{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:05:00Z","timestamp":1791475500610,"version":"4.3.4"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113577","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T07:24:57Z","timestamp":1731655497000},"page":"113577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"P3","title":["The interplay of TapSAKI and NEAT-1 as potential modulators in gentamicin-induced acute kidney injury via orchestrating miR-22-3p\/TLR4\/MyD88\/NF-\u049bB\/IL-1 \u03b2 milieu: Novel therapeutic approach of Betanin"],"prefix":"10.1016","volume":"143","author":[{"given":"Mai A.","family":"Abd-Elmawla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nourhan M.","family":"Elsamanoudie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manal Fouad","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olfat Ali","family":"Hammam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hekmat M.","family":"El Magdoub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0005","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ki.2010.337","article-title":"New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view","volume":"79","author":"Lopez-Novoa","year":"2011","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.intimp.2024.113577_b0010","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1177\/0897190014546836","article-title":"Aminoglycoside-induced nephrotoxicity","volume":"27","author":"Wargo","year":"2014","journal-title":"Pharm. Pract."},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0015","first-page":"e87617","article-title":"Acute Kidney Injury After Nephrotoxic Antibiotic Therapy in Patients with Infective Endocarditis","volume":"14","author":"Sadeghpour","year":"2019","journal-title":"Brieflands"},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0020","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1089\/ars.2016.6665","article-title":"Oxidant Mechanisms in Renal Injury and Disease","volume":"25","author":"Ratliff","year":"2016","journal-title":"Antioxid. Redox Signal."},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0025","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1681\/ASN.2007090982","article-title":"TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity","volume":"19","author":"Zhang","year":"2008","journal-title":"Am. Soc. Nephrol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0030","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/toxics11010048","article-title":"Diosmin mitigates gentamicin-induced nephrotoxicity in rats: Insights on miR-21 and-155 expression, Nrf2\/HO-1 and p38-MAPK\/NF-\u03baB pathways","volume":"11","author":"Nadeem","year":"2023","journal-title":"Toxics"},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2174\/1871526510808030144","article-title":"Toll-like receptors in skin infections and inflammatory diseases","volume":"8","author":"Lai","year":"2008","journal-title":"Infect. Disord. Drug Targets"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0040","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/nat.2012.0414","article-title":"Long non-coding RNAs: challenges for diagnosis and therapies","volume":"23","author":"S\u00e1nchez","year":"2013","journal-title":"Nucleic Acid Ther."},{"key":"10.1016\/j.intimp.2024.113577_b0045","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.omtn.2019.05.011","article-title":"Non-coding RNA-Associated ceRNA Networks in a New Contrast-Induced Acute Kidney Injury Rat Model","volume":"17","author":"Cheng","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0050","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1515\/med-2020-0401","article-title":"NEAT1 aggravates sepsis-induced acute kidney injury by sponging miR-22-3p","volume":"15","author":"Feng","year":"2020","journal-title":"Open Med (Wars)"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0055","doi-asserted-by":"crossref","first-page":"14743","DOI":"10.1038\/s41598-019-51409-0","article-title":"Endogenous intronic antisense long non-coding RNA, MGAT3-AS1, and kidney transplantation","volume":"9","author":"Nagarajah","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0060","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/jphp.13049","article-title":"LncRNA TapSAKI promotes inflammation injury in HK-2 cells and urine derived sepsis-induced kidney injury","volume":"71","author":"Shen","year":"2019","journal-title":"Pharm Pharmacol"},{"key":"10.1016\/j.intimp.2024.113577_b0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.omtn.2020.05.012","article-title":"Non-coding RNAs and Exosomes: Their Role in the