{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:39:34Z","timestamp":1793385574252,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009004","name":"Anhui University of Chinese Medicine","doi-asserted-by":"publisher","award":["AHUCM-rats-2022023"],"award-info":[{"award-number":["AHUCM-rats-2022023"]}],"id":[{"id":"10.13039\/501100009004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017128","name":"Science Fund for Distinguished Young Scholars of Anhui Province","doi-asserted-by":"publisher","award":["2022AH020044"],"award-info":[{"award-number":["2022AH020044"]}],"id":[{"id":"10.13039\/100017128","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017679","name":"Collaborative Innovation Project of Colleges and Universities of Anhui Province","doi-asserted-by":"publisher","award":["GXXT-2021-084"],"award-info":[{"award-number":["GXXT-2021-084"]}],"id":[{"id":"10.13039\/501100017679","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113636","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T17:25:55Z","timestamp":1732296355000},"page":"113636","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Qibai Pingfei Capsule ameliorated inflammation in chronic obstructive pulmonary disease (COPD) via HIF-1 \u03b1\/glycolysis pathway mediated of BMAL1"],"prefix":"10.1016","volume":"144","author":[{"given":"Xuejing","family":"Luan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113636_b0005","doi-asserted-by":"crossref","DOI":"10.1513\/AnnalsATS.202312-1062OC","article-title":"Nocturnal Hypoxemia Is Associated with Sarcopenia in COPD Patients","author":"Attaway","year":"2024","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.intimp.2024.113636_b0010","doi-asserted-by":"crossref","unstructured":"Gao M, Liang C, Hong W, Yu X, Zhou Y, Sun R, et al. Biomass-related PM2.5 induces mitochondrial fragmentation and dysfunction in human airway epithelial cells. Environ Pollut. 2022;292(Pt B):118464.","DOI":"10.1016\/j.envpol.2021.118464"},{"key":"10.1016\/j.intimp.2024.113636_b0015","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2147\/COPD.S366126","article-title":"Pathological Mechanism and Targeted Drugs of COPD","volume":"17","author":"Guo","year":"2022","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"10.1016\/j.intimp.2024.113636_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154431","article-title":"Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia","volume":"107","author":"Ma","year":"2022","journal-title":"Phytomedicine"},{"issue":"164","key":"10.1016\/j.intimp.2024.113636_b0025","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0028-2022","article-title":"Polyphenols, flavonoids and inflammasomes: the role of cigarette smoke in COPD","volume":"31","author":"Fu","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113636_b0030","article-title":"Increased Expression of LASI lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia","volume":"13","author":"Manevski","year":"2022","journal-title":"Front. Immunol."},{"issue":"9435","key":"10.1016\/j.intimp.2024.113636_b0035","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S0140-6736(04)16900-6","article-title":"Pathophysiology of airflow limitation in chronic obstructive pulmonary disease","volume":"364","author":"Hogg","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2016.05.011","article-title":"Inflammatory mechanisms in patients with chronic obstructive pulmonary disease","volume":"138","author":"Barnes","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12931-023-02511-5","article-title":"Acute cigarette smoke exposure leads to higher viral infection in human bronchial epithelial cultures by altering interferon, glycolysis and GDF15-related pathways","volume":"24","author":"Wang","year":"2023","journal-title":"Respir. Res."},{"issue":"14","key":"10.1016\/j.intimp.2024.113636_b0050","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1177\/15353702211008808","article-title":"Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease","volume":"246","author":"Xue","year":"2021","journal-title":"Exp. Biol. Med. (Maywood)"},{"issue":"7444","key":"10.1016\/j.intimp.2024.113636_b0055","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2024.113636_b0060","doi-asserted-by":"crossref","first-page":"9519","DOI":"10.1074\/jbc.M010144200","article-title":"Regulation of glut1 mRNA by hypoxia-inducible factor-1. Interaction between H-ras and hypoxia","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0065","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/resp.13722","article-title":"Hypoxia-inducible factor and bacterial infections in chronic obstructive