{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:22:38Z","timestamp":1793744558567,"version":"4.6.1"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.intimp.2024.113621","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T03:20:49Z","timestamp":1731727249000},"page":"113621","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"P3","title":["Inhibition of hepatic PCSK9 as a novel therapeutic target ameliorates metabolic steatohepatitis in mice"],"prefix":"10.1016","volume":"143","author":[{"given":"Tuoluonayi","family":"Mijiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaocui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiumin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3473-3718","authenticated-orcid":false,"given":"Bangdang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0005","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes","volume":"64","author":"Younossi","year":"2016","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0010","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11325-018-1678-7","article-title":"Non-alcoholic fatty liver disease is an independent risk factor for inflammation in obstructive sleep apnea syndrome in obese Asian Indians","volume":"23","author":"Bhatt","year":"2019","journal-title":"Sleep Breath."},{"issue":"5","key":"10.1016\/j.intimp.2024.113621_b0015","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1002\/hep.24001","article-title":"Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis","volume":"52","author":"Tilg","year":"2010","journal-title":"Hepatology"},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1017\/S0029665121003815","article-title":"Non-alcoholic fatty liver disease: a multi-system disease influenced by ageing and sex, and affected by adipose tissue and intestinal function","volume":"81","author":"Bilson","year":"2021","journal-title":"Proc. Nutr. Soc."},{"issue":"3","key":"10.1016\/j.intimp.2024.113621_b0025","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3390\/metabo12030256","article-title":"Insight into the evolving role of PCSK9","volume":"12","author":"Maliglowka","year":"2022","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.intimp.2024.113621_b0030","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1210\/endrev\/bnab035","article-title":"The multifaceted biology of PCSK9","volume":"43","author":"Seidah","year":"2022","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2024.113621_b0035","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41569-018-0107-8","article-title":"PCSK9 inhibitors: clinical evidence and implementation","volume":"16","author":"Sabatine","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113621_b0040","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s40256-021-00477-7","article-title":"A critical review of the efficacy and safety of inclisiran","volume":"21","author":"Hardy","year":"2021","journal-title":"Am. J. Cardiovasc. Drugs"},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0045","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/liv.14711","article-title":"PCSK9 rs11591147 R46L loss-of-function variant protects against liver damage in individuals with NAFLD","volume":"41","author":"Grimaudo","year":"2021","journal-title":"Liver Int."},{"key":"10.1016\/j.intimp.2024.113621_b0050","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.jhepr.2019.10.009","article-title":"Pcsk9 knockout exacerbates diet-induced non-alcoholic steatohepatitis, fibrosis and liver injury in mice","volume":"1","author":"Lebeau","year":"2019","journal-title":"JHEP Rep."},{"issue":"4","key":"10.1016\/j.intimp.2024.113621_b0055","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/hep4.1858","article-title":"Pcsk9 deletion promotes murine nonalcoholic steatohepatitis and hepatic carcinogenesis: role of cholesterol","volume":"6","author":"Ioannou","year":"2022","journal-title":"Hepatol Commun"},{"issue":"12","key":"10.1016\/j.intimp.2024.113621_b0060","article-title":"Hepatic and circulating levels of PCSK9 in morbidly obese patients: relation with severity of liver steatosis","volume":"1865","author":"Emma","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.intimp.2024.113621_b0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.atherosclerosis.2017.04.023","article-title":"New role of PCSK9 in atherosclerotic inflammation promotion involving the TLR4\/NF-\u03baB pathway","volume":"262","author":"Tang","year":"2017","journal-title":"Atherosclerosis"},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0070","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/TP.0000000000002480","article-title":"Nonalcoholic Fatty Liver Disease: Basic Pathogenetic Mechanisms in the Progression From NAFLD to NASH","volume":"103","author":"Pierantonelli","year":"2019","journal-title":"Transplantation"},{"issue":"6","key":"10.1016\/j.intimp.2024.113621_b0075","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.3390\/ijms20061499","article-title":"MicroRNA-29a Disrupts DNMT3b to Ameliorate Diet-Induced Non-Alcoholic Steatohepatitis in Mice","volume":"20","author":"Yang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2024.113621_b0080","doi-asserted-by":"crossref","first-page":"e0244762","DOI":"10.1371\/journal.pone.0244762","article-title":"A CD209 ligand and a sialidase inhibitor differentially modulate adipose tissue and liver macrophage populations and steatosis in mice on the Methionine and Choline-Deficient (MCD) diet","volume":"15","author":"Sun","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0085","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/ng1161","article-title":"Mutations in PCSK9 cause autosomal dominant hypercholesterolemia","volume":"34","author":"Abifadel","year":"2003","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0090","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/ng1509","article-title":"Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9","volume":"37","author":"Cohen","year":"2005","journal-title":"Nat. Genet."},{"issue":"15","key":"10.1016\/j.intimp.2024.113621_b0095","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1073\/pnas.0501652102","article-title":"Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9","volume":"102","author":"Rashid","year":"2005","journal-title":"PNAS"},{"issue":"12","key":"10.1016\/j.intimp.2024.113621_b0100","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1056\/NEJMoa054013","article-title":"Sequence variations in PCSK9, low LDL, and protection against coronary heart disease","volume":"354","author":"Cohen","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1194\/jlr.M078360","article-title":"PCSK9 deficiency reduces atherosclerosis, apolipoprotein B secretion, and endothelial dysfunction","volume":"59","author":"Sun","year":"2018","journal-title":"J. Lipid Res."