{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:43:04Z","timestamp":1792190584850,"version":"4.4.0"},"reference-count":178,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T00:00:00Z","timestamp":1733356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["17JR5RA272"],"award-info":[{"award-number":["17JR5RA272"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004775","name":"Natural Science Foundation of Gansu Province","doi-asserted-by":"publisher","award":["22JR5RA923"],"award-info":[{"award-number":["22JR5RA923"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113702","type":"journal-article","created":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T11:56:27Z","timestamp":1732622187000},"page":"113702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Emerging role of metabolic reprogramming in the immune microenvironment and immunotherapy of thyroid cancer"],"prefix":"10.1016","volume":"144","author":[{"given":"Shouhua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengtong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaili","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3049-5625","authenticated-orcid":false,"given":"Yong-xun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12020-022-03274-7","article-title":"Incidence and mortality of thyroid cancer in 50 countries: a joinpoint regression analysis of global trends","volume":"80","author":"Huang","year":"2023","journal-title":"Endocrine"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0010","doi-asserted-by":"crossref","first-page":"p. 23-+","DOI":"10.1016\/j.ecl.2018.10.002","article-title":"Evolving understanding of the epidemiology of thyroid cancer","volume":"48","author":"Seib","year":"2019","journal-title":"Endocrinol. Metab. Clin. North Am."},{"key":"10.1016\/j.intimp.2024.113702_b0015","doi-asserted-by":"crossref","first-page":"04108","DOI":"10.7189\/jogh.13.04108","article-title":"Geographic disparities in trends of thyroid cancer incidence and mortality from 1990 to 2019 and a projection to 2030 across income-classified countries and territories","volume":"13","author":"Wang","year":"2023","journal-title":"J. Glob. Health"},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0020","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/jama.2023.26348","article-title":"Thyroid cancer: a review","volume":"331","author":"Boucai","year":"2024","journal-title":"J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ecl.2021.11.020","article-title":"Anaplastic thyroid cancer: new horizons and challenges","volume":"51","author":"Maniakas","year":"2022","journal-title":"Endocrinol. Metab. Clin. North Am."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0030","first-page":"675","article-title":"Immunotherapy for anaplastic thyroid carcinoma: the present and future","volume":"50","author":"Lu","year":"2021","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0035","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1210\/er.2019-00007","article-title":"Targeted therapy for advanced thyroid cancer: kinase inhibitors and beyond","volume":"40","author":"Cabanillas","year":"2019","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0040","first-page":"974","article-title":"Immunotherapy in anaplastic thyroid cancer","volume":"12","author":"Ma","year":"2020","journal-title":"Am. J. Transl. Res."},{"issue":"16","key":"10.1016\/j.intimp.2024.113702_b0045","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.7150\/jca.44506","article-title":"Immune microenvironment of thyroid cancer","volume":"11","author":"Yin","year":"2020","journal-title":"J. Cancer"},{"issue":"20","key":"10.1016\/j.intimp.2024.113702_b0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232012578","article-title":"Cell component and function of tumor microenvironment in thyroid cancer","volume":"23","author":"Shin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12121214","article-title":"Reprogramming of cellular metabolism and its therapeutic applications in thyroid cancer","volume":"12","author":"Nagayama","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.intimp.2024.113702_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107753","article-title":"Tumor microenvironment as a therapeutic target in cancer","volume":"221","author":"Xiao","year":"2021","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0065","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1186\/s12967-023-04617-2","article-title":"The potential role of reprogrammed glucose metabolism: an emerging actionable codependent target in thyroid cancer","volume":"21","author":"Duan","year":"2023","journal-title":"J. Transl. Med."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0070","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ccell.2023.01.009","article-title":"Metabolic programming and immune suppression in the tumor microenvironment","volume":"41","author":"Arner","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.intimp.2024.113702_b0075","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-10015-4","article-title":"Competition for nutrients and its role in controlling immune responses","volume":"10","author":"Kedia-Mehta","year":"2019","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0080","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1182\/blood-2005-05-1795","article-title":"Tumor-derived lactic acid modulates dendritic cell activation and antigen expression","volume":"107","author":"Gottfried","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.113702_b0085","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1146\/annurev-immunol-020711-075024","article-title":"Regulation of immune responses by mTOR","volume":"30","author":"Powell","year":"2012","journal-title":"Annu. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0090","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/s41392-023-01569-3","article-title":"Amino acid metabolism in health and disease","volume":"8","author":"Ling","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0095","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3803\/EnM.2020.35.2.227","article-title":"Amino acid transporters as potential therapeutic targets in thyroid cancer","volume":"35","author":"Enomoto","year":"2020","journal-title":"Endocrinol. Metab. (Seoul)"},{"issue":"48","key":"10.1016\/j.intimp.2024.113702_b0100","doi-asserted-by":"crossref","first-page":"18782","DOI":"10.1073\/pnas.0810199105","article-title":"Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction","volume":"105","author":"Wise","year":"2008","journal-title":"PNAS"},{"issue":"33","key":"10.1016\/j.intimp.2024.113702_b0105","doi-asserted-by":"crossref","first-page":"53628","DOI":"10.18632\/oncotarget.10682","article-title":"Expression of glutamine metabolism-related proteins in thyroid cancer","volume":"7","author":"Kim","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2024.113702_b0110","doi-asserted-by":"crossref","first-page":"11321","DOI":"10.1038\/ncomms11321","article-title":"The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy","volume":"7","author":"Lukey","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13000-017-0661-0","article-title":"cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis","volume":"12","author":"Sakr","year":"2017","journal-title":"Diagn. Pathol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0120","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.cell.2013.04.023","article-title":"The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4","volume":"153","author":"Csibi","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.113702_b0125","doi-asserted-by":"crossref","first-page":"11971","DOI":"10.1038\/ncomms11971","article-title":"Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer","volume":"7","author":"Hao","year":"2016","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0130","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/onc.2009.358","article-title":"Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer","volume":"29","author":"DeBerardinis","year":"2010","journal-title":"Oncogene"},{"issue":"14","key":"10.1016\/j.intimp.2024.113702_b0135","doi-asserted-by":"crossref","first-page":"4423","DOI":"10.1073\/pnas.1504279112","article-title":"Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes","volume":"112","author":"Willinger","year":"2015","journal-title":"PNAS"},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0140","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1210\/jc.2011-1838","article-title":"Phenotypical analysis of lymphocytes with suppressive and regulatory properties (Tregs) and NK cells in the papillary carcinoma of thyroid","volume":"97","author":"Gogali","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0145","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/s41467-018-04719-2","article-title":"Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice","volume":"9","author":"Loftus","year":"2018","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0150","doi-asserted-by":"crossref","first-page":"C7","DOI":"10.1530\/ERC-11-0360","article-title":"Oxidative stress: a new risk factor for thyroid cancer","volume":"19","author":"Xing","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"issue":"10","key":"10.1016\/j.intimp.2024.113702_b0155","doi-asserted-by":"crossref","first-page":"4326","DOI":"10.1073\/pnas.1819473116","article-title":"Reactive oxygen species modulate macrophage immunosuppressive phenotype through the up-regulation of PD-L1","volume":"116","author":"Roux","year":"2019","journal-title":"PNAS"},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0160","doi-asserted-by":"crossref","first-page":"279","DOI":"10.4158\/EP-2018-0342","article-title":"Programmed cell death-ligand 1 overexpression in thyroid cancer","volume":"25","author":"Zhang","year":"2019","journal-title":"Endocr. Pract."},{"issue":"9","key":"10.1016\/j.intimp.2024.113702_b0165","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/ni.3796","article-title":"\u03b1-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming","volume":"18","author":"Liu","year":"2017","journal-title":"Nat. Immunol."},{"issue":"18","key":"10.1016\/j.intimp.2024.113702_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184413","article-title":"Immune and inflammatory cells in thyroid cancer microenvironment","volume":"20","author":"Ferrari","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0175","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13045-023-01453-1","article-title":"Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy","volume":"16","author":"Yang","year":"2023","journal-title":"J. Hematol. Oncol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/nu10111564","article-title":"Glutamine: metabolism and immune function, supplementation and clinical translation","volume":"10","author":"Cruzat","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0185","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1530\/ERC-13-0436","article-title":"Lymphocytic profiling in thyroid cancer provides clues for failure of tumor immunity","volume":"21","author":"Imam","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0190","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","article-title":"Serine is an essential metabolite for effector T cell expansion","volume":"25","author":"Ma","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.intimp.2024.113702_b0195","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-016-0915-8","article-title":"Expression of serine\/glycine metabolism-related proteins is different according to the thyroid cancer subtype","volume":"14","author":"Sun","year":"2016","journal-title":"J. Transl. Med."},{"issue":"7650","key":"10.1016\/j.intimp.2024.113702_b0200","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature22056","article-title":"Modulating the therapeutic response of tumours to dietary serine and glycine starvation","volume":"544","author":"Maddocks","year":"2017","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0205","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1158\/2159-8290.CD-14-0250","article-title":"Serine catabolism regulates mitochondrial redox control during hypoxia","volume":"4","author":"Ye","year":"2014","journal-title":"Cancer Discov."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0210","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.advnut.2023.05.007","article-title":"Serine metabolic reprogramming in tumorigenesis, tumor immunity, and clinical treatment","volume":"14","author":"Wang","year":"2023","journal-title":"Adv. Nutr."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0215","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1089\/thy.2020.0105","article-title":"High phosphoglycerate dehydrogenase expression induces stemness and aggressiveness in thyroid cancer","volume":"30","author":"Jeon","year":"2020","journal-title":"Thyroid"},{"issue":"7433","key":"10.1016\/j.intimp.2024.113702_b0220","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature11743","article-title":"Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells","volume":"493","author":"Maddocks","year":"2013","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0225","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41590-022-01145-x","article-title":"PERK is a critical metabolic hub for immunosuppressive function in macrophages","volume":"23","author":"Raines","year":"2022","journal-title":"Nat. