{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T11:46:58Z","timestamp":1792237618304,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100009392","name":"Prince Sattam bin Abdulaziz University","doi-asserted-by":"publisher","award":["PSAU\/2023\/R\/1444"],"award-info":[{"award-number":["PSAU\/2023\/R\/1444"]}],"id":[{"id":"10.13039\/100009392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/2(19)\/Pul.Med\/2021-NCD-II"],"award-info":[{"award-number":["3\/1\/2(19)\/Pul.Med\/2021-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113587","type":"journal-article","created":{"date-parts":[[2024,11,15]],"date-time":"2024-11-15T02:25:01Z","timestamp":1731637501000},"page":"113587","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"P3","title":["PAI-1 influences and curcumin destabilizes MMP-2, MMP-9 and basement membrane proteins during lung injury and fibrosis"],"prefix":"10.1016","volume":"143","author":[{"given":"Fathimath Muneesa","family":"Moideen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamudha Parveen","family":"Rahamathulla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakshitha","family":"Charavu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fayez","family":"Alghofaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohemmed","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2121-3561","authenticated-orcid":false,"given":"Yashodhar P.","family":"Bhandary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113587_b0005","doi-asserted-by":"crossref","first-page":"22527","DOI":"10.1074\/jbc.M512819200","article-title":"A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells","volume":"281","author":"Balsara","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.113587_b0010","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1160\/TH08-07-0427","article-title":"Plasminogen activator inhibitor-1: the double-edged sword in apoptosis","volume":"100","author":"Balsara","year":"2008","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.intimp.2024.113587_b0015","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1056\/NEJM199003293221304","article-title":"Depressed Bronchoalveolar Urokinase Activity in Patients with Adult Respiratory Distress Syndrome","volume":"322","author":"Bertozzi","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.113587_b0020","doi-asserted-by":"crossref","first-page":"L463","DOI":"10.1152\/ajplung.00099.2011","article-title":"Regulation of alveolar epithelial cell apoptosis and pulmonary fibrosis by coordinate expression of components of the fibrinolytic system","volume":"302","author":"Bhandary","year":"2012","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2024.113587_b0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.4114","article-title":"Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions","volume":"229","author":"Brown","year":"2013","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2024.113587_b0030","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0002-9440(10)63674-7","article-title":"Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1","volume":"163","author":"Chuang-Tsai","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.intimp.2024.113587_b0035","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1172\/JCI118396","article-title":"Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene","volume":"97","author":"Eitzman","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.113587_b0040","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/jocd.15905","article-title":"Curcumin alleviates hypertrophic scarring by inhibiting fibroblast activation and regulating tissue inflammation","volume":"23","author":"Fei","year":"2024","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.intimp.2024.113587_b0045","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1007\/s10753-019-01010-4","article-title":"Acute Lung Injury: IL-17A-Mediated Inflammatory Pathway and Its Regulation by Curcumin","volume":"42","author":"Gouda","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.113587_b0050","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1002\/jcb.26384","article-title":"Curcumin alleviates IL-17A-mediated p53-PAI-1 expression in bleomycin-induced alveolar basal epithelial cells","volume":"119","author":"Gouda","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.intimp.2024.113587_b0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41584-019-0324-5","article-title":"Evasion of apoptosis by myofibroblasts: a hallmark of fibrotic diseases","volume":"16","author":"Hinz","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.113587_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/jcm12103564","article-title":"A Real-World Prognosis in Idiopathic Pulmonary Fibrosis: A Special Reference to the Role of Antifibrotic Agents for the Elderly","volume":"12","author":"Honda","year":"2023","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2024.113587_b0065","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.exger.2014.11.018","article-title":"Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis","volume":"61","author":"Huang","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.intimp.2024.113587_b0070","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1111\/acel.12643","article-title":"Serpine 1 induces alveolar type II cell senescence through activating p53\u2013p21-Rb pathway in fibrotic lung disease","volume":"16","author":"Jiang","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.intimp.2024.113587_b0075","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12931-024-02898-9","article-title":"Regulation of myofibroblast dedifferentiation in pulmonary fibrosis","volume":"25","author":"Ju","year":"2024","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113587_b0080","doi-asserted-by":"crossref","unstructured":"Kim, K.K., Kugler, M.C., Wolters, P.J., Robillard, L., Galvez, M.G., Brumwell, A.N., Sheppard, D., Chapman, H.A., 2006. Alveolar epithelial cell mesenchymal transition develops <em>in vivo<\/em> during pulmonary fibrosis and is regulated by the extracellular matrix. Proc. Natl. Acad. Sci. 103, 13180 LP \u2013 13185. Doi: 10.1073\/pnas.0605669103.","DOI":"10.1073\/pnas.0605669103"},{"key":"10.1016\/j.intimp.2024.113587_b0085","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/ncb1448","article-title":"Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence","volume":"8","author":"Kortlever","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.intimp.2024.113587_b0090","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/ars.2007.1903","article-title":"Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis","volume":"10","author":"Liu","year":"2008","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2024.113587_b0095","doi-asserted-by":"crossref","first-page":"9428","DOI":"10.1074\/jbc.M114.601815","article-title":"Plasminogen activator inhibitor-1 suppresses profibrotic responses in fibroblasts from fibrotic lungs","volume":"290","author":"Marudamuthu","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2024.113587_b0100","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.intimp.2024.113587_b0105","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1164\/rccm.200708-1291OC","article-title":"An essential role for fibronectin extra type