{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:38:36Z","timestamp":1788565116114,"version":"build-2803163510"},"reference-count":79,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015624","name":"University of Jeddah","doi-asserted-by":"publisher","award":["UJ-23-DR-222"],"award-info":[{"award-number":["UJ-23-DR-222"]}],"id":[{"id":"10.13039\/501100015624","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.intimp.2025.114092","type":"journal-article","created":{"date-parts":[[2025,1,18]],"date-time":"2025-01-18T07:43:49Z","timestamp":1737186229000},"page":"114092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2\/HO-1 and FXR, and Suppressing ERK\/VCAM-1 and NF-\u03baB Pathways"],"prefix":"10.1016","volume":"148","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-9063","authenticated-orcid":false,"given":"Hanan S.","family":"Althagafy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad H.M.","family":"Hassanein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114092_b0005","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003088-198916040-00002","article-title":"Clinical pharmacology of 5-fluorouracil","volume":"16","author":"Diasio","year":"1989","journal-title":"Clin. Pharmacokinet."},{"issue":"5","key":"10.1016\/j.intimp.2025.114092_b0010","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s13277-011-0189-y","article-title":"White light-mediated Cu (II)\u20135FU interaction augments the chemotherapeutic potential of 5-FU: an in vitro study","volume":"32","author":"Chibber","year":"2011","journal-title":"Tumor Biol."},{"issue":"5","key":"10.1016\/j.intimp.2025.114092_b0015","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Cancer"},{"issue":"2","key":"10.1016\/j.intimp.2025.114092_b0020","first-page":"e1266","article-title":"Adverse effects of 5-fluorouracil: focus on rare side effects","volume":"3","author":"Thomas","year":"2016","journal-title":"Cancer Cell Microenviron"},{"issue":"7 Suppl 3","key":"10.1016\/j.intimp.2025.114092_b0025","first-page":"33","article-title":"Toxicity of 5-fluorouracil","volume":"13","author":"Macdonald","year":"1999","journal-title":"Oncology (Williston Park)"},{"issue":"2","key":"10.1016\/j.intimp.2025.114092_b0030","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/bbrc.1997.6943","article-title":"An Nrf2\/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements","volume":"236","author":"Itoh","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.intimp.2025.114092_b0035","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1152\/physrev.00023.2017","article-title":"The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis","volume":"98","author":"Yamamoto","year":"2018","journal-title":"Physiol. Rev."},{"issue":"6","key":"10.1016\/j.intimp.2025.114092_b0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1159\/000475890","article-title":"Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression","volume":"45","author":"Nezu","year":"2017","journal-title":"Am. J. Nephrol."},{"issue":"9","key":"10.1016\/j.intimp.2025.114092_b0045","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1080\/0886022X.2016.1216722","article-title":"18\u03b2-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2\/ARE\/HO-1 pathway and endogenous antioxidants","volume":"38","author":"Abd El-Twab","year":"2016","journal-title":"Ren. Fail."},{"key":"10.1016\/j.intimp.2025.114092_b0050","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.biopha.2016.12.047","article-title":"Possible involvement of Nrf2 and PPAR\u03b3 up-regulation in the protective effect of umbelliferone against cyclophosphamide-induced hepatotoxicity","volume":"86","author":"Mahmoud","year":"2017","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.intimp.2025.114092_b0055","doi-asserted-by":"crossref","unstructured":"A.M. Mahmoud, F.L. Wilkinson, A.M. Jones, J.A. Wilkinson, M. Romero, J. Duarte, M.Y. Alexander, A novel role for small molecule glycomimetics in the protection against lipid-induced endothelial dysfunction: Involvement of Akt\/eNOS and Nrf2\/ARE signaling, Biochimica et biophysica acta. General subjects 1861(1 Pt A) (2017) 3311-3322.","DOI":"10.1016\/j.bbagen.2016.08.013"},{"key":"10.1016\/j.intimp.2025.114092_b0060","doi-asserted-by":"crossref","unstructured":"S. Satta, A.M. Mahmoud, F.L. Wilkinson, M. Yvonne Alexander, S.J. White, The Role of Nrf2 in Cardiovascular Function and Disease, Oxidative medicine and cellular longevity 2017 (2017) 9237263.","DOI":"10.1155\/2017\/9237263"},{"key":"10.1016\/j.intimp.2025.114092_b0065","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3214196","article-title":"New Insights into the Nrf-2\/HO-1 Signaling Axis and Its Application in Pediatric Respiratory Diseases","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.intimp.2025.114092_b0070","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neuro.2019.05.010","article-title":"Protective mechanism of Taxifolin for chlorpyrifos