{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:05:11Z","timestamp":1789646711303,"version":"4.0.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019037","name":"Key Science and Technology Research Project in Jiangxi Province Department of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471756"],"award-info":[{"award-number":["82471756"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671548"],"award-info":[{"award-number":["81671548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.intimp.2024.113732","type":"journal-article","created":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T17:59:32Z","timestamp":1733162372000},"page":"113732","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL"],"prefix":"10.1016","volume":"144","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9972-5127","authenticated-orcid":false,"given":"Fei-Fei","family":"Huo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1584-2521","authenticated-orcid":false,"given":"Xue-Yang","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Wei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Guo","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10055","key":"10.1016\/j.intimp.2024.113732_b0005","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis[J]","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"issue":"10086","key":"10.1016\/j.intimp.2024.113732_b0010","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/S0140-6736(17)31472-1","article-title":"Pathogenetic insights from the treatment of rheumatoid arthritis[J]","volume":"389","author":"McInnes","year":"2017","journal-title":"Lancet"},{"issue":"23","key":"10.1016\/j.intimp.2024.113732_b0015","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis[J]","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"10086","key":"10.1016\/j.intimp.2024.113732_b0020","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis[J]","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0025","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1136\/annrheumdis-2013-204223","article-title":"Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA)[J]","volume":"73","author":"Dougados","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.intimp.2024.113732_b0030","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.coi.2006.06.004","article-title":"Genes, environment and immunity in the development of rheumatoid arthritis[J]","volume":"18","author":"Klareskog","year":"2006","journal-title":"Curr. Opin. Immunol."},{"issue":"7488","key":"10.1016\/j.intimp.2024.113732_b0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nature12873","article-title":"Genetics of rheumatoid arthritis contributes to biology and drug discovery[J]","volume":"506","author":"Okada","year":"2014","journal-title":"Nature"},{"issue":"42","key":"10.1016\/j.intimp.2024.113732_b0040","doi-asserted-by":"crossref","first-page":"71556","DOI":"10.18632\/oncotarget.17746","article-title":"A single nucleotide polymorphism of AIRE gene located in the 21q22.3 increases the risk of rheumatoid arthritis[J]","volume":"8","author":"Xu","year":"2017","journal-title":"Oncotarget"},{"issue":"4","key":"10.1016\/j.intimp.2024.113732_b0045","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri.2016.9","article-title":"AIRE expands: new roles in immune tolerance and beyond[J]","volume":"16","author":"Anderson","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113732_b0050","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2013.08.005","article-title":"Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4(+) T cells[J]","volume":"39","author":"Gardner","year":"2013","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0055","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17010038","article-title":"Aire-Overexpressing Dendritic Cells Induce Peripheral CD4(+) T Cell Tolerance[J]","volume":"17","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.intimp.2024.113732_b0060","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease[J]","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"issue":"10","key":"10.1016\/j.intimp.2024.113732_b0065","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1002\/art.39266","article-title":"Role of Bcl-3 in the development of follicular helper T cells and in the pathogenesis of rheumatoid arthritis[J]","volume":"67","author":"Meguro","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113732_b0070","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.4049\/jimmunol.175.4.2340","article-title":"The role of ICOS in the CXCR5+ follicular B helper T cell maintenance in vivo[J]","volume":"175","author":"Akiba","year":"2005","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113732_b0075","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.4049\/jimmunol.177.7.4927","article-title":"ICOS deficiency is associated with a severe reduction of CXCR5+CD4 germinal center Th cells[J]","volume":"177","author":"Bossaller","year":"2006","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.intimp.2024.113732_b0080","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.celrep.2015.05.042","article-title":"CD8alpha(-) Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses[J]","volume":"11","author":"Shin","year":"2015","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.intimp.2024.113732_b0085","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.imbio.2019.04.007","article-title":"Aire deficient dendritic cells promote the T follicular helper cells differentiation[J]","volume":"224","author":"Huo","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.intimp.2024.113732_b0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.intimp.2017.05.023","article-title":"Transplantation of Aire-overexpressing bone marrow-derived dendritic cells delays the onset of type 1 diabetes[J]","volume":"49","author":"Li","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113732_b0095","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1136\/annrheumdis-2013-204627","article-title":"The global burden of rheumatoid arthritis: estimates from the global burden of disease 2010 study[J]","volume":"73","author":"Cross","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"8","key":"10.1016\/j.intimp.2024.113732_b0100","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1111\/1756-185X.13028","article-title":"Burden of rheumatoid arthritis from a societal perspective: A prevalence-based study on cost of this illness for patients in China[J]","volume":"21","author":"Hu","year":"2018","journal-title":"Int. J. