{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:45:58Z","timestamp":1792896358577,"version":"4.5.0"},"reference-count":232,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T00:00:00Z","timestamp":1735344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100019305","name":"Manipal Academy of Higher Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019305","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["45\/21\/2022 - DDI BMS"],"award-info":[{"award-number":["45\/21\/2022 - DDI BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.intimp.2024.113979","type":"journal-article","created":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T13:58:51Z","timestamp":1735739931000},"page":"113979","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Network Pharmacology-driven therapeutic interventions for Interstitial Lung Diseases using Traditional medicines: A Narrative Review"],"prefix":"10.1016","volume":"147","author":[{"given":"Megh Pravin","family":"Vithalkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.S.","family":"Sandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.B.","family":"Bharath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Krishnaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.M.","family":"Fayaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Sathyanarayana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0508-1394","authenticated-orcid":false,"given":"Yogendra","family":"Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113979_b0005","doi-asserted-by":"crossref","first-page":"846","DOI":"10.2174\/1386207318666151019093606","article-title":"Network Pharmacology of ayurveda formulation triphala with special reference to anti-cancer property","volume":"18","author":"Chandran","year":"2015","journal-title":"Comb. Chem. High Throughput Screen."},{"key":"10.1016\/j.intimp.2024.113979_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/plants11233243","article-title":"Metabolomics and network pharmacology in the exploration of the multi-targeted therapeutic approach of traditional medicinal plants","volume":"11","author":"Sharma","year":"2022","journal-title":"Plants"},{"key":"10.1016\/j.intimp.2024.113979_b0015","article-title":"An integrated pharmacology-based strategy to investigate the potential mechanism of xiebai san in treating pediatric pneumonia","volume":"13","author":"Luo","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0020","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1073\/pnas.1820799116","article-title":"From single drug targets to synergistic network pharmacology in ischemic stroke","volume":"116","author":"Casas","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0025","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/978-981-16-0753-0_6","article-title":"Network pharmacology and modern drug R&D cases","author":"Zhang","year":"2021","journal-title":"Network Pharmacology, Singapore: Springer Singapore"},{"key":"10.1016\/j.intimp.2024.113979_b0030","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nbt1007-1110","article-title":"Network pharmacology","volume":"25","author":"Hopkins","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2024.113979_b0035","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.intimp.2024.113979_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4314\/jpb.v17i1.1","article-title":"Anti-inflammatory and analgesic activities of Clerodendrum capitatum (Willd) Schum. Thonn. (Verbenaceae) leaves","volume":"17","author":"Adamu","year":"2020","journal-title":"Journal of Pharmacy & Bioresources"},{"key":"10.1016\/j.intimp.2024.113979_b0045","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/S0140-6736(21)01826-2","article-title":"Treatment of fibrotic interstitial lung disease: current approaches and future directions","volume":"398","author":"Johannson","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.113979_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2023.154691","article-title":"Cellular mechanisms in the pathogenesis of interstitial lung diseases","volume":"248","author":"Singh","year":"2023","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.intimp.2024.113979_b0055","doi-asserted-by":"crossref","unstructured":"Liu GY, Budinger GRS, Dematte JE. Advances in the management of idiopathic pulmonary fibrosis and progressive pulmonary fibrosis. BMJ 2022:e066354. Doi: 10.1136\/bmj-2021-066354.","DOI":"10.1136\/bmj-2021-066354"},{"key":"10.1016\/j.intimp.2024.113979_b0060","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.crad.2024.01.015","article-title":"Complications of fibrotic interstitial lung disease for the general radiologist","volume":"79","author":"Watson","year":"2024","journal-title":"Clin. Radiol."},{"key":"10.1016\/j.intimp.2024.113979_b0065","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0076-2018","article-title":"Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases","volume":"27","author":"Cottin","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b0070","article-title":"Epidemiology and risk factors for interstitial lung diseases","volume":"11","author":"Jeganathan","year":"2024","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b0075","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12890-018-0651-3","article-title":"Symptom prevalence of patients with fibrotic interstitial lung disease: a systematic literature review","volume":"18","author":"Carvajalino","year":"2018","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0080","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/17476348.2023.2199156","article-title":"Challenges in the diagnosis of idiopathic pulmonary fibrosis: the importance of a multidisciplinary approach","volume":"17","author":"Comes","year":"2023","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12931-019-1161-4","article-title":"Antifibrotic therapy for idiopathic pulmonary fibrosis: time to treat","volume":"20","author":"Maher","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0090","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mam.2018.08.004","article-title":"Developmental pathways in the pathogenesis of lung fibrosis","volume":"65","author":"Chanda","year":"2018","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.intimp.2024.113979_b0095","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12931-017-0654-2","article-title":"Anti-fibrotic efficacy of nintedanib in pulmonary fibrosis via the inhibition of fibrocyte activity","volume":"18","author":"Sato","year":"2017","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0100","doi-asserted-by":"crossref","DOI":"10.15420\/cfr.2021.30","article-title":"Pirfenidone for Idiopathic Pulmonary Fibrosis and Beyond","volume":"8","author":"Aimo","year":"2022","journal-title":"Card. Fail. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b0105","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1186\/s12890-021-01783-1","article-title":"Efficacy of antifibrotic drugs, nintedanib and pirfenidone, in treatment of progressive pulmonary fibrosis in both idiopathic pulmonary fibrosis (IPF) and non-IPF: a systematic review and meta-analysis","volume":"21","author":"Finnerty","year":"2021","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0110","doi-asserted-by":"crossref","DOI":"10.1007\/s00408-019-00260-1","article-title":"Self-reported Gastrointestinal Side Effects of Antifibrotic Drugs in Dutch Idiopathic Pulmonary Fibrosis patients","volume":"197","author":"Proesmans","year":"2019","journal-title":"Lung"},{"key":"10.1016\/j.intimp.2024.113979_b0115","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1038\/s41598-017-01765-6","article-title":"Detecting the Molecular System Signatures of Idiopathic Pulmonary Fibrosis through Integrated Genomic Analysis","volume":"7","author":"Gangwar","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0120","article-title":"Interstitial lung disease: a review of classification, etiology, epidemiology, clinical diagnosis, pharmacological and non-pharmacological treatment","volume":"11","author":"Althobiani","year":"2024","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b0125","article-title":"A review on Interstitial Lung Diseases: an overview from diagnosis to innovative therapies. Working Paper of","volume":"11","author":"Bertolina","year":"2023","journal-title":"Public Health"},{"key":"10.1016\/j.intimp.2024.113979_b0130","article-title":"Post COVID-19 pulmonary fibrosis; a meta-analysis study","volume":"77","author":"Amin","year":"2022","journal-title":"Ann. Med. Surg."