neurotoxicity in BV2 cells","volume":"74","author":"Zhang","year":"2019","journal-title":"Neurotoxicology"},{"issue":"2","key":"10.1016\/j.intimp.2025.114092_b0075","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s12276-023-00932-2","article-title":"The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases","volume":"55","author":"Kim","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0080","doi-asserted-by":"crossref","first-page":"9815","DOI":"10.1038\/s41598-017-10168-6","article-title":"Farnesoid X receptor activation protects the kidney from ischemia-reperfusion damage","volume":"7","author":"Gai","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.intimp.2025.114092_b0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1385\/MB:31:2:151","article-title":"The ERK cascade: a prototype of MAPK signaling","volume":"31","author":"Rubinfeld","year":"2005","journal-title":"Mol. Biotechnol."},{"issue":"22","key":"10.1016\/j.intimp.2025.114092_b0090","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1038\/sj.onc.1210394","article-title":"Integrating signals from RTKs to ERK\/MAPK","volume":"26","author":"McKay","year":"2007","journal-title":"Oncogene"},{"issue":"11","key":"10.1016\/j.intimp.2025.114092_b0095","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nrm1743","article-title":"Coordinating ERK\/MAPK signalling through scaffolds and inhibitors","volume":"6","author":"Kolch","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114092_b0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041057","article-title":"Emerging Roles of Vascular Cell Adhesion Molecule-1 (VCAM-1) in Immunological Disorders and Cancer","volume":"19","author":"Kong","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.intimp.2025.114092_b0105","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1096\/fj.201701536R","article-title":"Endothelial microRNAs regulating the NF-\u03baB pathway and cell adhesion molecules during inflammation","volume":"32","author":"Zhong","year":"2018","journal-title":"Faseb j"},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s13659-020-00293-7","article-title":"Natural products in cancer therapy: Past, present and future","volume":"11","author":"Huang","year":"2021","journal-title":"Nat. Prod. Bioprospect."},{"issue":"5","key":"10.1016\/j.intimp.2025.114092_b0115","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.etp.2017.01.012","article-title":"The potential protective role of taurine against 5-fluorouracil-induced nephrotoxicity in adult male rats","volume":"69","author":"Yousef","year":"2017","journal-title":"Exp. Toxicol. Pathol."},{"issue":"4","key":"10.1016\/j.intimp.2025.114092_b0120","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1159\/000489210","article-title":"Camel Milk Ameliorates 5-Fluorouracil-Induced Renal Injury in Rats: Targeting MAPKs, NF-\u03baB and PI3K\/Akt\/eNOS Pathways","volume":"46","author":"Arab","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.intimp.2025.114092_b0125","first-page":"243","volume":"480","author":"Surh","year":"2001","journal-title":"Molecular Mechanisms Underlying Chemopreventive Activities of Anti-Inflammatory Phytochemicals: down-Regulation of COX-2 and iNOS through Suppression of NF-\u039ab Activation, Mutation Research."},{"key":"10.1016\/j.intimp.2025.114092_b0130","first-page":"673","volume":"52","author":"Middleton","year":"2000","journal-title":"The Effects of Plant Flavonoids on Mammalian Cells: Implications for Inflammation, Heart Disease, and Cancer"},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0135","first-page":"98","volume":"16","author":"Bosetti","year":"2007","journal-title":"Prevention, Flavonoids and the Risk of Renal Cell Carcinoma"},{"key":"10.1016\/j.intimp.2025.114092_b0140","first-page":"774","volume":"23","author":"Caselli","year":"2016","journal-title":"Morin: a Promising Natural Drug"},{"issue":"6","key":"10.1016\/j.intimp.2025.114092_b0145","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.lfs.2003.07.017","article-title":"Morin sulfates\/glucuronides exert anti-inflammatory activity on activated macrophages and decreased the incidence of septic shock","volume":"74","author":"Fang","year":"2003","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.intimp.2025.114092_b0150","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1007\/s10753-020-01208-x","article-title":"Morin Protects LPS-Induced Mastitis via Inhibiting NLRP3 Inflammasome and NF-\u03baB Signaling Pathways","volume":"43","author":"Yu","year":"2020","journal-title":"Inflammation"},{"issue":"6","key":"10.1016\/j.intimp.2025.114092_b0155","first-page":"2670","volume":"46","author":"Hyun","year":"2015","journal-title":"The Flavonoid Morin from Moraceae Induces Apoptosis by Modulation of Bcl-2 Family Members and Fas Receptor in HCT 116 Cells"},{"issue":"3","key":"10.1016\/j.intimp.2025.114092_b0160","first-page":"672","volume":"39","author":"Lee","year":"2017","journal-title":"Antioxidant and Cytoprotective Effects of Morin against Hydrogen Peroxide-Induced Oxidative Stress Are Associated with the Induction of Nrf-2\u2011mediated HO-1 Expression in V79-4 Chinese Hamster Lung Fibroblasts"},{"issue":"3","key":"10.1016\/j.intimp.2025.114092_b0165","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.cbi.2009.02.004","article-title":"Morin regulates the expression of NF-\u03baB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma","volume":"180","author":"Sivaramakrishnan","year":"2009","journal-title":"Chem. Biol. Interact."