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Agric. Food Chem."},{"issue":"4","key":"10.1016\/j.intimp.2025.114111_b1165","doi-asserted-by":"crossref","first-page":"632","DOI":"10.3892\/etm.2022.11569","article-title":"Citrulline protects against LPS\u2011induced acute lung injury by inhibiting ROS\/NLRP3\u2011dependent pyroptosis and apoptosis via the Nrf2 signaling pathway [J]","volume":"24","author":"Xue","year":"2022","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.intimp.2025.114111_b1170","doi-asserted-by":"crossref","unstructured":"HE G, CHEN K, WANG H, et al. Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP\/NLRP3\/GSDMD pathway [J]. European journal of pharmacology, 2022, 926(175047.","DOI":"10.1016\/j.ejphar.2022.175047"},{"key":"10.1016\/j.intimp.2025.114111_b1175","doi-asserted-by":"crossref","unstructured":"LIU B, WANG Z, HE R, et al. Buformin alleviates sepsis-induced acute lung injury via inhibiting NLRP3-mediated pyroptosis through an AMPK-dependent pathway [J]. 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