},{"key":"10.1016\/j.intimp.2024.113979_b0135","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0140-6736(22)01052-2","article-title":"Interstitial lung diseases","volume":"400","author":"Wijsenbeek","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.intimp.2024.113979_b0140","article-title":"Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA): Evolving concept of CT findings, pathology and management","volume":"9","author":"Yoo","year":"2022","journal-title":"Eur J Radiol Open"},{"key":"10.1016\/j.intimp.2024.113979_b0145","article-title":"The Role of Radiology in Progressive Fibrosing Interstitial Lung Disease","volume":"8","author":"Abu Qubo","year":"2021","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b0150","article-title":"Biomarkers in Progressive Fibrosing Interstitial Lung Disease: Optimizing Diagnosis, Prognosis, and Treatment Response","volume":"8","author":"Bowman","year":"2021","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b0155","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s10787-023-01193-1","article-title":"Thalidomide interaction with inflammation in idiopathic pulmonary fibrosis","volume":"31","author":"Dsouza","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.intimp.2024.113979_b0160","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/pgmj.2006.046417","article-title":"Interstitial lung disease: progress and problems","volume":"82","author":"Bourke","year":"2006","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.intimp.2024.113979_b0165","first-page":"519","article-title":"Blood-based Biomarkers for Early Diagnosis of Lung Cancer: A Review Article","volume":"58","author":"Maharjan","year":"2020","journal-title":"JNMA J. Nepal Med. Assoc."},{"key":"10.1016\/j.intimp.2024.113979_b0170","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.21037\/jtd-20-651","article-title":"Bronchoalveolar lavage as a diagnostic procedure: a review of known cellular and molecular findings in various lung diseases","volume":"12","author":"Davidson","year":"2020","journal-title":"J. Thorac. Dis."},{"key":"10.1016\/j.intimp.2024.113979_b0175","article-title":"Bronchoalveolar Lavage Fluid-Isolated Biomarkers for the Diagnostic and Prognostic Assessment of Lung Cancer","volume":"12","author":"Kalkanis","year":"2022","journal-title":"Diagnostics (basel)"},{"key":"10.1016\/j.intimp.2024.113979_b0180","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.2147\/JIR.S352085","article-title":"KL-6 as a biomarker of interstitial lung disease development in patients with sj\u00f6gren syndrome: a retrospective case-control study","volume":"15","author":"Chiu","year":"2022","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0185","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s11926-012-0246-6","article-title":"Interstitial Lung Disease in Myositis: Clinical Subsets, Biomarkers, and Treatment","volume":"14","author":"Mimori","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/jcm11010079","article-title":"Review: Serum Biomarkers of Lung Fibrosis in Interstitial Pneumonia with Autoimmune Features\u2014What Do We Already Know?","volume":"11","author":"Mi\u0105dlikowska","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/pr10061131","article-title":"An Overview of Herbal Medicines for Idiopathic Pulmonary Fibrosis","volume":"10","author":"Murthy","year":"2022","journal-title":"Processes"},{"key":"10.1016\/j.intimp.2024.113979_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phyplu.2022.100252","article-title":"Research on the mechanism of berberine in the treatment of COVID-19 pneumonia pulmonary fibrosis using network pharmacology and molecular docking","volume":"2","author":"Cao","year":"2022","journal-title":"Phytomedicine plus: International Journal of Phytotherapy and Phytopharmacology"},{"key":"10.1016\/j.intimp.2024.113979_b0205","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1002\/ptr.7062","article-title":"Evodiamine alleviates lipopolysaccharide\u2010induced pulmonary inflammation and fibrosis by activating apelin pathway","volume":"35","author":"Ye","year":"2021","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1055\/s-2005-837821","article-title":"Inhibitory Effects of Isoliensinine on Bleomycin-Induced Pulmonary Fibrosis in Mice","volume":"71","author":"Xiao","year":"2005","journal-title":"Planta Med."},{"key":"10.1016\/j.intimp.2024.113979_b0215","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1080\/21691401.2020.1814315","article-title":"Protective effects of isorhynchophylline against silicon-dioxide-induced lung injury in mice","volume":"48","author":"Qiu","year":"2020","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.intimp.2024.113979_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.00982","article-title":"Magnoflorine ameliorates lipopolysaccharide-induced acute lung injury via suppressing NF-\u03baB and MAPK activation","volume":"9","author":"Guo","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0225","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.biopha.2018.08.111","article-title":"Effects of plant extracts and bioactive compounds on attenuation of bleomycin-induced pulmonary fibrosis","volume":"107","author":"Hosseini","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113979_b0230","article-title":"Oxymatrine attenuates bleomycin-induced pulmonary fibrosis in mice via the inhibition of inducible nitric oxide synthase expression and the TGF-\u03b2\/Smad signaling pathway","author":"Li","year":"2012","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16849","article-title":"Benzylisoquinoline alkaloids inhibit lung fibroblast activation mainly via inhibiting TGF-\u03b21\/Smads and ERK1\/2 pathway proteins","volume":"9","author":"Ren","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2024.113979_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110715","article-title":"Indirubin alleviates bleomycin-induced pulmonary fibrosis in mice by suppressing fibroblast to myofibroblast differentiation","volume":"131","author":"Wang","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113979_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113506","article-title":"Pharmacological effects of indole alkaloids from Alstonia scholaris (L.) R. Br. on pulmonary fibrosis in vivo","volume":"267","author":"Zhao","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0250","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.lfs.2016.03.056","article-title":"Tetrahydropalmatine attenuates irradiation induced lung injuries in rats","volume":"153","author":"Yu","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0255","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.intimp.2011.11.017","article-title":"Traditional medicine alpinetin inhibits the inflammatory response in Raw 264.7 cells and mouse models","volume":"12","author":"Huo","year":"2012","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0260","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3892\/etm.2015.2885","article-title":"Apigenin protects against bleomycin-induced lung fibrosis in rats","volume":"11","author":"Chen","year":"2016","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0265","doi-asserted-by":"crossref","first-page":"229","DOI":"10.5455\/medarh.2015.69.229-231","article-title":"The Antioxidative Effect of Chamomile, Anthocyanoside and their Combination on Bleomycin-induced Pulmonary Fibrosis in Rat","volume":"69","author":"Javadi","year":"2015","journal-title":"Med. Arch."