},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cbi.2007.09.003","article-title":"Niranjali Devaraj, Attenuation of N-nitrosodiethylamine-induced hepatocellular carcinogenesis by a novel flavonol\u2014Morin","volume":"171","author":"Sivaramakrishnan","year":"2008","journal-title":"Chem. Biol. Interact."},{"issue":"6","key":"10.1016\/j.intimp.2025.114092_b0175","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/10520295.2021.2021449","article-title":"Morin mitigates ifosfamide induced nephrotoxicity by regulation of NF-kappaB\/p53 and Bcl-2 expression","volume":"97","author":"\u00c7omakl\u0131","year":"2022","journal-title":"Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission"},{"issue":"2","key":"10.1016\/j.intimp.2025.114092_b0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12291-023-01145-0","article-title":"Therapeutic Potential of Morin Hydrate Against Rifampicin Induced Hepato and Renotoxicity in Albino Wistar Rats: Modulation of Organ Function","volume":"39","author":"Rana","year":"2024","journal-title":"Oxidative Stress and Inflammatory Response, Indian Journal of Clinical Biochemistry : IJCB"},{"key":"10.1016\/j.intimp.2025.114092_b0185","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cbi.2019.05.017","article-title":"Protective effect of morin on doxorubicin-induced hepatorenal toxicity in rats","volume":"308","author":"Kuzu","year":"2019","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.intimp.2025.114092_b0190","doi-asserted-by":"crossref","DOI":"10.1007\/s11356-022-23314-z","article-title":"Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-\u03baB and caspase-3 activities","author":"Lokman","year":"2022","journal-title":"Environ Sci Pollut Res Int"},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0195","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0200","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0003-2697(78)90342-1","article-title":"Determination of malonaldehyde precursor in tissues by thiobarbituric acid test","volume":"86","author":"Mihara","year":"1978","journal-title":"Anal. Biochem."},{"issue":"1\u20132","key":"10.1016\/j.intimp.2025.114092_b0205","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0027-5107(85)90216-7","article-title":"Superoxide dismutase isoenzymes in tissues and plasma from New Zealand black mice, nude mice and normal BALB\/c mice","volume":"148","author":"Marklund","year":"1985","journal-title":"Mutat. Res."},{"key":"10.1016\/j.intimp.2025.114092_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.tice.2024.102576","article-title":"Attenuation of inflammation, oxidative stress and TGF-\u03b21\/Smad3 signaling and upregulation of Nrf2\/HO-1 signaling mediate the protective effect of diallyl disulfide against cadmium nephrotoxicity","volume":"91","author":"Alruhaimi","year":"2024","journal-title":"Tissue Cell"},{"issue":"6","key":"10.1016\/j.intimp.2025.114092_b0215","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1007\/s00210-023-02851-5","article-title":"Nifuroxazide attenuates indomethacin-induced renal injury by upregulating Nrf2\/HO-1 and cytoglobin and suppressing NADPH-oxidase, NF-\u03baB, and JAK-1\/STAT3 signals","volume":"397","author":"Hassanein","year":"2024","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"11","key":"10.1016\/j.intimp.2025.114092_b0220","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1021\/acs.jmedchem.8b00421","article-title":"Fragment-based discovery of a potent, orally bioavailable inhibitor that modulates the phosphorylation and catalytic activity of ERK1\/2","volume":"61","author":"Heightman","year":"2018","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.intimp.2025.114092_b0225","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1073\/pnas.92.12.5714","article-title":"The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 CD loop can inhibit VCAM-1-alpha 4 integrin interaction","volume":"92","author":"Wang","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1758-2946-3-33","article-title":"Open Babel: An open chemical toolbox","volume":"3","author":"O'Boyle","year":"2011","journal-title":"J. Cheminf."},{"issue":"16","key":"10.1016\/j.intimp.2025.114092_b0235","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.intimp.2025.114092_b0240","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.intimp.2025.114092_b0245","unstructured":"D.S.J.S.D. Biovia, CA, USA, Discovery studio visualizer, 936 (2017)."