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0230","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1530\/EC-21-0135","article-title":"SHMT2 expression as a diagnostic and prognostic marker for thyroid cancer","volume":"10","author":"Jin","year":"2021","journal-title":"Endocr. Connect."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0235","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8060842","article-title":"Indoleamine-2,3-dioxygenase in thyroid cancer cells suppresses natural killer cell function by inhibiting NKG2D and NKp46 expression via STAT signaling pathways","volume":"8","author":"Park","year":"2019","journal-title":"J. Clin. Med."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0240","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1210\/jc.2009-2564","article-title":"Tumor-associated lymphocytes and increased FoxP3+ regulatory T cell frequency correlate with more aggressive papillary thyroid cancer","volume":"95","author":"French","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"8","key":"10.1016\/j.intimp.2024.113702_b0245","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1089\/thy.2013.0423","article-title":"Expression of indoleamine 2,3-dioxygenase and infiltration of FOXP3+ regulatory T cells are associated with aggressive features of papillary thyroid microcarcinoma","volume":"24","author":"Ryu","year":"2014","journal-title":"Thyroid"},{"key":"10.1016\/j.intimp.2024.113702_b0250","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.mce.2014.10.006","article-title":"Inhibition of Foxp3 in cancer cells induces apoptosis of thyroid cancer cells","volume":"399","author":"Chu","year":"2015","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113702_b0255","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/895901","article-title":"Regulation of lymphocyte function by PPAR\u03b3: relevance to thyroid eye disease-related inflammation","author":"Lehmann","year":"2008","journal-title":"PPAR Res."},{"key":"10.1016\/j.intimp.2024.113702_b0260","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fonc.2018.00082","article-title":"Metabolic reprogramming in thyroid carcinoma","volume":"8","author":"Coelho","year":"2018","journal-title":"Front. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0265","doi-asserted-by":"crossref","first-page":"e22142","DOI":"10.1002\/ddr.22142","article-title":"AKR1C3 silencing inhibits autophagy-dependent glycolysis in thyroid cancer cells by inactivating ERK signaling","volume":"85","author":"Gao","year":"2024","journal-title":"Drug Dev. Res."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0270","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.cell.2015.08.016","article-title":"Metabolic competition in the tumor microenvironment is a driver of cancer progression","volume":"162","author":"Chang","year":"2015","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0275","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s12964-020-00586-x","article-title":"Regulators of glucose uptake in thyroid cancer cell lines","volume":"18","author":"Heydarzadeh","year":"2020","journal-title":"Cell Commun. Signal"},{"issue":"9","key":"10.1016\/j.intimp.2024.113702_b0280","doi-asserted-by":"crossref","first-page":"E1524","DOI":"10.1210\/jc.2012-4258","article-title":"Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer","volume":"98","author":"Feng","year":"2013","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0285","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1038\/s44318-024-00110-8","article-title":"PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer","volume":"43","author":"Wang","year":"2024","journal-title":"EMBO J."},{"issue":"9","key":"10.1016\/j.intimp.2024.113702_b0290","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41568-020-0273-y","article-title":"Metabolism of immune cells in cancer","volume":"20","author":"Leone","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0295","doi-asserted-by":"crossref","first-page":"9578","DOI":"10.1038\/s41598-020-66599-1","article-title":"Metabolic reprogramming related to whole-chromosome instability in models for H\u00fcrthle cell carcinoma","volume":"10","author":"Addie","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0300","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of t cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0305","doi-asserted-by":"crossref","first-page":"e1229725","DOI":"10.1080\/2162402X.2016.1229725","article-title":"Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages","volume":"5","author":"Arts","year":"2016","journal-title":"Oncoimmunology"},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0310","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1677\/ERC-08-0036","article-title":"Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer","volume":"15","author":"Ryder","year":"2008","journal-title":"Endocr. Relat. Cancer"},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0315","doi-asserted-by":"crossref","first-page":"5569","DOI":"10.1007\/s13277-015-4418-7","article-title":"TNF-\u03b1 increases the membrane expression of the chemokine receptor CCR6 in thyroid tumor cells, but not in normal thyrocytes: potential role in the metastatic spread of thyroid cancer","volume":"37","author":"Coperchini","year":"2016","journal-title":"Tumour Biol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0320","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.3892\/ol.2016.5153","article-title":"Promotion of metastasis of thyroid cancer cells via NRP-2-mediated induction","volume":"12","author":"Tu","year":"2016","journal-title":"Oncol. Lett."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0325","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/ni.3269","article-title":"Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants","volume":"16","author":"De Rosa","year":"2015","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0330","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41577-020-0406-2","article-title":"Lactate modulation of immune responses in inflammatory versus tumour microenvironments","volume":"21","author":"Certo","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.intimp.2024.113702_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107451","article-title":"Lactate\/GPR81 signaling and proton motive force in cancer: Role in angiogenesis, immune escape, nutrition, and Warburg phenomenon","volume":"206","author":"Brown","year":"2020","journal-title":"Pharmacol. Ther."