},{"key":"10.1016\/j.intimp.2024.113979_b0270","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/0748233711413799","article-title":"Baicalein inhibits oxidative stress-induced cellular damage via antioxidant effects","volume":"28","author":"Kang","year":"2012","journal-title":"Toxicol. Ind. Health"},{"key":"10.1016\/j.intimp.2024.113979_b0275","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1080\/13880209.2022.2160767","article-title":"Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression","volume":"61","author":"Ji-hong","year":"2023","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.intimp.2024.113979_b0280","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.3390\/nu14091841","article-title":"Fisetin Suppresses the Inflammatory Response and Oxidative Stress in Bronchial Epithelial Cells","volume":"14","author":"Wu","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2024.113979_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154680","article-title":"Hesperidin inhibits lung fibroblast senescence via IL-6\/STAT3 signaling pathway to suppress pulmonary fibrosis","volume":"112","author":"Han","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.113979_b0290","doi-asserted-by":"crossref","first-page":"11653","DOI":"10.1021\/jf1031668","article-title":"Luteolin Ameliorates Experimental Lung Fibrosis Both in Vivo and in Vitro: Implications for Therapy of Lung Fibrosis","volume":"58","author":"Chen","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2024.113979_b0295","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1139\/bcb-2017-0302","article-title":"Quercetin ameliorates pulmonary fibrosis by inhibiting SphK1\/S1P signaling","volume":"96","author":"Zhang","year":"2018","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.intimp.2024.113979_b0300","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1089\/dna.2019.4941","article-title":"Kaempferol modulates autophagy and alleviates silica-induced pulmonary fibrosis","volume":"38","author":"Liu","year":"2019","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.intimp.2024.113979_b0305","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1021\/acsptsci.3c00033","article-title":"Treatment of Idiopathic Pulmonary Fibrosis by Inhaled Silybin Dry Powder Prepared via the Nanosuspension Spray Drying Technology","volume":"6","author":"Ma","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0310","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jgr.2019.12.003","article-title":"Ginsenosides: potential therapeutic source for fibrosis-associated human diseases","volume":"44","author":"Li","year":"2020","journal-title":"J. Ginseng Res."},{"key":"10.1016\/j.intimp.2024.113979_b0315","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/19768354.2023.2244549","article-title":"Ginsenoside Rg3 attenuates pulmonary fibrosis by inhibiting endothelial to mesenchymal transition","volume":"27","author":"Yun","year":"2023","journal-title":"Anim Cells Syst (seoul)"},{"key":"10.1016\/j.intimp.2024.113979_b0320","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1002\/fft2.388","article-title":"Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9\u2013CXCR3 axis","volume":"5","author":"Yao","year":"2024","journal-title":"Food Front."},{"key":"10.1016\/j.intimp.2024.113979_b0325","doi-asserted-by":"crossref","first-page":"8743","DOI":"10.3390\/ijerph19148743","article-title":"Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K\/Akt\/mTOR Pathway","volume":"19","author":"Niu","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.intimp.2024.113979_b0330","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1002\/ptr.7907","article-title":"Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4\u2010ankyrin repeat domain","volume":"37","author":"Niu","year":"2023","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0335","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.jep.2014.07.049","article-title":"Prevention of pulmonary fibrosis with salvianolic acid A by inducing fibroblast cell cycle arrest and promoting apoptosis","volume":"155","author":"Pan","year":"2014","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0340","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.3390\/pharmaceutics15092235","article-title":"Salvianolic Acid B: A Review of Pharmacological Effects, Safety, Combination Therapy, New Dosage Forms, and Novel Drug Delivery Routes","volume":"15","author":"He","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.intimp.2024.113979_b0345","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/ptr.8070","article-title":"Salvianolic acid B protects against pulmonary fibrosis by attenuating stimulating protein 1-mediated macrophage and alveolar type 2 cell senescence","volume":"38","author":"Li","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0350","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2017.00193","article-title":"Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Paeonol","volume":"8","author":"Liu","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.intimp.2024.113979_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2024.100404","article-title":"Curcumin as a promising treatment for pulmonary fibrosis: Mechanism and therapeutic potential","volume":"10","author":"You","year":"2024","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.12659\/MSM.905496","article-title":"Emodin Attenuates bleomycin-induced pulmonary fibrosis via anti-inflammatory and anti-oxidative activities in rats","volume":"24","author":"Tian","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.intimp.2024.113979_b0365","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1515\/chem-2022-0266","article-title":"Chinese medicinal plant Polygonum cuspidatum ameliorates silicosis via suppressing the Wnt\/\u03b2-catenin pathway","volume":"20","author":"Jia","year":"2022","journal-title":"Open Chem."},{"key":"10.1016\/j.intimp.2024.113979_b0370","doi-asserted-by":"crossref","first-page":"9789","DOI":"10.1021\/acs.jafc.9b02730","article-title":"Effects of \u03b2-Sitosterol from Corn Silk on TGF-\u03b21-Induced Epithelial\u2013Mesenchymal Transition in Lung Alveolar Epithelial Cells","volume":"67","author":"Park","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.intimp.2024.113979_b0375","doi-asserted-by":"crossref","first-page":"128","DOI":"10.14715\/cmb\/2024.70.2.18","article-title":"Astragaloside IV inhibits idiopathic pulmonary fibrosis through activation of autophagy by miR-21-mediated PTEN\/PI3K\/AKT\/mTOR pathway","volume":"70","author":"Li","year":"2024","journal-title":"Cell. Mol. Biol."},{"key":"10.1016\/j.intimp.2024.113979_b0380","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.3892\/mmr.2015.3333","article-title":"Tanshinone IIA attenuates bleomycin-induced pulmonary fibrosis in rats","volume":"11","author":"He","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0385","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/bph.13421","article-title":"Madecassoside ameliorates bleomycin\u2010induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR\u2010\u03b3 in colon","volume":"173","author":"Xia","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0390","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.intimp.2024.113979_b0395","series-title":"Innovative Approaches in Drug Discovery","first-page":"127","article-title":"Chapter 5 - Network Pharmacology","author":"Chandran","year":"2017"},{"key":"10.1016\/j.intimp.2024.113979_b0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175479","article-title":"Integrated omics profiling and network pharmacology uncovers the prognostic genes and multi-targeted therapeutic bioactives to combat lung cancer","volume":"940","author":"Muthuramalingam","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0405","doi-asserted-by":"crossref","DOI":"10.3389\/fbinf.2023.1125949","article-title":"Translating desktop success to the web in the cytoscape project","volume":"3","author":"Pratt","year":"2023","journal-title":"Frontiers in Bioinformatics"},{"key":"10.1016\/j.intimp.2024.113979_b0410","first-page":"221","author":"Catharina","year":"2018","journal-title":"System Biology to Access Target Relevance in the Research and Development of Molecular Inhibitors"},{"key":"10.1016\/j.intimp.2024.113979_b0415","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/2193-9616-1-17","article-title":"Drug-target and disease networks: polypharmacology in the post-genomic era","volume":"1","author":"Masoudi-Nejad","year":"2013","journal-title":"In Silico Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0420","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nbt1338","article-title":"Drug\u2014target network","volume":"25","author":"Y\u0131ld\u0131r\u0131m","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.intimp.2024.113979_b0425","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbi.2019.103206","article-title":"Disease networks and their contribution to disease understanding: A review of their evolution, techniques and data sources","volume":"94","author":"Garc\u00eda del Valle","year":"2019","journal-title":"J. Biomed. Inform."