","article-title":"Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK\/PI3K\/Akt\/eNOS pathway","volume":"72","author":"Xing","year":"2015","journal-title":"Vasc. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113574_b0190","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/s41401-023-01057-y","article-title":"Notoginsenoside R1 protects against myocardial ischemia\/reperfusion injury in mice via suppressing TAK1-JNK\/p38 signaling","volume":"44","author":"Zeng","year":"2023","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.intimp.2024.113574_b0195","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.7150\/thno.80250","article-title":"GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1\/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis","volume":"13","author":"Zheng","year":"2023","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0200","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-19180-x","article-title":"Mendelian randomization study of the effect of coronary artery calcification on atherosclerotic cardiovascular diseases","volume":"12","author":"Sae-Jie","year":"2022","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2024.113574_b0205","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.2215\/CJN.03250708","article-title":"Arterial intima and media calcification: distinct entities with different pathogenesis or all the same?","volume":"3","author":"Dr\u00fceke","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"issue":"22","key":"10.1016\/j.intimp.2024.113574_b0210","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1161\/01.CIR.0000148131.41425.E9","article-title":"Spotty calcification typifies the culprit plaque in patients with acute myocardial infarction: an intravascular ultrasound study","volume":"110","author":"Ehara","year":"2004","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.intimp.2024.113574_b0215","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1161\/CIRCRESAHA.114.302721","article-title":"Mechanisms of plaque formation and rupture","volume":"114","author":"Bentzon","year":"2014","journal-title":"Circ. Res."},{"issue":"18","key":"10.1016\/j.intimp.2024.113574_b0220","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.jacc.2006.10.079","article-title":"Long-term prognosis associated with coronary calcification: observations from a registry of 25,253 patients","volume":"49","author":"Budoff","year":"2007","journal-title":"J. Am. Coll. Cardiol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113574_b0225","doi-asserted-by":"crossref","first-page":"Itc81","DOI":"10.7326\/AITC202306200","volume":"176","author":"Arvanitis","year":"2023","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.113574_b0230","doi-asserted-by":"crossref","DOI":"10.3390\/biom8030080","article-title":"Research Progress on the Relationship between Atherosclerosis and Inflammation","volume":"8","author":"Zhu","year":"2018","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.intimp.2024.113574_b0235","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1253\/circj.CJ-11-0395","article-title":"Cardiovascular calcification: an inflammatory disease","volume":"75","author":"New","year":"2011","journal-title":"Circ. J."},{"issue":"4","key":"10.1016\/j.intimp.2024.113574_b0240","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ. Res."},{"issue":"28","key":"10.1016\/j.intimp.2024.113574_b0245","doi-asserted-by":"crossref","first-page":"20351","DOI":"10.1074\/jbc.M702182200","article-title":"Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway","volume":"282","author":"Levine","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"14","key":"10.1016\/j.intimp.2024.113574_b0250","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147284","article-title":"Cellular crosstalk between endothelial and smooth muscle cells in vascular wall remodeling","volume":"22","author":"M\u00e9ndez-Barbero","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113574_b0255","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.atherosclerosis.2016.08.046","article-title":"Endothelial-mesenchymal transition in atherosclerotic lesion calcification","volume":"253","author":"Bostr\u00f6m","year":"2016","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0260","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2147\/IJHTS.S13459","article-title":"Endothelial cell vascular smooth muscle cell co-culture assay for high throughput screening assays for discovery of anti-angiogenesis agents and other therapeutic molecules","volume":"2010","author":"Truskey","year":"2010","journal-title":"Int J High Throughput Screen."},{"issue":"1","key":"10.1016\/j.intimp.2024.113574_b0265","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s42003-022-03313-z","article-title":"MFG-E8 promotes osteogenic transdifferentiation of smooth muscle cells and vascular calcification by regulating TGF-\u03b21 signaling","volume":"5","author":"Chiang","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.intimp.2024.113574_b0270","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41413-018-0018-7","article-title":"YAP promotes osteogenesis and suppresses adipogenic differentiation by regulating \u03b2-catenin signaling","volume":"6","author":"Pan","year":"2018","journal-title":"Bone Res."},{"issue":"12","key":"10.1016\/j.intimp.2024.113574_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101860","article-title":"YAP\/TAZ are required to suppress osteogenic differentiation of vascular smooth muscle cells","volume":"23","author":"Wang","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.intimp.2024.113574_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118121","article-title":"OGT knockdown counteracts high phosphate-induced vascular calcification in chronic kidney disease through autophagy activation by downregulating YAP","volume":"261","author":"Xu","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113574_b0285","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.vph.2016.01.002","article-title":"Metformin alleviates vascular calcification induced by vitamin D3 plus nicotine in rats via the AMPK pathway","volume":"81","author":"Zhang","year":"2016","journal-title":"Vasc.Pharmacol."}],"updated-by":[{"DOI":"10.1016\/j.intimp.2026.117312","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000}}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020964?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924020964?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T21:44:56Z","timestamp":1762551896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924020964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":57,"alternative-id":["S1567576924020964"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113574","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Notoginsenoside R1-Protocatechuic aldehyde reduces vascular inflammation and calcification through increasing the release of nitric oxide to inhibit TGF\u03b2R1-YAP\/TAZ pathway in vascular smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113574","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113574"}}