{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:37:16Z","timestamp":1792442236150,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.intimp.2024.113948","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T19:59:26Z","timestamp":1736193566000},"page":"113948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Aerosol inhalation of rhIL-10 improves acute lung injury in mice by affecting pulmonary neutrophil phenotypes through neutrophil-platelet aggregates"],"prefix":"10.1016","volume":"147","author":[{"given":"Huan","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiangang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyuan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.intimp.2024.113948_b0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/cei.13097","article-title":"Glucose-6-phosphate dehydrogenase inhibition attenuates acute lung injury through reduction in NADPH oxidase-derived reactive oxygen species","volume":"191","author":"Nadeem","year":"2018","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.intimp.2024.113948_b0010","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1146\/annurev-physiol-042222-030731","article-title":"A Razor's edge: vascular responses to acute inflammatory lung injury\/acute respiratory distress syndrome","volume":"86","author":"Price","year":"2024","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.intimp.2024.113948_b0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1125246","article-title":"The development of COVID-19 treatment","volume":"14","author":"Yuan","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113948_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106369","article-title":"Blockade of interleukin-2-inducible T-cell kinase signaling attenuates acute lung injury in mice through adjustment of pulmonary Th17\/Treg immune responses and reduction of oxidative stress","volume":"83","author":"Nadeem","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"7","key":"10.1016\/j.intimp.2024.113948_b0025","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.it.2019.04.012","article-title":"Neutrophil diversity in health and disease","volume":"40","author":"Silvestre-Roig","year":"2019","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113948_b0030","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1038\/s41467-022-35492-y","article-title":"Locally organised and activated Fth1(hi) neutrophils aggravate inflammation of acute lung injury in an IL-10-dependent manner","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"issue":"12","key":"10.1016\/j.intimp.2024.113948_b0035","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1055\/s-0040-1718732","article-title":"Neutrophil-platelet and monocyte-platelet aggregates in COVID-19 patients","volume":"120","author":"Le Joncour","year":"2020","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.intimp.2024.113948_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.825892","article-title":"Platelets as key factors in inflammation: focus on CD40L\/CD40","volume":"13","author":"Cognasse","year":"2022","journal-title":"Front. Immunol."},{"issue":"17","key":"10.1016\/j.intimp.2024.113948_b0045","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1182\/blood.2023019940","article-title":"A key role for platelet GPVI in neutrophil recruitment, migration, and NETosis in the early stages of acute lung injury","volume":"142","author":"Burkard","year":"2023","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.intimp.2024.113948_b0050","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190418","article-title":"Biology and therapeutic potential of interleukin-10","volume":"217","author":"Saraiva","year":"2020","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.intimp.2024.113948_b0055","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1097\/01.CCM.0000182815.78568.B2","article-title":"Interleukin-10 aerosol reduces proinflammatory mediators in bronchoalveolar fluid of endotoxemic rat","volume":"33","author":"Hofstetter","year":"2005","journal-title":"Crit. Care Med."},{"issue":"4","key":"10.1016\/j.intimp.2024.113948_b0060","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3109\/08820139.2016.1157814","article-title":"Dexamethasone attenuates LPS-induced acute lung injury through inhibition of NF-\u03baB, COX-2, and pro-inflammatory mediators","volume":"45","author":"Al-Harbi","year":"2016","journal-title":"Immunol. Invest."},{"key":"10.1016\/j.intimp.2024.113948_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110082","article-title":"Curdione ameliorates sepsis-induced lung injury by inhibiting platelet-mediated neutrophil extracellular trap formation","volume":"118","author":"Yang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113948_b0070","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.intimp.2017.04.010","article-title":"Acute lung injury leads to depression-like symptoms through upregulation of neutrophilic and neuronal NADPH oxidase signaling in a murine model","volume":"47","author":"Nadeem","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2024.113948_b0075","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1038\/s41467-023-38624-0","article-title":"Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles","volume":"14","author":"Graca","year":"2023","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.intimp.2024.113948_b0080","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s12964-024-01841-1","article-title":"STAT3 blockade ameliorates LPS-induced kidney injury through macrophage-driven inflammation","volume":"22","author":"Lee","year":"2024","journal-title":"Cell Commun. Signal"},{"issue":"23","key":"10.1016\/j.intimp.2024.113948_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233944","article-title":"Role of S100A8\/A9 in platelet-neutrophil complex formation during acute inflammation","volume":"11","author":"Revenstorff","year":"2022","journal-title":"Cells"},{"issue":"10","key":"10.1016\/j.intimp.2024.113948_b0090","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1042\/CS20220625","article-title":"Targeting TLR4\/3 using chlorogenic acid ameliorates LPS+POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3\/NF-\u03baB axis","volume":"137","author":"Jain","year":"2023","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.intimp.2024.113948_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.953195","article-title":"The role of neutrophil extracellular traps in acute lung injury","volume":"13","author":"Scozzi","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113948_b0100","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.intimp.2024.113948_b0105","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.thromres.2007.12.019","article-title":"Neutrophil CD40 enhances platelet-mediated inflammation","volume":"122","author":"Vanichakarn","year":"2008","journal-title":"Thromb. Res."