Pathogenesis of Sepsis","volume":"21","author":"Hashemian","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0070","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1515\/med-2021-0204","article-title":"Knockdown of lncRNA TapSAKI alleviates LPS-induced injury in HK-2 cells through the miR-205\/IRF3 pathway","volume":"16","author":"Han","year":"2021","journal-title":"Open Medicine"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0075","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1186\/s12885-018-4461-z","article-title":"Galectin-3 activates TLR4\/NF-\u03baB signaling to promote lung adenocarcinoma cell proliferation through activating lncRNA-NEAT1 expression","volume":"18","author":"Zhou","year":"2018","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0080","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00432-016-2248-7","article-title":"Plasma miR-22-3p, miR-642b-3p and miR-885-5p as diagnostic biomarkers for pancreatic cancer","volume":"143","author":"Hussein","year":"2017","journal-title":"Cancer Res Clin Oncol"},{"issue":"2","key":"10.1016\/j.intimp.2024.113577_b0085","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s11255-022-03321-2","article-title":"miR-22 alleviates sepsis-induced acute kidney injury via targeting the HMGB1\/TLR4\/NF-\u03baB signaling pathway","volume":"55","author":"Zhang","year":"2023","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.intimp.2024.113577_b0090","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.ijbiomac.2020.02.049","article-title":"Protective effect of Polygonatum sibiricum polysaccharides on gentamicin-induced acute kidney injury in rats via inhibiting p38 MAPK\/ATF2 pathway","volume":"151","author":"Han","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/mnfr.201400484","article-title":"Betanin\u2013a food colorant with biological activity","volume":"59","author":"Esatbeyoglu","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0100","article-title":"Natural Antioxidant Betanin Protects Rats from Paraquat-Induced Acute Lung Injury Interstitial Pneumonia","volume":"2015","author":"Han","year":"2015","journal-title":"Biomed Res. Int."},{"issue":"7","key":"10.1016\/j.intimp.2024.113577_b0105","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1080\/1354750X.2019.1642958","article-title":"Protective effects of betanin against paracetamol and diclofenac induced neurotoxicity and endocrine disruption in rats","volume":"24","author":"Motawi","year":"2019","journal-title":"Biomarkers"},{"key":"10.1016\/j.intimp.2024.113577_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12986-021-00621-9","article-title":"The anti-diabetic effects of betanin in streptozotocin-induced diabetic rats through modulating AMPK\/SIRT1\/NF-\u03baB signaling pathway","volume":"18","author":"Abedimanesh","year":"2021","journal-title":"Nutr. Metab."},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0115","doi-asserted-by":"crossref","first-page":"e0233088","DOI":"10.1371\/journal.pone.0233088","article-title":"Betanin purification from red beetroots and evaluation of its anti-oxidant and anti-inflammatory activity on LPS-activated microglial cells","volume":"15","author":"Ahmadi","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113577_b0120","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fct.2015.01.018","article-title":"Betanin attenuates oxidative stress and inflammatory reaction in kidney of paraquat-treated rat","volume":"78","author":"Tan","year":"2015","journal-title":"Food Chem. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/0960327116689716","article-title":"Protective effect of apocynin against gentamicin-induced nephrotoxicity in rats","volume":"37","author":"Abdelrahman","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113577_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/nu11091978","article-title":"Short-term betanin intake reduces oxidative stress in wistar rats","volume":"11","author":"da Silva","year":"2019","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0135","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/1354750X.2019.1697365","article-title":"Impact of betanin against paracetamol and diclofenac induced hepato-renal damage in rats","volume":"25","author":"Motawi","year":"2020","journal-title":"Biomarkers"},{"issue":"10","key":"10.1016\/j.intimp.2024.113577_b0140","doi-asserted-by":"crossref","first-page":"e0164528","DOI":"10.1371\/journal.pone.0164528","article-title":"Amelioration of Renal Inflammation, Endoplasmic Reticulum Stress and Apoptosis Underlies the Protective Effect of Low Dosage of Atorvastatin in