},{"key":"10.1016\/j.intimp.2024.113979_b0430","doi-asserted-by":"crossref","first-page":"7874","DOI":"10.1021\/jm5006463","article-title":"Polypharmacology: Challenges and Opportunities in Drug Discovery","volume":"57","author":"Anighoro","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.intimp.2024.113979_b0435","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2018.01134","article-title":"Network-Based Methods for Prediction of Drug-Target Interactions","volume":"9","author":"Wu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0440","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/B978-0-12-809414-3.00010-3","article-title":"Human Genomic Databases in Translational Medicine","author":"Katsila","year":"2018","journal-title":"Human Genome Informatics, Elsevier"},{"key":"10.1016\/j.intimp.2024.113979_b0445","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1093\/nar\/gkg105","article-title":"The Proteome Analysis database: a tool for the in silico analysis of whole proteomes","volume":"31","author":"Pruess","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.intimp.2024.113979_b0450","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11481-009-9157-3","article-title":"Database Resources in Metabolomics: An Overview","volume":"5","author":"Go","year":"2010","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0455","article-title":"Network Pharmacology Approach for Medicinal Plants","volume":"15","author":"Noor","year":"2022","journal-title":"Review and Assessment. Pharmaceuticals"},{"key":"10.1016\/j.intimp.2024.113979_b0460","first-page":"227","author":"Nithya","year":"2024","journal-title":"Hubs and Bottlenecks in Protein-Protein Interaction Networks"},{"key":"10.1016\/j.intimp.2024.113979_b0465","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.106055","article-title":"Polypharmacology: The science of multi-targeting molecules","volume":"176","author":"Kabir","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0470","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ipha.2024.01.010","article-title":"The importance of in-silico studies in drug discovery","volume":"2","author":"Roney","year":"2024","journal-title":"Intelligent Pharmacy"},{"key":"10.1016\/j.intimp.2024.113979_b0475","author":"Tang","year":"2014","journal-title":"Network Pharmacology Strategies toward Multi-Target Anticancer Therapies: from Computational Models to Experimental Design Principles"},{"key":"10.1016\/j.intimp.2024.113979_b0480","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-0-12-802104-0.00002-0","article-title":"Traditional Medicine","author":"Che","year":"2017","journal-title":"Pharmacognosy, Elsevier"},{"key":"10.1016\/j.intimp.2024.113979_b0485","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119802","article-title":"Synergistic anti-cancer action of salicylic acid and cisplatin on HeLa cells elucidated by network pharmacology and in vitro analysis","volume":"282","author":"Sidhu","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaim.2023.100814","article-title":"Ayurvedic practice, education and research, beyond dilemmas and confessions","volume":"14","author":"Pratibha","year":"2023","journal-title":"J Ayurveda Integr Med"},{"key":"10.1016\/j.intimp.2024.113979_b0495","article-title":"Ashwagandha (Withania somnifera)-Current Research on the Health-Promoting Activities","volume":"15","author":"Mikulska","year":"2023","journal-title":"A Narrative Review. Pharmaceutics"},{"key":"10.1016\/j.intimp.2024.113979_b0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.prmcm.2023.100222","article-title":"Curcuma longa (Turmeric): Ethnomedicinal uses, phytochemistry, pharmacological activities and toxicity profiles\u2014A review","volume":"6","author":"Iweala","year":"2023","journal-title":"Pharmacol. Res. Mod. Chin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0505","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9217567","article-title":"The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature","volume":"2017","author":"Jamshidi","year":"2017","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0510","article-title":"Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials","author":"Anh","year":"202012","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2024.113979_b0515","doi-asserted-by":"crossref","unstructured":"Matos LC, Machado JP, Monteiro FJ, Greten HJ. Understanding Traditional Chinese Medicine Therapeutics: An Overview of the Basics and Clinical Applications. Healthcare (Basel) 2021;9. Doi: 10.3390\/healthcare9030257.","DOI":"10.3390\/healthcare9030257"},{"key":"10.1016\/j.intimp.2024.113979_b0520","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1002\/ptr.8163","article-title":"Long COVID\u201019 gastrointestinal related disorders and traditional Chinese medicine: A network target\u2010based approach","volume":"38","author":"Mattioli","year":"2024","journal-title":"Phytother. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0525","doi-asserted-by":"crossref","unstructured":"Wahab S, Annadurai S, Abullais SS, Das G, Ahmad W, Ahmad MF, et al. Glycyrrhiza glabra (Licorice): A Comprehensive Review on Its Phytochemistry, Biological Activities, Clinical Evidence and Toxicology. Plants (Basel) 2021;10. Doi: 10.3390\/plants10122751.","DOI":"10.3390\/plants10122751"},{"key":"10.1016\/j.intimp.2024.113979_b0530","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1007\/s11434-016-1136-5","article-title":"Scutellaria baicalensis, the golden herb from the garden of Chinese medicinal plants","volume":"61","author":"Zhao","year":"2016","journal-title":"Sci Bull (beijing)"},{"key":"10.1016\/j.intimp.2024.113979_b0535","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8288818","article-title":"Ginkgo biloba: A Treasure of Functional Phytochemicals with Multimedicinal Applications","volume":"2022","author":"Noor-E-Tabassum","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0540","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2020\/8878569","article-title":"A Network Pharmacology to Explore the Mechanism of Astragalus Membranaceus in the Treatment of Diabetic Retinopathy","volume":"2020","author":"Jin","year":"2020","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.fitote.2024.106010","article-title":"Identification of bioactive ingredients and potential mechanisms of flowers of Hosta Plantaginea in treating pneumonia based on network pharmacology and experimental validation","volume":"176","author":"Li","year":"2024","journal-title":"Fitoterapia"},{"key":"10.1016\/j.intimp.2024.113979_b0550","doi-asserted-by":"crossref","DOI":"10.1016\/j.eujim.2021.101388","article-title":"Multitarget mechanism of Yiqi Jiedu Huayu decoction on diabetic cardiomyopathy based on network pharmacology","volume":"47","author":"Xuan","year":"2021","journal-title":"Eur J Integr Med"},{"key":"10.1016\/j.intimp.2024.113979_b0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175044","article-title":"Research on the effect and underlying molecular mechanism of Cangzhu in the treatment of gouty arthritis","volume":"927","author":"Li","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0560","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1080\/03639045.2020.1788070","article-title":"Network pharmacology and molecular docking analysis on molecular targets and mechanisms of Huashi Baidu formula in the treatment of COVID-19","volume":"46","author":"Tao","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.intimp.2024.113979_b0565","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/jep.12588","article-title":"Multimorbidity, P4 medicine and holism","volume":"23","author":"Marcum","year":"2017","journal-title":"J. Eval. Clin. Pract."},{"key":"10.1016\/j.intimp.2024.113979_b0570","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0110-2017","article-title":"From systems biology to P4 medicine: applications in respiratory medicine","volume":"27","author":"Noell","year":"2018","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b0575","article-title":"Prediction of a Competing Endogenous RNA Co-expression Network by Comprehensive Methods in Systemic Sclerosis-Related Interstitial Lung Disease","author":"Yan","year":"202112","journal-title":"Front. Genet."},{"key":"10.1016\/j.intimp.2024.113979_b0580","doi-asserted-by":"crossref","first-page":"888","DOI":"10.2174\/1573409920666230808120504","article-title":"Deciphering the Underlying Mechanisms of Sanleng-Ezhu for the Treatment of Idiopathic Pulmonary Fibrosis Based on Network Pharmacology and Single-cell RNA Sequencing Data","volume":"20","author":"Zhou","year":"2024","journal-title":"Curr. Comput. Aided Drug Des."