III domain A in pulmonary fibrosis","volume":"177","author":"Muro","year":"2008","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2024.113587_b0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/path.3992","article-title":"PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury","volume":"228","author":"Osterholzer","year":"2012","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2024.113587_b0115","doi-asserted-by":"crossref","first-page":"4503","DOI":"10.2147\/DDDT.S327378","article-title":"Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures","volume":"15","author":"Peng","year":"2021","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2024.113587_b0120","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1007\/s00018-020-03693-7","article-title":"Emerging cellular and molecular determinants of idiopathic pulmonary fibrosis","volume":"78","author":"Phan","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2024.113587_b0125","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00441-018-2934-7","article-title":"Basement membranes in the cornea and other organs that commonly develop fibrosis","volume":"374","author":"Saikia","year":"2018","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.intimp.2024.113587_b0130","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.sajb.2022.09.031","article-title":"Withania somnifera deploys immunomodulation and exerts anticancer effects on lung adenocarcinoma cells","volume":"151","author":"Sajida","year":"2022","journal-title":"South African J. Bot."},{"key":"10.1016\/j.intimp.2024.113587_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153639","article-title":"Anti-angiogenic, apoptotic and matrix metalloproteinase inhibitory activity of Withania somnifera (ashwagandha) on lung adenocarcinoma cells","volume":"90","author":"Sajida","year":"2021","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.113587_b0140","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/437695","article-title":"The Inflammatory Actions of Coagulant and Fibrinolytic Proteases in Disease","volume":"2015","author":"Schuliga","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.intimp.2024.113587_b0145","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1136\/thx.2009.119974","article-title":"Suppression of plasminogen activator inhibitor-1 by RNA interference attenuates pulmonary fibrosis","volume":"65","author":"Senoo","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.intimp.2024.113587_b0150","article-title":"Curcumin targets p53-fibrinolytic system in TGF-\u03b21 mediated alveolar epithelial mesenchymal transition in alveolar epithelial cells","author":"Shaikh","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets."},{"key":"10.1016\/j.intimp.2024.113587_b0155","doi-asserted-by":"crossref","first-page":"558","DOI":"10.2174\/1871530319666190823160230","article-title":"Curcumin Suppresses Epithelial Growth Factor Receptor (EGFR) and Proliferative Protein (Ki 67) in Acute Lung Injury and Lung Fibrosis In vitro and In vivo","volume":"20","author":"Shaikh","year":"2020","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"10.1016\/j.intimp.2024.113587_b0160","article-title":"Trials and Treatments: An Update on Pharmacotherapy for Idiopathic Pulmonary Fibrosis","volume":"13","author":"Thong","year":"2023","journal-title":"Life (Basel, Switzerland)"},{"key":"10.1016\/j.intimp.2024.113587_b0165","doi-asserted-by":"crossref","first-page":"L937","DOI":"10.1152\/ajplung.00150.2005","article-title":"Glutathione restores collagen degradation in TGF-beta-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen","volume":"289","author":"Vayalil","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2024.113587_bib167","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jfma.2017.12.014","article-title":"Curcumin inhibits TGF-\u03b21-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts","volume":"117","author":"Chen","year":"2018","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.intimp.2024.113587_bib168","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1523-1755.2004.00713.x","article-title":"Curcumin blocks multiple sites of the TGF-β signaling cascade in renal cells","volume":"66","author":"Gaedeke","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.intimp.2024.113587_bib169","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1159\/000287230","article-title":"Curcumin inhibits transforming growth factor-beta activity via inhibition of Smad signaling in HK-2 cells","volume":"31","author":"Hu","year":"2010","journal-title":"Am. J. Nephrol."},{"key":"10.1016\/j.intimp.2024.113587_bib170","article-title":"Curcumin Modulates Oxidative Stress, Fibrosis, and Apoptosis in Drug-Resistant Cancer Cell Lines","author":"Gabr","year":"2022","journal-title":"Life (Basel, Switzerland)"},{"key":"10.1016\/j.intimp.2024.113587_bib171","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173191","article-title":"Smad3-dependent CCN2 mediates fibronectin expression in human skin dermal fibroblasts","volume":"12","author":"Purohit","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113587_bib172","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2017.00461","article-title":"Targeting TGF-\u03b2 Mediated SMAD Signaling for the Prevention of Fibrosis","volume":"8","author":"Walton","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113587_bib173","doi-asserted-by":"crossref","unstructured":"Pourbagher-Shahri, A.M., Farkhondeh, T., Ashrafizadeh, M., Talebi, M., Samargahndian, S., 2021. Curcumin and cardiovascular diseases: Focus on cellular targets and cascades. Biomed. Pharmacother. 136, 111214.","DOI":"10.1016\/j.biopha.2020.111214"},{"key":"10.1016\/j.intimp.2024.113587_bib174","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16081554","article-title":"The Role of Curcumin in Cancer: A Focus on the PI3K\/Akt Pathway","author":"Zoi","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.intimp.2024.113587_bib175","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/1472-6882-12-156","article-title":"Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats","volume":"12","author":"Yao","year":"2012","journal-title":"BMC Complement. Altern. Med."},{"key":"10.1016\/j.intimp.2024.113587_bib176","doi-asserted-by":"crossref","first-page":"108498","DOI":"10.18632\/oncotarget.22590","article-title":"Curcumin downregulates the expression of Snail via suppressing Smad2 pathway to inhibit TGF-\u03b21-induced epithelial-mesenchymal transitions in hepatoma cells","volume":"8","author":"Cao","year":"2017","journal-title":"Oncotarget"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692402109X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692402109X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T23:24:53Z","timestamp":1733959493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692402109X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":43,"alternative-id":["S156757692402109X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113587","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PAI-1 influences and curcumin destabilizes MMP-2, MMP-9 and basement membrane proteins during lung injury and fibrosis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113587","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113587"}}