{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:05:20Z","timestamp":1789646720530,"version":"4.0.0"},"reference-count":120,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005088","name":"Beijing Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["303-01-001-0272-05"],"award-info":[{"award-number":["303-01-001-0272-05"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010270","name":"Capital Health Research and Development of Special Fund","doi-asserted-by":"publisher","award":["2024-1-2012"],"award-info":[{"award-number":["2024-1-2012"]}],"id":[{"id":"10.13039\/501100010270","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113687","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T19:52:20Z","timestamp":1732564340000},"page":"113687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-6649-4631","authenticated-orcid":false,"given":"Qijun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaikang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10191","key":"10.1016\/j.intimp.2024.113687_b0005","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","article-title":"Sarcopenia","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0010","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/ageing\/afz046","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"10","key":"10.1016\/j.intimp.2024.113687_b0015","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afac220","article-title":"Sarcopenia definition, diagnosis and treatment: consensus is growing","volume":"51","author":"Sayer","year":"2022","journal-title":"Age Ageing"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0020","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/ageing\/afw071","article-title":"Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men","volume":"45","author":"De Buyser","year":"2016","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/jcsm.12783","article-title":"Global prevalence of sarcopenia and severe sarcopenia: a systematic review and meta-analysis","volume":"13","author":"Petermann-Rocha","year":"2022","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0030","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/1747-0080.12287","article-title":"Sarcopenia and hospitalisation costs in older adults: a cross-sectional study","volume":"74","author":"Antunes","year":"2017","journal-title":"Nutr. Diet."},{"issue":"10","key":"10.1016\/j.intimp.2024.113687_b0035","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41577-021-00603-1","article-title":"Immune-mediated inflammatory disease therapeutics: past, present and future","volume":"21","author":"McInnes","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2024.113687_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103410","article-title":"Immune-mediated inflammatory diseases: common and different pathogenic and clinical features","volume":"22","author":"Monteleone","year":"2023","journal-title":"Autoimmun. Rev."},{"issue":"9746","key":"10.1016\/j.intimp.2024.113687_b0045","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/S0140-6736(10)60826-4","article-title":"Rheumatoid arthritis","volume":"376","author":"Scott","year":"2010","journal-title":"Lancet"},{"issue":"16","key":"10.1016\/j.intimp.2024.113687_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165678","article-title":"Sarcopenia in autoimmune and rheumatic diseases: a comprehensive review","volume":"21","author":"An","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0055","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2019.03.027","article-title":"Pleiotropy and specificity: insights from the Interleukin 6 family of cytokines","volume":"50","author":"Murakami","year":"2019","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052719","article-title":"The role of tumor necrosis factor alpha (TNF-alpha) in autoimmune disease and current TNF-alpha inhibitors in therapeutics","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.intimp.2024.113687_b0065","doi-asserted-by":"crossref","DOI":"10.3390\/nu11102281","article-title":"Characterization of sarcopenia in an IBD population attending an Italian Gastroenterology Tertiary Center","volume":"11","author":"Pizzoferrato","year":"2019","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0070","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2022-002600","article-title":"Prevalence of sarcopenia in patients with rheumatoid arthritis using the revised EWGSOP2 and the FNIH definition","volume":"8","author":"Dietzel","year":"2022","journal-title":"RMD Open"},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0075","first-page":"470","article-title":"Body composition phenotypes in systemic lupus erythematosus and rheumatoid arthritis: a comparative study of Caucasian female patients","volume":"29","author":"Santos","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113687_b0080","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nrrheum.2017.60","article-title":"Epidemiology of sarcopenia and insight into possible therapeutic targets","volume":"13","author":"Dennison","year":"2017","journal-title":"Nat. Rev. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ije\/dyg070","article-title":"'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease?","volume":"32","author":"Smith","year":"2003","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.intimp.2024.113687_b0090","article-title":"Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians","volume":"362","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.intimp.2024.113687_b0095","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73873","article-title":"Association of lipid-lowering drugs with COVID-19 outcomes from a Mendelian randomization study","volume":"10","author":"Huang","year":"2021","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0100","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s10194-023-01633-x","article-title":"Lipids, lipid-modifying drug target genes and migraine: a Mendelian randomization study","volume":"24","author":"Bi","year":"2023","journal-title":"J. Headache Pain"},{"key":"10.1016\/j.intimp.2024.113687_b0105","article-title":"Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration","volume":"375","author":"Skrivankova","year":"2021","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.intimp.2024.113687_b0110","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/ng.3434","article-title":"Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus","volume":"47","author":"Bentham","year":"2015","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0115","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng.3760","article-title":"Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease","volume":"49","author":"de Lange","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.intimp.2024.113687_b0120","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.34408","article-title":"The MR-Base platform supports systematic causal inference across the human phenome","volume":"7","author":"Hemani","year":"2018","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0125","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1007\/s12603-016-0753-7","article-title":"Appendicular lean mass and mortality among prefrail and frail older adults","volume":"21","author":"Brown","year":"2017","journal-title":"J. Nutr. Health Aging"},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0130","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0135","doi-asserted-by":"crossref","DOI":"10.1038\/s42003-020-01334-0","article-title":"The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study","volume":"3","author":"Pei","year":"2020","journal-title":"Commun. Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0140","article-title":"Genome-wide association study of self-reported walking pace suggests beneficial effects of brisk walking on health and survival","volume":"3","author":"Timmins","year":"2020","journal-title":"Commun. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0145","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1002\/sim.4197","article-title":"Bias in causal estimates from Mendelian randomization studies with weak instruments","volume":"30","author":"Burgess","year":"2011","journal-title":"Stat. Med."},{"issue":"22","key":"10.1016\/j.intimp.2024.113687_b0150","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations","volume":"35","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1007081","article-title":"Orienting the causal relationship between imprecisely measured traits using GWAS summary data","volume":"13","author":"Hemani","year":"2017","journal-title":"PLoS Genet."},{"issue":"383","key":"10.1016\/j.intimp.2024.113687_b0160","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag1166","article-title":"The druggable genome and support for target identification and validation in drug development","volume":"9","author":"Finan","year":"2017","journal-title":"Sci. Transl. Med."},{"issue":"Database issue","key":"10.1016\/j.intimp.2024.113687_b0165","doi-asserted-by":"crossref","first-page":"D1100","DOI":"10.1093\/nar\/gkr777","article-title":"ChEMBL: a large-scale bioactivity database for drug discovery","volume":"40","author":"Gaulton","year":"2012","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0170","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1038\/ng.2797","article-title":"Discovery and refinement of loci associated with lipid levels","volume":"45","author":"Willer","year":"2013","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0175","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0180","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/gepi.21965","article-title":"Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator","volume":"40","author":"Bowden","year":"2016","journal-title":"Genet. Epidemiol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0185","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/jcsm.13319","article-title":"Assessment of the bidirectional causal association between frailty and depression: a Mendelian randomization study","volume":"14","author":"Zhu","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"23","key":"10.1016\/j.intimp.2024.113687_b0190","doi-asserted-by":"crossref","first-page":"9160","DOI":"10.1002\/cam4.3493","article-title":"Depression and prostate cancer risk: a Mendelian randomization study","volume":"9","author":"Chen","year":"2020","journal-title":"Cancer Med."},{"key":"10.1016\/j.intimp.2024.113687_b0195","article-title":"Systemic inflammatory regulators and risk of acute-on-chronic liver failure: a bidirectional Mendelian-randomization study","volume":"11","author":"Wang","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0200","doi-asserted-by":"crossref","DOI":"10.1093\/ageing\/afad024","article-title":"Potential therapeutic targets for sarcopenia identified by Mendelian randomisation","volume":"52","author":"Jiang","year":"2023","journal-title":"Age Ageing"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0205","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/ng.3538","article-title":"Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets","volume":"48","author":"Zhu","year":"2016","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0210","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/s12967-023-04474-z","article-title":"Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study","volume":"21","author":"Cao","year":"2023","journal-title":"J. Transl. Med."