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0105","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/08916934.2017.1422124","article-title":"Deficiency of autoimmune regulator impairs the immune tolerance effect of bone marrow-derived dendritic cells in mice[J]","volume":"51","author":"Huo","year":"2018","journal-title":"Autoimmunity"},{"issue":"13","key":"10.1016\/j.intimp.2024.113732_b0110","doi-asserted-by":"crossref","first-page":"2680","DOI":"10.1093\/hmg\/ddr161","article-title":"The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population[J]","volume":"20","author":"Terao","year":"2011","journal-title":"Hum. Mol. Genet."},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0115","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1186\/ar4141","article-title":"Association of the AIRE gene with susceptibility to rheumatoid arthritis in a European population: a case control study[J]","volume":"15","author":"Garcia-Lozano","year":"2013","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0120","doi-asserted-by":"crossref","first-page":"14096","DOI":"10.1038\/s41598-017-14375-z","article-title":"Association between AIRE gene polymorphism and rheumatoid arthritis: a systematic review and meta-analysis of case-control studies[J]","volume":"7","author":"Berczi","year":"2017","journal-title":"Sci. Rep."},{"issue":"2018","key":"10.1016\/j.intimp.2024.113732_b0125","article-title":"The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance[J]","volume":"4","author":"Zhao","year":"2018","journal-title":"J. Immunol. Res."},{"key":"10.1016\/j.intimp.2024.113732_b0130","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/08916930701773941","article-title":"Expression of AIRE in thymocytes and peripheral lymphocytes[J]","volume":"41","author":"Suzuki","year":"2008","journal-title":"Autoimmunity"},{"issue":"11","key":"10.1016\/j.intimp.2024.113732_b0135","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/nri1714","article-title":"Follicular B helper T cells in antibody responses and autoimmunity[J]","volume":"5","author":"Vinuesa","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113732_b0140","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1002\/art.39020","article-title":"Circulating follicular helper-like T cells in systemic lupus erythematosus: association with disease activity[J]","volume":"67","author":"Choi","year":"2015","journal-title":"Arthritis Rheumatol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0145","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/cei.12703","article-title":"A comprehensive investigation on the distribution of circulating follicular T helper cells and B cell subsets in primary Sjogren's syndrome and systemic lupus erythematosus[J]","volume":"183","author":"Szabo","year":"2016","journal-title":"Clin. Exp. Immunol."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2024.113732_b0150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jneuroim.2012.12.001","article-title":"Expansion of circulating counterparts of follicular helper T cells in patients with myasthenia gravis[J]","volume":"256","author":"Luo","year":"2013","journal-title":"J. Neuroimmunol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113732_b0155","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s00125-015-3509-8","article-title":"IL-21 production by CD4+ effector T cells and frequency of circulating follicular helper T cells are increased in type 1 diabetes patients[J]","volume":"58","author":"Ferreira","year":"2015","journal-title":"Diabetologia"},{"issue":"10","key":"10.1016\/j.intimp.2024.113732_b0160","article-title":"Follicular T helper cells and IL-21 in rheumatic diseases[J]","volume":"63","author":"Rasmussen","year":"2016","journal-title":"Dan. Med. J."},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0165","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s13075-018-1690-0","article-title":"Enhanced IL-6\/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper\/T follicular regulatory cells in patients with rheumatoid arthritis[J]","volume":"20","author":"Niu","year":"2018","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.intimp.2024.113732_b0170","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.12659\/MSM.914868","article-title":"CD4+CXCR5+PD-1+ T Follicular Helper Cells Play a Pivotal Role in the Development of Rheumatoid Arthritis[J]","volume":"25","author":"Cao","year":"2019","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.intimp.2024.113732_b0175","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/827480","article-title":"Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis[J]","volume":"2012","author":"Ma","year":"2012","journal-title":"Clin. Dev. Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113732_b0180","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10238-018-0530-5","article-title":"Imbalance of circulating Tfr\/Tfh ratio in patients with rheumatoid arthritis[J]","volume":"19","author":"Wang","year":"2019","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.intimp.2024.113732_b0185","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.61406","article-title":"The kinase PDK1 is critical for promoting T follicular helper cell differentiation[J]","volume":"10","author":"Sun","year":"2021","journal-title":"Elife"}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924022549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:52:30Z","timestamp":1789645950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924022549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":37,"alternative-id":["S1567576924022549"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113732","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aire attenuate collagen-induced arthritis by suppressing T follicular helper cells through ICOSL","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113732","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113732"}}