{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T04:36:35Z","timestamp":1793248595641,"version":"4.5.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T00:00:00Z","timestamp":1732579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274637"],"award-info":[{"award-number":["82274637"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374566"],"award-info":[{"award-number":["82374566"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113700","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T20:07:06Z","timestamp":1733170026000},"page":"113700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Allogeneic platelet lysate activates the SIRT1-PINK1\/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration"],"prefix":"10.1016","volume":"144","author":[{"given":"Zhili","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaheng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangnan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113700_b0005","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.wneu.2021.09.066","article-title":"Fundamentals of intervertebral disc degeneration","volume":"157","author":"Kirnaz","year":"2022","journal-title":"World Neurosurg."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0010","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrrheum.2013.160","article-title":"Role of cytokines in intervertebral disc degeneration: pain and disc content","volume":"10","author":"Risbud","year":"2014","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2024.113700_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.933901","article-title":"New hope for treating intervertebral disc degeneration: microsphere-based delivery system","volume":"10","author":"Guo","year":"2022","journal-title":"Front. Bioeng. Biotech."},{"issue":"12","key":"10.1016\/j.intimp.2024.113700_b0020","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.3390\/biom12121804","article-title":"Role of pyroptosis in intervertebral disc degeneration and its therapeutic implications","volume":"12","author":"Luo","year":"2022","journal-title":"Biomolecules"},{"issue":"4","key":"10.1016\/j.intimp.2024.113700_b0025","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1038\/cr.2011.20","article-title":"Mitochondrial ROS fuel the inflammasome","volume":"21","author":"Sorbara","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.intimp.2024.113700_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.627837","article-title":"Mitochondrial reactive oxygen species and their contribution in chronic kidney disease progression through oxidative stress","volume":"12","author":"Tirichen","year":"2021","journal-title":"Front. Physiol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113700_b0035","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/os.13302","article-title":"Mitochondrial dysfunction in oxidative stress-mediated intervertebral disc degeneration","volume":"14","author":"Wang","year":"2022","journal-title":"Orthop. Surg."},{"issue":"2","key":"10.1016\/j.intimp.2024.113700_b0040","first-page":"249","article-title":"Effects of oxidative stress on mitochondrial functions and intervertebral disc cells","volume":"55","author":"Zhou","year":"2024","journal-title":"J. Sichuan Univ. (Med. Sci. Edit.)"},{"key":"10.1016\/j.intimp.2024.113700_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116001","article-title":"Regulating pyroptosis by mesenchymal stem cells and extracellular vesicles: A promising strategy to alleviate intervertebral disc degeneration","volume":"170","author":"Yang","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113700_b0050","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2147\/JIR.S434896","article-title":"Role of autophagy and pyroptosis in intervertebral disc degeneration","volume":"17","author":"Wang","year":"2024","journal-title":"J. Inflamm. Res."},{"issue":"13","key":"10.1016\/j.intimp.2024.113700_b0055","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1089\/ars.2014.5994","article-title":"Redox regulation of NLRP3 inflammasomes: ROS as trigger or effector?","volume":"22","author":"Abais","year":"2015","journal-title":"Antioxid. Redox Signal."},{"issue":"9","key":"10.1016\/j.intimp.2024.113700_b0060","doi-asserted-by":"crossref","first-page":"e13448","DOI":"10.1111\/cpr.13448","article-title":"Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif."},{"key":"10.1016\/j.intimp.2024.113700_b0065","doi-asserted-by":"crossref","first-page":"1052878","DOI":"10.3389\/fmolb.2022.1052878","article-title":"The role of ageing and oxidative stress in intervertebral disc degeneration","volume":"9","author":"Wen","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"4","key":"10.1016\/j.intimp.2024.113700_b0070","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/ar3914","article-title":"Platelet-rich plasma therapy - future or trend?","volume":"14","author":"Dhillon","year":"2012","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s40729-016-0052-4","article-title":"Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF)","volume":"2","author":"Masuki","year":"2016","journal-title":"Int. J. Implant Dent."