{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:04:25Z","timestamp":1789124665062,"version":"build-2803163510"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2017YFC1001400"],"award-info":[{"award-number":["2017YFC1001400"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2015CB943300"],"award-info":[{"award-number":["2015CB943300"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070915"],"award-info":[{"award-number":["32070915"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81490744"],"award-info":[{"award-number":["81490744"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81471548"],"award-info":[{"award-number":["81471548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971456"],"award-info":[{"award-number":["81971456"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.intimp.2024.113859","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T00:59:00Z","timestamp":1736038740000},"page":"113859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The double-edged role of IL-18 in reproductive endocrine and reproductive immune related disorders"],"prefix":"10.1016","volume":"147","author":[{"given":"Jing","family":"Shan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da-Jin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113859_b0005","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1189\/jlb.0602313","article-title":"Interleukin-18","volume":"73","author":"Gracie","year":"2003","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.intimp.2024.113859_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2022.103632","article-title":"Immunological microenvironment at the maternal-fetal interface","volume":"151","author":"Bian","year":"2022","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0015","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/imr.12285","article-title":"NLRP3 at the interface of metabolism and inflammation","volume":"265","author":"Haneklaus","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2024.113859_b0020","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/imr.12287","article-title":"Pyroptotic cell death defends against intracellular pathogens","volume":"265","author":"Jorgensen","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.intimp.2024.113859_b0025","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1146\/annurev.immunol.19.1.423","article-title":"Interleukin-18 regulates both Th1 and Th2 responses","volume":"19","author":"Nakanishi","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0030","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1359-6101(00)00015-0","article-title":"Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu","volume":"12","author":"Nakanishi","year":"2001","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.intimp.2024.113859_b0035","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fimmu.2017.00025","article-title":"Regulation of NK cell activation and effector functions by the IL-12 family of cytokines: the case of IL-27","volume":"8","author":"Zwirner","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0040","doi-asserted-by":"crossref","first-page":"626-+","DOI":"10.1038\/ni.3443","article-title":"Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs","volume":"17","author":"Silver","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0045","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/ni.3094","article-title":"Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets","volume":"16","author":"Robinette","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.it.2016.04.001","article-title":"Memory CD8(+) T cells: innate-like sensors and orchestrators of protection","volume":"37","author":"Lauvau","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3390\/ijms20030649","article-title":"Interleukin-18 in health and disease","volume":"20","author":"Yasuda","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0060","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/77811","article-title":"IL-18 induction of IgE: dependence on CD4+ t cells, IL-4 and STAT6","volume":"1","author":"Yoshimoto","year":"2000","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0065","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.cell.2016.08.076","article-title":"Host-protozoan interactions protect from mucosal infections through activation of the inflammasome","volume":"167","author":"Chudnovskiy","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.intimp.2024.113859_b0070","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3109\/13813455.2012.687003","article-title":"Analysis of cytokines in the peritoneal fluid of endometriosis patients as a function of the menstrual cycle stage using the Bio-Plex (R) platform","volume":"118","author":"Bersinger","year":"2012","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2024.113859_b0075","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1093\/humrep\/deh108","article-title":"Role of IL-18 in pathogenesis of endometriosis","volume":"19","author":"Oku","year":"2004","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.intimp.2024.113859_b0080","doi-asserted-by":"crossref","first-page":"11707","DOI":"10.3390\/ijms231911707","article-title":"PEG2-induced pyroptosis regulates the expression of HMGB1 and promotes hEM15A migration in endometriosis","volume":"23","author":"Huang","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2016.07.005","article-title":"Immune-inflammation gene signatures in endometriosis patients","volume":"106","author":"Ahn","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0090","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s10815-022-02662-2","article-title":"Increased expression of NLRP3 inflammasome components in granulosa cells and follicular fluid interleukin (IL)\u20111beta and IL\u201118 levels in fresh IVF\/ICSI cycles in women with endometriosis","volume":"40","author":"Fonseca","year":"2023","journal-title":"J. Assist. Reprod. Gen."