},{"issue":"9","key":"10.1016\/j.intimp.2024.113702_b0340","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41419-021-04081-0","article-title":"STAT3\/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis","volume":"12","author":"Huo","year":"2021","journal-title":"Cell Death Dis."},{"issue":"10","key":"10.1016\/j.intimp.2024.113702_b0345","doi-asserted-by":"crossref","first-page":"4814","DOI":"10.1111\/jcmm.16453","article-title":"HYOU1 facilitates proliferation, invasion and glycolysis of papillary thyroid cancer via stabilizing LDHB mRNA","volume":"25","author":"Wang","year":"2021","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2024.113702_b0350","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.drup.2018.03.001","article-title":"How the Warburg effect supports aggressiveness and drug resistance of cancer cells?","volume":"38","author":"Icard","year":"2018","journal-title":"Drug Resist. Updat."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0355","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1530\/ERC-21-0153","article-title":"Reduced MHC class II expression in medullary thyroid cancer identifies patients with poor prognosis","volume":"29","author":"Ruan","year":"2022","journal-title":"Endocr. Relat. Cancer"},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0360","doi-asserted-by":"crossref","first-page":"e1000293","DOI":"10.1371\/journal.pgen.1000293","article-title":"The genomic analysis of lactic acidosis and acidosis response in human cancers","volume":"4","author":"Chen","year":"2008","journal-title":"PLoS Genet."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0365","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/ijc.26410","article-title":"Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK\/c-Jun activation","volume":"131","author":"Mendler","year":"2012","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0370","doi-asserted-by":"crossref","first-page":"e26383","DOI":"10.4161\/onci.26383","article-title":"Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology","volume":"2","author":"Husain","year":"2013","journal-title":"Oncoimmunology"},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0375","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.tibs.2018.10.011","article-title":"Lactate: a metabolic driver in the tumour landscape","volume":"44","author":"Ippolito","year":"2019","journal-title":"Trends Biochem. Sci"},{"issue":"8","key":"10.1016\/j.intimp.2024.113702_b0380","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1093\/carcin\/bgu060","article-title":"Tumor-associated macrophages promote the metastatic potential of thyroid papillary cancer by releasing CXCL8","volume":"35","author":"Fang","year":"2014","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0385","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2217\/cns.13.20","article-title":"Lipid metabolism emerges as a promising target for malignant glioma therapy","volume":"2","author":"Guo","year":"2013","journal-title":"CNS Oncol"},{"issue":"13","key":"10.1016\/j.intimp.2024.113702_b0390","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25137129","article-title":"The role of lipid metabolism disorders in the development of thyroid cancer","volume":"25","author":"Lukasiewicz","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0395","doi-asserted-by":"crossref","first-page":"e22168","DOI":"10.1002\/ddr.22168","article-title":"Hypoxia expedites the progression of papillary thyroid carcinoma by promoting the CPT1A-mediated fatty acid oxidative pathway","volume":"85","author":"Liang","year":"2024","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.intimp.2024.113702_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155144","article-title":"Adipocytokines: are they the theory of everything?","volume":"133","author":"Maximus","year":"2020","journal-title":"Cytokine"},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0405","doi-asserted-by":"crossref","first-page":"T255","DOI":"10.1530\/ERC-14-0070","article-title":"Obesity and thyroid cancer","volume":"21","author":"Marcello","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0410","doi-asserted-by":"crossref","first-page":"E2023","DOI":"10.1210\/jc.2010-1908","article-title":"Circulating adiponectin is inversely associated with risk of thyroid cancer: in vivo and in vitro studies","volume":"96","author":"Mitsiades","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0415","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.beem.2013.11.005","article-title":"Multifaceted roles of adiponectin in cancer","volume":"28","author":"Hebbard","year":"2014","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.113702_b0420","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2018.00314","article-title":"Role of chemokines in thyroid cancer microenvironment: is CXCL8 the main player?","volume":"9","author":"Rotondi","year":"2018","journal-title":"Front. Endocrinol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113702_b0425","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/eji.201041349","article-title":"Adiponectin is a negative regulator of antigen-activated T cells","volume":"41","author":"Wilk","year":"2011","journal-title":"Eur. J. Immunol."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0430","doi-asserted-by":"crossref","first-page":"2592","DOI":"10.4049\/jimmunol.1102588","article-title":"Adiponectin induces dendritic cell activation via PLC\u03b3\/JNK\/NF-\u03baB pathways, leading to Th1 and Th17 polarization","volume":"188","author":"Jung","year":"2012","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.intimp.2024.113702_b0435","doi-asserted-by":"crossref","first-page":"6153","DOI":"10.1074\/jbc.M109.088708","article-title":"Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype","volume":"285","author":"Ohashi","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.intimp.2024.113702_b0440","first-page":"637","article-title":"Role of leptin and its receptors in the pathogenesis of thyroid cancer","volume":"4","author":"Uddin","year":"2011","journal-title":"Int. J. Clin. Exp. Path."},{"issue":"9","key":"10.1016\/j.intimp.2024.113702_b0445","volume":"6","author":"Nepal","year":"2015","journal-title":"Autophagy Induction by Leptin Contributes to Suppression of Apoptosis in Cancer Cells and Xenograft Model: Involvement of p53\/FoxO3A Axis."