},{"issue":"6","key":"10.1016\/j.intimp.2024.113700_b0080","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1111\/jocd.15653","article-title":"Study of platelet-rich plasma application for skin and plastic surgery in recent 20\u2009years: A bibliometric analysis","volume":"22","author":"Li","year":"2023","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.intimp.2024.113700_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcot.2021.101534","article-title":"Human platelet lysate - A potent (and overlooked) orthobiologic","volume":"21","author":"da Fonseca","year":"2021","journal-title":"J. Clin. Orthop. Trauma"},{"issue":"3","key":"10.1016\/j.intimp.2024.113700_b0090","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.3892\/etm.2017.4726","article-title":"Optimization of pure platelet-rich plasma preparation: A comparative study of pure platelet-rich plasma obtained using different centrifugal conditions in a single-donor model","volume":"14","author":"Yin","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2024.113700_b0095","doi-asserted-by":"crossref","first-page":"9563693","DOI":"10.1155\/2022\/9563693","article-title":"Intradiscal autologous platelet-rich plasma injection for discogenic low back pain: A clinical trial","volume":"2022","author":"Zhang","year":"2022","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.intimp.2024.113700_b0100","article-title":"Regulation of SIRT1 and its roles in inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.intimp.2024.113700_b0105","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41556-020-00579-5","article-title":"SIRT1 is downregulated by autophagy in senescence and ageing","volume":"22","author":"Xu","year":"2020","journal-title":"Nat. Cell Biol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113700_b0110","doi-asserted-by":"crossref","first-page":"e13057","DOI":"10.1111\/cpr.13057","article-title":"NF\u2010\u03baB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration","volume":"54","author":"Zhang","year":"2021","journal-title":"Cell Prolif."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0115","first-page":"E215","article-title":"SIRT1 inhibits the catabolic effect of IL-1\u03b2 through TLR2\/SIRT1\/NF-\u03baB pathway in human degenerative nucleus pulposus cells","volume":"19","author":"Shen","year":"2016","journal-title":"Pain Physician"},{"key":"10.1016\/j.intimp.2024.113700_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108671","article-title":"SIRT1 alleviates IL-1\u03b2 induced nucleus pulposus cells pyroptosis via mitophagy in intervertebral disc degeneration","volume":"107","author":"Ma","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"10\u201312","key":"10.1016\/j.intimp.2024.113700_b0125","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 inflammasome and reactive oxygen species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.intimp.2024.113700_b0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4103\/0974-2077.150734","article-title":"Principles and methods of preparation of platelet-rich plasma: A review and author's perspective","volume":"7","author":"Dhurat","year":"2014","journal-title":"J. Cutan Aesthet. Surg."},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.113700_b0135","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.4103\/idoj.idoj_269_21","article-title":"Preparation of platelet-rich plasma: National IADVL PRP taskforce recommendations","volume":"12","author":"Dashore","year":"2021","journal-title":"Indian Dermatol. Online J."},{"issue":"12","key":"10.1016\/j.intimp.2024.113700_b0140","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1177\/0363546515608481","article-title":"Comparison of the cellular composition and cytokine-release kinetics of various platelet-rich plasma preparations","volume":"43","author":"Oh","year":"2015","journal-title":"Am. J. Sports Med."},{"issue":"4","key":"10.1016\/j.intimp.2024.113700_b0145","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.cvsm.2022.02.005","article-title":"Platelet-rich plasma as an orthobiologic: Clinically relevant considerations","volume":"52","author":"Carr","year":"2022","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0150","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1742-4933-10-23","article-title":"Platelet-rich plasma (PRP) in dental and oral surgery: from the wound healing to bone regeneration","volume":"10","author":"Albanese","year":"2013","journal-title":"Immun. Ageing"},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0155","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13287-015-0172-4","article-title":"The differential effects of leukocyte-containing and pure platelet-rich plasma (PRP) on tendon stem\/progenitor cells - implications of PRP application for the clinical treatment of tendon injuries","volume":"6","author":"Zhou","year":"2015","journal-title":"Stem Cell Res. Ther."