Gentamicin-Induced Nephrotoxicity","volume":"11","author":"Jaikumkao","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2024.113577_b0145","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jbt.21667","article-title":"A comparison between the nephrotoxic profile of gentamicin and gentamicin nanoparticles in mice","volume":"29","author":"Jamshidzadeh","year":"2015","journal-title":"Biochem Mol Toxicol"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0150","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s43094-021-00318-z","article-title":"Nephroprotective role of diosgenin in gentamicin-induced renal toxicity: biochemical, antioxidant, immunological and histopathological approach","volume":"7","author":"Mishra","year":"2021","journal-title":"Future J. Pharmaceutical Sci."},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0155","first-page":"344","article-title":"Effect of a short-term fast on ketamine-xylazine anesthesia in rats","volume":"50","author":"Struck","year":"2011","journal-title":"Am Assoc Lab Anim Sci"},{"key":"10.1016\/j.intimp.2024.113577_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/cc6823","article-title":"The histopathology of septic acute kidney injury: a systematic review","volume":"12","author":"Langenberg","year":"2008","journal-title":"Crit. Care"},{"issue":"12","key":"10.1016\/j.intimp.2024.113577_b0165","first-page":"553","article-title":"The determination of urea in plasma and serum by a urease\/Berthelot method, adapted to the Greiner Electronic Selective Analyzer GSA II (author's transl)","volume":"11","author":"Richterich","year":"1973","journal-title":"Z. Klin. Chem. Klin. Biochem."},{"key":"10.1016\/j.intimp.2024.113577_b0170","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1055\/s-0028-1111251","article-title":"Plasma creatinine as rough indicator of renal function","volume":"89","author":"Schirmeister","year":"1964","journal-title":"Dtsch. Med. Wochenschr."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0175","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2024.113577_b0180","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.intimp.2024.113577_b0185","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"Lab Clin Med"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0190","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/kjm2.12442","article-title":"Long non-coding RNA XIST alleviates sepsis-induced acute kidney injury through inhibiting inflammation and cell apoptosis via regulating miR-155-5p\/WWC1 axis","volume":"38","author":"Wang","year":"2022","journal-title":"Kaohsiung J. Med. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0195","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ncrna.2017.04.001","article-title":"TGF-\u03b21 signaling in kidney disease: From Smads to long non-coding RNAs","volume":"2","author":"Tang","year":"2017","journal-title":"Non-coding RNA Res."},{"issue":"8","key":"10.1016\/j.intimp.2024.113577_b0200","doi-asserted-by":"crossref","first-page":"3486","DOI":"10.21037\/tau-21-623","article-title":"CYR61, regulated by miR-22-3p and MALAT1, promotes autophagy in HK-2 cell inflammatory model","volume":"10","author":"Guo","year":"2021","journal-title":"Trans. Androl."},{"issue":"6","key":"10.1016\/j.intimp.2024.113577_b0205","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1002\/ar.23525","article-title":"Effect of lycopene and rosmarinic acid on gentamicin induced renal cortical oxidative stress, apoptosis, and autophagy in adult male albino rat","volume":"300","author":"Bayomy","year":"2017","journal-title":"Anat Rec (hoboken)"},{"key":"10.1016\/j.intimp.2024.113577_b0210","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00441-018-2886-y","article-title":"Reno-protective effects of ursodeoxycholic acid against gentamicin-induced nephrotoxicity through modulation of NF-\u03baB, eNOS and caspase-3 expressions","volume":"374","author":"Abd-Elhamid","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.intimp.2024.113577_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114279","article-title":"The emerging role of miRNAs in pituitary adenomas: From molecular signatures to diagnostic potential","author":"Doghish","year":"2024","journal-title":"Exp. Cell Res."