{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:08:17Z","timestamp":1792886897805,"version":"4.5.0"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010618","name":"Guangzhou University of Chinese Medicine","doi-asserted-by":"publisher","award":["A1-2606-24-415-110Z07"],"award-info":[{"award-number":["A1-2606-24-415-110Z07"]}],"id":[{"id":"10.13039\/501100010618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.intimp.2025.114214","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T08:06:10Z","timestamp":1739433970000},"page":"114214","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Study on the effect and mechanism of ZeXie decoction in treating MSU-induced acute gouty arthritis model through PI3K-AKT-mTOR signaling pathway"],"prefix":"10.1016","volume":"150","author":[{"given":"Mei-Feng","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-bao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Na","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Song","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Ping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8510-6127","authenticated-orcid":false,"given":"Qiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114214_b0005","doi-asserted-by":"crossref","DOI":"10.34133\/research.0373","article-title":"Spatiotemporal Observation of Monosodium Urate Crystals Deposition in Synovial Organoids Using Label-Free Stimulated Raman Scattering","volume":"7","author":"Chen","year":"2024","journal-title":"Research"},{"issue":"2","key":"10.1016\/j.intimp.2025.114214_b0010","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/BOR.0000000000000861","article-title":"Update on gout management: what is old and what is new","volume":"34","author":"Afinogenova","year":"2022","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.intimp.2025.114214_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117262","article-title":"Fuling-Zexie formula attenuates hyperuricemia-induced nephropathy and inhibits JAK2\/STAT3 signaling and NLRP3 inflammasome activation in mice","volume":"319","author":"Lu","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114214_b0020","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-024-02539-9","article-title":"Mild hyperthermia enhanced synergistic uric acid degradation and multiple ROS elimination for an effective acute gout therapy","volume":"22","author":"Zhao","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.intimp.2025.114214_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139444","article-title":"Food-derived bioactive peptides with anti-hyperuricemic activity: A comprehensive review","volume":"451","author":"Mehmood","year":"2024","journal-title":"Food Chem."},{"key":"10.1016\/j.intimp.2025.114214_b0030","doi-asserted-by":"crossref","DOI":"10.1038\/s41584-024-01117-5","article-title":"Treat-to-target or treat-to-dissolve strategy to improve gout treatment","author":"Richette","year":"2024","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.intimp.2025.114214_b0035","doi-asserted-by":"crossref","unstructured":"C. Javed, R. Noreen, S.g. Niazi, M.M. Kiyani, Q. Ul Ain, Anti-gouty arthritis and anti-inflammatory effects of curcumin nanoparticles in monosodium urate crystals induced Balb\/C mice, Inflammopharmacology 32(3) (2024) 1929-1940.doi:10.1007\/s10787-024-01450-x.","DOI":"10.1007\/s10787-024-01450-x"},{"key":"10.1016\/j.intimp.2025.114214_b0040","doi-asserted-by":"crossref","unstructured":"S.K. Rai, S. Wang, Y. Hu, F.B. Hu, M. Wang, H.K. Choi, Q. Sun, Adherence to Healthy and Unhealthy Plant-Based Diets and the Risk of Gout, JAMA Netw. Open 7(5) (2024).doi:10.1001\/jamanetworkopen.2024.11707.","DOI":"10.1001\/jamanetworkopen.2024.11707"},{"key":"10.1016\/j.intimp.2025.114214_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155036","article-title":"Zexie decoction reduce glucose-dependent lipid accumulation and oxidative stress in Caenorhabditis elegans","volume":"120","author":"Shi","year":"2023","journal-title":"Phytomedicine"},{"issue":"2","key":"10.1016\/j.intimp.2025.114214_b0050","doi-asserted-by":"crossref","first-page":"375","DOI":"10.21147\/j.issn.1000-9604.2019.02.12","article-title":"Alisol B 23-acetate-induced HepG2 hepatoma cell death through mTOR signaling-initiated G 1 cell cycle arrest and apoptosis: A quantitative proteomic study","volume":"31","author":"Xia","year":"2019","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.intimp.2025.114214_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.1045805","article-title":"Dietary intake of fructose increases purine de novo synthesis: A crucial mechanism for hyperuricemia","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Nutr."