{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:45:27Z","timestamp":1791557127527,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T00:00:00Z","timestamp":1732233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012175","name":"Zhejiang Administration Bureau of Traditional Chinese Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012175","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010248","name":"Zhejiang Province Public Welfare Technology Application Research Project","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010248","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113695","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T19:51:04Z","timestamp":1732650664000},"page":"113695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies"],"prefix":"10.1016","volume":"144","author":[{"given":"Li","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeju","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexuan","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longtao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheyuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Bi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0989-1658","authenticated-orcid":false,"given":"Li","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9991","key":"10.1016\/j.intimp.2024.113695_b0005","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.113695_b0010","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.72","article-title":"Osteoarthritis","volume":"2","author":"Martel-Pelletier","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"4","key":"10.1016\/j.intimp.2024.113695_b0015","doi-asserted-by":"crossref","first-page":"e195","DOI":"10.1016\/S2665-9913(24)00006-7","article-title":"When should we treat knee osteoarthritis and with which treatments?","volume":"6","author":"Haber","year":"2024","journal-title":"Lancet Rheumatol."},{"issue":"9783","key":"10.1016\/j.intimp.2024.113695_b0020","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/S0140-6736(11)60243-2","article-title":"Osteoarthritis: an update with relevance for clinical practice","volume":"377","author":"Bijlsma","year":"2011","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.intimp.2024.113695_b0025","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.joca.2017.11.014","article-title":"Osteoarthritis year in review 2017: clinical","volume":"26","author":"Nelson","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.intimp.2024.113695_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta21060","article-title":"Autologous chondrocyte implantation in the knee: systematic review and economic evaluation","volume":"21","author":"Mistry","year":"2017","journal-title":"Health Technol. Assess."},{"issue":"7","key":"10.1016\/j.intimp.2024.113695_b0035","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.joca.2011.02.010","article-title":"Failures, re-operations, and complications after autologous chondrocyte implantation\u2013a systematic review","volume":"19","author":"Harris","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"10.1016\/j.intimp.2024.113695_b0040","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1038\/s12276-022-00879-w","article-title":"The natural product salicin alleviates osteoarthritis progression by binding to IRE1\u03b1 and inhibiting endoplasmic reticulum stress through the IRE1\u03b1-I\u03baB\u03b1-p65 signaling pathway","volume":"54","author":"Zhu","year":"2022","journal-title":"Exp. Mol. Med."},{"issue":"20","key":"10.1016\/j.intimp.2024.113695_b0045","doi-asserted-by":"crossref","first-page":"6881","DOI":"10.1080\/10408398.2023.2176815","article-title":"Unraveling the role of natural functional oils in modulating osteoarthritis related complications","volume":"64","author":"Shabbir","year":"2024","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.intimp.2024.113695_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116219","article-title":"Marein, a novel natural product for restoring chemo-sensitivity to cancer cells through competitive inhibition of ABCG2 function","volume":"228","author":"Li","year":"2024","journal-title":"Biochem. Pharmacol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113695_b0055","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s12012-024-09882-1","article-title":"Marein alleviates doxorubicin-induced cardiotoxicity through FAK\/AKT pathway modulation while potentiating its anticancer activity","volume":"24","author":"Xu","year":"2024","journal-title":"Cardiovasc. Toxicol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113695_b0060","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1080\/13880209.2022.2117386","article-title":"Antioxidant properties of polyphenols from snow chrysanthemum (Coreopsis tinctoria) and the modulation on intestinal microflora in vitro","volume":"60","author":"Zhang","year":"2022","journal-title":"Pharm. Biol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113695_b0065","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1080\/10715762.2016.1222374","article-title":"Marein protects against methylglyoxal-induced apoptosis by activating the AMPK pathway in PC12 cells","volume":"50","author":"Jiang","year":"2016","journal-title":"Free Radic. Res."},{"key":"10.1016\/j.intimp.2024.113695_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.106126","article-title":"Marein protects human nucleus pulposus cells against high glucose-induced injury and extracellular matrix degradation at least partly by inhibition of ROS\/NF-\u03baB pathway","volume":"80","author":"Yao","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113695_b0075","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.jep.2018.06.003","article-title":"Protective effects of flavonoids from Coreopsis tinctoria Nutt. on experimental acute pancreatitis via Nrf-2\/ARE-mediated antioxidant pathways","volume":"224","author":"Du","year":"2018","journal-title":"J. Ethnopharmacol."