pulmonary disease","volume":"25","author":"Shukla","year":"2020","journal-title":"Respirology"},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"issue":"1\u20133","key":"10.1016\/j.intimp.2024.113636_b0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejphar.2010.04.019","article-title":"ATP and the pathogenesis of COPD","volume":"638","author":"Mortaz","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113636_b0080","article-title":"Blocking the HIF-1alpha\/glycolysis axis inhibits allergic airway inflammation by reducing ILC2 metabolism and function","author":"Zhang","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2024.113636_b0085","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/2689600","article-title":"The Link between Circadian Clock Genes and Autophagy in Chronic Obstructive Pulmonary Disease","volume":"2021","author":"Hu","year":"2021","journal-title":"Mediators Inflamm."},{"issue":"3","key":"10.1016\/j.intimp.2024.113636_b0090","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1165\/rcmb.2014-0476TR","article-title":"Circadian clock-coupled lung cellular and molecular functions in chronic airway diseases","volume":"53","author":"Sundar","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0095","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1096\/fj.13-232629","article-title":"Circadian clock function is disrupted by environmental tobacco\/cigarette smoke, leading to lung inflammation and injury via a SIRT1-BMAL1 pathway","volume":"28","author":"Hwang","year":"2014","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.intimp.2024.113636_b0100","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1165\/rcmb.2014-0474OC","article-title":"Disruption of Sirtuin 1-Mediated Control of Circadian Molecular Clock and Inflammation in Chronic Obstructive Pulmonary Disease","volume":"53","author":"Yao","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.intimp.2024.113636_b0105","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.54090","article-title":"Bmal1 integrates mitochondrial metabolism and macrophage activation","volume":"9","author":"Alexander","year":"2020","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0110","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1186\/s12967-022-03481-w","article-title":"The treatment of Qibai Pingfei Capsule on chronic obstructive pulmonary disease may be mediated by Th17\/Treg balance and gut-lung axis microbiota","volume":"20","author":"Jia","year":"2022","journal-title":"J. Transl. Med."},{"issue":"11","key":"10.1016\/j.intimp.2024.113636_b0115","first-page":"987","article-title":"Effect of Qibai Pingfei Capsule on the BODE Index of Chronic Obstructive Pulmonary Disease Patients","volume":"51","author":"Zegeng. Li","year":"2010","journal-title":"J. Tradit. Chin. Med."},{"issue":"01","key":"10.1016\/j.intimp.2024.113636_b0120","first-page":"44","article-title":"Therapeutic Effect Analysis of Qibai Pingfei Capsule on Phlegm and Blood Stasis Obstructing the Lung Type of COPD Patients","volume":"30","author":"Jiabing. Tong","year":"2012","journal-title":"Chin. Arch. Tradit. Chin. Med."},{"issue":"11","key":"10.1016\/j.intimp.2024.113636_b0125","first-page":"1497","article-title":"Qibaipingfei Capsule down-regulate the levels of calcineurin and nuclear factor of activated T-cells isoform c3 (NFATc3) in chronic obstructive pulmonary disease","volume":"31","author":"Zhu","year":"2015","journal-title":"Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi"},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s13105-023-00990-0","article-title":"Quercetin improved hepatic circadian rhythm dysfunction in middle-aged mice fed with vitamin D-deficient diet","volume":"80","author":"Li","year":"2024","journal-title":"J. Physiol. Biochem."},{"issue":"10","key":"10.1016\/j.intimp.2024.113636_b0135","doi-asserted-by":"crossref","first-page":"16408","DOI":"10.1002\/jcb.28587","article-title":"The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose","volume":"120","author":"Liu","year":"2019","journal-title":"J. Cell. Biochem."},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0140","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s41522-024-00498-5","article-title":"Ginseng extracts improve circadian clock gene expression and reduce inflammation directly and indirectly through gut microbiota and PI3K signaling pathway","volume":"10","author":"Zhang","year":"2024","journal-title":"npj Biofilms Microbiomes"},{"issue":"2","key":"10.1016\/j.intimp.2024.113636_b0145","doi-asserted-by":"crossref","first-page":"661","DOI":"10.7150\/ijbs.65861","article-title":"Regulation of lung epithelial cell senescence in smoking-induced COPD\/emphysema by microR-125a-5p via Sp1 mediation of SIRT1\/HIF-1a","volume":"18","author":"Wu","year":"2022","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0150","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12931-022-02072-z","article-title":"Blocking P2X purinoceptor 4 signalling alleviates cigarette smoke induced pulmonary inflammation","volume":"23","author":"Schneider","year":"2022","journal-title":"Respir. Res."