},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0450","first-page":"1721","article-title":"Differential roles of leptin in regulating cell migration in thyroid cancer cells","volume":"23","author":"Cheng","year":"2010","journal-title":"Oncol. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0455","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1210\/en.2009-0565","article-title":"Leptin: a critical regulator of CD4+ T-cell polarization in vitro and in vivo","volume":"151","author":"Batra","year":"2010","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0460","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030730","article-title":"The balance of Th17 versus treg cells in autoimmunity","volume":"19","author":"Lee","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113702_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2019.103994","article-title":"Leptin induces immunosenescence in human B cells","volume":"348","author":"Frasca","year":"2020","journal-title":"Cell. Immunol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0470","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1007\/s00428-021-03137-y","article-title":"Diagnostic and prognostic value of tumor-infiltrating B cells in lymph node metastases of papillary thyroid carcinoma","volume":"479","author":"Yang","year":"2021","journal-title":"Virchows Arch."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0475","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.yexcr.2019.01.021","article-title":"IL-10-producing B cells in differentiated thyroid cancer suppress the effector function of T cells but improve their survival upon activation","volume":"376","author":"Wang","year":"2019","journal-title":"Exp. Cell Res."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0480","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.4049\/jimmunol.174.11.6820","article-title":"Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming 1","volume":"174","author":"Mattioli","year":"2005","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0485","doi-asserted-by":"crossref","first-page":"18","DOI":"10.5603\/FHC.2014.0002","article-title":"Dendritic cells in autoimmune disorders and cancer of the thyroid","volume":"52","author":"Lewinski","year":"2014","journal-title":"Folia Histochem. Cytobiol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0490","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.4158\/EP-2020-0347","article-title":"Cholesterol review: a metabolically important molecule","volume":"26","author":"Schade","year":"2020","journal-title":"Endocr. Pract."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0495","doi-asserted-by":"crossref","first-page":"10260","DOI":"10.1038\/s41598-019-46727-2","article-title":"Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness","volume":"9","author":"Revilla","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.113702_b0500","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46727-2","article-title":"Cholesterol and 27-hydroxycholesterol promote thyroid carcinoma aggressiveness","volume":"9","author":"Revilla","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0505","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.atherosclerosis.2011.04.028","article-title":"Thyroid hormone enhances the ability of serum to accept cellular cholesterol via the ABCA1 transporter","volume":"218","author":"Boone","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.intimp.2024.113702_b0510","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109791","article-title":"SREBP1 as a potential biomarker predicts levothyroxine efficacy of differentiated thyroid cancer","volume":"123","author":"Li","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"30","key":"10.1016\/j.intimp.2024.113702_b0515","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.1705304114","article-title":"mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells","volume":"114","author":"Eid","year":"2017","journal-title":"PNAS"},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0520","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s42255-020-0174-0","article-title":"Cholesterol metabolism in cancer: mechanisms and therapeutic opportunities","volume":"2","author":"Huang","year":"2020","journal-title":"Nat. Metab."},{"key":"10.1016\/j.intimp.2024.113702_b0525","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-981-33-6785-2_5","article-title":"Lipid metabolism in tumor-associated natural killer cells","volume":"1316","author":"Chen","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.intimp.2024.113702_b0530","doi-asserted-by":"crossref","unstructured":"Tumor Cells Scavenge Cholesterol from Tumor-Associated Macrophages Cancer Discov. 9(6) (2019) 691.","DOI":"10.1158\/2159-8290.CD-RW2019-056"},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0535","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.cmet.2019.02.016","article-title":"Membrane cholesterol efflux drives tumor-associated macrophage reprogramming and tumor progression","volume":"29","author":"Goossens","year":"2019","journal-title":"Cell Metab."},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0540","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1210\/jc.2009-2147","article-title":"Identifying genetic alterations in poorly differentiated thyroid cancer: a rewarding pursuit","volume":"94","author":"Xing","year":"2009","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7596","key":"10.1016\/j.intimp.2024.113702_b0545","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nature17412","article-title":"Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism","volume":"531","author":"Yang","year":"2016","journal-title":"Nature"},{"issue":"6382","key":"10.1016\/j.intimp.2024.113702_b0550","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science"},{"issue":"40","key":"10.1016\/j.intimp.2024.113702_b0555","doi-asserted-by":"crossref","first-page":"5175","DOI":"10.1038\/onc.2014.441","article-title":"Mast cells induce epithelial-to-mesenchymal transition and stem cell features in human thyroid cancer cells through an IL-8\u2013Akt\u2013Slug pathway","volume":"34","author":"Visciano","year":"2015","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0560","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.bbadis.2019.04.006","article-title":"Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice","volume":"1865","author":"Zhang","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0565","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.immuni.2024.03.021","article-title":"25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages","volume":"57","author":"Xiao","year":"2024","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0570","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1056\/NEJMoa075853","article-title":"Motesanib diphosphate in progressive differentiated thyroid cancer","volume":"359","author":"Sherman","year":"2008","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0575","article-title":"Immunotherapy-induced thyroid dysfunction: an updated review","volume":"35","author":"Baraka","year":"2023","journal-title":"Egyptian J. Intern. Med."