},{"issue":"Suppl 1","key":"10.1016\/j.intimp.2024.113700_b0160","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/j.jcot.2019.05.008","article-title":"Leukocyte-rich PRP versus leukocyte-poor PRP - The role of monocyte\/macrophage function in the healing cascade","volume":"10","author":"Lana","year":"2019","journal-title":"J. Clin. Orthop. Trauma"},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1186\/s13018-021-02417-2","article-title":"Comprehensive analysis of lumbar disc degeneration and autophagy-related candidate genes, pathways, and targeting drugs","volume":"16","author":"Xu","year":"2021","journal-title":"J. Orthop. Surg. Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0170","doi-asserted-by":"crossref","first-page":"8059622","DOI":"10.1155\/2022\/8059622","article-title":"Leukocyte-rich platelet-rich plasma as an effective source of molecules that modulate local immune and inflammatory cell responses","volume":"2022","author":"Dejnek","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.intimp.2024.113700_b0175","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/ars.2017.7290","article-title":"The role of sirtuins in antioxidant and redox signaling","volume":"28","author":"Singh","year":"2018","journal-title":"Antioxid. Redox Signal."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0180","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/ncomms1001","article-title":"Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer","volume":"1","author":"Herranz","year":"2010","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0185","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1186\/s12964-023-01177-2","article-title":"Involvement of the SIRT1-NLRP3 pathway in the inflammatory response","volume":"21","author":"Chen","year":"2023","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.intimp.2024.113700_b0190","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3389\/fimmu.2020.01115","article-title":"Critical Role for the NLRP3 Inflammasome in Mediating IL-1\u03b2 Production in Shigella sonnei-Infected Macrophages","volume":"11","author":"Li","year":"2020","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113700_b0195","doi-asserted-by":"crossref","first-page":"484","DOI":"10.7150\/ijbs.78654","article-title":"Novel role of the SIRT1 in endocrine and metabolic diseases","volume":"19","author":"Lu","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2024.113700_b0200","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fendo.2018.00614","article-title":"High levels of SIRT1 expression as a protective mechanism against disease-related conditions","volume":"9","author":"Elibol","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113700_b0205","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.3390\/ijms21113858","article-title":"Relevance of SIRT1-NF-\u03baB axis as therapeutic target to ameliorate inflammation in liver disease","volume":"21","author":"de Gregorio","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113700_b0210","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.890823","article-title":"PINK1\/Parkin pathway activation for mitochondrial quality control - which is the best molecular target for therapy?","volume":"14","author":"Silvian","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.intimp.2024.113700_b0215","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3892\/etm.2022.11193","article-title":"Sirtuin 1 participates in intervertebral disc degeneration via the nicotinamide phosphoribosyl transferase\/nicotinamide adenine dinucleotide\/sirtuin 1 pathway responsible for regulating autophagy of nucleus pulposus cells","volume":"23","author":"Shi","year":"2022","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.113700_b0220","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13024-020-00367-7","article-title":"PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease","volume":"15","author":"Ge","year":"2020","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.intimp.2024.113700_b0225","doi-asserted-by":"crossref","first-page":"4665530","DOI":"10.1155\/2022\/4665530","article-title":"The potential role of voltage-dependent anion channel in the treatment of parkinson's disease","volume":"2022","author":"He","year":"2022","journal-title":"Oxid. Med. Cell. Longev."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022227?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022227?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:39:54Z","timestamp":1789645194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924022227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":45,"alternative-id":["S1567576924022227"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113700","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Allogeneic platelet lysate activates the SIRT1-PINK1\/Parkin pathway: A promising approach for improving mitochondrial function in an in vitro model of intervertebral disc degeneration","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113700"}}