},{"key":"10.1016\/j.intimp.2024.113859_b0095","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/j.fertnstert.2003.09.074","article-title":"Decreased levels of interleukin-18 in peritoneal fluid but not in serum of patients with endometriosis","volume":"81","author":"Zhang","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0100","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0897.2012.01147.x","article-title":"Imbalance in cytokines from interleukin-1 family-role in pathogenesis of endometriosis","volume":"68","author":"Sikora","year":"2012","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0105","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1590\/S0100-879X2009001100007","article-title":"Peritoneal and serum interleukin-18 levels are not increased in women with minimum or mild endometriosis","volume":"42","author":"Glitz","year":"2009","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0110","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.fertnstert.2007.11.060","article-title":"Interleukin-12 but not interleukin-18 is associated with severe endometriosis","volume":"91","author":"Fairbanks","year":"2009","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0115","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2916070","article-title":"Decreased cytotoxicity of peripheral and peritoneal natural killer cell in endometriosis","volume":"2016","author":"Jeung","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2024.113859_b0120","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1093\/humrep\/del516","article-title":"Endometriosis: an inflammatory disease with a Th2 immune response component","volume":"22","author":"Podgaec","year":"2007","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.intimp.2024.113859_b0125","doi-asserted-by":"crossref","first-page":"6679","DOI":"10.4049\/jimmunol.0903354","article-title":"The interactions of multiple cytokines control NK cell maturation","volume":"185","author":"Brady","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0130","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00108","article-title":"IL-17A modulates peritoneal macrophage recruitment and M2 polarization in endometriosis","volume":"11","author":"Miller","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00334","article-title":"Interleukin-18 amplifies macrophage polarization and morphological alteration, leading to excessive angiogenesis","volume":"9","author":"Kobori","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0140","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1136\/ard.2009.127241","article-title":"Interleukin 18 induces angiogenesis in vitro and in vivo via Src and Jnk kinases","volume":"69","author":"Amin","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.113859_b0145","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.imlet.2005.10.020","article-title":"Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways","volume":"103","author":"Cho","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.intimp.2024.113859_b0150","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1007\/s11033-023-08316-5","article-title":"Single nucleotide polymorphisms of Interleukin-4, Interleukin-18, FCRL3 and sPLA2IIa genes and their association in pathogenesis of endometriosis","volume":"50","author":"Balunathan","year":"2023","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.intimp.2024.113859_b0155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0165-5728(00)00407-0","article-title":"Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation","volume":"112","author":"Giedraitis","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.intimp.2024.113859_b0160","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.fertnstert.2010.07.1046","article-title":"Functional association of interleukin-18 gene-607 C\/A promoter polymorphisms with endometriosis","volume":"95","author":"Ayaz","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0165","first-page":"163","article-title":"The effects of Campsis grandiflora on the model rats with endometriosis","volume":"23","author":"Zheng","year":"2012","journal-title":"Biomed. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0170","first-page":"298","article-title":"Acupuncture improves the effects of Chinese herbal medicine in treating endometriosis model rats","volume":"23","author":"Shi","year":"2013","journal-title":"J. Anim. Plant. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0175","doi-asserted-by":"crossref","first-page":"817","DOI":"10.4314\/tjpr.v19i4.20","article-title":"Anti-endometriotic effect of Angelica sinensis (Oliv.) Diels extract in human endometrioc cells and rats","volume":"19","author":"Xiong","year":"2020","journal-title":"Trop. J. Pharm. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26020288","article-title":"Alpha-lipoic acid plays a role in endometriosis: new evidence on inflammasome-mediated interleukin production, cellular adhesion and invasion","volume":"26","author":"Di Nicuolo","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2024.113859_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117859","article-title":"Juan-tong-yin potentially impacts endometriosis pathophysiology by enhancing autophagy of endometrial stromal cells via unfolded protein reaction-triggered endoplasmic reticulum stress","volume":"325","author":"Meng","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113859_b0190","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1046\/j.8755-8920.2003.00126.x","article-title":"Abnormal first trimester serum interleukin 18 levels are associated with a poor outcome in women with a history of recurrent miscarriage","volume":"51","author":"Wilson","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0195","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/09513590.2016.1212829","article-title":"Effects of human chorionic gonadotropin, estradiol, and progesterone on interleukin-18 expression in human decidual tissues","volume":"33","author":"Wang","year":"2017","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2021.103432","article-title":"The role of interleukin-18 in recurrent early pregnancy loss","volume":"148","author":"Lob","year":"2021","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0205","article-title":"Inflammosome in the human endometrium: further step in the evaluation of the \u201cmaternal side\u201d","volume":"105","author":"D\u2019ippolito","year":"2016","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0210","first-page":"1935","article-title":"NLRP3 inflammasome as the potential target mechanism and therapy in recurrent spontaneous abortions","volume":"19","author":"Lu","year":"2019","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.113859_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.fertnstert.2015.08.011","article-title":"Role of inflammatory mediators in patients with recurrent pregnancy loss","volume":"104","author":"Comba","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0220","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jri.2011.07.002","article-title":"Expression and localization of IL-18 in the hypothalamic-pituitary-ovarian axis of non-pregnant, pregnant, and abortive rats","volume":"92","author":"Wang","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0225","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejogrb.2003.11.029","article-title":"Abnormal cytokine levels in nonpregnant women with a history of recurrent miscarriage","volume":"115","author":"Wilson","year":"2004","journal-title":"Eur. J. Obstet. Gyn. R. B."},{"key":"10.1016\/j.intimp.2024.113859_b0230","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7150\/ijbs.22809","article-title":"Effect of IL-18 on the expansion and phenotype of human natural killer cells: application to cancer immunotherapy","volume":"14","author":"Senju","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0235","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jri.2015.05.001","article-title":"Characterization of the subsets of human NKT-like cells and the expression of Th1\/Th2 cytokines in patients with unexplained recurrent spontaneous abortion","volume":"110","author":"Yuan","year":"2015","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.fertnstert.2012.08.034","article-title":"Proinflammatory cytokines induced altered expression of cyclooxygenase-2 gene results in unreceptive endometrium in women with idiopathic recurrent spontaneous miscarriage","volume":"99","author":"Banerjee","year":"2013","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0245","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.5713\/ajas.2013.13101","article-title":"Effects of IFN-gamma on IL-18 expression in pregnant rats and pregnancy outcomes","volume":"26","author":"Si","year":"2013","journal-title":"Asia Austral. J. Anim."},{"key":"10.1016\/j.intimp.2024.113859_b0250","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.biopha.2017.06.001","article-title":"Effect of Intravenous immunoglobulin on Th1 and Th2 lymphocytes and improvement of pregnancy outcome in recurrent pregnancy loss (RPL)","volume":"92","author":"Ahmadi","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113859_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101527","article-title":"Intravenous immunoglobulin treatment in women with four or more recurrent pregnancy losses: a double-blind, randomised, placebo-controlled trial","volume":"50","author":"Yamada","year":"2022","journal-title":"Eclinicalmedicine"},{"key":"10.1016\/j.intimp.2024.113859_b0260","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/1471-0528.13192","article-title":"Intravenous immunoglobulin treatment for secondary recurrent miscarriage: a randomised, double-blind, placebo-controlled trial","volume":"122","author":"Christiansen","year":"2015","journal-title":"BJOG"},{"key":"10.1016\/j.intimp.2024.113859_b0265","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1159\/000078154","article-title":"Effect of IgG therapy on lymphocyte subpopulations in the peripheral blood of Kuwaiti women experiencing recurrent pregnancy loss","volume":"58","author":"Mahmoud","year":"2004","journal-title":"Gynecol. Obstet. Invest."