},{"key":"10.1016\/j.intimp.2024.113702_b0580","doi-asserted-by":"crossref","DOI":"10.1007\/s40618-023-02294-y","article-title":"Targeting glutamine metabolism exhibits anti-tumor effects in thyroid cancer","author":"Zhang","year":"2024","journal-title":"J. Endocrinol. Invest."},{"issue":"6468","key":"10.1016\/j.intimp.2024.113702_b0585","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.aav2588","article-title":"Glutamine blockade induces divergent metabolic programs to overcome tumor immune evasion","volume":"366","author":"Leone","year":"2019","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.intimp.2024.113702_b0590","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.trecan.2021.04.003","article-title":"Enhancing the efficacy of glutamine metabolism inhibitors in cancer therapy","volume":"7","author":"Yang","year":"2021","journal-title":"Trends Cancer"},{"issue":"7","key":"10.1016\/j.intimp.2024.113702_b0595","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.10.001","article-title":"Distinct regulation of Th17 and Th1 cell differentiation by glutaminase-dependent metabolism","volume":"175","author":"Johnson","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0600","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2018.04.002","article-title":"The GSK3 signaling axis regulates adaptive glutamine metabolism in lung squamous cell carcinoma","volume":"33","author":"Momcilovic","year":"2018","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0605","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1111\/jcmm.14972","article-title":"Aminooxyacetic acid attenuates post-infarct cardiac dysfunction by balancing macrophage polarization through modulating macrophage metabolism in mice","volume":"24","author":"Zhao","year":"2020","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2024.113702_b0610","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8678363","article-title":"Cystathionine \u03b2-synthase regulates the proliferation, migration, and invasion of thyroid carcinoma cells","volume":"2022","author":"Jiang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2024.113702_b0615","doi-asserted-by":"crossref","unstructured":"High Phosphoglycerate Dehydrogenase Expression Induces Stemness and Aggressiveness in Thyroid Cancer. 2020. 30(11): p. 1625-1638.","DOI":"10.1089\/thy.2020.0105"},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0620","doi-asserted-by":"crossref","first-page":"158","DOI":"10.3892\/ijo.2020.5158","article-title":"Serine, glycine and one\u2011carbon metabolism in cancer (Review)","volume":"58","author":"Pan","year":"2021","journal-title":"Int. J. Oncol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0625","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1124\/mol.119.117937","article-title":"Cellular pharmacodynamics of a novel pyrrolo[3,2-d]pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism","volume":"97","author":"Dekhne","year":"2020","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113702_b0630","doi-asserted-by":"crossref","DOI":"10.1158\/1535-7163.MCT-23-0550","article-title":"Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer","author":"Wallace-Povirk","year":"2024","journal-title":"Mol. Cancer Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0635","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s12276-020-0375-3","article-title":"Amino acids in cancer","volume":"52","author":"Lieu","year":"2020","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.intimp.2024.113702_b0640","first-page":"1170","article-title":"A glance at the actual role of glutamine metabolism in thyroid tumorigenesis","volume":"20","author":"Abooshahab","year":"2021","journal-title":"EXCLI J."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0645","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00018-015-2070-4","article-title":"Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression","volume":"73","author":"Li","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"8","key":"10.1016\/j.intimp.2024.113702_b0650","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.21037\/gs-21-481","article-title":"Upregulated circRAD18 promotes tumor progression by reprogramming glucose metabolism in papillary thyroid cancer","volume":"10","author":"Chen","year":"2021","journal-title":"Gland Surg."},{"key":"10.1016\/j.intimp.2024.113702_b0655","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.taap.2017.12.004","article-title":"Antitumor action of 3-bromopyruvate implicates reorganized tumor growth regulatory components of tumor milieu, cell cycle arrest and induction of mitochondria-dependent tumor cell death","volume":"339","author":"Yadav","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0660","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.surg.2021.05.055","article-title":"Glycolytic inhibition with 3-bromopyruvate suppresses tumor growth and improves survival in a murine model of anaplastic thyroid cancer","volume":"171","author":"Zhao","year":"2022","journal-title":"Surgery"},{"key":"10.1016\/j.intimp.2024.113702_b0665","article-title":"Targeting glucose metabolism enzymes in cancer treatment: current and emerging strategies","volume":"14","author":"Zhang","year":"2022","journal-title":"Cancers"},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0670","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.2000137","article-title":"Metformin and 2-deoxyglucose collaboratively suppress human CD4(+) T cell effector functions and activation-induced metabolic reprogramming","volume":"205","author":"Tan","year":"2020","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0675","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.3892\/ol.2015.3518","article-title":"Inflammatory mediators, tumor necrosis factor-\u03b1 and interferon-\u03b3, induce EMT in human PTC cell lines","volume":"10","author":"Lv","year":"2015","journal-title":"Oncol. Lett."