},{"key":"10.1016\/j.intimp.2024.113979_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155912","article-title":"Analyzing how SiMiao Wan regulates ferroptosis to prevent RA-ILD using metabolomics and cyberpharmacology","volume":"133","author":"Chen","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.intimp.2024.113979_b0590","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.2174\/1568026616666160530181328","article-title":"Drug Repositioning Through Network Pharmacology","volume":"16","author":"Ye","year":"2016","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.intimp.2024.113979_b0595","article-title":"Network-based drug repurposing for the treatment of COVID-19 patients in different clinical stages","volume":"9","author":"Wang","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.intimp.2024.113979_b0600","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1755-8794-4-8","article-title":"Systems biology of interstitial lung diseases: integration of mRNA and microRNA expression changes","volume":"4","author":"Cho","year":"2011","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.intimp.2024.113979_b0605","doi-asserted-by":"crossref","unstructured":"Dinda B, Dinda M. Natural Products, a Potential Source of New Drugs Discovery to Combat Obesity and Diabetes: Their Efficacy and Multi-targets Actions in Treatment of These Diseases, 2022, p. 101\u2013275. Doi: 10.1007\/978-3-030-92196-5_4.","DOI":"10.1007\/978-3-030-92196-5_4"},{"key":"10.1016\/j.intimp.2024.113979_b0610","doi-asserted-by":"crossref","first-page":"184","DOI":"10.3390\/ddc3010011","article-title":"Plant-Derived Natural Products: A Source for Drug Discovery and Development","volume":"3","author":"Chaachouay","year":"2024","journal-title":"Drugs and Drug Candidates"},{"key":"10.1016\/j.intimp.2024.113979_b0615","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.3390\/molecules27134060","article-title":"From Traditional Ethnopharmacology to Modern Natural Drug Discovery: A Methodology Discussion and Specific Examples","volume":"27","author":"Pirintsos","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2024.113979_b0620","article-title":"The Traditional Medicine and Modern Medicine from Natural Products","author":"Yuan","year":"201621","journal-title":"Molecules"},{"key":"10.1016\/j.intimp.2024.113979_b0625","article-title":"Pulmonary Fibrosis as a Result of Acute Lung Inflammation: Molecular Mechanisms, Relevant In Vivo Models, Prognostic and Therapeutic Approaches","author":"Savin","year":"202223","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0630","doi-asserted-by":"crossref","unstructured":"Ortiz-zapater E, Signes\u2010costa J, Montero P, Roger I. Lung Fibrosis and Fibrosis in the Lungs: Is It All about Myofibroblasts? Biomedicines 2022;10. Doi: 10.3390\/biomedicines10061423.","DOI":"10.3390\/biomedicines10061423"},{"key":"10.1016\/j.intimp.2024.113979_b0635","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-3-8","article-title":"Idiopathic pulmonary fibrosis","volume":"3","author":"Meltzer","year":"2008","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.intimp.2024.113979_b0640","doi-asserted-by":"crossref","DOI":"10.1016\/j.disamonth.2022.101484","article-title":"Idiopathic pulmonary fibrosis: Diagnosis, biomarkers and newer treatment protocols","volume":"69","author":"Patel","year":"2023","journal-title":"Dis. Mon."},{"key":"10.1016\/j.intimp.2024.113979_b0645","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s12931-021-01791-z","article-title":"Global incidence and prevalence of idiopathic pulmonary fibrosis","volume":"22","author":"Maher","year":"2021","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0650","article-title":"Idiopathic Pulmonary Fibrosis: Epidemiology, Natural History, Phenotypes","author":"Sauleda","year":"20186","journal-title":"Med Sci (basel)"},{"key":"10.1016\/j.intimp.2024.113979_b0655","article-title":"Idiopathic pulmonary fibrosis and lung cancer: future directions and challenges","volume":"18","author":"Abu Qubo","year":"2022","journal-title":"Breathe (Sheff.)"},{"key":"10.1016\/j.intimp.2024.113979_b0660","doi-asserted-by":"crossref","first-page":"4318","DOI":"10.1038\/s41598-021-81591-z","article-title":"Occupational and environmental risk factors of idiopathic pulmonary fibrosis: a systematic review and meta-analyses","volume":"11","author":"Park","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0665","article-title":"Idiopathic Pulmonary Fibrosis: Epidemiology, Natural History, Phenotypes","author":"Sauleda Roig","year":"20186","journal-title":"Med Sci (basel)"},{"key":"10.1016\/j.intimp.2024.113979_b0670","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.120283","article-title":"Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis","volume":"291","author":"Velagacherla","year":"2022","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0675","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.tips.2019.12.008","article-title":"Targeting GPCR Signaling for Idiopathic Pulmonary Fibrosis Therapies","volume":"41","author":"Haak","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0680","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/14728222.2021.2006186","article-title":"Emerging therapeutic targets for idiopathic pulmonary fibrosis: preclinical progress and therapeutic implications","volume":"25","author":"Yanagihara","year":"2021","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.intimp.2024.113979_b0685","article-title":"Epithelial Injury and Dysfunction in the Pathogenesis of Idiopathic Pulmonary Fibrosis","author":"Winters","year":"2019357","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0690","doi-asserted-by":"crossref","first-page":"21486","DOI":"10.3390\/ijms160921486","article-title":"The Role of Mitochondrial DNA in Mediating Alveolar Epithelial Cell Apoptosis and Pulmonary Fibrosis","volume":"16","author":"Kim","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0695","doi-asserted-by":"crossref","unstructured":"Salton F, Volpe MC, Confalonieri M. Epithelial-mesenchymal transition in the pathogenesis of idiopathic pulmonary fibrosis. Medicina (Lithuania) 2019;55. Doi: 10.3390\/medicina55040083.","DOI":"10.3390\/medicina55040083"},{"key":"10.1016\/j.intimp.2024.113979_b0700","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12931-023-02403-8","article-title":"Biomarkers of cellular senescence in idiopathic pulmonary fibrosis","volume":"24","author":"Aversa","year":"2023","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0705","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.3892\/mmr.2016.5960","article-title":"PI3K\/Akt signaling is involved in the pathogenesis of bleomycin-induced pulmonary fibrosis via regulation of epithelial-mesenchymal transition","volume":"14","author":"Zhang","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0710","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12931-018-0834-8","article-title":"Epithelial mesenchymal transition (EMT): a universal process in lung diseases with implications for cystic fibrosis pathophysiology","volume":"19","author":"Rout-Pitt","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0715","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.apsb.2021.07.023","article-title":"Targeting PI3K\/AKT signaling for treatment of idiopathic pulmonary fibrosis","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.intimp.2024.113979_b0720","first-page":"1","article-title":"Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases","volume":"2018","author":"Wang","year":"2018","journal-title":"Biomed Res. Int."