{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T12:41:21Z","timestamp":1791981681041,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113718","type":"journal-article","created":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T08:21:21Z","timestamp":1733473281000},"page":"113718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Epiberberine ameliorates MNNG-induced chronic atrophic gastritis by acting on the EGFR-IL33 axis"],"prefix":"10.1016","volume":"145","author":[{"given":"Juan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiantao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxia","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyuan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"zhengcai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.intimp.2024.113718_b0005","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1053\/j.gastro.2021.06.078","article-title":"AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review","volume":"161","author":"Shah","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.intimp.2024.113718_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118903","article-title":"Berberine regulates macrophage polarization through IL-4-STAT6 signaling pathway in Helicobacter pylori-induced chronic atrophic gastritis","volume":"266","author":"Yang","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113718_b0015","article-title":"Incidence of gastric cancer among patients with gastric precancerous lesions: observational cohort study in a low risk Western population","volume":"351","author":"Song","year":"2015","journal-title":"BMJ (Clin. Res. Ed.)"},{"issue":"8","key":"10.1016\/j.intimp.2024.113718_b0020","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nrurol.2017.69","article-title":"Oxidative stress and male infertility","volume":"14","author":"Bisht","year":"2017","journal-title":"Nat. Rev. Urol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113718_b0025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1053\/j.gastro.2021.10.036","article-title":"Cellular plasticity, reprogramming, and regeneration: metaplasia in the stomach and beyond","volume":"162","author":"Goldenring","year":"2022","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.intimp.2024.113718_b0030","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.gie.2009.12.029","article-title":"The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis","volume":"71","author":"Capelle","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"10.1016\/j.intimp.2024.113718_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153619","article-title":"Therapeutic effects and potential mechanism of dehydroevodiamine on N-methyl-N\u2032-nitro-N-nitrosoguanidine-induced chronic atrophic gastritis","volume":"91","author":"Wen","year":"2021","journal-title":"Phytomedicine"},{"issue":"9","key":"10.1016\/j.intimp.2024.113718_b0040","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1136\/gutjnl-2015-309252","article-title":"Kyoto global consensus report on Helicobacter pylori gastritis","volume":"64","author":"Sugano","year":"2015","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.intimp.2024.113718_b0045","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2299352","article-title":"Medicine for chronic atrophic gastritis: a systematic review, meta- and network pharmacology analysis","volume":"55","author":"Weng","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.intimp.2024.113718_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2021.153837","article-title":"Network pharmacology to unveil the mechanism of Moluodan in the treatment of chronic atrophic gastritis","volume":"95","author":"Zhou","year":"2022","journal-title":"Phytomedicine"},{"issue":"Pt A","key":"10.1016\/j.intimp.2024.113718_b0055","article-title":"Pharmacodynamics and pharmacological mechanism of Moluodan concentrated pill in the treatment of atrophic gastritis: A network pharmacological study and in vivo experiments","volume":"318","author":"Lou","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113718_b0060","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.2147\/DDDT.S454758","article-title":"Integrated approaches revealed the therapeutic mechanisms of Zuojin pill against gastric mucosa injury in a rat model with chronic atrophic gastritis","volume":"18","author":"Chen","year":"2024","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.intimp.2024.113718_b0065","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3389\/fphar.2016.00362","article-title":"Rhizoma coptidis: a potential cardiovascular protective agent","volume":"7","author":"Tan","year":"2016","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113718_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2020.104771","article-title":"Multifunctional epiberberine mediates multi-therapeutic effects","volume":"147","author":"Liu","year":"2020","journal-title":"Fitoterapia"},{"key":"10.1016\/j.intimp.2024.113718_b0075","article-title":"Current advances in Coptidis rhizoma for gastrointestinal and other cancers","volume":"12","author":"He","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113718_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106440","article-title":"Berberine for gastric cancer prevention and treatment: Multi-step actions on the Correa's cascade underlie its therapeutic effects","volume":"184","author":"Liu","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"Pt B","key":"10.1016\/j.intimp.2024.113718_b0085","article-title":"Epiberberine