},{"issue":"44","key":"10.1016\/j.intimp.2025.114214_b0060","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehab619","article-title":"Cardiovascular risk associated with allopurinol vs. benzbromarone in patients with gout","volume":"42","author":"Kang","year":"2021","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.intimp.2025.114214_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.661282","article-title":"Association Between Chinese Herbal Medicine Therapy and the Risk of Chronic Kidney Disease in Gout Patients","volume":"12","author":"Xiao","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"5","key":"10.1016\/j.intimp.2025.114214_b0070","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1161\/ATVBAHA.124.319851","article-title":"Colchicine's Role in Cardiovascular Disease Management","volume":"44","author":"Buckley","year":"2024","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.intimp.2025.114214_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109112","article-title":"Study on the effect and mechanism of quercetin in treating gout arthritis","volume":"111","author":"Feng","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"22","key":"10.1016\/j.intimp.2025.114214_b0080","first-page":"6183","article-title":"Zexie Decoction regulates Akt\/TFEB signaling pathway to promote lipophagy in hepatocytes","volume":"47","author":"Wang","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.intimp.2025.114214_b0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbrc.2022.09.097","article-title":"ZeXie decoction alleviates non-alcoholic fatty liver disease in rats: the study of genes, lipids, and gut microbiotas","volume":"632","author":"Zhang","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.intimp.2025.114214_b0090","doi-asserted-by":"crossref","unstructured":"W. Zhou, X. Han, Y. Wu, G. Shi, S. Xu, M. Wang, W. Yuan, J. Cui, Z. Li, High-performance grating-like SERS substrate based on machine learning for ultrasensitive detection of Zexie-Baizhu decoction, Heliyon 10(9) (2024).doi:10.1016\/j.heliyon.2024.e30499.","DOI":"10.1016\/j.heliyon.2024.e30499"},{"issue":"1","key":"10.1016\/j.intimp.2025.114214_b0095","doi-asserted-by":"crossref","first-page":"294","DOI":"10.7150\/ijbs.78097","article-title":"Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury","volume":"19","author":"Zhang","year":"2023","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.intimp.2025.114214_b0100","doi-asserted-by":"crossref","unstructured":"K. Futosi, T. Nemeth, A.I. Horvath, C.L. Abram, S. Tusnady, C.A. Lowell, Z. Helyes, A. Mocsai, Myeloid Src-family kinases are critical for neutrophil-mediated autoinflammation in gout and motheaten models, J. Exp. Med. 220(7) (2023).doi:10.1084\/jem.20221010.","DOI":"10.1084\/jem.20221010"},{"issue":"5","key":"10.1016\/j.intimp.2025.114214_b0105","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1136\/annrheumdis-2018-214656","article-title":"mTOR inhibition by metformin impacts monosodium urate crystal-induced inflammation and cell death in gout: a prelude to a new add-on therapy?","volume":"78","author":"Vazirpanah","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.intimp.2025.114214_b0110","article-title":"3 \u03b2,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy, Evid.-based Complement Altern","volume":"2022","author":"Lou","year":"2022","journal-title":"Med."},{"key":"10.1016\/j.intimp.2025.114214_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115875","article-title":"Qingre Huazhuo Jiangsuan Decoction promotes autophagy by inhibiting PI3K\/AKT\/mTOR signaling pathway to relieve acute gouty arthritis","volume":"302","author":"Liu","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"10","key":"10.1016\/j.intimp.2025.114214_b0120","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s41374-022-00798-4","article-title":"Distinct macrophage polarization in acute and chronic gout","volume":"102","author":"Zhao","year":"2022","journal-title":"Lab. Invest."},{"issue":"1","key":"10.1016\/j.intimp.2025.114214_b0125","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/JLB.3HI0518-193R","article-title":"Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated arachidonic acid metabolism in macrophages by salidroside alleviates gouty arthritis","volume":"105","author":"Liu","year":"2019","journal-title":"J. Leukoc. Biol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925002048?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925002048?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T04:18:08Z","timestamp":1763785088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925002048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":25,"alternative-id":["S1567576925002048"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114214","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Study on the effect and mechanism of ZeXie decoction in treating MSU-induced acute gouty arthritis model through PI3K-AKT-mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114214","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114214"}}