},{"key":"10.1016\/j.intimp.2025.114092_b0250","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fct.2014.01.026","article-title":"Mitigation of 5-Fluorouracil induced renal toxicity by chrysin via targeting oxidative stress and apoptosis in wistar rats","volume":"66","author":"Rashid","year":"2014","journal-title":"Food Chem. Toxicol."},{"issue":"12","key":"10.1016\/j.intimp.2025.114092_b0255","doi-asserted-by":"crossref","first-page":"9681","DOI":"10.3390\/curroncol29120760","article-title":"The Nephrotoxicity of Drugs Used in Causal Oncological Therapies","volume":"29","author":"Ha\u0142ka","year":"2022","journal-title":"Current Oncology (toronto, Ont.)"},{"issue":"8","key":"10.1016\/j.intimp.2025.114092_b0260","first-page":"777","article-title":"Melatonin protected against kidney impairment induced by 5-fluorouracil in mice, Journal of experimental zoology","volume":"339","author":"Elbanan","year":"2023","journal-title":"Part a, Ecological and Integrative Physiology"},{"issue":"6","key":"10.1016\/j.intimp.2025.114092_b0265","first-page":"2538","article-title":"Effects of adenosine triphosphate, Lacidipine, and Benidipine on 5-fluorouracil-induced kidney damage in rats","volume":"28","author":"Dagel","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.intimp.2025.114092_b0270","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.2147\/JIR.S389017","article-title":"Effect of Telmisartan and Quercetin in 5 Fluorouracil-Induced Renal Toxicity in Rats","volume":"15","author":"Ali","year":"2022","journal-title":"J. Inflamm. Res."},{"issue":"12","key":"10.1016\/j.intimp.2025.114092_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2021.101513","article-title":"Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in chicks","volume":"100","author":"Gao","year":"2021","journal-title":"Poult. Sci."},{"key":"10.1016\/j.intimp.2025.114092_b0280","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.intimp.2018.01.031","article-title":"Morin hydrate ameliorates cisplatin-induced ER stress, inflammation and autophagy in HEK-293 cells and mice kidney via PARP-1 regulation","volume":"56","author":"Singh","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.intimp.2025.114092_b0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111190","article-title":"Protective effects of morin against acrylamide-induced hepatotoxicity and nephrotoxicity: A multi-biomarker approach","volume":"138","author":"Kandemir","year":"2020","journal-title":"Food Chem. Toxicol."},{"issue":"3","key":"10.1016\/j.intimp.2025.114092_b0290","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bone.2004.04.027","article-title":"Effects of acute 5-fluorouracil chemotherapy and insulin-like growth factor-I pretreatment on growth plate cartilage and metaphyseal bone in rats","volume":"35","author":"Xian","year":"2004","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.intimp.2025.114092_b0295","first-page":"304","volume":"42","author":"Kinhult","year":"2003","journal-title":"Effects of Probucol on Endothelial Damage by 5-Fluorouracil"},{"key":"10.1016\/j.intimp.2025.114092_b0300","first-page":"580","article-title":"Evaluation of Protective effect of reduced Glutathione on 5-Fluorouracil-induced changes in","volume":"3","author":"Ray","year":"2011","journal-title":"Cholesterol Profile, Int.J. PharmTech Res."},{"key":"10.1016\/j.intimp.2025.114092_b0305","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/bs.vh.2022.09.002","article-title":"The antioxidant glutathione","volume":"121","author":"Averill-Bates","year":"2023","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.intimp.2025.114092_b0310","doi-asserted-by":"crossref","unstructured":"K. Aquilano, S. Baldelli, M.R. Ciriolo, Glutathione: new roles in redox signaling for an old antioxidant, 5 (2014).","DOI":"10.3389\/fphar.2014.00196"},{"issue":"34","key":"10.1016\/j.intimp.2025.114092_b0315","doi-asserted-by":"crossref","first-page":"47046","DOI":"10.1007\/s11356-021-13969-5","article-title":"The protective effects of hesperidin and curcumin on 5-fluorouracil-induced nephrotoxicity in mice","volume":"28","author":"Gelen","year":"2021","journal-title":"Environ Sci Pollut Res Int"},{"issue":"8","key":"10.1016\/j.intimp.2025.114092_b0320","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1080\/0886022X.2016.1209380","article-title":"Protective effect of Bu-zhong-yi-qi decoction, the water extract of Chinese traditional herbal medicine, on 5-fluorouracil-induced renal injury in mice","volume":"38","author":"Xiong","year":"2016","journal-title":"Ren Fail"},{"issue":"7","key":"10.1016\/j.intimp.2025.114092_b0325","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.jsps.2023.05.021","article-title":"Sinapic acid alleviates 5-fluorouracil-induced nephrotoxicity in rats via Nrf2\/HO-1 signalling","volume":"31","author":"Ahmad Ansari","year":"2023","journal-title":"Saudi Pharm J"},{"issue":"8","key":"10.1016\/j.intimp.2025.114092_b0330","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1080\/0886022X.2016.1209383","article-title":"Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity","volume":"38","author":"Kaltalioglu","year":"2016","journal-title":"Ren. Fail."