},{"issue":"2","key":"10.1016\/j.intimp.2024.113577_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2024.114272","article-title":"Emerging insights: miRNA modulation of ferroptosis pathways in lung cancer","volume":"442","author":"Elsakka","year":"2024","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.intimp.2024.113577_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155093","article-title":"miRNAs as modulators of neuroinflammation and excitotoxicity: Implications for stroke therapeutics","author":"Elballal","year":"2024","journal-title":"Pathology-Research and Practice"},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10142-024-01450-8","article-title":"LncRNAs orchestration of gastric cancer-particular emphasis on the etiology, diagnosis, and treatment resistance","volume":"24","author":"Elimam","year":"2024","journal-title":"Funct. Integr. Genomics"},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0235","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1373\/clinchem.2014.230359","article-title":"Circulating long noncoding RNATapSaki is a predictor of mortality in critically ill patients with acute kidney injury","volume":"61","author":"Lorenzen","year":"2015","journal-title":"Clin. Chem."},{"key":"10.1016\/j.intimp.2024.113577_b0240","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2164-8-39","article-title":"A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains","volume":"8","author":"Hutchinson","year":"2007","journal-title":"BMC Genomics"},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0245","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3390\/ijms20030627","article-title":"The Implications of the Long Non-Coding RNA NEAT1 in Non-Cancerous Diseases","volume":"20","author":"Prinz","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.intimp.2024.113577_b0250","doi-asserted-by":"crossref","first-page":"4900","DOI":"10.1111\/jcmm.15197","article-title":"MicroRNA regulatory networks in the pathogenesis of sarcopenia","volume":"24","author":"Yin","year":"2020","journal-title":"J. Cellular Mol. Med."},{"issue":"8","key":"10.1016\/j.intimp.2024.113577_b0255","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1113\/EP089575","article-title":"microRNA-22-3p plays a protective role in a murine asthma model through the inhibition of the NLRP3-caspase-1-IL-1\u03b2 axis","volume":"106","author":"Guo","year":"2021","journal-title":"Exp. Physiol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113577_b0260","doi-asserted-by":"crossref","first-page":"e2929","DOI":"10.1038\/cddis.2017.321","article-title":"lncRNA MIAT functions as a competing endogenous RNA to upregulate DAPK2 by sponging miR-22-3p in diabetic cardiomyopathy","volume":"8","author":"Zhou","year":"2017","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0265","first-page":"2647","article-title":"Apple phenolic extracts ameliorate lead-induced cognitive impairment and depression-and anxiety-like behavior in mice by abating oxidative stress","volume":"13","author":"Ren","year":"2022","journal-title":"Inflammation and Apoptosis via the miR-22-3p\/SIRT1 Axis."},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0270","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000514311","article-title":"MiR-22-3p suppresses vascular remodeling and oxidative stress by targeting CHD9 during the development of hypertension","volume":"58","author":"Chen","year":"2021","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.intimp.2024.113577_b0275","article-title":"Long non-coding RNAs as biomarkers and therapeutic targets in sepsis","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113577_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2022.101716","article-title":"The role of long noncoding RNA (lncRNA) nuclear-enriched abundant transcript 1 (NEAT1) in immune diseases","author":"Jing","year":"2022","journal-title":"Transpl. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113577_b0285","doi-asserted-by":"crossref","first-page":"816","DOI":"10.3390\/ijms22020816","article-title":"Toll-Like Receptors in Acute Kidney Injury","volume":"22","author":"V\u00e1zquez-Carballo","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0290","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/ki.2010.381","article-title":"Toll-like receptor 4 regulates early endothelial activation during ischemic acute kidney injury","volume":"79","author":"Chen","year":"2011","journal-title":"Kidney Int."