},{"issue":"3","key":"10.1016\/j.intimp.2024.113979_b0725","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1165\/rcmb.2011-0237OC","article-title":"MEK-ERK pathway modulation ameliorates pulmonary fibrosis associated with epidermal growth factor receptor activation","volume":"46","author":"Madala","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.intimp.2024.113979_b0730","doi-asserted-by":"crossref","unstructured":"Mao C, Du Y, Niu K, Yang F, Bai C, Zhou B, et al. Investigation of the Mechanism of Action of Qingzaojiufei Decoction on Idiopathic Pulmonary Fibrosis Based on Network Pharmacology and Experimental Validation. Nat Prod Commun 2024;19. Doi: 10.1177\/1934578X241242274.","DOI":"10.1177\/1934578X241242274"},{"key":"10.1016\/j.intimp.2024.113979_b0735","doi-asserted-by":"crossref","unstructured":"Song S, Wang J, Liu G, Ding L, Li Y, Qi H, et al. Protective Effects of the Wenfei Buqi Tongluo Formula on the Inflammation in Idiopathic Pulmonary Fibrosis through Inhibiting the TLR4\/MyD88\/NF- \u03ba B Pathway. Biomed Res Int 2022;2022. Doi: 10.1155\/2022\/8752325.","DOI":"10.1155\/2022\/8752325"},{"key":"10.1016\/j.intimp.2024.113979_b0740","article-title":"Research into the anti-pulmonary fibrosis mechanism of Renshen Pingfei formula based on network pharmacology, metabolomics, and verification of AMPK\/PPAR-\u03b3 pathway of active ingredients","author":"Yan","year":"2023317","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0745","doi-asserted-by":"crossref","unstructured":"Zhong Y, Hu L, Chen W, Wang B, Sun J, Dong J. Exploring the comorbidity mechanisms between asthma and idiopathic pulmonary fibrosis and the pharmacological mechanisms of Bu-Shen-Yi-Qi decoction therapy via network pharmacology. BMC Complement Med Ther 2022;22. Doi: 10.1186\/s12906-022-03637-7.","DOI":"10.1186\/s12906-022-03637-7"},{"key":"10.1016\/j.intimp.2024.113979_b0750","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1097\/CM9.0000000000001461","article-title":"Pneumoconiosis: current status and future prospects","volume":"134","author":"Qi","year":"2021","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.intimp.2024.113979_b0755","doi-asserted-by":"crossref","DOI":"10.1080\/20018525.2017.1264711","article-title":"A systematic review of occupational exposure to coal dust and the risk of interstitial lung diseases","volume":"4","author":"Beer","year":"2017","journal-title":"Eur Clin Respir J"},{"key":"10.1016\/j.intimp.2024.113979_b0760","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/9781119867371.ch5","article-title":"Silicosis and Asbestosis","author":"Mapa","year":"2023","journal-title":"Medical Geology, Wiley"},{"key":"10.1016\/j.intimp.2024.113979_b0765","doi-asserted-by":"crossref","DOI":"10.1016\/j.fuel.2024.131876","article-title":"A systematic review of the physiological and environmental impacts of coal dust and its control technologies","volume":"371","author":"Nyabire Akanyange","year":"2024","journal-title":"Fuel"},{"key":"10.1016\/j.intimp.2024.113979_b0770","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/j.jaci.2018.09.040","article-title":"Hypersensitivity pneumonitis: A fibrosing alveolitis produced by inhalation of diverse antigens","volume":"143","author":"Greenberger","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.intimp.2024.113979_b0775","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12931-020-1291-8","article-title":"Trends in prevalence and incidence of chronic respiratory diseases from 1990 to 2017","volume":"21","author":"Xie","year":"2020","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0780","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/s12890-022-02040-9","article-title":"Global and national burden and trends of mortality and disability-adjusted life years for silicosis, from 1990 to 2019: results from the Global Burden of Disease study 2019","volume":"22","author":"Chen","year":"2022","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0785","doi-asserted-by":"crossref","unstructured":"Han L, Yao W, Bian Z, Zhao Y, Zhang H, Ding B, et al. Characteristics and Trends of Pneumoconiosis in the Jiangsu Province, China, 2006\u22122017. Int J Environ Res Public Health 2019;16. Doi: 10.3390\/ijerph16030437.","DOI":"10.3390\/ijerph16030437"},{"key":"10.1016\/j.intimp.2024.113979_b0790","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4104\/pcrj.2013.00055","article-title":"Pneumoconiosis","volume":"22","author":"Cullinan","year":"2013","journal-title":"Prim. Care Respir. J."},{"key":"10.1016\/j.intimp.2024.113979_b0795","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1111\/all.14202","article-title":"Silica\u2010related diseases in the modern world","volume":"75","author":"Hoy","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.intimp.2024.113979_b0800","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00063198-200003000-00010","article-title":"Pathology and pathophysiology of pneumoconiosis","volume":"6","author":"Fujimura","year":"2000","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0805","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1164\/rccm.201505-1014OC","article-title":"Lung Pathology in U.S. Coal Workers with Rapidly Progressive Pneumoconiosis Implicates Silica and Silicates","volume":"193","author":"Cohen","year":"2016","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2024.113979_b0810","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0250-2021","article-title":"Understanding the pathogenesis of occupational coal and silica dust-associated lung disease","volume":"31","author":"Vanka","year":"2022","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b0815","first-page":"311","article-title":"The Role of Fibrocyte in the Pathogenesis of Silicosis","volume":"31","author":"Li","year":"2018","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0820","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/s12931-019-1223-7","article-title":"YY1 mediates TGF-\u03b21-induced EMT and pro-fibrogenesis in alveolar epithelial cells","volume":"20","author":"Zhang","year":"2019","journal-title":"Respir. Res."},{"key":"10.1016\/j.intimp.2024.113979_b0825","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1093\/hmg\/ddu551","article-title":"Indications for distinct pathogenic mechanisms of asbestos and silica through gene expression profiling of the response of lung epithelial cells","volume":"24","author":"Perkins","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.intimp.2024.113979_b0830","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1007\/s11033-011-1287-z","article-title":"The role of reactive oxygen species in silicon dioxide nanoparticle-induced cytotoxicity and DNA damage in HaCaT cells","volume":"39","author":"Gong","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0835","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190103","article-title":"Transforming growth factor\u2013\u03b2 in tissue fibrosis","volume":"217","author":"Frangogiannis","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0840","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1513\/AnnalsATS.202109-1064OC","article-title":"Pathology and Mineralogy Demonstrate Respirable Crystalline Silica Is a Major Cause of Severe Pneumoconiosis in U.S. Coal Miners","volume":"19","author":"Cohen","year":"2022","journal-title":"Ann. Am. Thorac. Soc."},{"key":"10.1016\/j.intimp.2024.113979_b0845","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.232157","article-title":"The cross-talk between TGF-\u03b2 and PDGFR\u03b1 signaling pathways regulates stromal fibro\/adipogenic progenitors\u2019 fate","author":"Contreras","year":"2019","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0850","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00646-2019","article-title":"A spatially restricted fibrotic niche in pulmonary fibrosis is sustained by M-CSF\/M-CSFR signalling in monocyte-derived alveolar macrophages","volume":"55","author":"Joshi","year":"2020","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.intimp.2024.113979_b0855","article-title":"Insulin-Like Growth Factor-1 Signaling in Lung Development and Inflammatory Lung Diseases","volume":"2018","author":"Wang","year":"2018","journal-title":"Biomed Res. Int."},{"key":"10.1016\/j.intimp.2024.113979_b0860","article-title":"The role of inflammation in silicosis","volume":"15","author":"Liu","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0865","first-page":"156","article-title":"Daily use of guaifenesin (Mucinex) in a patient with chronic bronchitis and pathologic mucus hypersecretion: A case report","volume":"23","author":"Storms","year":"2018","journal-title":"Respir. Med. Case. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b0870","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24097849","article-title":"Efficacy of Pirfenidone and Nintedanib in Interstitial Lung Diseases Other than Idiopathic Pulmonary Fibrosis: A Systematic Review","volume":"24","author":"Amati","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0875","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0080-2016","article-title":"Oxygen therapy for interstitial lung disease: a systematic review","volume":"26","author":"Bell","year":"2017","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b0880","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41392-022-00959-3","article-title":"Gefitinib and fostamatinib target EGFR and SYK to attenuate silicosis: a multi-omics study with drug exploration","volume":"7","author":"Wang","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.intimp.2024.113979_b0885","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111068","article-title":"Celastrol as a candidate drug for silicosis: From bioinformatics and network pharmacology to experimental validation","volume":"125","author":"Liang","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b0890","doi-asserted-by":"crossref","DOI":"10.1007\/s10753-023-01964-6","article-title":"Tetrandrine Alleviates Silica-induced Pulmonary Fibrosis Through PI3K\/AKT Pathway: Network Pharmacology Investigation and Experimental Validation","author":"Ma","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/j.intimp.2024.113979_b0895","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s13020-023-00787-9","article-title":"Yangqing Chenfei formula alleviates silica-induced pulmonary inflammation in rats by inhibiting macrophage M1 polarization","volume":"18","author":"Tian","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0900","series-title":"Connective Tissue Diseases: the Concept and Approach","first-page":"103","author":"Handa","year":"2021"},{"key":"10.1016\/j.intimp.2024.113979_b0905","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/v16030461","article-title":"Hereditary Connective Tissue Diseases and Risk of Post-Acute SARS-CoV-2","volume":"16","author":"Bartlett","year":"2024","journal-title":"Viruses"},{"key":"10.1016\/j.intimp.2024.113979_b0910","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12920-022-01321-w","article-title":"Clinical genetics evaluation and testing of connective tissue disorders: a cross-sectional study","volume":"15","author":"Veatch","year":"2022","journal-title":"BMC Med. Genomics"},{"key":"10.1016\/j.intimp.2024.113979_b0915","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/ajmg.a.61054","article-title":"Heritable disorders of connective tissue: Description of a data repository and initial cohort characterization","volume":"179","author":"Bascom","year":"2019","journal-title":"Am. J. Med. Genet. A"},{"key":"10.1016\/j.intimp.2024.113979_b0920","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.684699","article-title":"Interstitial Lung Disease in Connective Tissue Disease: A Common Lesion With Heterogeneous Mechanisms and Treatment Considerations","volume":"12","author":"Shao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113979_b0925","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0272327","article-title":"Pharmacological treatment for connective tissue disease-associated interstitial lung involvement: Protocol for an overview of systematic reviews and meta-analyses","volume":"17","author":"Karassa","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.intimp.2024.113979_b0930","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1295647","article-title":"Advances in understanding the pathogenesis of and designing therapies for connective tissue disease-associated interstitial lung disease","volume":"14","author":"Duan","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2024.113979_b0935","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.mayocp.2018.09.002","article-title":"Interstitial Lung Disease and Other Pulmonary Manifestations in Connective Tissue Diseases","volume":"94","author":"Mira-Avendano","year":"2019","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.intimp.2024.113979_b0940","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/acr2.11253","article-title":"Detection and Management of Interstitial Lung Diseases Associated With Connective Tissue Diseases","volume":"3","author":"Castelino","year":"2021","journal-title":"ACR Open Rheumatol"},{"key":"10.1016\/j.intimp.2024.113979_b0945","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1136\/annrheumdis-2020-217455","article-title":"Progressive interstitial lung disease in patients with systemic sclerosis-associated interstitial lung disease in the EUSTAR database","volume":"80","author":"Hoffmann-Vold","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2024.113979_b0950","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1164\/rccm.201903-0486OC","article-title":"Tracking Impact of Interstitial Lung Disease in Systemic Sclerosis in a Complete Nationwide Cohort","volume":"200","author":"Hoffmann-Vold","year":"2019","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2024.113979_b0955","volume":"7","author":"Amarnani","year":"2021","journal-title":"Lupus and the Lungs: the Assessment and Management of Pulmonary Manifestations of Systemic Lupus Erythematosus. Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b0960","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/rheumatology\/kes311","volume":"52","author":"Palm","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.intimp.2024.113979_b0965","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10214830","article-title":"Interstitial Lung Disease in Connective Tissue Diseases: Survival Patterns in a Population-Based Cohort","volume":"10","author":"Hyldgaard","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0970","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00408-016-9896-x","article-title":"Assessment of Mortality in Autoimmune Myositis With and Without Associated Interstitial Lung Disease","volume":"194","author":"Johnson","year":"2016","journal-title":"Lung"},{"key":"10.1016\/j.intimp.2024.113979_b0975","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X211037519","article-title":"Natural history and screening of interstitial lung disease in systemic autoimmune rheumatic disorders","volume":"13","author":"Panagopoulos","year":"2021","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.intimp.2024.113979_b0980","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1038\/nm.3642","article-title":"Lung regeneration: mechanisms, applications and emerging stem cell populations","volume":"20","author":"Kotton","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0985","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.3390\/ijms24032405","article-title":"Understanding Interstitial Lung Diseases Associated with Connective Tissue Disease (CTD-ILD): Genetics, Cellular Pathophysiology, and Biologic Drivers","volume":"24","author":"Cerro Chiang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113979_b0990","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1186\/s12967-022-03566-6","article-title":"Evidence of pyroptosis and ferroptosis extensively involved in autoimmune diseases at the single-cell transcriptome level","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.intimp.2024.113979_b0995","doi-asserted-by":"crossref","unstructured":"Shan Y, Zhao J, Wei K, Jiang P, Xu L, Chang C, et al. A comprehensive review of Tripterygium wilfordii hook. f. in the treatment of rheumatic and autoimmune diseases: Bioactive compounds, mechanisms of action, and future directions. Front Pharmacol 2023;14:1282610. Doi: 10.3389\/fphar.2023.1282610.","DOI":"10.3389\/fphar.2023.1282610"},{"key":"10.1016\/j.intimp.2024.113979_b1000","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1080\/07853890.2022.2034931","article-title":"The mechanism of triptolide in the treatment of connective tissue disease-related interstitial lung disease based on network pharmacology and molecular docking","volume":"54","author":"Zhu","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1005","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105725","article-title":"Mechanism of action of celastrol against rheumatoid arthritis: A network pharmacology analysis","volume":"74","author":"Song","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2024.113979_b1010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117063","article-title":"Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology","volume":"240","author":"Xinqiang","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.intimp.2024.113979_b1015","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1142\/S0192415X20500275","article-title":"The Role of Th17\/Treg Axis in the Traditional Chinese Medicine Intervention on Immune-Mediated Inflammatory Diseases: A Systematic Review","volume":"48","author":"Xu","year":"2020","journal-title":"Am J Chin Med (gard City N