{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:13:25Z","timestamp":1791951205688,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.intimp.2024.113997","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T07:58:52Z","timestamp":1736323132000},"page":"113997","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["ACNO hydrogel enhances diabetic wound healing by modulating the Bcl-2\/Bax\/Caspase-3\/PARP pathway"],"prefix":"10.1016","volume":"147","author":[{"given":"Penghui","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingqian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rifang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jitao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqiang","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2024.113997_b0005","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/jama.2023.10578","article-title":"Diabetic Foot Ulcers","volume":"330","author":"Armstrong","year":"2023","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.intimp.2024.113997_b0010","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jds.2023.04.008","article-title":"Mitochondrial reactive oxygen species promote mitochondrial damage in high glucose-induced dysfunction and apoptosis of human dental pulp cells","volume":"19","author":"Tao","year":"2024","journal-title":"J. Dent Sci."},{"key":"10.1016\/j.intimp.2024.113997_b0015","article-title":"Microenvironment\u2010Based Diabetic Foot Ulcer Nanomedicine","volume":"10","author":"Huang","year":"2023","journal-title":"Adv. Sci."},{"key":"10.1016\/j.intimp.2024.113997_b0020","article-title":"Autophagy and skin wound healing, Burns","volume":"10","author":"Ren","year":"2022","journal-title":"Trauma"},{"key":"10.1016\/j.intimp.2024.113997_b0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.trsl.2021.05.006","article-title":"Macrophage polarization and diabetic wound healing","volume":"236","author":"Louiselle","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.intimp.2024.113997_b0030","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1111\/bph.15139","article-title":"Exploring microRNAs in diabetic chronic cutaneous ulcers: Regulatory mechanisms and therapeutic potential","volume":"177","author":"Nie","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.intimp.2024.113997_b0035","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202104229","article-title":"All\u2010in\u2010One: Multifunctional Hydrogel Accelerates Oxidative Diabetic Wound Healing through Timed\u2010Release of Exosome and Fibroblast Growth Factor","volume":"18","author":"Xiong","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.intimp.2024.113997_b0040","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/s41598-021-81886-1","article-title":"Efficacy of hyperbaric oxygen therapy for diabetic foot ulcer, a systematic review and meta-analysis of controlled clinical trials","volume":"11","author":"Sharma","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2024.113997_b0045","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.jacc.2020.06.052","article-title":"Long-Term Survival After Surgical or Percutaneous Revascularization in Patients With Diabetes and MultivesselCoronary Disease","volume":"76","author":"Tam","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.intimp.2024.113997_b0050","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/brain\/awab079","article-title":"Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management","volume":"144","author":"Jensen","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.intimp.2024.113997_b0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.trsl.2021.05.001","article-title":"Diabetic wound healing in soft and hard oral tissues","volume":"236","author":"Ko","year":"2021","journal-title":"Transl. Res."},{"key":"10.1016\/j.intimp.2024.113997_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113203","article-title":"Pien Tze Huang accelerated wound healing by inhibition of abnormal fibroblast apoptosis in Streptozotocin induced diabetic mice","volume":"261","author":"Yan","year":"2020","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113997_b0065","doi-asserted-by":"crossref","DOI":"10.1088\/1478-3975\/13\/3\/031001","article-title":"Apoptosis: its origin, history, maintenance and the medical implications for cancer and aging","volume":"13","author":"Kaczanowski","year":"2016","journal-title":"Phys. Biol."},{"key":"10.1016\/j.intimp.2024.113997_b0070","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1080\/15548627.2020.1816342","article-title":"Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing","volume":"17","author":"Qiang","year":"2021","journal-title":"Autophagy"},{"key":"10.1016\/j.intimp.2024.113997_b0075","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.metabol.2009.05.025","article-title":"Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats","volume":"58","author":"Boor","year":"2009","journal-title":"Metabolism"},{"key":"10.1016\/j.intimp.2024.113997_b0080","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5462633","article-title":"Pharmacological Effects of Centella asiatica on Skin Diseases: Evidence and Possible Mechanisms","volume":"2021","author":"Park","year":"2021","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.113997_b0085","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3390\/nu12020411","article-title":"Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB\/c Mice","volume":"12","author":"Lee","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.intimp.2024.113997_b0090","doi-asserted-by":"crossref","first-page":"5227","DOI":"10.1039\/D1BM00904D","article-title":"Asiaticoside-laden silk nanofiber hydrogels to regulate inflammation and angiogenesis for scarless skin regeneration","volume":"9","author":"Liu","year":"2021","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.intimp.2024.113997_b0095","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.2174\/1566524023666221024120825","article-title":"Asiaticoside Prevents Oxidative Stress and Apoptosis in Endothelial Cells by Activating ROS-dependent p53\/Bcl-2\/Caspase-3 Signaling