inhibits Helicobacter pylori and reduces host apoptosis and inflammatory damage by down-regulating urease expression","volume":"318","author":"Wu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113718_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153216","article-title":"Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice","volume":"76","author":"Yu","year":"2020","journal-title":"Phytomedicine"},{"issue":"4","key":"10.1016\/j.intimp.2024.113718_b0095","article-title":"Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis","volume":"1869","author":"Zhou","year":"2023","journal-title":"Biochim. Biophys. Acta"},{"issue":"4","key":"10.1016\/j.intimp.2024.113718_b0100","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/path.5214","article-title":"Interferon-\u03b3 directly induces gastric epithelial cell death and is required for progression to metaplasia","volume":"247","author":"Osaki","year":"2019","journal-title":"J. Pathol."},{"key":"10.1016\/j.intimp.2024.113718_b0105","doi-asserted-by":"crossref","first-page":"860344","DOI":"10.3389\/fcell.2022.860344","article-title":"Ferroptosis and its role in gastric cancer","volume":"10","author":"Gu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113718_b0110","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2008.01.071","article-title":"Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands","volume":"134","author":"de Vries","year":"2008","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.intimp.2024.113718_b0115","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"Correa","year":"2011","journal-title":"J. Dig. Dis."},{"key":"10.1016\/j.intimp.2024.113718_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112451","article-title":"Effect of kaempferol on hedgehog signaling pathway in rats with --chronic atrophic gastritis - Based on network pharmacological screening and experimental verification","volume":"145","author":"Tu","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113718_b0125","doi-asserted-by":"crossref","first-page":"104771","DOI":"10.1016\/j.fitote.2020.104771","article-title":"Multifunctional epiberberine mediates multi-therapeutic effects","volume":"147","author":"Liu","year":"2020","journal-title":"Fitoterapia"},{"issue":"5","key":"10.1016\/j.intimp.2024.113718_b0130","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41419-018-0493-1","article-title":"Helicobacter pylori-induced IL-33 modulates mast cell responses, benefits bacterial growth, and contributes to gastritis","volume":"9","author":"Lv","year":"2018","journal-title":"Cell Death Dis."},{"issue":"20","key":"10.1016\/j.intimp.2024.113718_b0135","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.3390\/cells11203237","article-title":"Dual immune regulatory roles of interleukin-33 in pathological conditions","volume":"11","author":"Guo","year":"2022","journal-title":"Cells"},{"issue":"6","key":"10.1016\/j.intimp.2024.113718_b0140","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.7150\/ijbs.93573","article-title":"IL-33 accelerates chronic atrophic gastritis through AMPK-ULK1 axis mediated autolysosomal degradation of GKN1","volume":"20","author":"Liu","year":"2024","journal-title":"Int. J. Biol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2024.113718_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11523-018-0554-5","article-title":"Treatment of EGFR T790M-positive non-small cell lung cancer","volume":"13","author":"Choo","year":"2018","journal-title":"Target Oncol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113718_b0150","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.micinf.2014.11.011","article-title":"Epithelial cell ADAM17 activation by Helicobacter pylori: role of ADAM17 C-terminus and Threonine-735 phosphorylation","volume":"17","author":"McClurg","year":"2015","journal-title":"Microbes Infect."},{"issue":"5","key":"10.1016\/j.intimp.2024.113718_b0155","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1086\/596660","article-title":"Helicobacter pylori regulates cellular migration and apoptosis by activation of phosphatidylinositol 3-kinase signaling","volume":"199","author":"Nagy","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"16","key":"10.1016\/j.intimp.2024.113718_b0160","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.1111\/bph.13535","article-title":"Epidermal growth factor is a critical regulator of the cytokine IL\u201033 in intestinal epithelial cells","volume":"173","author":"Islam","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113718_b0165","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/jid.2015.85","article-title":"Epidermal expression and regulation of interleukin-33 during homeostasis and inflammation: strong species differences","volume":"135","author":"Sundnes","year":"2015","journal-title":"J. Invest. Dermatol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022409?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022409?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:40:56Z","timestamp":1734637256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924022409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":33,"alternative-id":["S1567576924022409"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113718","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epiberberine ameliorates MNNG-induced chronic atrophic gastritis by acting on the EGFR-IL33 axis","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113718"}}