},{"issue":"10300","key":"10.1016\/j.intimp.2024.113948_b0110","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/S0140-6736(21)00439-6","article-title":"Acute respiratory distress syndrome","volume":"398","author":"Meyer","year":"2021","journal-title":"Lancet"},{"issue":"7","key":"10.1016\/j.intimp.2024.113948_b0115","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41419-023-05954-2","article-title":"B cell-derived IL-10 promotes the resolution of lipopolysaccharide-induced acute lung injury","volume":"14","author":"Sun","year":"2023","journal-title":"Cell Death Dis."},{"issue":"18","key":"10.1016\/j.intimp.2024.113948_b0120","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1182\/blood-2016-12-758185","article-title":"T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10","volume":"129","author":"Kapur","year":"2017","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.intimp.2024.113948_b0125","doi-asserted-by":"crossref","first-page":"L841","DOI":"10.1152\/ajplung.00329.2004","article-title":"Pulmonary overexpression of IL-10 augments lung fibrosis and Th2 responses induced by silica particles","volume":"288","author":"Barbarin","year":"2005","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.intimp.2024.113948_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2019.101335","article-title":"Title: IL-10-producing T cells and their dual functions","volume":"44","author":"Bedke","year":"2019","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.intimp.2024.113948_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.rmed.2021.106728","article-title":"Bronchiectasis and inhaled tobramycin: A literature review","volume":"192","author":"Elborn","year":"2022","journal-title":"Respir. Med."},{"issue":"170","key":"10.1016\/j.intimp.2024.113948_b0140","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0084-2023","article-title":"How inhaled corticosteroids target inflammation in COPD","volume":"32","author":"Lea","year":"2023","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113948_b0145","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.intimp.2018.12.062","article-title":"Inhibition of spleen tyrosine kinase signaling protects against acute lung injury through blockade of NADPH oxidase and IL-17A in neutrophils and \u03b3\u03b4 T cells respectively in mice","volume":"68","author":"Nadeem","year":"2019","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.intimp.2024.113948_b0150","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.tmrv.2020.08.002","article-title":"Evaluation of platelet responses in transfusion-related acute lung injury (TRALI)","volume":"34","author":"Zeeuw van der Laan","year":"2020","journal-title":"Transfus. Med. Rev."},{"issue":"5","key":"10.1016\/j.intimp.2024.113948_b0155","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1111\/trf.15814","article-title":"The contribution of recipient platelets in TRALI: has the jury reached a verdict?","volume":"60","author":"Semple","year":"2020","journal-title":"Transfusion"},{"issue":"2","key":"10.1016\/j.intimp.2024.113948_b0160","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167299","article-title":"Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke-induced severe flu","volume":"9","author":"Kaminski","year":"2024","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.intimp.2024.113948_b0165","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.jaci.2018.02.026","article-title":"CD40 ligand deficiency causes functional defects of peripheral neutrophils that are improved by exogenous IFN-\u03b3","volume":"142","author":"Cabral-Marques","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"2","key":"10.1016\/j.intimp.2024.113948_b0170","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbrc.2008.12.082","article-title":"Mechanisms of LPS-induced CD40 expression in human peripheral blood monocytic cells","volume":"379","author":"Wu","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"9","key":"10.1016\/j.intimp.2024.113948_b0175","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1182\/blood-2005-02-0759","article-title":"LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia","volume":"106","author":"Qin","year":"2005","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.intimp.2024.113948_b0180","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2019.03.020","article-title":"IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation","volume":"50","author":"Ouyang","year":"2019","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.intimp.2024.113948_b0185","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.molimm.2014.09.009","article-title":"The role of poly(ADP-ribose) polymerase-1 inhibitor in carrageenan-induced lung inflammation in mice","volume":"63","author":"Ahmad","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.intimp.2024.113948_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2015.09.001","article-title":"Diosmin downregulates the expression of T cell receptors, pro-inflammatory cytokines and NF-\u03baB activation against LPS-induced acute lung injury in mice","volume":"102","author":"Imam","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.intimp.2024.113948_b0195","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-\u03baB and STAT3 - key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"issue":"4","key":"10.1016\/j.intimp.2024.113948_b0200","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1007\/s10787-021-00800-3","article-title":"Orchestrated modulation of rheumatoid arthritis via crosstalking intracellular signaling pathways","volume":"29","author":"Ibrahim","year":"2021","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.intimp.2024.113948_b0205","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1007\/s13238-013-2084-3","article-title":"NF-\u03baB and STAT3 signaling pathways collaboratively link inflammation to cancer","volume":"4","author":"Fan","year":"2013","journal-title":"Protein Cell"},{"key":"10.1016\/j.intimp.2024.113948_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154551","article-title":"Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2\/STAT3\/SOCS3 and NF-\u03baB signaling pathway","volume":"109","author":"Li","year":"2023","journal-title":"Phytomedicine"},{"issue":"5","key":"10.1016\/j.intimp.2024.113948_b0215","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.4049\/jimmunol.169.5.2354","article-title":"Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages","volume":"169","author":"Wesemann","year":"2002","journal-title":"J. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924024706?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924024706?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T19:55:15Z","timestamp":1740599715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924024706"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":43,"alternative-id":["S1567576924024706"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113948","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aerosol inhalation of rhIL-10 improves acute lung injury in mice by affecting pulmonary neutrophil phenotypes through neutrophil-platelet aggregates","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113948"}}