},{"key":"10.1016\/j.intimp.2024.113859_b0270","first-page":"28","article-title":"The effectiveness of IVIG therapy in pregnancy and live birth rate of women with recurrent implantation failure (RIF): a systematic review and meta-analysis","volume":"134\u2013135","author":"Samaneh","year":"2019","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0275","article-title":"Intravenous immunoglobulin for patients with unexplained recurrent implantation failure: a 6-year single center retrospective review of clinical outcomes","volume":"14","author":"Einav","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.113859_b0280","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/aji.12170","article-title":"Intravenous immunoglobulin treatment for repeated IVF\/ICSI failure and unexplained infertility: a systematic review and a meta-analysis","volume":"70","author":"Li","year":"2013","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0285","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.clim.2015.08.005","article-title":"Potentiation of cytokine-induced proliferation of human Natural Killer cells by intravenous immunoglobulin G","volume":"161","author":"Issekutz","year":"2015","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180642","article-title":"Synthetic PreImplantation Factor (PIF) prevents fetal loss by modulating LPS induced inflammatory response","volume":"12","author":"Di Simone","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113859_b0295","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1177\/1933719112459240","article-title":"Bacterial LPS differently modulates inflammasome gene expression and IL-1 beta secretion in trophoblast cells, decidual stromal cells, and decidual endothelial cells","volume":"20","author":"Pontillo","year":"2013","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0300","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124001","article-title":"Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia","volume":"10","author":"Xue","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113859_b0305","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.117796","article-title":"Jianpi Antai formula prevents miscarriage by repressing M1 polarization of decidual macrophages through ubiquitination of NLRP3 mediated by MARCH7","volume":"324","author":"Zhao","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113859_b0310","article-title":"Association between genetic polymorphisms in interleukin genes and recurrent pregnancy loss-a systematic review and meta-analysis","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113859_b0315","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.fertnstert.2011.06.079","article-title":"Analysis of interleukin-18 promoter polymorphisms and changes in interleukin-18 serum levels underscores the involvement of interleukin-18 in recurrent spontaneous miscarriage","volume":"96","author":"Al-Khateeb","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0320","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jri.2011.12.002","article-title":"Interleukin-18 promoter polymorphisms and risk of idiopathic recurrent pregnancy loss in a Tunisian population","volume":"93","author":"Messaoudi","year":"2012","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0325","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1080\/09513590.2018.1528220","article-title":"Association of IL-10, IL-18, and IL-33 genetic polymorphisms with recurrent pregnancy loss risk in Iranian women","volume":"35","author":"Soheilyfar","year":"2019","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0330","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1080\/15513815.2019.1652379","article-title":"Association of promoter region polymorphisms of IL-6 and IL-18 genes with risk of recurrent pregnancy loss: a systematic review and meta-analysis fetal and pediatric pathology","volume":"39","author":"Salimi","year":"2020","journal-title":"Fetal Pediatr. Pathol."},{"key":"10.1016\/j.intimp.2024.113859_b0335","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1111\/jog.12800","article-title":"Interleukin-18 gene polymorphisms and risk of recurrent pregnancy loss: a systematic review and meta-analysis","volume":"41","author":"Chen","year":"2015","journal-title":"J. Obstet. Gynaecol. Re."},{"key":"10.1016\/j.intimp.2024.113859_b0340","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.3390\/ijms16024180","article-title":"Genetic variant in Interleukin-18 Is associated with idiopathic recurrent miscarriage in Chinese Han population","volume":"16","author":"Yue","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0345","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1210\/jc.2003-031365","article-title":"Serum interleukin-18 concentrations are increased in the polycystic ovary syndrome: relationship to insulin resistance and to obesity","volume":"89","author":"Escobar-Morreale","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.intimp.2024.113859_b0350","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13048-019-0548-7","article-title":"Abnormal expression of HSP70 may contribute to PCOS pathology","volume":"12","author":"Wu","year":"2019","journal-title":"J. Ovarian. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0355","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13048-020-00650-7","article-title":"The effect of glutamine on dehydroepiandrosterone-induced polycystic ovary syndrome rats","volume":"13","author":"Wu","year":"2020","journal-title":"J. Ovarian. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144352","article-title":"Elevated expression of IL-18 but not IL-1\u03b2 gene is associated with NALP3 and AIM2 inflammasome in polycystic ovary syndrome","volume":"731","author":"Rostamtabar","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.intimp.2024.113859_b0365","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.fertnstert.2008.10.070","article-title":"Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors","volume":"93","author":"Kaya","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0370","doi-asserted-by":"crossref","first-page":"3","DOI":"10.20945\/2359-3997000000442","article-title":"Elevated levels of interleukin-18 are associated with several indices of general and visceral adiposity and insulin resistance in women with polycystic ovary syndrome","volume":"66","author":"Kabakchieva","year":"2022","journal-title":"Arch. Endocrin. Metab."