},{"issue":"3","key":"10.1016\/j.intimp.2024.113636_b0155","first-page":"32","article-title":"FNDC5\/PPARa Pathway Alleviates THP-1-derived Macrophage Pyroptosis and Its Mechanism","volume":"29","author":"Zhou","year":"2023","journal-title":"Altern. Ther. Health Med."},{"issue":"8","key":"10.1016\/j.intimp.2024.113636_b0160","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S2213-2600(17)30207-2","article-title":"Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort","volume":"5","author":"Han","year":"2017","journal-title":"Lancet Respir. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0165","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1038\/s41467-019-10991-7","article-title":"Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis","volume":"10","author":"Yoshida","year":"2019","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.intimp.2024.113636_b0170","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1513\/pats.200504-045SR","article-title":"Pathogenesis of chronic obstructive pulmonary disease","volume":"2","author":"MacNee","year":"2005","journal-title":"Proc. Am. Thorac. Soc."},{"key":"10.1016\/j.intimp.2024.113636_b0175","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abo7728","article-title":"Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration","author":"Mikami","year":"2023156997728","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.intimp.2024.113636_b0180","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.freeradbiomed.2021.03.039","article-title":"Developing a novel strategy for COPD therapy by targeting Nrf2 and metabolism reprogramming simultaneously","volume":"169","author":"Wang","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.113636_b0185","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.intimp.2024.113636_b0190","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4187\/respcare.10551333","article-title":"Sleep-disordered breathing and COPD: the overlap syndrome","volume":"55","author":"Owens","year":"2010","journal-title":"Respir. Care"},{"issue":"1","key":"10.1016\/j.intimp.2024.113636_b0195","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1186\/s12890-022-02237-y","article-title":"Circadian clock gene Clock-Bmal1 regulates cellular senescence in Chronic obstructive pulmonary disease","volume":"22","author":"Li","year":"2022","journal-title":"BMC Pulm. Med."},{"issue":"10","key":"10.1016\/j.intimp.2024.113636_b0200","doi-asserted-by":"crossref","first-page":"5474","DOI":"10.1073\/pnas.95.10.5474","article-title":"The basic-helix-loop-helix-PAS orphan MOP3 forms transcriptionally active complexes with circadian and hypoxia factors","volume":"95","author":"Hogenesch","year":"1998","journal-title":"PNAS"},{"issue":"12","key":"10.1016\/j.intimp.2024.113636_b0205","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202302148","article-title":"Activation of the JNK\/COX-2\/HIF-1alpha axis promotes M1 macrophage via glycolytic shift in HIV-1 infection","volume":"6","author":"Zhang","year":"2023","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.intimp.2024.113636_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1258138","article-title":"Integration of metabolomics and network pharmacology to reveal the protective mechanism underlying Qibai Pingfei capsule on chronic obstructive pulmonary disease","volume":"14","author":"Xie","year":"2023","journal-title":"Front. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924021581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924021581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:47:14Z","timestamp":1789645634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924021581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":42,"alternative-id":["S1567576924021581"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113636","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Qibai Pingfei Capsule ameliorated inflammation in chronic obstructive pulmonary disease (COPD) via HIF-1 \u03b1\/glycolysis pathway mediated of BMAL1","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113636","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113636"}}