{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T20:32:08Z","timestamp":1779309128563,"version":"3.51.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["IPA\/2020\/000007"],"award-info":[{"award-number":["IPA\/2020\/000007"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["P\/569\/2016\\u20131\/TDT"],"award-info":[{"award-number":["P\/569\/2016\\u20131\/TDT"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Immunopharmacology"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.intimp.2025.114295","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:42:11Z","timestamp":1740026531000},"page":"114295","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Evaluation of Immunopharmacological efficacy of live Leishmania donovani overexpressing Ld_\u03b61domain for protection against experimental human visceral Leishmaniasis."],"prefix":"10.1016","volume":"151","author":[{"given":"Ruby","family":"Bansal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadat","family":"Shafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prachi","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aakriti","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neha","family":"Jha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhalak","family":"Singhal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gajala Deethamvali Ghouse","family":"Peer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramendra Pati","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Subhajit","family":"Basu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shailja","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.intimp.2025.114295_bb0005","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12879-024-09069-7","article-title":"Isoenzyme characterization of Leishmania infantum toward checking the antioxidant activity of superoxide dismutase and glutathione peroxidase","volume":"24","author":"Alishvandi","year":"2024","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.intimp.2025.114295_bb0010","unstructured":"Leishmaniasis, (n.d.). https:\/\/www.who.int\/health-topics\/leishmaniasis (accessed July 4, 2024)."},{"key":"10.1016\/j.intimp.2025.114295_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2020.579891","article-title":"Use of natural products in Leishmaniasis chemotherapy: an overview","volume":"8","author":"Gervazoni","year":"2020","journal-title":"Front. Chem."},{"key":"10.1016\/j.intimp.2025.114295_bb0020","doi-asserted-by":"crossref","first-page":"S153","DOI":"10.1016\/j.vaccine.2023.01.057","article-title":"Vaccine value profile for leishmaniasis","volume":"41","author":"Kaye","year":"2023","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2025.114295_bb0025","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1326369","article-title":"Live attenuated-nonpathogenic Leishmania and DNA structures as promising vaccine platforms against leishmaniasis: innovations can make waves","volume":"15","author":"Seyed","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2025.114295_bb0030","doi-asserted-by":"crossref","first-page":"17065","DOI":"10.1038\/s41598-020-74154-1","article-title":"Photodynamic inactivation of Leishmania braziliensis doubly sensitized with uroporphyrin and diamino-phthalocyanine activates effector functions of macrophages in vitro","volume":"10","author":"Sharma","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.intimp.2025.114295_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41541-022-00449-1","article-title":"Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis","volume":"7","author":"Volpedo","year":"2022","journal-title":"Npj Vaccines"},{"key":"10.1016\/j.intimp.2025.114295_bb0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004963","article-title":"Live attenuated Leishmania donovani Centrin Knock out parasites generate non-inferior protective immune response in aged mice against visceral Leishmaniasis","volume":"10","author":"Bhattacharya","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.intimp.2025.114295_bb0045","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1128\/IAI.70.1.62-68.2002","article-title":"Reduced infectivity of a Leishmania donovani Biopterin transporter genetic mutant and its use as an attenuated strain for vaccination","volume":"70","author":"Papadopoulou","year":"2002","journal-title":"Infect. Immun."