},{"key":"10.1016\/j.intimp.2024.113859_b0375","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1477-7827-9-7","article-title":"Is interleukin-18 associated with polycystic ovary syndrome?","volume":"9","author":"Yang","year":"2011","journal-title":"Reprod. Biol. Endocrin."},{"key":"10.1016\/j.intimp.2024.113859_b0380","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/09513590.2017.1395835","article-title":"The relationship between IL-18 and atherosclerotic cardiovascular risk in Egyptian lean women with polycystic ovary syndrome","volume":"34","author":"Dawood","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0385","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1080\/09513590.2018.1459548","article-title":"Downregulation of serum long noncoding RNA GAS5 may contribute to insulin resistance in PCOS patients","volume":"34","author":"Lin","year":"2018","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0390","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/humrep\/der096","article-title":"No difference in markers of adipose tissue inflammation between overweight women with polycystic ovary syndrome and weight-matched controls","volume":"26","author":"Lindholm","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.intimp.2024.113859_b0395","doi-asserted-by":"crossref","first-page":"665","DOI":"10.4414\/smw.2008.12276","article-title":"Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance","volume":"138","author":"Osborn","year":"2008","journal-title":"Swiss Med. Wkly."},{"key":"10.1016\/j.intimp.2024.113859_b0400","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.clnu.2019.03.027","article-title":"Postprandial inflammatory responses after oral glucose, lipid and protein challenges: influence of obesity, sex and polycystic ovary syndrome","volume":"39","author":"Martinez-Garcia","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.intimp.2024.113859_b0405","first-page":"3851","article-title":"Determination of IL-18, C3 and Insulin in IRAQI females with polycystic ovary syndrome (PCOS)","volume":"19","author":"Al-Kubaisi","year":"2019","journal-title":"Biochem. Cell. Arch."},{"key":"10.1016\/j.intimp.2024.113859_b0410","first-page":"80","article-title":"Silver nanoparticles biofabricated from cinnamomum zeylanicum reduce IL-6, IL-18, and TNF-\u0251 in female rats with polycystic ovarian syndrome","volume":"17","author":"Alwan","year":"2023","journal-title":"Int. J. Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0415","doi-asserted-by":"crossref","DOI":"10.1016\/j.metop.2022.100201","article-title":"Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: histomorphometric evaluation and biochemical assessment","volume":"15","author":"Adelakun","year":"2022","journal-title":"Metabolism. Open"},{"key":"10.1016\/j.intimp.2024.113859_b0420","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s40618-016-0590-x","article-title":"Expression of mRNA and protein of IL-18 and its receptor in human follicular granulosa cells","volume":"40","author":"Salmassi","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.intimp.2024.113859_b0425","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1034\/j.1600-0897.2001.d01-23.x","article-title":"Expression of Interleukin-18 and its receptor in mouse ovary","volume":"46","author":"Tsuji","year":"2001","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2020.103083","article-title":"IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with unexplained infertility to PCOS during in vitro fertilization","volume":"138","author":"Zhang","year":"2020","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0435","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1210\/clinem\/dgac281","article-title":"Elevated levels of follicular fatty acids induce ovarian inflammation via ERK1\/2 and inflammasome activation in PCOS","volume":"107","author":"Lai","year":"2022","journal-title":"J. Clin. Endocr. Metab."},{"key":"10.1016\/j.intimp.2024.113859_b0440","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13048-019-0585-2","article-title":"Baicalin ameliorates polycystic ovary syndrome through AMP-activated protein kinase","volume":"12","author":"Wang","year":"2019","journal-title":"J. Ovarian. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0445","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s40618-013-0021-1","article-title":"Mild\/minimal stimulation protocol for ovarian stimulation of patients at high risk of developing ovarian hyperstimulation syndrome","volume":"37","author":"Rinaldi","year":"2014","journal-title":"J. Endocrinol. Invest."