},{"issue":"7","key":"10.1016\/j.intimp.2024.113702_b0680","article-title":"2-Deoxy-D-glucose can complement doxorubicin and sorafenib to suppress the growth of papillary thyroid carcinoma cells","volume":"10","author":"Wang","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0685","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/ijc.28114","article-title":"Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity","volume":"133","author":"Ohashi","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0690","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/jphp.12655","article-title":"Dichloroacetate induces regulatory T-cell differentiation and suppresses Th17-cell differentiation by pyruvate dehydrogenase kinase-independent mechanism","volume":"69","author":"Makita","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2024.113702_b0695","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3892\/ol_00000158","article-title":"Medullary thyroid carcinoma relapse reversed with dichloroacetate: a case report","volume":"1","author":"Flavin","year":"2010","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.intimp.2024.113702_b0700","article-title":"Tumor-associated macrophages as a potential therapeutic target in thyroid cancers. Cancer Immunology","author":"Zhu","year":"2023","journal-title":"Immunotherapy"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0705","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1530\/JME-16-0134","article-title":"Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo","volume":"58","author":"Shen","year":"2017","journal-title":"J. Mol. Endocrinol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0710","doi-asserted-by":"crossref","DOI":"10.3390\/biom12040574","article-title":"Metformin in differentiated thyroid cancer: molecular pathways and its clinical implications","volume":"12","author":"Garc\u00eda-S\u00e1enz","year":"2022","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0715","doi-asserted-by":"crossref","first-page":"E427","DOI":"10.1210\/jc.2014-3045","article-title":"Metformin reverts the secretion of CXCL8 induced by TNF-\u03b1 in primary cultures of human thyroid cells: an additional indirect anti-tumor effect of the drug","volume":"100","author":"Rotondi","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0720","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s11427-019-1735-4","article-title":"Emerging role of metabolic reprogramming in tumor immune evasion and immunotherapy","volume":"64","author":"Fan","year":"2021","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.intimp.2024.113702_b0725","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.685522","article-title":"Metformin reverses Hashimoto's thyroiditis by regulating key immune events","volume":"9","author":"Jia","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113702_b0730","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.3892\/or.2015.3805","article-title":"Synergistic anti-proliferative effect of metformin and sorafenib on growth of anaplastic thyroid cancer cells and their stem cells","volume":"33","author":"Chen","year":"2015","journal-title":"Oncol. Rep."},{"issue":"10","key":"10.1016\/j.intimp.2024.113702_b0735","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1038\/s41416-021-01297-x","article-title":"Development of a rational strategy for integration of lactate dehydrogenase A suppression into therapeutic algorithms for head and neck cancer","volume":"124","author":"Chen","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0740","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s12943-018-0786-0","article-title":"Novel targeted therapies and immunotherapy for advanced thyroid cancers","volume":"17","author":"Naoum","year":"2018","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0745","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40880-018-0301-4","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun. (Lond.)"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0750","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41416-019-0650-z","article-title":"Reprogramming of fatty acid metabolism in cancer","volume":"122","author":"Koundouros","year":"2020","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.intimp.2024.113702_b0755","doi-asserted-by":"crossref","first-page":"19445","DOI":"10.1038\/srep19445","article-title":"Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury","volume":"6","author":"Wang","year":"2016","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0760","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/bph.15277","article-title":"Identification and characterization of a novel adiponectin receptor agonist adipo anti-inflammation agonist and its anti-inflammatory effects in vitro and in vivo","volume":"178","author":"Qiu","year":"2021","journal-title":"Br. J. Pharmacol."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0765","first-page":"3992","article-title":"Effect of IL-6 on proliferation of human thyroid anaplastic cancer stem cells","volume":"12","author":"Zheng","year":"2019","journal-title":"Int. J. Clin. Exp. Path."},{"issue":"16","key":"10.1016\/j.intimp.2024.113702_b0770","doi-asserted-by":"crossref","DOI":"10.3390\/cells12162101","article-title":"The adiponectin receptor agonist, ALY688: a promising therapeutic for fibrosis in the dystrophic muscle","volume":"12","author":"Dubuisson","year":"2023","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.intimp.2024.113702_b0775","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.biopha.2012.03.008","article-title":"Regulation of leptin receptor expression in human papillary thyroid cancer cells","volume":"66","author":"Cheng","year":"2012","journal-title":"Biomed. Pharmacother."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0780","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.exphem.2011.08.004","article-title":"Impact of the hypomethylating agent 5-azacytidine on dendritic cells function","volume":"39","author":"Frikeche","year":"2011","journal-title":"Exp. Hematol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0785","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.mce.2009.03.020","article-title":"Re-differentiation of thyroid carcinoma cell lines treated with 5-Aza-2\u2032-deoxycytidine and retinoic acid","volume":"307","author":"Vivaldi","year":"2009","journal-title":"Mol. Cell. Endocrinol."