{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:10:54Z","timestamp":1785114654605,"version":"3.55.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"The First Hospital of Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004032","name":"Jilin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004032","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.intimp.2025.114220","type":"journal-article","created":{"date-parts":[[2025,2,9]],"date-time":"2025-02-09T12:57:43Z","timestamp":1739105863000},"page":"114220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning"],"prefix":"10.1016","volume":"149","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-7892","authenticated-orcid":false,"given":"Yongjie","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiquan","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenshan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinwei","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aijun","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5101-9906","authenticated-orcid":false,"given":"Longfei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7721-5304","authenticated-orcid":false,"given":"Shaokun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.intimp.2025.114220_b0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/S1474-4422(21)00464-6","article-title":"Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials","volume":"21","author":"Zipser","year":"2022","journal-title":"Lancet. Neurol."},{"issue":"3","key":"10.1016\/j.intimp.2025.114220_b0010","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/s41393-021-00695-5","article-title":"Epidemiologic changes in nontraumatic spinal cord injury for the last 30 years (1990-2019) in South Korea","volume":"60","author":"Lee","year":"2022","journal-title":"Spinal Cord"},{"issue":"4","key":"10.1016\/j.intimp.2025.114220_b0015","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1602\/neurorx.1.4.424","article-title":"Cellular transplantation strategies for spinal cord injury and translational neurobiology","volume":"1","author":"Reier","year":"2004","journal-title":"NeuroRx: J. Am. Soc. Exp. NeuroTherapeutics"},{"key":"10.1016\/j.intimp.2025.114220_b0020","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neuroscience.2014.12.061","article-title":"Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury","volume":"289","author":"Wang","year":"2015","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.intimp.2025.114220_b0025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tins.2019.11.005","article-title":"Fiery Cell Death: Pyroptosis in the Central Nervous System","volume":"43","author":"McKenzie","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.intimp.2025.114220_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105069","article-title":"Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals","volume":"160","author":"Abbaszadeh","year":"2020","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.114220_b0035","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12992","article-title":"Programmed cell death in spinal cord injury pathogenesis and therapy","volume":"54","author":"Shi","year":"2021","journal-title":"Cell Prolif."},{"issue":"10","key":"10.1016\/j.intimp.2025.114220_b0040","doi-asserted-by":"crossref","first-page":"e3090","DOI":"10.1038\/cddis.2017.490","article-title":"Neuron and microglia\/macrophage-derived FGF10 activate neuronal FGFR2\/PI3K\/Akt signaling and inhibit microglia\/macrophages TLR4\/NF-\u03baB-dependent neuroinflammation to improve functional recovery after spinal cord injury","volume":"8","author":"Chen","year":"2017","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.intimp.2025.114220_b0045","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nchembio.83","article-title":"Identification of RIP1 kinase as a specific cellular target of necrostatins","volume":"4","author":"Degterev","year":"2008","journal-title":"Nat. Chem. Biol."},{"issue":"5","key":"10.1016\/j.intimp.2025.114220_b0050","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00497-16","article-title":"The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process","volume":"37","author":"Huang","year":"2017","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.intimp.2025.114220_b0055","doi-asserted-by":"crossref","first-page":"e269","DOI":"10.1002\/ctm2.269","article-title":"CD73 alleviates GSDMD-mediated microglia pyroptosis in spinal cord injury through PI3K\/AKT\/Foxo1 signaling","volume":"11","author":"Xu","year":"2021","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.intimp.2025.114220_b0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fncel.2017.00063","article-title":"NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies","volume":"11","author":"Song","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.intimp.2025.114220_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117138","article-title":"A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications","volume":"240","author":"Yu","year":"2020","journal-title":"Life Sci."},{"issue":"13","key":"10.1016\/j.intimp.2025.114220_b0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.intimp.2025.114220_b0075","doi-asserted-by":"crossref","first-page":"787","DOI":"10.4049\/jimmunol.0901363","article-title":"Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression","volume":"183","author":"Bauernfeind","year":"2009","journal-title":"J. Immunol. (Baltimore, Md. 1950)"},{"key":"10.1016\/j.intimp.2025.114220_b0080","doi-asserted-by":"crossref","unstructured":"Barrett, T., Wilhite, S.E., Ledoux, P., et al., NCBI GEO: archive for functional genomics data sets--update, Nucleic acids research 41(Database issue) (2013) D991-5. DOI: 10.1093\/nar\/gks1193.","DOI":"10.1093\/nar\/gks1193"},{"key":"10.1016\/j.intimp.2025.114220_b0085","article-title":"Combination of single-cell and bulk RNA seq reveals the immune infiltration landscape and targeted therapeutic drugs in spinal cord injury","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Immunol."