},{"issue":"3","key":"10.1016\/j.intimp.2024.113621_b0110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.jhep.2014.10.039","article-title":"Molecular mechanism of PPAR\u03b1 action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease","volume":"62","author":"Pawlak","year":"2015","journal-title":"J. Hepatol."},{"key":"10.1016\/j.intimp.2024.113621_b0115","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1073\/pnas.0501652102","article-title":"Decreased plasma cholesterol and hypersensitivity","volume":"102","author":"Shirya Rashid","year":"2005","journal-title":"PNAS"},{"issue":"6","key":"10.1016\/j.intimp.2024.113621_b0120","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1172\/JCI128073","article-title":"Hepatic Slug epigenetically promotes liver lipogenesis, fatty liver disease, and type 2 diabetes","volume":"130","author":"Liu","year":"2020","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0125","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI81542","article-title":"E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis","volume":"126","author":"Denechaud","year":"2015","journal-title":"J. Clin. Investig."},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0130","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev-nutr-071812-161220","article-title":"Structure-Function of CD36 and Importance of Fatty Acid Signal Transduction in Fat Metabolism","volume":"34","author":"Pepino","year":"2014","journal-title":"Annu. Rev. Nutr."},{"issue":"7","key":"10.1016\/j.intimp.2024.113621_b0135","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPAR\u03b1 is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"Montagner","year":"2016","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0140","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1038\/s41598-020-63579-3","article-title":"Hepatocyte-specific deletion of Pparalpha promotes NAFLD in the context of obesity","volume":"10","author":"Regnier","year":"2020","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0145","doi-asserted-by":"crossref","first-page":"6489","DOI":"10.1038\/s41598-020-63579-3","article-title":"Hepatocyte-specific deletion of PPAR\u03b1 promotes NAFLD in the context of obesity","volume":"10","author":"R\u00e9gnier","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.intimp.2024.113621_b0150","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0155","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1172\/JCI121842","article-title":"STING-mediated inflammation in Kupffer cells contributes to progression of nonalcoholic steatohepatitis","volume":"129","author":"Yu","year":"2019","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.intimp.2024.113621_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.803037","article-title":"Macrophage Polarization and Its Role in Liver Disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2024.113621_b0165","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"4","key":"10.1016\/j.intimp.2024.113621_b0170","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1002\/hep.23122","article-title":"Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice","volume":"50","author":"Spruss","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.intimp.2024.113621_b0175","doi-asserted-by":"crossref","first-page":"5791915","DOI":"10.1155\/2022\/5791915","article-title":"MFG-E8 knockout aggravated nonalcoholic steatohepatitis by promoting the activation of TLR4\/NF-\u03baB signaling in mice","volume":"2022","author":"Hu","year":"2022","journal-title":"Mediat. Inflamm."},{"issue":"599","key":"10.1016\/j.intimp.2024.113621_b0180","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe1692","article-title":"Hepatocyte TLR4 triggers inter-hepatocyte Jagged1\/Notch signaling to determine NASH-induced fibrosis","volume":"13","author":"Yu","year":"2021","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0185","doi-asserted-by":"crossref","first-page":"4383","DOI":"10.1038\/s41467-018-06318-7","article-title":"Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations","volume":"9","author":"MacParland","year":"2018","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.intimp.2024.113621_b0190","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1159\/000490077","article-title":"Activation of TGF-\u03b21\/\u03b1-SMA\/Col I profibrotic pathway in fibroblasts by galectin-3 contributes to atrial fibrosis in experimental models and patients","volume":"47","author":"Shen","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2024.113621_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1106875","article-title":"Qingrequzhuo capsule alleviated methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice through regulating gut microbiota, enhancing gut tight junction and inhibiting the activation of TLR4\/NF-\u03baB signaling pathway","volume":"13","author":"Lv","year":"2023","journal-title":"Front. Endocrinol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113621_b0200","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.4254\/wjh.v12.i12.1258","article-title":"Effects of proprotein convertase subtilisin\/kexin type-9 inhibitors on fatty liver","volume":"12","author":"Shafiq","year":"2020","journal-title":"World J. Hepatol."},{"key":"10.1016\/j.intimp.2024.113621_b0205","doi-asserted-by":"crossref","DOI":"10.12659\/AJCR.932961","article-title":"A New Potential Strategy for Acute Non-Alcoholic Steatohepatitis (NASH)","volume":"22","author":"Sekhon","year":"2021","journal-title":"Am. J. Case Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.113621_b0210","first-page":"1","article-title":"PCSK9 inhibition as a novel therapeutic target for alcoholic liver disease","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692402143X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S156757692402143X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T04:25:41Z","timestamp":1733977541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S156757692402143X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"alternative-id":["S156757692402143X"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113621","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of hepatic PCSK9 as a novel therapeutic target ameliorates metabolic steatohepatitis in mice","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113621","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113621"}}