},{"issue":"6","key":"10.1016\/j.intimp.2024.113577_b0295","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20200527","article-title":"MiR-22-3p suppresses sepsis-induced acute kidney injury by targeting PTEN","volume":"40","author":"Wang","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.intimp.2024.113577_b0300","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.omtn.2019.12.037","article-title":"The biomarker TCONS_00016233 drives septic AKI by targeting the miR-22-3p\/AIFM1 signaling axis","volume":"19","author":"Zhang","year":"2020","journal-title":"Molecular Therapy-Nucleic Acids"},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0305","doi-asserted-by":"crossref","DOI":"10.1177\/0300060519887251","article-title":"Lnc-NEAT1 induces cell apoptosis and inflammation but inhibits proliferation in a cellular model of hepatic ischemia\/reperfusion injury","volume":"49","author":"Wang","year":"2021","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.intimp.2024.113577_b0310","article-title":"Analysis of the therapeutic effect of holmium laser intervention on patients with complicated kidney stones and the relationship between serum LncRNA TapSAKI, MCP-1, IL-6 and prognosis of patients","author":"Wang","year":"2022","journal-title":"Research Square"},{"key":"10.1016\/j.intimp.2024.113577_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2019.144144","article-title":"miR-22 inhibits synovial fibroblasts proliferation and proinflammatory cytokine production in RASF via targeting SIRT1","volume":"724","author":"Zhang","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2024.113577_b0320","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/978-3-642-59430-4_10","article-title":"MyD88 as a bottle neck in Toll\/IL-1 signaling","author":"Takeuchi","year":"2002","journal-title":"Toll-like receptor family members and their ligands"},{"key":"10.1016\/j.intimp.2024.113577_b0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106194","article-title":"5-O-methyldihydroquercetin and cilicicone B isolated from Spina Gleditsiae ameliorate lipopolysaccharide-induced acute kidney injury in mice by inhibiting inflammation and oxidative stress via the TLR4\/MyD88\/TRIF\/NLRP3 signaling pathway","volume":"80","author":"Zeng","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0330","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1080\/0886022X.2017.1361838","article-title":"Atorvastatin attenuates experimental contrast-induced acute kidney injury: a role for TLR4\/MyD88 signaling pathway","volume":"39","author":"Yue","year":"2017","journal-title":"Ren. Fail."},{"issue":"8","key":"10.1016\/j.intimp.2024.113577_b0335","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.3390\/nu14081620","article-title":"Geraniol ameliorates doxorubicin-mediated kidney injury through alteration of antioxidant status, inflammation, and apoptosis: potential roles of NF-\u03baB and Nrf2\/Ho-1","volume":"14","author":"AlAsmari","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2024.113577_b0340","doi-asserted-by":"crossref","DOI":"10.1021\/acschemneuro.2c00653","article-title":"MAGI2-AS3 and miR-374b-5p as Putative Regulators of Multiple Sclerosis via Modulating the PTEN\/AKT\/IRF-3\/IFN-\u03b2 Axis: New Clinical Insights","author":"Kortam","year":"2023","journal-title":"ACS Chem. Nerosci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0345","doi-asserted-by":"crossref","first-page":"480","DOI":"10.3390\/ijms14010480","article-title":"Recent insights and novel bioinformatics tools to understand the role of microRNAs binding to 5'untranslated region","volume":"14","author":"Da Sacco","year":"2012","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113577_b0350","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/ncrna7010017","article-title":"The Implications of ncRNAs in The Development of Human Diseases","volume":"7","author":"L\u00f3pez-Jim\u00e9nez","year":"2021","journal-title":"Non-Coding RNA"},{"key":"10.1016\/j.intimp.2024.113577_b0355","unstructured":"Abd Elaleem, W.S., et al., Attenuation of p38 MAPK\/NF\u2010\u03baB\/TRPV1\/CGRP is involved in the antinociceptive effect of hesperidin methyl chalcone and taxifolin in paclitaxel\u2010induced peripheral neuropathy. BioFactors."},{"key":"10.1016\/j.intimp.2024.113577_b0360","first-page":"1","article-title":"Natural products and long noncoding RNA signatures in gallbladder cancer: a review focuses on pathogenesis, diagnosis, and drug resistance","author":"Elimam","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113577_b0365","doi-asserted-by":"crossref","first-page":"4375","DOI":"10.1016\/j.sjbs.2021.04.030","article-title":"Protective effect of diosmin against doxorubicin-induced nephrotoxicity","volume":"28","author":"Ali","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"issue":"5","key":"10.1016\/j.intimp.2024.113577_b0370","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3109\/15376516.2012.759306","article-title":"Alleviation of doxorubicin-induced nephrotoxicity and hepatotoxicity by chrysin in Wistar