y)"},{"key":"10.1016\/j.intimp.2024.113979_b1020","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13020-023-00853-2","article-title":"Network pharmacology: a bright guiding light on the way to explore the personalized precise medication of traditional Chinese medicine","volume":"18","author":"Li","year":"2023","journal-title":"Chin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1025","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.mayocpiqo.2019.04.006","article-title":"Clinical Manifestations, Diagnosis, and Treatment of Sarcoidosis","volume":"3","author":"Ungprasert","year":"2019","journal-title":"Mayo Clin Proc Innov Qual Outcomes"},{"key":"10.1016\/j.intimp.2024.113979_b1030","article-title":"Pulmonary sarcoidosis: A comprehensive review: Past to present","author":"Belperio","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.intimp.2024.113979_b1035","article-title":"Pulmonary sarcoidosis with and without extrapulmonary involvement: a cross-sectional and observational study in China","volume":"8","author":"Li","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.intimp.2024.113979_b1040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0034-1376861","article-title":"Cellular Activation in the Immune Response of Sarcoidosis","volume":"35","author":"Zissel","year":"2014","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.intimp.2024.113979_b1045","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1084\/jem.20050648","article-title":"The immune paradox of sarcoidosis and regulatory T cells","volume":"203","author":"Miyara","year":"2006","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1050","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/jomfp.jomfp_373_21","article-title":"Sarcoidosis - A review article","volume":"26","author":"Sreeja","year":"2022","journal-title":"J Oral Maxillofac Pathol"},{"key":"10.1016\/j.intimp.2024.113979_b1055","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1183\/13993003.00477-2016","article-title":"Sarcoidosis incidence and prevalence: a nationwide register-based assessment in Sweden","volume":"48","author":"Arkema","year":"2016","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.intimp.2024.113979_b1060","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3390\/jcm9041081","article-title":"Sarcoidosis: Causes, Diagnosis, Clinical Features, and Treatments","volume":"9","author":"Jain","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1065","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1080\/07853890.2022.2063375","article-title":"Comorbidities of sarcoidosis","volume":"54","author":"Tana","year":"2022","journal-title":"Ann. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1070","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040766","article-title":"Sarcoidosis: A Clinical Overview from Symptoms to Diagnosis","volume":"10","author":"S\u00e8ve","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.intimp.2024.113979_b1075","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/MCP.0000000000000709","article-title":"Looking into the future of sarcoidosis: what is next for treatment?","volume":"26","author":"Miedema","year":"2020","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1080","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.revmed.2016.01.010","article-title":"Lung sarcoidosis: Clinical features and therapeutic issues","volume":"37","author":"Uzunhan","year":"2016","journal-title":"Rev. Med. Interne"},{"key":"10.1016\/j.intimp.2024.113979_b1085","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S2213-2600(15)00199-X","article-title":"New treatment strategies for pulmonary sarcoidosis: Antimetabolites, biological drugs, and other treatment approaches","volume":"3","author":"Baughman","year":"2015","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.intimp.2024.113979_b1090","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/14712598.2018.1427727","article-title":"Potential immunotherapies for sarcoidosis","volume":"18","author":"Le","year":"2018","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/j.intimp.2024.113979_b1095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103179","article-title":"Developmental drugs for sarcoidosis","author":"Obi","year":"2024","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.intimp.2024.113979_b1100","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.rmr.2020.02.006","article-title":"Is hypoxia a factor in the progression of pulmonary sarcoidosis?; [L\u2019hypoxie est-elle un facteur impactant l\u2019\u00e9volution de la sarco\u00efdose pulmonaire\u00a0?].","volume":"37","author":"Jeny","year":"2020","journal-title":"Rev. Mal. Respir."},{"key":"10.1016\/j.intimp.2024.113979_b1105","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-69281-8","article-title":"Novel protein pathways in development and progression of pulmonary sarcoidosis","volume":"10","author":"Bhargava","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.113979_b1110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4103\/0973-7847.134229","article-title":"Polyherbal formulation: Concept of ayurveda","volume":"8","author":"Parasuraman","year":"2014","journal-title":"Pharmacogn. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b1115","first-page":"85","article-title":"Role of Indian Herbal Medicine in the Treatment of Pulmonary Diseases. Medicinal Plants for Lung Diseases","author":"Ovia","year":"2021","journal-title":"Singapore: Springer Singapore"},{"key":"10.1016\/j.intimp.2024.113979_b1120","doi-asserted-by":"crossref","first-page":"25","DOI":"10.5114\/ceji.2016.58311","article-title":"A natural herbal remedy modulates angiogenic activity of bronchoalveolar lavage cells from sarcoidosis patients","volume":"41","author":"Radomska-Le\u015bniewska","year":"2016","journal-title":"Cent Eur J Immunol"},{"key":"10.1016\/j.intimp.2024.113979_b1125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104910","article-title":"Tetrastigma hemsleyanum alleviates sarcoidosis through metabolomic regulation and Th17\/Treg immune homeostasis","volume":"88","author":"Ji","year":"2022","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.intimp.2024.113979_b1130","article-title":"Novel diagnostic techniques in interstitial lung disease","volume":"10","author":"Glenn","year":"2023","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b1135","article-title":"Recent Advances in the Treatment of Interstitial Lung Diseases","volume":"15","author":"Bang","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/j.intimp.2024.113979_b1140","article-title":"Recent advances in the treatment of systemic sclerosis associated interstitial lung disease","volume":"10","author":"Kamenova","year":"2023","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b1145","article-title":"Present and future perspectives in early diagnosis and monitoring for progressive fibrosing interstitial lung diseases","volume":"10","author":"Stanel","year":"2023","journal-title":"Front Med (lausanne)"},{"key":"10.1016\/j.intimp.2024.113979_b1150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18332\/pne\/161867","article-title":"What is new in the treatment of interstitial lung diseases","volume":"36","author":"Sotiropoulou","year":"2023","journal-title":"Pneumon"},{"key":"10.1016\/j.intimp.2024.113979_b1155","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0021-2017","article-title":"Systems medicine advances in interstitial lung disease","volume":"26","author":"Greiffo","year":"2017","journal-title":"Eur. Respir. Rev."},{"key":"10.1016\/j.intimp.2024.113979_b1160","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1205948","article-title":"Progress in understanding and treating idiopathic pulmonary fibrosis: recent insights and emerging therapies","volume":"14","author":"Guo","year":"2023","journal-title":"Front. Pharmacol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924025013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924025013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:58:59Z","timestamp":1778619539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924025013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":232,"alternative-id":["S1567576924025013"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113979","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network Pharmacology-driven therapeutic interventions for Interstitial Lung Diseases using Traditional medicines: A Narrative Review","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"113979"}}