},{"issue":"9","key":"10.1016\/j.intimp.2024.113687_b0215","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"Vosa","year":"2021","journal-title":"Nat. Genet."},{"issue":"6509","key":"10.1016\/j.intimp.2024.113687_b0220","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0225","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/jcsm.13174","article-title":"Causal linkage of tobacco smoking with ageing: Mendelian randomization analysis towards telomere attrition and sarcopenia","volume":"14","author":"Park","year":"2023","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0230","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in Mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int. J. Epidemiol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0235","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.intimp.2024.113687_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105033","article-title":"Phenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease","volume":"101","author":"Yuan","year":"2024","journal-title":"EBioMedicine"},{"issue":"6960","key":"10.1016\/j.intimp.2024.113687_b0245","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nature02055","article-title":"The DNA sequence and analysis of human chromosome 6","volume":"425","author":"Mungall","year":"2003","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2024.113687_b0250","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrg1489","article-title":"Gene map of the extended human MHC","volume":"5","author":"Horton","year":"2004","journal-title":"Nat. Rev. Genet."},{"issue":"5\u20136","key":"10.1016\/j.intimp.2024.113687_b0255","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2119\/2007-00123.Lee","article-title":"Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus","volume":"14","author":"Lee","year":"2008","journal-title":"Mol. Med."},{"issue":"6","key":"10.1016\/j.intimp.2024.113687_b0260","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1001\/jamapsychiatry.2021.0005","article-title":"Association of antihypertensive drug target genes with psychiatric disorders: a Mendelian randomization study","volume":"78","author":"Chauquet","year":"2021","journal-title":"JAMA Psychiat."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0265","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0270","doi-asserted-by":"crossref","DOI":"10.1186\/s13059-019-1758-4","article-title":"Cytoscape Automation: empowering workflow-based network analysis","volume":"20","author":"Otasek","year":"2019","journal-title":"Genome Biol."},{"issue":"D1","key":"10.1016\/j.intimp.2024.113687_b0275","doi-asserted-by":"crossref","first-page":"D1302","DOI":"10.1093\/nar\/gkaa1027","article-title":"Open Targets Platform: supporting systematic drug-target identification and prioritisation","volume":"49","author":"Ochoa","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"Web Server issue","key":"10.1016\/j.intimp.2024.113687_b0280","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Warde-Farley","year":"2010","journal-title":"Nucleic Acids Res."},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0285","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/rheumatology\/kex260","article-title":"The worldwide incidence and prevalence of systemic lupus erythematosus: a systematic review of epidemiological studies","volume":"56","author":"Rees","year":"2017","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0290","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-022-02526-0","article-title":"Female gender, dissatisfaction with weight, and number of IBD related surgeries as independent risk factors for eating disorders among patients with inflammatory bowel diseases","volume":"22","author":"Stoleru","year":"2022","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.intimp.2024.113687_b0295","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1042751","article-title":"Immune-mediated inflammatory diseases and risk of venous thromboembolism: a Mendelian randomization study","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113687_b0300","article-title":"Causal association between celiac disease and inflammatory bowel disease: A two-sample bidirectional Mendelian randomization study","volume":"13","author":"Yuan","year":"2022","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113687_b0305","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/COC.0000000000000924","article-title":"A phase I study of apolizumab, an anti-HLA-DR ss-chain monoclonal antibody, in patients with solid tumor malignancies","volume":"45","author":"Fracasso","year":"2022","journal-title":"Am. J. Clin. Oncol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113687_b0310","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.3109\/10428190903186486","article-title":"A phase I\/II dose escalation study of apolizumab (Hu1D10) using a stepped-up dosing schedule in patients with chronic lymphocytic leukemia and acute leukemia","volume":"50","author":"Lin","year":"2009","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.intimp.2024.113687_b0315","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2377-14-12","article-title":"Effect of TTP488 in patients with mild to moderate Alzheimer's disease","volume":"14","author":"Burstein","year":"2014","journal-title":"BMC Neurol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0320","doi-asserted-by":"crossref","DOI":"10.1038\/s41523-023-00564-9","article-title":"RAGE inhibitor TTP488 (Azeliragon) suppresses metastasis in triple-negative breast cancer","volume":"9","author":"Magna","year":"2023","journal-title":"npj Breast Cancer"},{"key":"10.1016\/j.intimp.2024.113687_b0325","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1752-0509-4-41","article-title":"Integrated network analysis of transcriptomic and proteomic data in psoriasis","volume":"4","author":"Piruzian","year":"2010","journal-title":"BMC Syst. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0330","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10051133","article-title":"Significantly altered serum levels of NAD, AGE, RAGE, CRP, and elastin as potential biomarkers of psoriasis and aging-a case-control study","volume":"10","author":"Karas","year":"2022","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.intimp.2024.113687_b0335","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1046\/j.1365-2133.1998.02552.x","article-title":"HLA-DRB1*0701 and DRB1*1401 are associated with genetic susceptibility to psoriasis vulgaris in a Taiwanese population","volume":"139","author":"Jee","year":"1998","journal-title":"Br. J. Dermatol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0340","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/ard.2007.071399","article-title":"Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis","volume":"67","author":"Ho","year":"2008","journal-title":"Ann. Rheum. Dis."},{"issue":"7","key":"10.1016\/j.intimp.2024.113687_b0345","doi-asserted-by":"crossref","first-page":"12323","DOI":"10.18632\/oncotarget.12468","article-title":"Hypomethylation of HLA-DRB1 and its clinical significance in psoriasis","volume":"8","author":"Zong","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0350","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1002\/jcsm.13456","article-title":"Mapping the causal associations of cytokines with sarcopenia and aging traits: evidence from bidirectional Mendelian randomization","volume":"15","author":"Liu","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0355","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-20918-w","article-title":"Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women","volume":"12","author":"Jones","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0360","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcsm.13461","article-title":"Leukocyte telomere length is associated with MRI-thigh fat-free muscle volume: data from 16 356 UK Biobank adults","volume":"15","author":"Kirk","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.arcmed.2024.103007","article-title":"Telomere length is associated with the prevalence, persistence, and incidence of sarcopenia","volume":"55","author":"Salinas-Rodriguez","year":"2024","journal-title":"Arch. Med. Res."},{"issue":"12","key":"10.1016\/j.intimp.2024.113687_b0370","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/art.42304","article-title":"Telomere length and development of systemic lupus erythematosus: a Mendelian randomization study","volume":"74","author":"Wang","year":"2022","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0375","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s13059-024-03269-9","article-title":"Breaking down causes, consequences, and mediating effects of telomere length variation on human health","volume":"25","author":"Moix","year":"2024","journal-title":"Genome Biol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0380","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13694-1","article-title":"Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities","volume":"10","author":"Migliavacca","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.113687_b0385","doi-asserted-by":"crossref","DOI":"10.18632\/aging.101574","article-title":"A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women","author":"Zhao","year":"2018","journal-title":"Aging"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0390","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/s42255-024-01046-3","article-title":"Adipose tissue as a linchpin of organismal ageing","volume":"6","author":"Nguyen","year":"2024","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0395","article-title":"Can biological drugs diminish the risk of sarcopenia in psoriatic patients? A systematic review","volume":"12","author":"Pietowska","year":"2022","journal-title":"Life (Basel)"},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0400","first-page":"322","article-title":"SARCOSPA - Sarcopenia in spondyloarthritis patients","volume":"39","author":"Aguiar","year":"2014","journal-title":"Acta Reumatol. Port."},{"issue":"8","key":"10.1016\/j.intimp.2024.113687_b0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237598","article-title":"Psoriatic disease and body composition: a systematic review and narrative synthesis","volume":"15","author":"Blake","year":"2020","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0410","doi-asserted-by":"crossref","first-page":"215","DOI":"10.5114\/reum.2017.71627","article-title":"Changes in body composition and bone mineral density in postmenopausal women with psoriatic arthritis","volume":"55","author":"Krajewska-Wlodarczyk","year":"2017","journal-title":"Reumatologia"},{"key":"10.1016\/j.intimp.2024.113687_b0415","article-title":"Psoriasis is associated with myosteatosis but not sarcopenia: a case-control study","volume":"8","author":"Chen","year":"2021","journal-title":"Front. Med. (Lausanne)"},{"issue":"12","key":"10.1016\/j.intimp.2024.113687_b0420","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1093\/rheumatology\/keac196","article-title":"Muscle involvement in systemic lupus erythematosus: multimodal ultrasound assessment and relationship with physical performance","volume":"61","author":"Di Matteo","year":"2022","journal-title":"Rheumatology (Oxford)"},{"issue":"6","key":"10.1016\/j.intimp.2024.113687_b0425","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1177\/0961203318758504","article-title":"Increased visceral adipose tissue and altered