},{"issue":"42","key":"10.1016\/j.intimp.2024.113695_b0080","article-title":"Definition, pathology and pathogenesis of osteoarthritis","volume":"182","author":"Bliddal","year":"2020","journal-title":"Ugeskr. Laeger"},{"issue":"4","key":"10.1016\/j.intimp.2024.113695_b0085","doi-asserted-by":"crossref","first-page":"216","DOI":"10.2519\/jospt.1998.28.4.216","article-title":"Pathomechanics and classification of cartilage lesions, facilitation of repair","volume":"28","author":"Walker","year":"1998","journal-title":"J. Orthop. Sports Phys. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.113695_b0090","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41413-022-00201-4","article-title":"PGE2 activates EP4 in subchondral bone osteoclasts to regulate osteoarthritis","volume":"10","author":"Jiang","year":"2022","journal-title":"Bone Res."},{"issue":"10","key":"10.1016\/j.intimp.2024.113695_b0095","doi-asserted-by":"crossref","first-page":"6366","DOI":"10.1002\/jcp.29607","article-title":"Role of iNOS in osteoarthritis: Pathological and therapeutic aspects","volume":"235","author":"Ahmad","year":"2020","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.intimp.2024.113695_b0100","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bcp.2019.02.036","article-title":"Chondrocyte dedifferentiation and osteoarthritis (OA)","volume":"165","author":"Charlier","year":"2019","journal-title":"Biochem. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113695_b0105","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.joca.2017.02.791","article-title":"ADAMTS and ADAM metalloproteinases in osteoarthritis - looking beyond the 'usual suspects'","volume":"25","author":"Yang","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.intimp.2024.113695_b0110","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrrheum.2010.196","article-title":"Role of proinflammatory cytokines in the pathophysiology of osteoarthritis","volume":"7","author":"Kapoor","year":"2011","journal-title":"Nat. Rev. Rheumatol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113695_b0115","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/ten.teb.2013.0377","article-title":"The roles of catabolic factors in the development of osteoarthritis","volume":"20","author":"Blasioli","year":"2014","journal-title":"Tissue Eng. B Rev."},{"issue":"1","key":"10.1016\/j.intimp.2024.113695_b0120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2024.113695_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.114935","article-title":"Itaconate attenuates osteoarthritis by inhibiting STING\/NF-\u03baB axis in chondrocytes and promoting M2 polarization in macrophages","volume":"198","author":"Ni","year":"2022","journal-title":"Biochem. Pharmacol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113695_b0130","doi-asserted-by":"crossref","first-page":"4865","DOI":"10.1039\/C8FO01095A","article-title":"Downregulating PI3K\/Akt\/NF-\u03baB signaling with allicin for ameliorating the progression of osteoarthritis: in vitro and vivo studies","volume":"9","author":"Qian","year":"2018","journal-title":"Food Funct."},{"issue":"17","key":"10.1016\/j.intimp.2024.113695_b0135","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1089\/ars.2017.7342","article-title":"Transcriptional regulation by Nrf2","volume":"29","author":"Tonelli","year":"2018","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.intimp.2024.113695_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109567","article-title":"Icariin modulates carrageenan-induced acute inflammation through HO-1\/Nrf2 and NF-kB signaling pathways","volume":"120","author":"El-Shitany","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113695_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.11.017","article-title":"NRF2 and NF-\u049bB interplay in cerebrovascular and neurodegenerative disorders: molecular mechanisms and possible therapeutic approaches","volume":"21","author":"Sivandzade","year":"2019","journal-title":"Redox Biol."},{"issue":"42","key":"10.1016\/j.intimp.2024.113695_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202102598","article-title":"A targeted nanosystem for detection of inflammatory diseases via fluorescent\/optoacoustic imaging and therapy via modulating Nrf2\/NF-\u03baB pathways","volume":"17","author":"Ouyang","year":"2021","journal-title":"Small"},{"issue":"1","key":"10.1016\/j.intimp.2024.113695_b0155","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-022-33800-0","article-title":"The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis","volume":"13","author":"Shen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.intimp.2024.113695_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112601","article-title":"Liensinine inhibits IL-1\u03b2-stimulated inflammatory response in chondrocytes and attenuates papain-induced osteoarthritis in rats","volume":"138","author":"Wang","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113695_b0165","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-021-02512-z","article-title":"Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-\u03baB pathways","volume":"23","author":"Lu","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.113695_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109624","article-title":"Indirubin protects chondrocytes and alleviates OA by inhibiting the MAPK and NF-\u03baB pathways","volume":"115","author":"Wang","year":"2023","journal-title":"Int. Immunopharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022173?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022173?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:33:26Z","timestamp":1789644806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924022173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":34,"alternative-id":["S1567576924022173"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113695","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Marein ameliorates the progression of osteoarthritis: An in vitro and in vivo studies","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113695"}}