},{"issue":"8","key":"10.1016\/j.intimp.2025.114092_b0335","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1177\/0960327111431090","article-title":"Effects of morin-5'-sulfonic acid sodium salt (NaMSA) on cyclophosphamide-induced changes in oxido-redox state in rat liver and kidney","volume":"31","author":"Merwid-L\u0105d","year":"2012","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.intimp.2025.114092_b0340","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8416763","article-title":"Oxidative Stress: Harms and Benefits for Human Health","volume":"2017","author":"Pizzino","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"10.1016\/j.intimp.2025.114092_b0345","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.freeradbiomed.2004.02.074","article-title":"Nrf2 signaling in coordinated activation of antioxidant gene expression","volume":"36","author":"Jaiswal","year":"2004","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.intimp.2025.114092_b0350","doi-asserted-by":"crossref","unstructured":"Q. Ma, Role of Nrf2 in Oxidative Stress and Toxicity, 53(Volume 53, 2013) (2013) 401-426.","DOI":"10.1146\/annurev-pharmtox-011112-140320"},{"key":"10.1016\/j.intimp.2025.114092_b0355","doi-asserted-by":"crossref","first-page":"e005","DOI":"10.1621\/nrs.08005","article-title":"Deciphering the nuclear bile acid receptor FXR paradigm","volume":"8","author":"Modica","year":"2010","journal-title":"Nucl Recept Signal"},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0360","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1681\/ASN.2017020222","article-title":"FXR\/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity","volume":"29","author":"Wang","year":"2018","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.intimp.2025.114092_b0365","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1074\/jbc.M115.694323","article-title":"Farnesoid X Receptor Protects against Kidney Injury in Uninephrectomized Obese Mice","volume":"291","author":"Gai","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.intimp.2025.114092_b0370","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102382","article-title":"Farnesoid X receptor protects against cisplatin-induced acute kidney injury by regulating the transcription of ferroptosis-related genes","volume":"54","author":"Kim","year":"2022","journal-title":"Redox Biol"},{"issue":"24","key":"10.1016\/j.intimp.2025.114092_b0375","article-title":"Nanogold Particles Suppresses 5-Flurouracil-Induced Renal Injury: An Insight into the Modulation of Nrf-2 and Its Downstream Targets, HO-1 and \u03b3-GCS, Molecules (Basel","volume":"26","author":"El-Sherbiny","year":"2021","journal-title":"Switzerland)"},{"issue":"3","key":"10.1016\/j.intimp.2025.114092_b0380","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2174\/011871529X274030231102065433","article-title":"Amelioration of 5-Fluorouracil Induced Nephrotoxicity by Acacia catechu through Overcoming Oxidative Damage and Inflammation in Wistar Rats","volume":"23","author":"Gadekar","year":"2023","journal-title":"Cardiovasc. Hematol. Disord. Drug Targets"},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0385","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.intimp.2015.07.009","article-title":"Renoprotective mechanisms of morin in cisplatin-induced kidney injury","volume":"28","author":"Wei","year":"2015","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0390","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/sj.ki.5002242","article-title":"Cisplatin-induced nephrotoxicity is mediated by tumor necrosis factor-alpha produced by renal parenchymal cells","volume":"72","author":"Zhang","year":"2007","journal-title":"Kidney Int."},{"issue":"1","key":"10.1016\/j.intimp.2025.114092_b0395","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1742-4658.2009.07366.x","article-title":"ERK and cell death: mechanisms of ERK-induced cell death\u2013apoptosis, autophagy and senescence","volume":"277","author":"Cagnol","year":"2010","journal-title":"FEBS J."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925000815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925000815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T19:59:14Z","timestamp":1740599954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925000815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":79,"alternative-id":["S1567576925000815"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114092","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morin Mitigates 5-Fluorouracil-Induced Nephrotoxicity by Activating Nrf2\/HO-1 and FXR, and Suppressing ERK\/VCAM-1 and NF-\u03baB Pathways","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114092"}}