},{"key":"10.1016\/j.intimp.2024.113859_b0450","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.fertnstert.2004.03.024","article-title":"Interleukin-18 levels correlate with severe ovarian hyperstimulation syndrome","volume":"82","author":"Barak","year":"2004","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0455","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/1933719116653681","article-title":"Overexpression of IL-18 in the proliferative phase endometrium of patients with polycystic ovary syndrome","volume":"24","author":"Long","year":"2017","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.intimp.2024.113859_b0460","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jri.2007.03.010","article-title":"Post-ovulatory rise of endometrial CD16(-) natural killer cells: in situ proliferation of residual cells or selective recruitment from circulating peripheral blood?","volume":"76","author":"Kitaya","year":"2007","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0465","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1182\/blood-2007-08-105965","article-title":"Recruitment of circulating NK cells through decidual tissues: a possible mechanism controlling NK cell accumulation in the uterus during early pregnancy","volume":"111","author":"Carlino","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.intimp.2024.113859_b0470","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.fertnstert.2010.01.049","article-title":"Reduced percentage of natural killer cells associated with impaired cytokine network in the secretory endometrium of infertile women with polycystic ovary syndrome","volume":"94","author":"Matteo","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0475","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/2635375","article-title":"Integrated network pharmacology and clinical study to reveal the effects and mechanisms of Bushen Huoxue Huatan decoction on polycystic ovary syndrome","volume":"2022","author":"Ding","year":"2022","journal-title":"Evid-Based. Compl. Alt."},{"key":"10.1016\/j.intimp.2024.113859_b0480","doi-asserted-by":"crossref","DOI":"10.1080\/09513590.2023.2254848","article-title":"The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K\/AKT\/NF-\u03baB and Nrf2\/HO-1 pathways","volume":"39","author":"Ye","year":"2023","journal-title":"Gynecol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0485","doi-asserted-by":"crossref","DOI":"10.1111\/jcmm.18464","article-title":"Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress-apoptosis gene expression in PBMCs of women with PCOS","volume":"28","author":"Jabarpour","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.intimp.2024.113859_b0490","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejogrb.2011.12.008","article-title":"Association of IL-18 genotype with impaired glucose regulation in Korean women with polycystic ovary syndrome","volume":"161","author":"Kim","year":"2012","journal-title":"Eur. J. Obstet. Gyn. R. B."},{"key":"10.1016\/j.intimp.2024.113859_b0495","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1477-7827-8-125","article-title":"Association of polymorphisms of interleukin-18 gene promoter region with polycystic ovary syndrome in Chinese population","volume":"8","author":"Yang","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0500","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s10815-015-0449-7","article-title":"Associations between TNF-\u03b1 and interleukin gene polymorphisms with polycystic ovary syndrome risk: a systematic review and meta-analysis","volume":"32","author":"Wu","year":"2015","journal-title":"J. Assist. Reprod. Gen."},{"key":"10.1016\/j.intimp.2024.113859_b0505","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.numecd.2008.10.002","article-title":"IL-18 gene polymorphism and metabolic syndrome","volume":"19","author":"Presta","year":"2009","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"10.1016\/j.intimp.2024.113859_b0510","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1600-0897.2004.00172.x","article-title":"Interleukin-18 is high in the serum of IVF pregnancies with ovarian hyperstimulation syndrome","volume":"51","author":"Gutman","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0515","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/606459","article-title":"Follicular proinflammatory cytokines and chemokines as markers of IVF success","author":"Sarapik","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0520","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/6379850","article-title":"The role of Interleukin-18 in serum and follicular fluid during in vitro fertilization and intracytoplasmic sperm injection","volume":"2016","author":"Gunther","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.intimp.2024.113859_b0525","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.fertnstert.2004.11.021","article-title":"Role of the endometrial tripod interleukin-18, -15, and -12 in inadequate uterine receptivity in patients with a history of repeated in vitro fertilization-embryo transfer failure","volume":"83","author":"Ledee-Bataille","year":"2005","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0530","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1530\/rep.0.1260149","article-title":"Uterine natural killer cells: insights into their cellular and molecular biology from mouse modelling","volume":"126","author":"Croy","year":"2003","journal-title":"Reproduction"},{"key":"10.1016\/j.intimp.2024.113859_b0535","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jri.2007.07.006","article-title":"Endometrial vascularity by three-dimensional power Doppler ultrasound and cytokines: a complementary approach to assess uterine receptivity","volume":"77","author":"Ledee","year":"2008","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0540","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jri.2011.01.007","article-title":"New pre-conception immune biomarkers for clinical practice: interleukin-18, interleukin-15 and TWEAK on the endometrial side, G-CSF on the follicular side","volume":"88","author":"Ledee","year":"2011","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0545","doi-asserted-by":"crossref","first-page":"463","DOI":"10.5604\/17322693.1050036","article-title":"IL-18 and IL-18 binding protein concentration in ovarian follicular fluid of women with \u201ctubal factor\u201d subjected to in vitro fertilization","volume":"67","author":"Radwan","year":"2013","journal-title":"Postep. Hig. Med. Dosw."