},{"issue":"190","key":"10.1016\/j.intimp.2025.114295_bb0050","first-page":"2138","article-title":"Live attenuated Leishmania donovani p27 gene knockout parasites are non-pathogenic and elicit long term protective immunity in BALB\/c mice","volume":"1950","author":"Dey","year":"2013","journal-title":"J. Immunol. Baltim. Md"},{"key":"10.1016\/j.intimp.2025.114295_bb0055","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1046\/j.1365-2958.2001.02286.x","article-title":"Characterization of the A2\u2013A2rel gene cluster in Leishmania donovani: involvement of A2 in visceralization during infection","volume":"39","author":"Zhang","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.intimp.2025.114295_bb0060","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.179.5.3161","article-title":"SIR2-deficient Leishmania infantum induces a defined IFN-\u03b3\/IL-10 pattern that correlates with Protection1","volume":"179","author":"Silvestre","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.intimp.2025.114295_bb0065","unstructured":"Molecular Study of Acinetobacter baumannii that Lacking Some Essentials Genes Responsible of Toxin-Antitoxin System - PubMed, (n.d.). https:\/\/pubmed.ncbi.nlm.nih.gov\/35891726\/ (accessed June 5, 2024)."},{"key":"10.1016\/j.intimp.2025.114295_bb0070","doi-asserted-by":"crossref","first-page":"732","DOI":"10.3389\/fmicb.2018.00732","article-title":"The higBA toxin-antitoxin module from the opportunistic pathogen Acinetobacter baumannii - regulation, activity, and evolution","volume":"9","author":"Armalyt\u0117","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.intimp.2025.114295_bb0075","doi-asserted-by":"crossref","DOI":"10.1117\/12.827439","article-title":"Toxins and antimicrobial peptides: interactions with membranes","volume":"7397","author":"Schlamadinger","year":"2009","journal-title":"Proc. SPIE"},{"key":"10.1016\/j.intimp.2025.114295_bb0080","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00253-021-11134-z","article-title":"Toxin-antitoxin systems and their medical applications: current status and future perspective","volume":"105","author":"Srivastava","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.intimp.2025.114295_bb0085","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/1873-3468.13429","article-title":"Identification and functional characterization of a bacterial homologue of zeta toxin in Leishmania donovani","volume":"593","author":"Srivastava","year":"2019","journal-title":"FEBS Lett."},{"key":"10.1016\/j.intimp.2025.114295_bb0090","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1022448","article-title":"Three types of Leishmania mexicana amastigotes: proteome comparison by quantitative proteomic analysis","volume":"12","author":"Pacakova","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.intimp.2025.114295_bb0095","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cyto.2009.10.003","article-title":"Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFalpha and IL-1beta","volume":"49","author":"Hong","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.intimp.2025.114295_bb0100","article-title":"Phenotypical characterization of spleen remodeling in murine experimental visceral Leishmaniasis","volume":"11","author":"de Melo","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.intimp.2025.114295_bb0105","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.3390\/pathogens10111356","article-title":"Hepatomegaly associated with non-obstructive sinusoidal dilation in experimental visceral Leishmaniasis","volume":"10","author":"Maeda","year":"2021","journal-title":"Pathogens"},{"issue":"179","key":"10.1016\/j.intimp.2025.114295_bb0110","first-page":"3161","article-title":"SIR2-deficient Leishmania infantum induces a defined IFN-gamma\/IL-10 pattern that correlates with protection","volume":"1950","author":"Silvestre","year":"2007","journal-title":"J. Immunol. Baltim. Md"},{"key":"10.1016\/j.intimp.2025.114295_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006854","article-title":"EAPB0503: an Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica","volume":"12","author":"El Hajj","year":"2018","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.intimp.2025.114295_bb0120","doi-asserted-by":"crossref","unstructured":"Toxin release by conditional remodelling of ParDE1 from Mycobacterium tuberculosis leads to gyrase inhibition | Nucleic Acids Research | Oxford Academic, (n.d.). https:\/\/academic.oup.com\/nar\/article\/52\/4\/1909\/7479384 (accessed June 5, 2024).","DOI":"10.1093\/nar\/gkad1220"},{"key":"10.1016\/j.intimp.2025.114295_bb0125","doi-asserted-by":"crossref","unstructured":"S. Masachis, N.J. Tourasse, C. Lays, M. Faucher, S. Chabas, I. Iost, F. Darfeuille, A genetic selection reveals functional metastable structures embedded in a toxin-encoding mRNA, ELife 8 (n.d.) e47549. Doi: https:\/\/doi.org\/10.7554\/eLife.47549.","DOI":"10.7554\/eLife.47549"},{"key":"10.1016\/j.intimp.2025.114295_bb0130","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.micinf.2015.04.003","article-title":"Inducible suicide vector systems for Trypanosoma cruzi","volume":"17","author":"Ma","year":"2015","journal-title":"Microbes Infect."