adiposity distribution in premenopausal lupus patients: correlation with cardiovascular risk factors","volume":"27","author":"Seguro","year":"2018","journal-title":"Lupus"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0430","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1002\/jcsm.12381","article-title":"Myopenia is associated with joint damage in rheumatoid arthritis: a cross-sectional study","volume":"10","author":"Lin","year":"2019","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"7","key":"10.1016\/j.intimp.2024.113687_b0435","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1093\/rheumatology\/ker004","article-title":"Abnormal body composition phenotypes in Vietnamese women with early rheumatoid arthritis","volume":"50","author":"Dao","year":"2011","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0440","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/s10067-023-06779-2","article-title":"Factors associated with sarcopenia in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study","volume":"43","author":"Nakayama","year":"2024","journal-title":"Clin. Rheumatol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113687_b0445","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.clnu.2016.10.004","article-title":"Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy","volume":"36","author":"Zhang","year":"2017","journal-title":"Clin. Nutr."},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0450","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/ibd.20504","article-title":"Sarcopenia is prevalent in patients with Crohn's disease in clinical remission","volume":"14","author":"Schneider","year":"2008","journal-title":"Inflamm. Bowel Dis."},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0455","article-title":"Serial changes in body composition and the association with disease activity during treatment in patients with Crohn's disease","volume":"12","author":"Lee","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.intimp.2024.113687_b0460","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-016-1155-z","article-title":"Is there a relation between pre-sarcopenia, sarcopenia, cachexia and osteoporosis in patients with ankylosing spondylitis?","volume":"17","author":"El Maghraoui","year":"2016","journal-title":"BMC Musculoskelet. Disord."},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0465","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/jid.2008.348","article-title":"Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone","volume":"129","author":"Foitzik","year":"2009","journal-title":"J. Invest. Dermatol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0470","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1080\/07420528.2018.1493490","article-title":"The effects of 12-week progressive strength training on strength, functional capacity, metabolic biomarkers, and serum hormone concentrations in healthy older women: morning versus evening training","volume":"35","author":"Krcmarova","year":"2018","journal-title":"Chronobiol. Int."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0475","first-page":"192","article-title":"Heavy resistance training and supplementation with the alleged testosterone booster Nmda has no effect on body composition, muscle performance, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained males","volume":"13","author":"Willoughby","year":"2014","journal-title":"J. Sports Sci. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0480","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrrheum.2010.231","article-title":"Sexual dimorphism of RA manifestations: genes, hormones and behavior","volume":"7","author":"Kovacs","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.113687_b0485","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.797243","article-title":"Gonadotropins at advanced age - perhaps they are not so bad? Correlations between gonadotropins and sarcopenia indicators in older adults","volume":"12","author":"Guligowska","year":"2021","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0490","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/ard.2006.060293","article-title":"Are there gender differences in severity of ankylosing spondylitis? Results from the PSOAS cohort","volume":"66","author":"Lee","year":"2007","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0495","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF02031066","article-title":"Free and serum testosterone levels in 276 males: a comparative study of rheumatoid arthritis, ankylosing spondylitis and healthy controls","volume":"8","author":"Spector","year":"1989","journal-title":"Clin. Rheumatol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113687_b0500","first-page":"2389","article-title":"Serum testosterone levels are not elevated in patients with ankylosing spondylitis","volume":"25","author":"Giltay","year":"1998","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113687_b0505","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s00404-020-05824-8","article-title":"Ovarian reserve in patients with ankylosing spondylitis","volume":"303","author":"Yalcin Bahat","year":"2021","journal-title":"Arch. Gynecol. Obstet."},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0510","doi-asserted-by":"crossref","first-page":"721","DOI":"10.5114\/biolsport.2021.107314","article-title":"The effect of the menstrual cycle on collagen metabolism, growth hormones and strength in young physically active women","volume":"38","author":"Iwanska","year":"2021","journal-title":"Biol. Sport"},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0515","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/jcsm.13479","article-title":"Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for sarcopenia","volume":"15","author":"Yin","year":"2024","journal-title":"J. Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.intimp.2024.113687_b0520","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155994","article-title":"Identifying genetic determinants of sarcopenia-related traits: a Mendelian randomization study of druggable genes","volume":"160","author":"Wu","year":"2024","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0525","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1039\/C7MD00633K","article-title":"Approaches to target tractability assessment - a practical perspective","volume":"9","author":"Brown","year":"2018","journal-title":"MedChemComm"},{"issue":"10","key":"10.1016\/j.intimp.2024.113687_b0530","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41573-021-00245-x","article-title":"The PROTACtable genome","volume":"20","author":"Schneider","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0535","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/jcsm.12561","article-title":"Targeting RAGE prevents muscle wasting and prolongs survival in cancer cachexia","volume":"11","author":"Chiappalupi","year":"2020","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"11","key":"10.1016\/j.intimp.2024.113687_b0540","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00251-002-0521-1","article-title":"Novel mutations in the RFXANK gene: RFX complex containing in-vitro-generated RFXANK mutant binds the promoter without transactivating MHC II","volume":"54","author":"Wiszniewski","year":"2003","journal-title":"Immunogenetics"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytox.2020.100023","article-title":"IFN-gamma and CIITA modulate IL-6 expression in skeletal muscle","volume":"2","author":"Adhikari","year":"2020","journal-title":"Cytokine X"},{"issue":"5","key":"10.1016\/j.intimp.2024.113687_b0550","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/iji.12548","article-title":"CIITA gene polymorphism (rs3087456) in systemic lupus erythematosus and rheumatoid arthritis: a population-based cohort study","volume":"48","author":"Lima","year":"2021","journal-title":"Int. J. Immunogenet."},{"issue":"8","key":"10.1016\/j.intimp.2024.113687_b0555","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/gene.2011.36","article-title":"The rs4774 CIITA missense variant is associated with risk of systemic lupus erythematosus","volume":"12","author":"Bronson","year":"2011","journal-title":"Genes Immun."},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0560","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00403-002-0301-7","article-title":"Gene polymorphisms (G82S, 1704G\/T, 2184A\/G and 2245G\/A) of the receptor of advanced glycation end products (RAGE) in plaque psoriasis","volume":"294","author":"Vasku","year":"2002","journal-title":"Arch. Dermatol. Res."},{"issue":"39\u201340","key":"10.1016\/j.intimp.2024.113687_b0565","first-page":"541","article-title":"HLA-DRB1 association in Turkish psoriasis vulgaris patients","volume":"133","author":"Fatma","year":"2003","journal-title":"Swiss Med. Wkly."},{"issue":"4","key":"10.1016\/j.intimp.2024.113687_b0570","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s12223-012-0213-7","article-title":"HLA-C, DRB1 and DQB1 alleles involved in genetic predisposition to psoriasis vulgaris in the Slovak population","volume":"58","author":"Shawkatova","year":"2013","journal-title":"Folia Microbiol. (Praha)"},{"key":"10.1016\/j.intimp.2024.113687_b0575","article-title":"Microbiota-induced S100A11-RAGE axis underlies immune evasion in right-sided colon adenomas and is a therapeutic target to boost anti-PD1 efficacy","author":"Zhou","year":"2024","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.intimp.2024.113687_b0580","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.169138","article-title":"Macrophage RAGE activation is proinflammatory in NASH","volume":"9","author":"Parthasarathy","year":"2024","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0585","doi-asserted-by":"crossref","first-page":"149","DOI":"10.14283\/jpad.2018.18","article-title":"Development of Azeliragon, an oral small molecule antagonist of the receptor for advanced glycation endproducts, for the potential slowing of loss of cognition in mild Alzheimer's disease","volume":"5","author":"Burstein","year":"2018","journal-title":"J. Prev. Alzheimers Dis."},{"key":"10.1016\/j.intimp.2024.113687_b0590","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.bone.2019.04.012","article-title":"Short-term pharmacologic RAGE inhibition differentially affects bone and skeletal muscle in middle-aged mice","volume":"124","author":"Davis","year":"2019","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0595","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jcsm.12268","article-title":"Pitfalls in the measurement of muscle mass: a need for a reference standard","volume":"9","author":"Buckinx","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"2","key":"10.1016\/j.intimp.2024.113687_b0600","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1093\/ajcn\/76.2.378","article-title":"Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method","volume":"76","author":"Kim","year":"2002","journal-title":"Am. J. Clin. Nutr."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022094?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022094?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:41:12Z","timestamp":1789645272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924022094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":120,"alternative-id":["S1567576924022094"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113687","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113687"}}