},{"key":"10.1016\/j.intimp.2024.113859_b0550","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s00011-010-0237-x","article-title":"Chlamydia trachomatis heat shock proteins 60 and 10 induce apoptosis in endocervical epithelial cells","volume":"60","author":"Jha","year":"2011","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.intimp.2024.113859_b0555","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/humrep\/der108","article-title":"Microbial colonization of follicular fluid: alterations in cytokine expression and adverse assisted reproduction technology outcomes","volume":"26","author":"Pelzer","year":"2011","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.intimp.2024.113859_b0560","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.fertnstert.2009.10.049","article-title":"Tumor necrosis factor like weak inducer of apoptosis (TWEAK)\/fibroblast growth factor inducible-14 might regulate the effects of interleukin 18 and 15 in the human endometrium","volume":"94","author":"Petitbarat","year":"2010","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.intimp.2024.113859_b0565","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0014497","article-title":"TWEAK appears as a modulator of endometrial IL-18 related cytotoxic activity of uterine natural killers","volume":"6","author":"Petitbarat","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113859_b0570","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.00546","article-title":"Protective effects and possible mechanisms of actions of Bushen Cuyun recipe on diminished ovarian reserve induced by cyclophosphamide in rats","volume":"11","author":"Jiang","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113859_b0575","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1600-0897.2006.00401.x","article-title":"Downregulation of human endometrial IL-18 by exogenous ovarian steroids","volume":"56","author":"Ledee","year":"2006","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0580","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1477-7827-8-33","article-title":"Endometrial caspase 1 and interleukin-18 expression during the estrous cycle and peri-implantation period of porcine pregnancy and response to early exogenous estrogen administration","volume":"8","author":"Ashworth","year":"2010","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.intimp.2024.113859_b0585","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1262\/jrd.17029","article-title":"Estrogen inhibits interleukin-18 mRNA expression in the mouse uterus","volume":"51","author":"Murakami","year":"2005","journal-title":"J. Reprod. Dev."},{"key":"10.1016\/j.intimp.2024.113859_b0590","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300784","article-title":"\u0251-Ketoglutarate improves ovarian reserve function in primary ovarian insufficiency by inhibiting NLRP3-mediated pyroptosis of granulosa cells","volume":"68","author":"Liu","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.intimp.2024.113859_b0595","article-title":"Moxibustion against cyclophosphamide-induced premature ovarian failure in rats through inhibiting NLRP3-\/caspase-1-\/GSDMD-dependent pyroptosis","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid-Based. Compl. Alt."},{"key":"10.1016\/j.intimp.2024.113859_b0600","doi-asserted-by":"crossref","first-page":"337","DOI":"10.5114\/ceji.2015.54596","article-title":"Cytokines in the blood and semen of infertile patients","volume":"40","author":"Havrylyuk","year":"2015","journal-title":"Cent. Eur. J. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0605","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1136\/annrheumdis-2017-212608","article-title":"Open-label, multicentre, dose-escalating phase II clinical trial on the safety and efficacy of tadekinig alfa (IL-18BP) in adult-onset Still's disease","volume":"77","author":"Gabay","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.113859_b0610","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.jaci.2016.10.022","article-title":"Life threatening NLRC4-associated hyperinflammation successfully treated with IL-18 inhibition","volume":"139","author":"Canna","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2024.113859_b0615","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2013.00289","article-title":"Interleukin-18 and IL-18 binding protein","volume":"4","author":"Dinarello","year":"2013","journal-title":"Front. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924023816?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924023816?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:11:02Z","timestamp":1777619462000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924023816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":123,"alternative-id":["S1567576924023816"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113859","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The double-edged role of IL-18 in reproductive endocrine and reproductive immune related disorders","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113859"}}