},{"issue":"8","key":"10.1016\/j.intimp.2024.113702_b0790","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/1878-0261.12070","article-title":"Synergistic activity of everolimus and 5-aza-2\u2032-deoxycytidine in medullary thyroid carcinoma cell lines","volume":"11","author":"Vitale","year":"2017","journal-title":"Mol. Oncol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0795","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3906\/sag-1708-106","article-title":"Thyroid volumes and serum VEGF levels in dyslipidemic patients: effects of statin treatment","volume":"49","author":"Ayd\u0131n","year":"2019","journal-title":"Turk. J. Med. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0800","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1530\/JOE-10-0411","article-title":"Rosuvastatin induces apoptosis in cultured human papillary thyroid cancer cells","volume":"210","author":"Zeybek","year":"2011","journal-title":"J. Endocrinol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0805","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.bbrc.2016.08.101","article-title":"Atorvastatin and rosuvastatin improve physiological parameters and alleviate immune dysfunction in metabolic disorders","volume":"478","author":"Lee","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.intimp.2024.113702_b0810","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1016\/j.bcp.2011.08.021","article-title":"Lovastatin inhibits proliferation of anaplastic thyroid cancer cells through up-regulation of p27 by interfering with the Rho\/ROCK-mediated pathway","volume":"82","author":"Zhong","year":"2011","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0815","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijcard.2008.10.044","article-title":"Modulation of human T cells signaling transduction by lovastatin","volume":"140","author":"Cheng","year":"2010","journal-title":"Int. J. Cardiol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113702_b0820","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1089\/thy.2010.0304","article-title":"Is there a treatment advantage when paclitaxel and lovastatin are combined to dose anaplastic thyroid carcinoma cell lines?","volume":"21","author":"Chung","year":"2011","journal-title":"Thyroid"},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0825","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005940","article-title":"Statin drugs enhance responses to immune checkpoint blockade in head and neck cancer models","volume":"11","author":"Kansal","year":"2023","journal-title":"J. Immunother. Cancer"},{"issue":"12","key":"10.1016\/j.intimp.2024.113702_b0830","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18122690","article-title":"Simvastatin inhibits cell proliferation and migration in human anaplastic thyroid cancer","volume":"18","author":"Chen","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0835","first-page":"52","article-title":"Recent developments in application of single-cell RNA sequencing in the tumour immune microenvironment and cancer therapy","volume":"9","author":"Li","year":"2022","journal-title":"Mil. Med. Res."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0840","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41388-023-02889-y","article-title":"Dual targeting of MAPK and PI3K pathways unlocks redifferentiation of Braf-mutated thyroid cancer organoids","volume":"43","author":"Lasolle","year":"2024","journal-title":"Oncogene"},{"issue":"21","key":"10.1016\/j.intimp.2024.113702_b0845","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.1039\/D4BM00815D","article-title":"Programmable bionanomaterials for revolutionizing cancer immunotherapy","volume":"12","author":"Sharma","year":"2024","journal-title":"Biomater. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2024.113702_b0850","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12943-024-01981-5","article-title":"Cancer immunometabolism: advent, challenges, and perspective","volume":"23","author":"Dang","year":"2024","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.intimp.2024.113702_b0855","article-title":"Identification and validation of a novel senescence-related biomarker for thyroid cancer to predict the prognosis and immunotherapy","volume":"14","author":"Hong","year":"2023","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113702_b0860","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.immuni.2015.09.001","article-title":"Metabolic reprogramming of immune cells in cancer progression","volume":"43","author":"Biswas","year":"2015","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.intimp.2024.113702_b0865","first-page":"1579","article-title":"Metabolic reprogramming and its clinical application in thyroid cancer","volume":"18","author":"Wen","year":"2019","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.intimp.2024.113702_b0870","unstructured":"S. Jin et al., Signaling Pathways in Thyroid Cancer and Their Therapeutic Implications 2016, 2016."},{"key":"10.1016\/j.intimp.2024.113702_b0875","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jare.2021.04.001","article-title":"Gut microbiota changes and its potential relations with thyroid carcinoma","volume":"35","author":"Yu","year":"2022","journal-title":"J. Adv. Res."},{"issue":"18","key":"10.1016\/j.intimp.2024.113702_b0880","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241813767","article-title":"CTC, ctDNA, and exosome in thyroid cancers: a review","volume":"24","author":"Wang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"16","key":"10.1016\/j.intimp.2024.113702_b0885","doi-asserted-by":"crossref","first-page":"15449","DOI":"10.1021\/acsnano.3c01215","article-title":"Multifunctional calcium-manganese nanomodulator provides antitumor treatment and improved immunotherapy via reprogramming of the tumor microenvironment","volume":"17","author":"Luo","year":"2023","journal-title":"ACS Nano"},{"issue":"16","key":"10.1016\/j.intimp.2024.113702_b0890","doi-asserted-by":"crossref","first-page":"e18587","DOI":"10.1111\/jcmm.18587","article-title":"The evolving process of ferroptosis in thyroid cancer: novel mechanisms and opportunities","volume":"28","author":"Yin","year":"2024","journal-title":"J. Cell Mol. Med."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:44:09Z","timestamp":1789645449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924022240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":178,"alternative-id":["S1567576924022240"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113702","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging role of metabolic reprogramming in the immune microenvironment and immunotherapy of thyroid cancer","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113702","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113702"}}