},{"issue":"7","key":"10.1016\/j.intimp.2025.114220_b0090","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.intimp.2025.114220_b0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"issue":"1","key":"10.1016\/j.intimp.2025.114220_b0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41698-024-00570-5","article-title":"Pan-cancer evaluation of regulated cell death to predict overall survival and immune checkpoint inhibitor response","volume":"8","author":"Zhang","year":"2024","journal-title":"npj Precis. Oncol."},{"issue":"12","key":"10.1016\/j.intimp.2025.114220_b0105","first-page":"1572","article-title":"ConsensusClusterPlus: a class discovery tool with confidence assessments and item tracking","volume":"26","author":"Wilkerson","year":"2010","journal-title":"Bioinformatics (oxford, England)"},{"issue":"D1","key":"10.1016\/j.intimp.2025.114220_b0110","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.intimp.2025.114220_b0115","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s13148-019-0730-1","article-title":"Statistical predictions with glmnet","volume":"11","author":"Engebretsen","year":"2019","journal-title":"Clin. Epigenetics"},{"issue":"1","key":"10.1016\/j.intimp.2025.114220_b0120","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1186\/s12859-018-2451-4","article-title":"SVM-RFE: selection and visualization of the most relevant features through non-linear kernels","volume":"19","author":"Sanz","year":"2018","journal-title":"BMC Bioinf."},{"issue":"7269","key":"10.1016\/j.intimp.2025.114220_b0125","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nature08460","article-title":"Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1","volume":"462","author":"Barbie","year":"2009","journal-title":"Nature"},{"issue":"43","key":"10.1016\/j.intimp.2025.114220_b0130","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"PNAS"},{"issue":"11","key":"10.1016\/j.intimp.2025.114220_b0135","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"3","key":"10.1016\/j.intimp.2025.114220_b0140","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/s41593-020-0597-7","article-title":"Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2","volume":"23","author":"Zhou","year":"2020","journal-title":"Nat. Neurosci."},{"issue":"23","key":"10.1016\/j.intimp.2025.114220_b0145","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202201319","article-title":"Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5","volume":"11","author":"Ma","year":"2022","journal-title":"Adv. Healthc. Mater."},{"issue":"1","key":"10.1016\/j.intimp.2025.114220_b0150","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s12951-023-01986-0","article-title":"UTX deletion promotes M2 macrophage polarization by epigenetically regulating endothelial cell-macrophage crosstalk after spinal cord injury","volume":"21","author":"Peng","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.intimp.2025.114220_b0155","unstructured":"Huang, T., Shen, J., Lin, J., et al., [Effect of M2-like macrophage\/microglia-derived mitochondria transplantation in treatment of mouse spinal cord injury], Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 36(6) (2022) 751-759. DOI: 10.7507\/1002-1892.202201040."},{"issue":"2","key":"10.1016\/j.intimp.2025.114220_b0160","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41556-023-01339-x","article-title":"Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders","volume":"26","author":"Wang","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"52","key":"10.1016\/j.intimp.2025.114220_b0165","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2112095118","article-title":"Neuronal ROS-induced glial lipid droplet formation is altered by loss of Alzheimer's disease-associated genes","volume":"118","author":"Moulton","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.intimp.2025.114220_b0170","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85279","article-title":"Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease","volume":"12","author":"Daniels","year":"2023","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.intimp.2025.114220_b0175","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/jnc.15032","article-title":"Cathepsin B inhibition blocks neurite outgrowth in cultured neurons by regulating lysosomal trafficking and remodeling","volume":"155","author":"Jiang","year":"2020","journal-title":"J. Neurochem."},{"key":"10.1016\/j.intimp.2025.114220_b0180","article-title":"Blocking M2-like macrophage polarization using decoy oligodeoxynucleotide-based gene therapy prevents immune evasion for pancreatic cancer treatment","author":"Chen","year":"2024","journal-title":"Mol. Cancer Ther."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925002103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925002103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T01:02:36Z","timestamp":1740618156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925002103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":36,"alternative-id":["S1567576925002103"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114220","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis and validation of programmed cell death genes associated with spinal cord injury progression based on bioinformatics and machine learning","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114220"}}