},{"key":"10.1016\/j.intimp.2025.114295_bb0135","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1021\/acschembio.2c00518","article-title":"Development of a new DHFR-based destabilizing domain with enhanced basal turnover and applicability in mammalian systems","volume":"17","author":"Nakahara","year":"2022","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.intimp.2025.114295_bb0140","doi-asserted-by":"crossref","first-page":"7583","DOI":"10.1073\/pnas.0901698106","article-title":"Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins","volume":"106","author":"Madeira da Silva","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.intimp.2025.114295_bb0145","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1017\/S0031182013000012","article-title":"BnSP-7 toxin, a basic phospholipase A2 from Bothrops pauloensis snake venom, interferes with proliferation, ultrastructure and infectivity of Leishmania (Leishmania) amazonensis","volume":"140","author":"Nunes","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/j.intimp.2025.114295_bb0150","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/pathogens9020079","article-title":"Suicidal Leishmania","volume":"9","author":"Pode\u0161vov\u00e1","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.intimp.2025.114295_bb0155","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.molbiopara.2017.03.008","article-title":"Inducible protein stabilization system in Leishmania mexicana","volume":"214","author":"Pode\u0161vov\u00e1","year":"2017","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.intimp.2025.114295_bb0160","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/tropicalmed8050276","article-title":"Leishmaniasis: immune cells crosstalk in macrophage polarization","volume":"8","author":"Almeida","year":"2023","journal-title":"Trop. Med. Infect. Dis."},{"key":"10.1016\/j.intimp.2025.114295_bb0165","doi-asserted-by":"crossref","unstructured":"A.K. Gupta, S. Das, M. Kamran, S.A. Ejazi, N. Ali, The pathogenicity and virulence of Leishmania - interplay of virulence factors with host defenses, Virulence 13 (n.d.) 903\u2013935. Doi: https:\/\/doi.org\/10.1080\/21505594.2022.2074130.","DOI":"10.1080\/21505594.2022.2074130"},{"key":"10.1016\/j.intimp.2025.114295_bb0170","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.1016\/j.vaccine.2014.05.009","article-title":"Generation of growth arrested Leishmania amastigotes: a tool to develop live attenuated vaccine candidates against visceral leishmaniasis","volume":"32","author":"Selvapandiyan","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2025.114295_bb0175","doi-asserted-by":"crossref","unstructured":"F. Pasha, S. Saleem, T. Nazir, J. Tariq, K. Qureshi, Visceral Leishmaniasis (kala-azar): a triumph against a trickster disease, Cureus 14 (n.d.) e25698. Doi: https:\/\/doi.org\/10.7759\/cureus.25698.","DOI":"10.7759\/cureus.25698"},{"key":"10.1016\/j.intimp.2025.114295_bb0180","doi-asserted-by":"crossref","first-page":"2724","DOI":"10.1016\/j.immuni.2021.09.021","article-title":"Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells","volume":"54","author":"Formaglio","year":"2021","journal-title":"Immunity"},{"key":"10.1016\/j.intimp.2025.114295_bb0185","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.vaccine.2020.11.064","article-title":"Lipophosphoglycan-3 protein from Leishmania infantum chagasi plus saponin adjuvant: a new promising vaccine against visceral leishmaniasis","volume":"39","author":"de Oliveira Emerick","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/j.intimp.2025.114295_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2014.00134","article-title":"Live vaccination tactics: possible approaches for controlling visceral Leishmaniasis","volume":"5","author":"Saljoughian","year":"2014","journal-title":"Front. Immunol."}],"container-title":["International Immunopharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925002851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1567576925002851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T14:43:14Z","timestamp":1741272194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1567576925002851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":38,"alternative-id":["S1567576925002851"],"URL":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114295","relation":{},"ISSN":["1567-5769"],"issn-type":[{"value":"1567-5769","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of Immunopharmacological efficacy of live Leishmania donovani overexpressing Ld_\u03b61domain for protection against experimental human visceral Leishmaniasis.","name":"articletitle","label":"Article Title"},{"value":"International Immunopharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.intimp.2025.114295","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114295"}}