Pathway","volume":"23","author":"Liang","year":"2023","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.intimp.2024.113997_b0100","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.2741\/4792","article-title":"Qi-dan-di-huang decoction alleviates diabetic nephropathy by inhibiting the NF-kappaB pathway","volume":"24","author":"Luo","year":"2019","journal-title":"Front Biosci"},{"key":"10.1016\/j.intimp.2024.113997_b0105","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1177\/15347346211029078","article-title":"Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits","volume":"22","author":"Fatima","year":"2023","journal-title":"Int. J. Low. Extrem. Wounds"},{"key":"10.1016\/j.intimp.2024.113997_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112707","article-title":"Nitric oxide-releasing biomaterials for promoting wound healing in impaired diabetic wounds: State of the art and recent trends","volume":"149","author":"Ahmed","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.intimp.2024.113997_bib188","doi-asserted-by":"crossref","first-page":"106109","DOI":"10.1016\/j.intimp.2019.106109","article-title":"Asiaticoside nitric oxide gel accelerates diabetic cutaneous ulcers healing by activating Wnt\/\u03b2-catenin signaling pathway","volume":"79","author":"Nie","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.intimp.2024.113997_b0115","article-title":"Preparation and Safety Evaluation of Centella asiatica Total Glycosides Nitric Oxide Gel and Its Therapeutic Effect on Diabetic Cutaneous Ulcers","volume":"2022","author":"Liu","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.intimp.2024.113997_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117266","article-title":"Asiaticoside-nitric oxide promoting diabetic wound healing through the miRNA-21-5p\/TGF-\u03b21\/SMAD7\/TIMP3 signaling pathway","volume":"319","author":"Liu","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.intimp.2024.113997_b0125","doi-asserted-by":"crossref","first-page":"1049251","DOI":"10.3389\/fendo.2022.1049251","article-title":"Differentially expressed tRNA-derived fragments and their roles in primary cardiomyocytes stimulated by high glucose","volume":"13","author":"Zhao","year":"2023","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.intimp.2024.113997_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.sjbs.2022.103330","article-title":"Polyherbal formulation exerts wound healing, anti-inflammatory, angiogenic and antimicrobial properties: Potential role in the treatment of diabetic foot ulcers","volume":"29","author":"Chumpolphant","year":"2022","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.intimp.2024.113997_b0135","first-page":"2583","article-title":"Puerarin prevents high glucose-induced apoptosis of Schwann cells by inhibiting oxidative stress","volume":"7","author":"Wu","year":"2012","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.intimp.2024.113997_b0140","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00018-014-1757-2","article-title":"Cell death controlling complexes and their potential therapeutic role","volume":"72","author":"Zamaraev","year":"2015","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.intimp.2024.113997_b0145","doi-asserted-by":"crossref","DOI":"10.1177\/14791641221094322","article-title":"Plasma proteomics reveals an improved cardio-metabolic profile in patients with type 2 diabetes post-liraglutide treatment","volume":"19","author":"Ekhzaimy","year":"2022","journal-title":"Diab. Vasc. Dis. Res."},{"key":"10.1016\/j.intimp.2024.113997_b0150","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1056\/NEJMra1615439","article-title":"Diabetic Foot Ulcers and Their Recurrence","volume":"376","author":"Armstrong","year":"2017","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.intimp.2024.113997_b0155","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound Healing: A Cellular Perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.intimp.2024.113997_b0160","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4049\/jimmunol.1700223","article-title":"Macrophage-Mediated Inflammation in Normal and Diabetic Wound Healing","volume":"199","author":"Boniakowski","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2024.113997_b0165","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023267","article-title":"Wound Healing and Skin Regeneration","volume":"5","author":"Takeo","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.intimp.2024.113997_b0170","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.3390\/ijms17122085","article-title":"Inflammation in Chronic Wounds","volume":"17","author":"Zhao","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.intimp.2024.113997_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2022.101085","article-title":"Caspase mechanisms in the regulation of inflammation","volume":"88","author":"Bibo-Verdugo","year":"2022","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.intimp.2024.113997_b0180","first-page":"171","article-title":"The role of myofibroblasts in wound healing","volume":"64","author":"Hinz","year":"2016","journal-title":"Curr. Res. Transl. Med."},{"key":"10.1016\/j.intimp.2024.113997_b0185","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.actbio.2022.04.041","article-title":"Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing","volume":"146","author":"Chen","year":"2022","journal-title":"Acta Biomater."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924025190?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576924025190?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T19:55:59Z","timestamp":1740599759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576924025190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":38,"alternative-id":["S1567576924025190"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113997","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ACNO hydrogel enhances diabetic wound healing by modulating the Bcl-2\/Bax\/Caspase-3\/PARP pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2024.113997","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"113997"}}