rats","volume":"23","author":"Rashid","year":"2013","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.intimp.2024.113577_b0375","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fct.2014.01.026","article-title":"Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats","volume":"66","author":"Rashid","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113577_b0380","article-title":"Betanin, a natural food additive: Stability, bioavailability, antioxidant and preservative ability assessments","volume":"24","author":"da Silva","year":"2019","journal-title":"Molecules"},{"issue":"12","key":"10.1016\/j.intimp.2024.113577_b0385","first-page":"4318","article-title":"Scientific Opinion on the re-evaluation of beetroot red (E 162) as a food additive","volume":"13","author":"EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS)","year":"2015","journal-title":"EFSA Journal"},{"issue":"6","key":"10.1016\/j.intimp.2024.113577_b0390","article-title":"Betanin prohibits cisplatin-induced nephrotoxicity through targeting mitochondria","volume":"23","author":"Zununi vahed","year":"2019","journal-title":"J. Res. Pharm."},{"issue":"9","key":"10.1016\/j.intimp.2024.113577_b0395","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1248\/bpb.b21-00042","article-title":"Betanin prevents experimental abdominal aortic aneurysm progression by modulating the TLR4\/NF-\u03baB and Nrf2\/HO-1 pathways","volume":"44","author":"Qiu","year":"2021","journal-title":"Biolog. Pharmaceutical Bulletin"},{"issue":"8","key":"10.1016\/j.intimp.2024.113577_b0400","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1002\/ejp.1790","article-title":"Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain","volume":"25","author":"Kwankaew","year":"2021","journal-title":"Eur. J. Pain"},{"issue":"12","key":"10.1016\/j.intimp.2024.113577_b0405","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.3390\/nu12123884","article-title":"Hylocereus polyrhizus peel extract retards alcoholic liver disease progression by modulating oxidative stress and inflammatory responses in C57Bl\/6 mice","volume":"12","author":"Yeh","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.intimp.2024.113577_b0410","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1080\/10408398.2020.1822277","article-title":"Betanin as a multipath oxidative stress and inflammation modulator: A beetroot pigment with protective effects on cardiovascular disease pathogenesis","volume":"62","author":"Silva","year":"2021","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.intimp.2024.113577_b0415","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jnutbio.2017.01.001","article-title":"Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer","volume":"42","author":"Beaver","year":"2017","journal-title":"Nutritional Biochem."},{"key":"10.1016\/j.intimp.2024.113577_b0420","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biopha.2018.03.071","article-title":"Sanguinarine inhibits epithelial ovarian cancer development via regulating long non-coding RNA CASC2-EIF4A3 axis and\/or inhibiting NF-\u03baB signaling or PI3K\/AKT\/mTOR pathway","volume":"102","author":"Zhang","year":"2018","journal-title":"Biomed. Pharmacotherapy"},{"issue":"11","key":"10.1016\/j.intimp.2024.113577_b0425","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22899","article-title":"Lutein exerts its cardioprotective effect against the experimental model of isoprenaline-induced myocardial infarction via MIAT\/miR-200a\/Nrf2\/TXINP pathway","volume":"35","author":"Abdelmonem","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113577_b0430","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1017\/S0007114513001645","article-title":"Betanin, a beetroot component, induces nuclear factor erythroid-2-related factor 2-mediated expression of detoxifying\/antioxidant enzymes in human liver cell lines","volume":"110","author":"Krajka-Ku\u017aniak","year":"2013","journal-title":"Br. J. Nutr."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692402099X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692402099X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:24:42Z","timestamp":1733977482000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692402099X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":86,"alternative-id":["S156757692402099X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113577","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interplay of TapSAKI and NEAT-1 as potential modulators in gentamicin-induced acute kidney injury via orchestrating miR-22-3p\/TLR4\/MyD88\/NF-\u049bB\/IL-1 \u03b2 milieu: Novel therapeutic approach of Betanin","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113577"}}